MycoData

Studies have demonstrated the potential for utilizing agro-industrial byproducts for Pleurotus spp. Extracts containing polysaccharides from mushrooms obtained through solid culture, as well as from mycelial biomass obtained through liquid culture (endopolysaccharides), can regulate the immune response and increase….

Immune supportMetabolic health

High relevance

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Exogenous trehalose increased polysaccharide content and altered their properties and metabolism in Lentinula edodes mycelium.

Trehalose promotes polysaccharide synthesis in edible mushrooms, yet its effect on the antioxidant activity and structure of Lentinula edodes mycelium polysaccharides is still unknown. We investigated the effect of trehalose on the antioxidant activity of L.

Immune supportMetabolic health

High relevance

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function

Morchella esculenta, a nutritious and medicinal edible mushroom, has gained an increasing attention due to the bioactive properties of its polysaccharides. This study employed in vitro simulated human digestion and fecal fermentation models to evaluate the effects of M..

Immune supportMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function.

Immune supportMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics

This study isolated a high-molecular-weight Morchella esculenta polysaccharide (MEP-1), mainly composed of glucose with a triple-helix structure. MEP-1 alleviated high-fat diet (HFD)-induced hepatic lipid metabolic disorders and inflammation by significantly reducing the levels of TC, TG, LDL-C, TNF-α, IL-6, and….

Immune supportMetabolic healthLiver support

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics.

Immune supportMetabolic healthLiver support

High relevance

Enoki · 2025 · Research Article · Frontiers in nutrition

Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice.

INTRODUCTION: Mounting evidence has shown that Flammulina velutipes mycorrhizae dietary fiber (Fv-DF) has the potential to significantly improve health outcomes by addressing lipid metabolic disorders..

Metabolic healthLiver support

High relevance

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina Velutipes polysaccharides ameliorate cisplatin-induced acute kidney injury in mice via regulation of gut microbiota and Ferroptosis pathway.

Acute kidney injury (AKI) is a common and serious clinical complication with high incidence. Polysaccharides extracted from Flammulina velutipes (FVPs) have been proven to possess anti-inflammatory and antioxidant properties..

Immune supportMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2025 · Journal Article · Enzyme and microbial technology

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids

Cytochrome P450 monooxygenases (P450) play crucial roles in the diversification of secondary metabolic systems in living organisms. Basidiomycetes produce a wide variety of natural products as secondary metabolites, with their relevance to pharmaceutical and agricultural applications garnering significant interest..

Energy & fatigueMetabolic health

High relevance

Turkey Tail · 2025 · Journal Article · Enzyme and microbial technology

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids.

Energy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Functional characterization of Ganoderma lucidum polysaccharide and the mechanism of inducing tomato resistance to Tomato yellow leaf curl virus.

Using functional polysaccharides as elicitors to induce plant disease resistance has emerged as an effective plant protection strategy. In this study, we found that crude polysaccharides derived from by-products of Ganoderma lucidum can effectively prevent and control the Tomato Yellow Leaf Curl Virus (TYLCV)..

Immune supportEnergy & fatigueMetabolic healthRespiratory

High relevance

Reishi · 2025 · Journal Article · Journal of the science of food and agriculture

Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice.

BACKGROUND: There are few studies about the differences in the composition of moisture, ash, crude protein, crude fat, crude polysaccharide and ergothioneine in Ganoderma lucidum spore powder (GLSP) from different origins. As for GLSP after oil extraction (OE-GLSP), there are still lots of bioactive substance in it..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.

BACKGROUND: Natural aging of the brain is commonly accompanied by a decline in cognitive ability, which is driven by oxidative stress, inflammation, and metabolic dysregulation. These pathological processes are further exacerbated by gut microbiota dysbiosis..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Almond Mushroom · 2025 · Journal Article · International Journal of Biological Macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice

This study aims to isolate and characterize the physicochemical properties and evaluate the cytoprotective and gastroprotective potential of polysaccharides from the Agaricus blazei Murill mushroom (PAbM). The PAbM were isolated and characterized chemically..

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice.

OncologyImmune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

General control nonderepressible 4 activates the transcription of trehalose phosphorylase to improve trehalose production and abiotic stress tolerance in Ganoderma lucidum

Trehalose plays an important role in enhancing abiotic stress tolerance. Although studies have reported the induction of trehalose by adverse environments, the molecular mechanism underlying its induction in fungi is unclear..

Metabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

General control nonderepressible 4 activates the transcription of trehalose phosphorylase to improve trehalose production and abiotic stress tolerance in Ganoderma lucidum.

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Food Research International

Green tea fermented by Ganoderma lucidum presented anti-obesity properties via enhanced thermogenesis in vitro and on C57BL/6J mice

High-fat diets contribute to obesity and metabolic disorders. Ganoderma lucidum is renowned for its abundant bioactive compounds and diverse pharmacological effects.

Metabolic healthLiver support

High relevance

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Green tea fermented by Ganoderma lucidum presented anti-obesity properties via enhanced thermogenesis in vitro and on C57BL/6J mice.

High-fat diets contribute to obesity and metabolic disorders. Ganoderma lucidum is renowned for its abundant bioactive compounds and diverse pharmacological effects.

Metabolic healthLiver support

High relevance

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharides Alleviated Cyclophosphamide-Induced Intestinal Injury Based on Microbiota, Metabolite and Immune Axis Modulation.

Grifola frondosa polysaccharides (GFP), which possess antitumor properties, can counteract intestinal injury induced by cyclophosphamide (CTX). The objective of this research was to evaluate the efficacy of GFP in protecting the intestinal barrier of mice and investigate the mechanisms behind this effect..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.

The functional food application of edible fungus polysaccharides has been widely studied based on their variety of potential pharmacological activities. However, the hepatoprotective effects and mechanisms of Morchella esculenta polysaccharide against nonalcoholic fatty liver disease (NAFLD) remain unknown..

Immune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Hericinosides A-M, Cyathane Diterpene Glycosides with α-Glucosidase Inhibitory Activity from the Medicinal Fungus Hericium erinaceus.

Thirteen new cyathane diterpene glycosides, hericinosides A-M (1-13), and six known analogs, were isolated from the rice media fermentation of the medicinal fungus Hericium erinaceus. The sugar parts of 1 and 2 were highly modified, forming a unique 5/6/7/5/5/5 ring new skeleton system..

Metabolic health

High relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.

Dietary interventions with food-derived natural products have emerged as a promising strategy to alleviate obesity. This study aims to investigate the anti-obesity effect of Hericium erinaceus protein (HEP) and its underlying mechanism..

Metabolic healthGut & microbiomeLiver support

High relevance

Lion's Mane · 2025 · Research Article · Biology

Hypoglycemic Effect of Pleurotus citrinopileatus and Hericium erinaceus Buccal Tablets on Diabetic Mice.

Diabetes mellitus poses a global health challenge, necessitating natural adjuvants with minimal side effects. The aims of this study were to optimize the concentrations of chromium (Cr), zinc (Zn), and germanium (Ge) in the liquid fermentation media of Pleurotus citrinopileatus and Hericium erinaceus and to evaluate….

Metabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Ecotoxicology and environmental safety

Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging.

Long-term formaldehyde (FA) exposure causes cognitive dysfunction, often associated with metabolic disorders. While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease..

Immune supportCognition & nervesMetabolic health

High relevance

Reishi · 2025 · Research Article · Pharmacological reports: PR

Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells.

BACKGROUND: The proper functioning of the nervous system determines the homeostasis of the entire body. There are many known approaches designed to positively stimulate the functions of the central nervous system by applying various plants and fungal extracts, but their course of action is poorly understood..

OncologyCognition & nervesMetabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Influence and underlying mechanism of soluble dietary fiber derived from Ganoderma Lucidum-fermented sweet potato residue on the physicochemical-digestive characteristics of wheat starch.

Chronic overconsumption of starchy foods has been associated with health risks including cardiovascular diseases and diabetes. Soluble dietary fiber (SDF) presents a promising solution for modifying starch-based food products..

Metabolic healthGut & microbiome

High relevance

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Influence of different bond types and polymerization degrees of glucose polymers on the fermentation of Inonotus obliquus for the production of hypoglycemic activity polysaccharides.

This research aimed to investigate the impact of different glycosidic polymers, such as maltose, cellobiose, starch, and β-glucan, on the production of bioactive polysaccharides via deep liquid fermentation using Inonotus obliquus (I. obliquus)..

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · Food chemistry

Innovative submerged directed fermentation: Producing high molecular weight polysaccharides from Ganoderma lucidum.

Polysaccharides from Ganoderma lucidum (GLPs) exhibit unique bioactivity, but traditional cultivation yields low quantities and unstable quality, limiting their research and application..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2025 · Journal Article · Journal of hazardous materials

Integrated enzymatic, transcriptomic, and metabolite identification insights into the degradation of diverse endocrine-disrupting compounds by Pleurotus ostreatus GEMB-PO1.

Endocrine-disrupting compounds (EDCs) represent a significant class of micropollutants that persist in environments and threaten ecological and human health. In this study, the white-rot fungus Pleurotus ostreatus GEMB-PO1 was investigated for its ability to degrade eight representative EDCs-bisphenol A (BPA),….

Metabolic health

High relevance

Reishi · 2025 · Research Article · Frontiers in pharmacology

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.

Granulomatous pulmonary nodules represent a substantial health threat, with no available targeted therapies. Interventions based on medicinal plants approaches are pivotal for prevention and treatment.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Proteomics and Metabolomics Reveal Regulatory Pathways Underlying Quality Differences Between Wild and Cultivated Ophiocordyceps sinensis.

Ophiocordyceps sinensis, is an entomopathogenic fungus renowned for its medicinal properties, thriving in the frigid and high-altitude regions of the Qinghai-Tibet plateau. Given the limited availability of wild resources and the increasing recognition of their medicinal value, the cultivation of O..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Research Article · BMC genomics

Integrated transcriptomic and metabolomic analysis reveals stage-associated molecular profiles in Ophiocordyceps sinensis.

Ophiocordyceps sinensis is globally recognized for its exceptional nutritional and medicinal properties. Variations in the edible qualities and tonic values of O.

Metabolic health

High relevance

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Investigation of the fingerprint-activity relationship of Tremella fuciformis polysaccharides and its mitigating effect on radiation-induced intestinal injury.

The aim of this study was to conduct a comprehensive analysis of the relationship between the fingerprint of Tremella fuciformis polysaccharides (TFPs) sourced from China and their bioactivities, with an emphasis on identifying the most bioactive TFP variety that significantly mitigated radiation-induced intestinal….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the β-1,3-Glucosyltransferase Gene gl20535.

Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. β-1,3-glucosyltransferase (GL20535) plays an important role in polysaccharide synthesis by catalyzing the transfer of UDP-glucose to extend sugar chains, but its underlying mechanism remains unclear..

Immune supportMetabolic health

High relevance

Chaga · 2025 · Journal Article · Chemistry & biodiversity

Microwave Extraction of New Polysaccharides From Inonotus obliquus, Structural Characterization, and Antioxidant Activity.

To address the low extraction yield and structural degradation issues of conventional methods, this study optimized microwave-assisted extraction (61°C, 64 min, 30:1 mL/g ratio) to obtain Inonotus obliquus polysaccharides (IOP), followed by DEAE-52 and Sephadex G-100 purification to isolate two fractions: neutral….

Immune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Mitochondrial energy homeostasis-mediated respiration suppression: A novel mechanism for combating wilting of Hericium erinaceus via electron beam generated X-ray irradiation

This study explored the mechanism of Hericium erinaceus wilting delayed by 1.0 kGy electron-beam generated X-ray (EBGX) irradiation from modulating respiratory pathways and energy homeostasis perspectives..

Energy & fatigueMetabolic healthRespiratory

High relevance

Cordyceps · 2025 · Journal Article · Environmental toxicology

Modulatory Effects of Ophiocordyceps sinensis Mycelia on Hepatosteatosis Development in a High-Fat Dietary Habit.

The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges..

Immune supportMetabolic healthLiver support

High relevance

Yellow Morel · 2025 · Research Article · Biochemistry research international

Morchella esculenta (L.) Pers. Wild of the Province of Taza, Morocco: Toxicity Assessment in In Vitro and In Vivo Models, Antioxidant Activities and Correlation With the Chemical Composition of Aqueous and Organic Extracts.

Mushrooms are a source of nutrients and bioactive substances. This work, carried out for the first time, aims to evaluate in vitro and in vivo toxicity and antioxidant potential of the wild edible mushroom from the province of Taza, Morocco: Morchella esculenta (L.) Pers., the extraction is carried out using two….

Metabolic health

High relevance

Reishi · 2025 · Research Article · Scientific reports

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.

Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Multiomics Provides a New Understanding of the Effect of Temperature Change on the Fermentation Quality of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a medicinal fungus with significant nutritional and utilization value. Temperature is a crucial factor influencing its growth, as temperature changes can impact enzyme activity, metabolite content, and gene expression during fungal cultivation..

OncologyEnergy & fatigueMetabolic health

High relevance

Enoki · 2025 · Journal Article · Food chemistry

Naringenin-loaded Flammulina velutipes chitin-glucan complexes gel system: structural modulation and dual lipid-lowering mechanisms.

This study developed a synergistic lipid-lowering system using chitin-glucan complex (CGC) from Flammulina velutipes through green preparation and structural optimization..

Immune supportMetabolic health

High relevance

Enoki · 2025 · Journal Article · ACS applied materials & interfaces

Photo-Cross-Linked and Photothermal Flammulina velutipes Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing.

Diabetic ulcers remain a persistent global health challenge. Developing therapeutic systems with antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic properties presents a promising strategy for effectively and rapidly treating diabetic wounds and preventing the development of diabetic ulcers..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Oyster Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Pleurotus ostreatus Copper Nanoparticles: In Vitro and In Silico Evaluation of the Antioxidant, Antibacterial, and Antidiabetic Activities.

The rapid growth of nanotechnology has opened new frontiers in biomedical applications, particularly through the use of metal nanoparticles. This study explores the green synthesis of copper nanoparticles (CuNPs) using an aqueous extract of Pleurotus ostreatus (PO-CuNPs) and their characterization through UV-visible….

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Metabolic brain disease

Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation.

Oxidative stress and mitochondrial dynamics imbalance are key contributors to AD pathogenesis. GLPS, an extract from Ganoderma lucidum spores, exhibits anti-inflammatory, antioxidant, and immunomodulatory properties..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2025 · Journal Article · Chemistry & biodiversity

Polysaccharides from Tremella Fuciformis Enhance Glucose and Lipid Metabolism in HepG2 Cells Through Activating the AMPK Signaling Pathway.

Polysaccharides have gained substantial attention for their diverse biological activities. The present study was conucted to elucidate the effects and molecular mechanisms of Tremella fuciformis-derived polysaccharides (PTP-3a) on glucose and lipid metabolism in palmitic acid (PA) - treated HepG2 cells..

Immune supportMetabolic healthLiver support

High relevance

Yellow Morel · 2025 · Journal Article · Food & function

Preparation of Morchella esculenta protein and its preventive effect on nonalcoholic fatty liver disease in mice.

Morchella esculenta is a valuable edible fungus with multidimensional bioactivities; however, research on M. esculenta protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited.

Metabolic healthGut & microbiomeLiver support

High relevance

Shiitake · 2025 · Journal Article · Biological & pharmaceutical bulletin

Protective Effects of Maternal Administration of a Standardized Extract of Cultured Lentinula edodes Mycelia against Radiation-Induced Fetal Morphological Abnormalities

Exposure to ionizing radiation during early pregnancy poses serious risks to fetal development, particularly during organogenesis. In this study, we evaluated the protective effects of AHCC®, a standardized extract of Lentinula edodes mycelia with known immunomodulatory and metabolic properties, using an ICR mouse….

Immune supportMetabolic health

High relevance

Reishi · 2025 · Research Article · BMC genomics

Proteome study of dikaryotic and monokaryotic mycelia reveals the transfer between biological processes contributing to dikaryon growth advantage of the medicinal fungus Ganoderma lucidum.

BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate in its dikaryotic mycelia compared to monokaryons, and this is essential for its fruiting body formation and medicinal utilization..

Energy & fatigueMetabolic health

High relevance

Turkey Tail · 2025 · Journal Article · Phytochemistry

Reverse chemical ecology to study the defense of the plant host Sextonia rubra and the chemical mediators of its endophyte Fusarium falciforme against phytopathogen Trametes versicolor

Sextonia rubra is a tropical tree endemic to the Guiana Shield and the Brazilian Amazon. Despite its renowned wood durability, it remains susceptible to degradation by white-rot fungi such as Trametes versicolor..

Metabolic healthGut & microbiome