MycoData

OncologyImmune supportRespiratory

Almond Mushroom · 2022 · Case Reports · Case reports in gastroenterology

Interstitial Lung Disease Associated with Agaricus blazei Murill in a Patient with Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine-Based Therapy.

A male in his sixties with locally advanced pancreatic ductal adenocarcinoma (PDAC) was administered gemcitabine plus nab-paclitaxel therapy. Computed tomography (CT) scans after five courses revealed nonspecific interstitial pneumonitis in addition to PDAC aggravation..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2022 · Research Support, Non U.S. Gov'T · Frontiers in endocrinology

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora.

Type 2 diabetes mellitus (T2DM) poses a significant risk to human health. Previous research demonstrated that Inonotus obliquus possesses good hypolipidemic, anti-inflammatory, and anti-tumor properties..

Reishi · 2021 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Sporoderm-Removed Ganoderma lucidum Spore Powder May Suppress the Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells Through PI3K/AKT/mTOR and Erk Pathway.

Tumor metastasis is a key factor of therapeutic failure in tumor patients, but the underlying molecular mechanism remains to be explored and novel effective curative strategies are urgently required..

OncologySkin & hydration

Cordyceps · 2020 · Preprint · journal metadata

Immune modulation of macrophage response by Cordyceps militaris extracts

Backgrounds:: Cordyceps militaris is a well-known medicinal fungus. Cordycepin, a metabolite of this fungus, has strong biological activities against leukemia, oxidative stress, aging, tumors, and inflammation.

Chaga · 2018 · Preprint · journal metadata

Inonotus Obliquus extracts as an inhibitor of α-MSH-induced melanogenesis in B16F10 mouse melanoma cells

Melanogenesis is a biosynthetic pathway for producing of the pigment melanin in human skin. Tyrosinase, a key enzyme, catalyzing is the first step in melanogenesis and the downregulation of the tyrosinase enzyme activity is the most reported method for anti-melanogenesis..

OncologySkin & hydration

OncologyEnergy & fatigueLiver supportRespiratory

Cordyceps · 2023 · English Abstract · Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].

OBJECTIVE: To evaluate the inhibitory effect of cordycepin on oral cancer xenograft in nude mice and explore the underlying mechanisms. METHODS: Sixteen BALB/c mice bearing subcutaneous human tongue squamous cell carcinoma (TSCC) TCA-8113 cell xenografts were randomized into model group and cordycepin treatment group….

OncologyMetabolic healthRespiratory

Maitake · 2023 · Preprint · journal metadata

Anti-α-glucosidase, anti-proliferative and anti-enterovirus 71 activity of secondary metabolites identified from Grifola frondosa

Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G.

OncologyImmune supportMetabolic health

Reishi · 2023 · Preprint · journal metadata

Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities

Ganoderma lucidum ( G. lucidum ) is a medical mushroom known for its tendency to produce physiologically active compounds with far-reaching effects on human health..

Reishi · 2022 · Preprint · journal metadata

Overexpression of purine nucleoside phosphorylase increases the adenosine content in Ganoderma lucidum

Adenosine has been getting increasing attention due to its positive role in immunomodulation, anti-inflammation, and anti-cancer, etc.. The low production of Ganoderma adenosine is a bottleneck for clinical trials and commercial applications..

Reishi · 2022 · Preprint · journal metadata

Overexpression of purine nucleoside phosphorylase increases the adenosine content in Ganoderma lucidum

Background: Adenosine has been getting increasing attention due to its positive role in immunomodulation, anti-inflammation, and anti-cancer, etc.. The low production of Ganoderma adenosine is a bottleneck for clinical trials and commercial applications..

Mesima · 2021 · Preprint · journal metadata

Clinical Trial to Analyze the Effect of Oral Intake of Phellinus Linteus(Sanghuang) Extract on Immune Function: A Study Protocol for a Randomized, Double-blind Controlled Trial

Abstract Background: As Korea becomes an aging society, interest in health care has increased. In particular, there is an increasing demand for immune function improvement to prevent infectious diseases.

Chaga · 2021 · Preprint · journal metadata

Genome Sequencing of Inonotus Obliquus Reveals Insights Into Candidate Genes Involved In Secondary Metabolite Biosynthesis

Background: Inonotus obliquus is an important edible and medicinal mushroom that was shown to have many pharmacological activities in preclinical trials, including anti-inflammatory, antitumor, immunomodulatory, and antioxidant effects..

Chaga · 2021 · Preprint · journal metadata

Lignin-Degrading Enzymes From a Pathogenic Canker-Rot Fungus, Inonotus Obliquus Strain IO-B2 (NBRC 113408)

Inonotus obliquus is pathogenic fungus on living trees and has been widely used as a traditional medicine for cancer therapy. Although it has been reported that lignocellulose-degrading enzymes are involved in the early stage of host infection, the parasitic life cycle of this fungus has not been fully clarified..

Chaga · 2021 · Preprint · journal metadata

Potential Target Screening and Molecular Docking of Newly Isolated Compound From Inonotus Obliquus

Compound (1-(4-hydroxyphenyl)-3-methoxypropan-1-one) is a newly isolated compound from Inonotus obliquus. In this paper, four target protein prediction methods were used to search the potential targets of compounds.

OncologyImmune supportEnergy & fatigue

Shiitake · 2021 · Preprint · journal metadata

Selenium-Containing Exopolysaccharides Isolated from the Culture Medium of Lentinula edodes: Structure and Biological Activity

In continuation of our research on the influence of selenium incorporation on the biosynthesis, structure, immunomodulatory and antioxidant activities of polysaccharides of fungal origin, we have isolated from a post-culture medium of Lentinula edodes a selenium (Se)-containing exopolysaccharide fraction composed….

OncologyImmune supportLiver support

Maitake · 2020 · Journal Article · International journal of biological macromolecules

A β-glucan from Grifola frondosa effectively delivers therapeutic oligonucleotide into cells via dectin-1 receptor and attenuates TNFα gene expression.

Grifola frondosa is an edible and medicinal mushroom with great nutritional values and bioactivities. In the present study, a soluble homogeneous β-glucan, GFPS, with high molecular mass of 5.42 × 106 Da was purified from the fruit bodies of Grifola frondosa using 5% cold NaOH..

Almond Mushroom · 2020 · Research Article · Oncology letters

Agaricus blazei extract (FA-2-b-β) induces apoptosis in chronic myeloid leukemia cells.

Agaricus blazei Murill (AbM) is a mushroom belonging to the Basidiomycetes family, which is believed to have antitumor and antioxidative activities. Proteoglycans and ergosterol are considered the key compounds of AbM for antitumor properties and so are used in complementary and alternative medicine as an anticancer….

Enoki · 2020 · Journal Article · International journal of medicinal mushrooms

Antibacterial Activity of Fruiting Body Extracts from Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes) against Oral Pathogen Streptococcus mutans.

The edible medicinal mushroom Flammulina velutipes (enokitake) has many applications as food and medicine, but its application in dentistry is unknown. This study aims to investigate the inhibitory effect of fruiting body extracts from F..

Cordyceps · 2020 · Research Article · Mycobiology

Antithrombotic and Antiplatelet Effects of Cordyceps militaris.

Cordyceps is a genus of ascomycete fungi and is well known as one of the important medical fungi in Chinese, Korea, and other Asian countries, because of its various beneficial effects on human health..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2020 · Research Article · Mycobiology

Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production.

Cordyceps militaris has been reported to the diverse pharmaceutical effects including cancer, inflammatory diseases, and bacteria or virus infection. However, the effect of C.

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2020 · Journal Article · International journal of medicinal mushrooms

Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Mycelia Attenuates Doxorubicin-Induced Oxidative Stress and Upregulates Krebs Cycle Dehydrogenases Activity and ATP Level in Rat Brain.

Post-chemotherapy-induced cognitive dysfunction remains one of the challenges in cancer survivors. Cytokine-induced neurotoxicity manifests in subjects at any time after doxorubicin (DOX) chemotherapy..

Cordyceps · 2020 · Research Article · Molecules (Basel, Switzerland)

Cordyceps militaris Fungus Extracts-Mediated Nanoemulsion for Improvement Antioxidant, Antimicrobial, and Anti-Inflammatory Activities.

This study aimed to produce and optimize a Cordyceps militaris-based oil-in-water (O/W) nanoemulsion (NE) encapsulated in sea buckthorn oil (SBT) using an ultrasonication process. Herein, a nonionic surfactant (Tween 80) and chitosan cosurfactant were used as emulsifying agents..

Cordyceps · 2020 · Research Article · BMC complementary medicine and therapies

Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation.

BACKGROUND: Cordyceps militaris (L.) Fr. (C.

Cordyceps · 2020 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer.

Cordyceps militaris has been widely used as a traditional medicine in East Asia. Its effects against breast cancer have been reported previously.

Cordyceps · 2020 · Journal Article · International journal of biological macromolecules

Cordyceps militaris polysaccharide converts immunosuppressive macrophages into M1-like phenotype and activates T lymphocytes by inhibiting the PD-L1/PD-1 axis between TAMs and T lymphocytes.

Tumour-associated macrophages (TAMs) inhibit the killing effect of T lymphocytes on tumour cells through the immunocheckpoint programmed death ligand-1 (PD-L1)/programmed death-1 (PD-1) axis. TAMs-targeted therapy is a promising approach that could be used to reverse the immunosuppressive tumour microenvironment..

Chaga · 2020 · Research Article · Analytical cellular pathology (Amsterdam)

Effects of Inonotus obliquus Polysaccharides on Proliferation, Invasion, Migration, and Apoptosis of Osteosarcoma Cells.

OBJECTIVES: To observe the effect of Inonotus obliquus polysaccharide (IOP) on the proliferation, invasion, migration, and apoptosis of osteosarcoma cells and to elucidate its underlying molecular mechanism..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2020 · Research Article · Biotechnology reports (Amsterdam, Netherlands)

Enhanced production of cordycepin in Ophiocordyceps sinensis using growth supplements under submerged conditions.

Cordycepin is a crucial bioactive compound produced by the fungus Cordyceps spp. Its therapeutic potential has been recognized for a wide range of biological properties such as anticancer, anti-diabetic, antidepressant, antioxidant, immunomodulation, etc..

OncologyLiver supportSkin & hydration

Cordyceps · 2020 · Research Article · Nanomaterials (Basel, Switzerland)

Enhancement of Chemical Stability and Dermal Delivery of Cordyceps militaris Extracts by Nanoemulsion.

This study aimed to develop nanoemulsions for enhancing chemical stability and dermal delivery of Cordyceps militaris extracts. C.

Lion's Mane · 2020 · Journal Article · Anti-cancer agents in medicinal chemistry

Erinacerins, Novel Glioma Inhibitors from Hericium erinaceus, Induce Apoptosis of U87 Cells through Bax/Capase-2 Pathway.

BACKGROUND: Glioma is the most common tumor of the central nervous system. Hericium erinaceus, which has been reported to have a variety of pharmacological activities, is a widely used Traditional Chinese Medicine (TCM), and also a kind of delicious food accepted by the public..

OncologyImmune supportLiver support

Oyster Mushroom · 2020 · Research Article · Biochemistry and biophysics reports

Exopolysaccharide-peptide complex from oyster mushroom (Pleurotus ostreatus) protects against hepatotoxicity in rats.

Liver damage involves oxidative stress and a progression from chronic hepatitis to hepatocellular carcinoma (HCC). The increased incidence of liver disease in Egypt and other countries in the last decade, coupled with poor prognosis, justify the critical need to introduce alternative chemopreventive agents that may….

Chaga · 2020 · Research Article · Nutrients

Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity.

Natural products have attracted great interest for some time as alternative methods against cancers by fulfilling immunomodulating properties. In this study, we investigated the activity of hot water extracts (120 °C, >30 min) of Phellinus linteus, fresh leaves of Kumaizasa bamboo and Chaga mushroom which we called….

OncologyImmune supportEnergy & fatigueMetabolic health

Lion's Mane · 2020 · Journal Article · Food & function

Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways.

The fruiting bodies of Hericium erinaceus (Bull.) Pers. are commonly used in China in the treatment of digestive system diseases.

Reishi · 2020 · Research Article · Pharmaceuticals (Basel, Switzerland)

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury.

Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer activities are well known. Moreover, lately, there has been an increasing interest from pharmaceutical companies in antiaging G..

OncologyCognition & nervesMetabolic health

King Oyster · 2020 · Research Article · Applied microbiology and biotechnology

High-level expression of aryl-alcohol oxidase 2 from Pleurotus eryngii in Pichia pastoris for production of fragrances and bioactive precursors.

The fungal secretome comprises various oxidative enzymes participating in the degradation of lignocellulosic biomass as a central step in carbon recycling. Among the secreted enzymes, aryl-alcohol oxidases (AAOs) are of interest for biotechnological applications including production of bio-based precursors for….

OncologyCognition & nervesLiver support

Oyster Mushroom · 2020 · Journal Article · Nutricion hospitalaria

In vivo assessment of the protection conferred by β-glucans from Pleurotus ostreatus against the harmful effects of acrylamide intake (Part I).

Introduction: acrylamide is formed in food through Maillard's reaction during thermal processing, and has been shown to be neurotoxic in humans, and a possible carcinogen. Studies have shown that β-glucans from Pleurotus ostreatus have diverse biological properties such as antioxidant and anticancer activities..

OncologyCognition & nervesLiver support

Oyster Mushroom · 2020 · Journal Article · Nutricion hospitalaria

In-vivo assessment of the protection of β-glucans of Pleurotus ostreatus against oxidative stress caused by acrylamide intake (part II).

Introduction: in April 2002, the National Food Authority of Sweden published a study in which the presence of a carcinogen was reported for the first time in experimental animals, and was identified as acrylamide..

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2020 · Research Article · Frontiers in pharmacology

Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome.

Inonotus obliquus polysaccharide (IOP), the primary constituent of the parasitic fungus Inonotus obliquus, has anti-tumor, anti-inflammatory, anti-oxidation effects. However, the roles of IOP on colitis-associated cancer (CAC) are still unclear..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2020 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis.

The present study explores the mechanisms underlying the anti-cancer action of Inonotus obliquus polysaccharides (IOP). Thus, we characterized the IOP components extracted from Chaga sclerotium and, found that the extracts contained 70% polysaccharides with an average molecular weight of 4.5 × 104 Da consisting of 75%….

OncologyImmune supportMetabolic health

Shiitake · 2020 · Journal Article · Carbohydrate polymers

Isolation and comparison of α- and β-D-glucans from shiitake mushrooms (Lentinula edodes) with different biological activities.

A polysaccharide-enriched extract obtained from Lentinula edodes was submitted to several purification steps to separate three different D-glucans with β-(1→6), β-(1→3),(1→6) and α-(1→3) linkages, being characterized through GC-MS, FT-IR, NMR, SEC and colorimetric/fluorimetric determinations..

Shiitake · 2020 · Journal Article · Applied microbiology and biotechnology

Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.

Due to the high mortality rate and an increase in breast cancer incidence, it has been challenging for researchers to come across an effective chemotherapeutic strategy with minimum side effects. Therefore, the need for the development of effective chemotherapeutic drugs is still on the verge..

OncologyEnergy & fatigue

Cordyceps · 2020 · Journal Article · International journal of medicinal mushrooms

Lipids in an Ethyl Acetate Fraction of Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycetes), Reduce Nitric Oxide Production in BV2 Cells via NRF2 and NF-κB Pathways.

Cordyceps militaris is known for its curative properties. The present study was undertaken to evaluate the reduction of nitric oxide production by BV2 cells by the bioactive fraction of stroma powder of C.

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2020 · Research Article · Scientific reports

Molecular insights and cell cycle assessment upon exposure to Chaga (Inonotus obliquus) mushroom polysaccharides in zebrafish (Danio rerio).

Chaga (Inonotus obliquus) mushroom is considered as one of the most powerful antioxidants across the world. Though the therapeutic effects of Chaga components are well characterized in vitro, the in vivo developmental effects are not elucidated in detail..

Cordyceps · 2020 · Journal Article · Chinese journal of natural medicines

Overexpression of ribonucleotide reductase small subunit, RNRM, increases cordycepin biosynthesis in transformed Cordyceps militaris.

Cordycepin was the first adenosine analogue used as an anticancer and antiviral agent, which is extracted from Cordyceps militaris and hasn't been biosynthesized until now..

OncologyRespiratory

OncologyImmune supportMetabolic health

King Oyster · 2020 · Journal Article · Journal of food science

Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti-inflammation activities potential.

The anti-inflammatory effects of two newly identified Pleurotus eryngii polysaccharides (WPEP, NPEP) were determined in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in this study..

OncologyImmune supportCognition & nerves

King Oyster · 2020 · Journal Article · International journal of medicinal mushrooms

Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on β-Amyloid-Induced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies.

Pleurotus eryngii (PE) contains polysaccharides and vitamins, and has been reported to have antidepression properties. P.

Reishi · 2020 · Research Article · Frontiers in pharmacology

Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia.

Ganoderma lucidum, also known as LINGZHI, has a long tradition of use in folk medicine of the Far East, which is documented in the oldest Chinese pharmacopoeia, declaring it a superior medicine. LINGZHI-8 (LZ-8) is an immunoregulatory fungal protein isolated from the fruiting body of Ganoderma lucidum..

OncologyImmune supportEnergy & fatigue

Maitake · 2020 · Journal Article · Glycoconjugate journal

Relationship between heat treatment on structural properties and antitumor activity of the cold-water soluble polysaccharides from Grifola frondosa.

Grifola frondosa is a basidiomycete fungus with potential biomedical applications owing to the presence of bioactive polysaccharides. The activities of polysaccharides are influenced by many factors, particularly temperature; however, the optimal temperature and conditions for preparation of polysaccharides from this….

Cordyceps · 2020 · Journal Article · Food & function

Study on the effect of regulation of Cordyceps militaris polypeptide on the immune function of mice based on a transcription factor regulatory network.

BACKGROUND: The pathogenesis of the abnormality of the immune system is still not clear at present. Chemosynthetic drugs, human or animal immune products and microbiological drugs are used as the main drugs in clinics currently, but these drugs have different side effects..