MycoData

A new type of acidic exopolysaccharide (AESP-II) was extracted and separated from the fermentation broth of Cordyceps militaris (C. militaris), which was further purified to elucidate its structural characteristics and immunological activity..

Immune supportMetabolic health

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King Oyster · 2022 · Research Article · Molecules (Basel, Switzerland)

Isolation, Structural Characterization, and Hypoglycemic Activities In Vitro of Polysaccharides from Pleurotus eryngii.

Pleurotus eryngii (PE) is an edible mushroom with high nutritional value. Pleurotus eryngii polysaccharides (PEPs) are one of the main active ingredients and manifest a great variety of biological activities..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Lucidumol A, Purified Directly from Ganoderma lucidum, Exhibits Anticancer Effect and Cellular Inflammatory Response in Colorectal Cancer.

Colorectal cancer (CRC) is a deadly disease regardless of sex, and a few therapeutic approaches have been fully developed at advanced stages, even if some strategies have durable clinical benefits, such as immunotherapy and chemotherapy..

OncologyImmune supportSkin & hydration

High relevance

Oyster Mushroom · 2022 · Journal Article · Meat science

Mechanism of improving emulsion stability of emulsion-type sausage with oyster mushroom (Pleurotus ostreatus) powder as a phosphate replacement

This research evaluated the potentiality of oyster mushroom powder (OMP) as a phosphate alternative by improving emulsion stability of emulsion-type sausage. Sausage without phosphate (NC), with 0.2% sodium triphosphate (PC), and with 1 and 2% OMP (M1 and M2) were prepared..

Immune support

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Oyster Mushroom · 2022 · Journal Article · Meat science

Mechanism of improving emulsion stability of emulsion-type sausage with oyster mushroom (Pleurotus ostreatus) powder as a phosphate replacement.

Immune support

High relevance

Cordyceps · 2022 · Journal Article · Ceska a Slovenska farmacie: casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti

Medicinal mushrooms Ophiocordyceps sinensis and Cordyceps militaris.

The main component of Ophiocordyceps sinensis and Cordyceps militaris extracts are polysaccharides. These are natural biopolymers that represent a large class of biologically active components.

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2022 · Research Article · Biomedicines

Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice.

BACKGROUND: A growing body of research suggests that oxidative stress and neuroinflammation are early pathogenic features of neurodegenerative disorders. In recent years, the vitagene system has emerged as a potential target, as it has been shown to have a high neuroprotective power..

OncologyImmune supportCognition & nervesEnergy & fatigue

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King Oyster · 2022 · Journal Article · Journal of food composition and analysis

Naturally methylated mannogalactans from the edible mushrooms Pholiota nameko and Pleurotus eryngii

This study reports the presence of mannogalactans in Pholiota nameko and Pleurotus eryngii edible mushrooms, with their purification and detailed structural characterization. Two mannogalactans (R30PN and E30PN) were reported in P.

OncologyImmune support

High relevance

Shiitake · 2022 · Journal Article · Journal of food biochemistry

Network pharmacology-based study to identify the significant pathways of Lentinula edodes against cancer.

Lentinula edodes (LE) is known as a good food source with potent anticancer efficacy, but its active chemical compounds and pathways against cancer have not been revealed. This study was to uncover the active chemical constituents and pathways of LE against cancer through network pharmacology..

OncologyImmune supportEnergy & fatigue

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Shiitake · 2022 · Journal Article · Journal of food biochemistry

Network pharmacology‐based study to identify the significant pathways of Lentinula edodes against cancer

OncologyImmune supportEnergy & fatigue

High relevance

Cordyceps · 2022 · Journal Article · Journal of agricultural and food chemistry

Novel Selenium Peptides Obtained from Selenium-Enriched Cordyceps militaris Alleviate Neuroinflammation and Gut Microbiota Dysbacteriosis in LPS-Injured Mice.

Increasing attention focuses on the relationship between neuroinflammation and Alzheimer's disease (AD). The reports on the microbiota-gut-brain axis reveal that the regulation by gut microbiota is an effective way to intervene in neuroinflammation-related AD..

Immune supportCognition & nervesGut & microbiome

High relevance

Reishi · 2022 · Journal Article · International journal of biological macromolecules

Novelkaraya gum micro-particles loaded Ganoderma lucidum polysaccharide regulate sex hormones, oxidative stress and inflammatory cytokine levels in cadmium induced testicular toxicity in experimental animals.

Presented research aimed to develop a spray drying process without the use of organic solvents for the preparation of novel Karaya gum polymer microparticles (MPs) of Ganoderma lucidum polysaccharide (GLP). The prepared microparticles were characterized and evaluated..

Immune support

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Cordyceps · 2022 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)

Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus.

The purpose of this study was to express human FGF21 (hFGF21) using Cordyceps militaris (C. militaris) as a bioreactor and to observe its hypoglycemic and lipid-lowering effects on type II diabetes.

OncologyImmune supportMetabolic healthLiver support

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Chaga · 2022 · Research Article · American journal of translational research

Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis in mice.

OBJECTIVE: Endometritis bacterial pathogenic condition that affects both humans and animals develops in the inner lining of the uterus. Inonotus obliquus polysaccharide (IOP), an active cocktail of Inonotus obliquus, has been shown to have a relatively wide range of biological activities and can play a role in various….

OncologyImmune support

High relevance

Reishi · 2022 · Research Article · Food chemistry: X

Polysaccharide prediction in Ganoderma lucidum fruiting body by hyperspectral imaging.

Ganoderma lucidum is a traditional Chinese healthy food with many kinds of nutritious activities, and polysaccharide is one of its main active components. Ganoderma lucidum polysaccharide plays a vital role in improving human immunity and anti-oxidation..

Immune supportEnergy & fatigue

High relevance

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Polysaccharide-Protein Complex Isolated from Fruiting Bodies and Cultured Mycelia of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Attenuates Doxorubicin-Induced Oxidative Stress and Myocardial Injury in Rats.

This study aimed to evaluate the effect of the polysaccharide-protein complex isolated from the fruiting bodies (GLFPPC) and cultured mycelia (GLMPPC) of a highly valued medicinal mushroom, Ganoderma lucidum, to alleviate doxorubicin (DOX)-induced cardiotoxicity..

Immune supportEnergy & fatigue

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Lion's Mane · 2022 · Research Article · Nutrients

Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism.

Five fractions from crude Hericium erinaceus polysaccharides (HEPs), including HEP-1, HEP-2, HEP-3, HEP-4 and HEP-5, were obtained through column chromatography with a DEAE Cellulose-52 column and Sephadex G-100 column. The contents of total carbohydrates and uronic acid in HEPs were 53.36% and 32.56%, respectively..

OncologyImmune supportMetabolic health

High relevance

King Oyster · 2022 · Journal Article · Carbohydrate polymers

Polysaccharides from Pleurotus eryngii: Selective extraction methodologies and their modulatory effects on THP-1 macrophages

Polysaccharides from P. eryngii mushroom were selectively extracted using low-cost technologies (water at different conditions of temperature and pressure).

OncologyImmune support

High relevance

Cordyceps · 2022 · Research Article · Polymers

Preparation, Characterization and Anti-Complementary Activity of Three Novel Polysaccharides from Cordyceps militaris.

This investigation focuses on the three novel polysaccharides from Cordyceps militaris and then discusses their characterization and anti-complementary activity. The three polysaccharides from C.

Immune support

High relevance

Cordyceps · 2022 · Research Article · Nutrients

Protective Effect of a Water-Soluble Carotenoid-Rich Extract of Cordyceps militaris against Light-Evoked Functional Vision Deterioration in Mice.

Light-evoked retinal photodamage is considered an important factor contributing to functional vision deterioration and can even lead to light maculopathy or dry age-related macular degeneration..

Immune supportEnergy & fatigue

High relevance

Oyster Mushroom · 2022 · Journal Article · Journal of food science

Protective role of ergothioneine isolated from Pleurotus ostreatus against dextran sulfate sodium-induced ulcerative colitis in rat model.

The well-acknowledged sulfur-containing amino acid ergothioneine (EGT), which is usually perceived to be produced from fungi, cyanobacteria, and mushrooms, has been increasingly demonstrated as a diet-derived antioxidant with therapeutic potential..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Enoki · 2022 · Journal Article · International journal of medicinal mushrooms

Residues of Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes), Cultivation as a Potential Source of Functional Skin Substitute with Multiple Bioactivities.

Residues generated during the cultivation of edible mushroom Flammulina velutipes are abundant and utilized with low efficiency. In this study, the composition and bioactivities of a skin substitute named TG05 obtained from residues of the F.

OncologyImmune supportSkin & hydration

High relevance

Lion's Mane · 2022 · Research Article · Molecules (Basel, Switzerland)

Secondary Metabolites from Hericium erinaceus and Their Anti-Inflammatory Activities.

Hericium erinaceus, a culinary and medicinal mushroom, is widely consumed in Asian countries. Chemical investigation on the fruiting bodies of Hericium erinaceus led to the isolation of one new ergostane-type sterol fatty acid ester, erinarol K (1); and eleven known compounds: 5α,8α -epidioxyergosta-6,22-dien-3β-yl….

Immune supportCognition & nerves

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Reishi · 2022 · Research Article · Food & nutrition research

Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.

OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidum (SSPL) against obese mice fed with a high-fat diet..

OncologyImmune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2022 · Journal Article · Food chemistry

Structural characterization of two Hericium erinaceus polysaccharides and their protective effects on the alcohol-induced gastric mucosal injury.

Hericium erinaceus, a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. However, the relationship between the structural characteristics of Hericium erinaceus and its stomach-protecting activity remains unclear..

Immune supportGut & microbiome

High relevance

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Structure Characterization and Anti-Inflammatory Activity of Polysaccharides from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) by Microwave-Assisted Freeze-Thaw Extraction.

A water-soluble polysaccharide (GLP-2) was isolated and purified from Ganoderma lucidum by the microwave-assisted freeze-thaw method. Microwave-assisted rapid thawing treatment can greatly improve the extraction yield of polysaccharides..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · Carbohydrate polymers

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation

Ganoderma lucidum has been shown to have anti-obesity effects. However, polysaccharide extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) against obesity and its underlying mechanisms have never been reported..

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2022 · Journal Article · Journal of agricultural and food chemistry

The in Vitro Fermentation of Cordyceps militaris Polysaccharides Changed the Simulated Gut Condition and Influenced Gut Bacterial Motility and Translocation.

The motility ability of intestinal lipopolysaccharide (LPS)-producing bacteria determines their translocation to the enterohepatic circulation and works as an infectious complication..

Immune supportGut & microbiomeLiver support

High relevance

Cordyceps · 2022 · Journal Article · International journal of medicinal mushrooms

Transcriptome Sequencing to Identify Candidate Genes for Mycelium Period Metabolism of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), Exposed to Light Treatment.

The Chinese caterpillar mushroom, Ophiocordyceps sinensis, is rare in traditional Chinese herbal medicine. It was reported that the development of ascospores in sexual stage of Chinese Cordyceps requires certain UV irradiation, but whether light has effect on the asexual stage of O.

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2022 · Research Article · Frontiers in pharmacology

Transcriptomic analysis of the anti-inflammatory effect of Cordyceps militaris extract on acute gouty arthritis.

Background: Gouty arthritis (GA) is a common inflammatory disease that causes pain due to the deposition of monosodium urate (MSU) crystals into joints and surrounding tissues. Anti-inflammatory drugs have significant clinical anti-inflammatory and analgesic effects, but they have many side effects..

Immune support

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Chaga · 2022 · Journal Article · Journal of food biochemistry

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

King Oyster · 2022 · Journal Article · Carbohydrate polymers

Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1

The mushroom cell wall contains polysaccharides that can activate cells of the innate immune system through receptors such as Toll-like receptors (TLR) and dectin-1..

Immune support

High relevance

King Oyster · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

A Multiomic Approach to Understand How Pleurotus eryngii Transforms Non-Woody Lignocellulosic Material.

Pleurotus eryngii is a grassland-inhabiting fungus of biotechnological interest due to its ability to colonize non-woody lignocellulosic material. Genomic, transcriptomic, exoproteomic, and metabolomic analyses were combined to explain the enzymatic aspects underlaying wheat-straw transformation..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Almond Mushroom · 2021 · Journal Article · Journal of food biochemistry

Agaricus blazei polypeptide exerts a protective effect on D‐galactose‐induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways

This experiment mainly optimized the extraction technology of Agaricus blazei polypeptide (ABp) and evaluated its protective effect on aging mice. In this study, a novel single component, the M is 3 kD, was isolated and purified from Agaricus blazei.

Immune supportCognition & nervesEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2021 · Research Article · Foods (Basel, Switzerland)

Anti-Hyperlipidemia and Gut Microbiota Community Regulation Effects of Selenium-Rich Cordyceps militaris Polysaccharides on the High-Fat Diet-Fed Mice Model.

Supplementation of polysaccharides is a promising gut microbiota-targeted therapeutic method for obesity and metabolic diseases. Biological activities of Cordyceps militaris polysaccharides have been well reported, but the effect of selenium (Se)-rich C..

Immune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2021 · Journal Article · Phytochemistry

Anti-neuroinflammatory polyoxygenated lanostanoids from Chaga mushroom Inonotus obliquus.

Chaga mushroom, Inonotus obliquus, was used as food and nutrient food and traditional herbs in Russia, China and Japan, with anti-inflammatory and anticancer activities. Chemical investigations of the fruiting bodies of Chaga were carried to uncover the bioactive metabolites..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2021 · Research Article · AMB Express

Anti-tumor effect of polysaccharide from Pleurotus ostreatus on H22 mouse Hepatoma ascites in-vivo and hepatocellular carcinoma in-vitro model.

Hepatocellular carcinoma is one of the leading causes of cancer-associated death across the globe. Malignant ascites are the major clinical attributes in cancer patients..

OncologyImmune supportLiver support

High relevance

Reishi · 2021 · Research Article · Asian Pacific journal of cancer prevention: APJCP

Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways.

BACKGROUND: The statin drug Atorvastatin (AT) used for cholesterol reduction and Ganoderma lucidum (Gl) mushroom extract exhibited satisfactory antitumor activities towards various types of cancer..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model.

ETHNOPHARMACOLOGY RELEVANCE: Cordyceps militaris (Linn.) Link (CM) is a medicinal mushroom traditionally used in tonics for treating several neurological disorders, including epilepsy and anxiety, in Asia..

Immune supportCognition & nerves

High relevance

Reishi · 2021 · Research Article · Frontiers in pharmacology

Antimetastatic Effects of Ganoderma lucidum Polysaccharide Peptide on B16-F10-luc-G5 Melanoma Mice With Sleep Fragmentation.

Ganoderma lucidum (Lingzhi) polysaccharide peptide (GL-pp) is a component of the globally acknowledged traditional Chinese medicine Ganoderma lucidum; Ganoderma lucidum is known for its sedative, hypnotic, immune regulatory, antitumor, and other pharmacological effects..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

King Oyster · 2021 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-ageing effects of enzymatic polysaccharide from Pleurotus eryngii residue.

The wide industrial cultivation of Pleurotus eryngii (P. eryngii) has resulted in the massive production of mushroom residues (MR) with low-efficiency utilization.

Immune supportCognition & nervesLiver supportSkin & hydration

High relevance

Mesima · 2021 · Research Article · Mycobiology

Artificial Cultivation Characteristics and Bioactive Effects of Novel Tropicoporus linteus (Syn. Phellinus linteus) Strains HN00K9 and HN6036 in Korea.

Phellinus strains were collected from different areas in Korea. Of them, the fast mycelial growing strains were artificially cultivated on the oak logs to produce fruiting body.

OncologyImmune supportGut & microbiome

High relevance

Cordyceps · 2021 · Journal Article · International journal of medicinal mushrooms

Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Aβ1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation.

The deposition of amyloid beta (Aβ) is a neuropathological feature of Alzheimer's disease (AD). Cordyceps militaris is an edible medicinal fungus in Asian countries with antioxidative, antiaging, antitumor, and immunomodulatory effects.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Chaga · 2021 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Terpenoids May Interfere with SARS-CoV-2 Spike Protein Recognition of the Host Cell: A Molecular Docking Study.

The most challenging threat facing the global community today is the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)..

Immune supportCognition & nervesRespiratory

High relevance

Chaga · 2021 · Research Article · Heliyon

Chaga mushroom (Inonotus obliquus) polysaccharides exhibit genoprotective effects in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes.

Chaga mushroom is one of the promising beneficial mushrooms thriving in the colder parts of Northern hemisphere. Chaga polysaccharides (IOP) have been reported to enhance immune response and alleviate oxidative stress during development..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2021 · Journal Article · International journal of medicinal mushrooms

Chemical Compounds and Computational Prediction of Their Inhibitory Effects on the HIV-1 gp120 Receptor by Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with Antler-Like Morphology of Fruiting Bodies.

In this study, crude extracts of Ganoderma lucidum (NGCs) were compared to the crude extracts of G. lucidum that has antler-like fruiting bodies (AGCs) for their cytotoxicity, inhibitory effects on the attachment of human immunodeficiency virus (HIV)-1 glycoprotein 120 (gp120) to cluster of differentiation 4 (CD4),….

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Almond Mushroom · 2021 · Journal Article · Chemistry & biodiversity

Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti-HIV Activity.

AIDS, caused by HIV-1, is one of the most dangerous infectious diseases in the world. Therefore, it is necessary to develop new drugs with more potent bioactivities, less toxicity and higher tolerability for controlling the viral load, particularly by using the raw materials that are widely available..

Immune supportRespiratory

High relevance

Reishi · 2021 · Journal Article · International journal of food science & technology

Comparative evaluation of physicochemical properties of Lingzhi (Ganoderma lucidum) as affected by drying conditions and extraction methods

Lingzhi (Ganoderma lucidum) is a high‐potential mushroom which is used as a dietary supplement or a source of nutrients and antioxidant agents. The aims were to investigate the effect of drying conditions (hot air and vacuum dry) and to compare the extraction methods of microwave‐assisted extraction (MAE) and pulsed….

Immune supportMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Comparison of effects on colitis-associated tumorigenesis and gut microbiota in mice between Ophiocordyceps sinensis and Cordyceps militaris.

BACKGROUND: Gut microbiota plays an indispensable role in the treatment of inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). As traditional medicinal fungi, previous studies have shown that Ophiocordyceps sinensis could better maintain intestinal health via promoting the growth of probiotics in….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Comparison of Polysaccharides Extracted from Cultivated Mycelium of Inonotus obliquus with Polysaccharide Fractions Obtained from Sterile Conk (Chaga) and Birch Heart Rot.

The polysaccharides of the sterile conk of Inonotus obliquus (Chaga) have demonstrated multiple bioactivities. The mycelium of this basidiomycete, obtained after submerged cultivation, has been considered a feasible alternative to the sterile conk for the production of polysaccharides..

Immune supportGut & microbiome