MycoData

The growth characteristics of Phellinus linteus mycelium were assessed and compared under solid-state fermentation (SSF) and submerged liquid fermentation (SLF) systems on whey permeate medium..

Medium relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Stimulatory Agents Simultaneously Improving the Production and Antioxidant Activity of Polyphenols from Inonotus obliquus by Submerged Fermentation.

Polyphenols are important secondary metabolites from the edible and medicinal mushroom Inonotus obliquus. Both the rarity of I.

Immune support

Medium relevance

Mesima · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Structural features and antitumor activity of a novel polysaccharide from alkaline extract of Phellinus linteus mycelia.

A novel high molecular weight polysaccharide (PL-N1) was isolated from alkaline extract of the cultured Phellinus linteus mycelia. The weight average molecular weight (Mw) of PL-N1 was estimated at 343,000kDa.

OncologyImmune supportMetabolic health

Medium relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Synthesis and characterization of a new Inonotus obliquus polysaccharide-iron(III) complex.

A new Inonotus obliquus polysaccharide-iron(III) complex (IOPS-iron) was synthesized and characterized. The preparation conditions of IOPS-iron(III) were optimized and the physicochemical properties were characterized by physicochemical methods, scanning electron microscopy (SEM), electron paramagnetic resonance (EPR)….

Immune supportGut & microbiome

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Chemosphere

Synthesis and characterization of biomatrixed-gold nanoparticles by the mushroom Flammulina velutipes and its heterogeneous catalytic potential.

Sustainable and greener synthesis of intracellular gold nanoparticles using mushroom Flammulina velutipes is reported. Incubation of a mushroom in chloroaurate solution resulted in the synthesis and immobilization of stable gold nanoparticles inside the mushroom mycelia..

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · BioMed research international

The Ethanolic Extract of Taiwanofungus camphoratus (Antrodia camphorata) Induces Cell Cycle Arrest and Enhances Cytotoxicity of Cisplatin and Doxorubicin on Human Hepatocellular Carcinoma Cells.

Taiwanofungus camphoratus (synonym Antrodia camphorata) is a widely used medicinal fungus in the folk medicine of Taiwan with several pharmacological features such as anti-inflammatory, liver protection, antihypertensive, and antioxidative activities. The ethanolic extract of T..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Gene

The multigene family of fungal laccases and their expression in the white rot basidiomycete Flammulina velutipes.

Fungal laccases play important roles in matrix degradation. Eleven laccase genes, including three novel ones (designated lac1, lac2 and lac4) were identified after sequencing the entire genome of the edible, white-rot fungus Flammulina velutipes..

Medium relevance

Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · Scientific reports

Transcriptome analysis of genes involved in defence response in Polyporus umbellatus with Armillaria mellea infection.

Polyporus umbellatus, a species symbiotic with Armillaria mellea and it also exhibits substantial defence response to Armillaria mellea infection. There are no genomics resources databases for understanding the molecular mechanism underlying the infection stress of P.

Medium relevance

Chaga · 2014 · Comparative Study · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Comparison of component from different species of Inonotus obliquus].

In this paper, water content, mineral element and active ingredient concentration on fifteen Inonotus obliquus which comes from all over the world were studied. In the aspect of water content, the free water content of Finnish birch was the highest, reaching 77.21%, significantly better than that of other strains..

Immune support

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Inducible and constitutive expression of fip-fve from Flammulina velutipes in Pichia pastoris GS115].

We transformed the fip-fve gene into Pichia pastoris GS115 for inducible and constitutive expression to obtain feasible bioactvie recombinant Fip-fve. The fip-fve gene was cloned from Flammulina velutipes fruting body by PCR and ligated to pPIC9 to construct inducible expression vector pPIC9-FIP-fve, and promotor pgap….

Metabolic healthGut & microbiome

Medium relevance

Zhu Ling · 2014 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Physicochemical properties of medicinal fungus Polyporus umbellatus sclerotial exudate].

This study was conducted to investigate the physicochemical properties of Polyporus umbellatus sclerotial exudate. Morphological characteristics of the sclerotia and its exudate were observed during different stages of sclerotial formation.

Immune supportSkin & hydration

Medium relevance

Maitake · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

A heteropolysaccharide, L-fuco-D-manno-1,6-α-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative.

The tumor growth and metastasis are angiogenesis dependent, thus blockade of angiogenesis is a promising approach for treatment of cancer. Herein we reported the structural and biological features of a novel water-soluble polysaccharide named GFPW from the fruit body of Grifola frondosa..

OncologyImmune support

Medium relevance

Maitake · 2014 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

A novel breeding strategy for new strains of Hypsizygus marmoreus and Grifola frondosa based on ligninolytic enzymes.

A novel breeding strategy for new strains of Hypsizygus marmoreus and Grifola frondosa using ligninolytic enzymes as markers was evaluated with the detection and analysis of activities and composition of 15 edible fungi..

Gut & microbiome

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of immunology research

Activation effects of polysaccharides of Flammulina velutipes mycorrhizae on the T lymphocyte immune function.

Flammulina velutipes mycorrhizae have increasingly been produced with increasing of F. velutipes production.

OncologyImmune support

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Colloids and surfaces. B, Biointerfaces

Adsorption of Trametes versicolor laccase to soil iron and aluminum minerals: enzyme activity, kinetics and stability studies.

Laccases play an important role in the degradation of soil phenol or phenol-like substance and can be potentially used in soil remediation through immobilization. Iron and aluminum minerals can adsorb extracellular enzymes in soil environment..

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Toxins

Aflatoxin control in maize by Trametes versicolor.

Aspergillus flavus is a well-known ubiquitous fungus able to contaminate both in pre- and postharvest period different feed and food commodities. During their growth, these fungi can synthesise aflatoxins, secondary metabolites highly hazardous for animal and human health..

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Antiviral research

Alleviation of respiratory syncytial virus replication and inflammation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes.

Respiratory syncytial virus (RSV) causes bronchiolitis in children followed by inflammation and asthma-like symptoms. The development of preventive therapy for this virus continues to pose a challenge.

Immune supportRespiratory

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Analytical and bioanalytical chemistry

Analysis of cyathane-type diterpenoids from Cyathus striatus and Hericium erinaceus by high-resolution MALDI MS imaging.

Fungal secondary metabolites in both fruiting bodies and pellets from submerged cultures of basidiomycetes were analyzed by atmospheric pressure matrix-assisted laser desorption/ionization-mass spectrometry imaging at a lateral resolution of 15 μm, a mass resolution of 140,000 at m/z 200 and a mass accuracy of better….

OncologyCognition & nerves

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of natural products

Antcamphins A-L, ergostanoids from Antrodia camphorata.

Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A..

OncologyRespiratory

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Food & function

Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata.

Antrodia camphorata is a fungus native to Taiwan, and it is considered a precious medicinal agent. We analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in A.

OncologyImmune supportEnergy & fatigue

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers.

ETHNOPHARMACOLOGICAL RELEVANCE: Hericium is a genus of mushrooms (fungus) in the Hericiaceae family. Hericium erinaceus (HE) has been used for the treatment of digestive diseases for over 2000 years in China..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · PloS one

Antimicrobial activity of Antrodia camphorata extracts against oral bacteria.

Antrodia camphorata (A. camphorata) is a unique, endemic and extremely rare mushroom species native to Taiwan, and both crude extracts of and purified chemical compounds from A.

OncologyImmune support

Medium relevance

Snow Fungus · 2014 · Research Support, Non U.S. Gov'T · Journal of food science

Antioxidant and anti-inflammatory activities of methanol extracts of Tremella fuciformis and its major phenolic acids.

Methanol extract subfractions of the edible white jelly mushroom (Tremella fuciformis), were assessed for the following antioxidant properties: ABTS(+) radical scavenging activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and inhibitory activity of human low-density lipoprotein (LDL)….

Immune support

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential.

DNA methyltransferase 1 (DNMT1) catalyzes DNA methylation and is overexpressed in various human diseases, including cancer. A rational approach to preventing tumorigenesis involves the use of pharmacologic inhibitors of DNA methylation; these inhibitors should reactivate tumor suppressor genes (TSGs) in tumor cells….

OncologySkin & hydration

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Water research

Biodegradation of the X-ray contrast agent iopromide and the fluoroquinolone antibiotic ofloxacin by the white rot fungus Trametes versicolor in hospital wastewaters and identification of degradation products.

This paper describes the degradation of the X-ray contrast agent iopromide (IOP) and the antibiotic ofloxacin (OFLOX) by the white-rot-fungus Trametes versicolor..

Medium relevance

Mesima · 2014 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents.

Phellinus linteus and its constituent hispolon induce potent anti-inflammatory activity in macrophages. Efficient production of the effective constituent and the biological function of P.

OncologyImmune support

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Bioproduction of baccatin III, an advanced precursor of paclitaxol, with transgenic Flammulina velutipes expressing the 10-deacetylbaccatin III-10-O-acetyl transferase gene.

BACKGROUND: 10-Deacetylbaccatin III (10-DAB) and baccatin III are intermediates in the biosynthesis of Taxol (an anti-cancer drug) and useful precursors for semi-synthesis of the drug..

Oncology

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Journal of natural products

Chemical constituents from Inonotus obliquus and their biological activities.

Seven new triterpenes, inonotusol A-G (1-7), one new diterpene, inonotusic acid (8), and 22 known compounds were isolated from Inonotus obliquus. Their structures were elucidated on the basis of spectroscopic analysis, including homonuclear and heteronuclear correlation NMR ((1)H-(1)H COSY, ROESY, HSQC, and HMBC)….

OncologyLiver support

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Cloning and characterization of two allelic glyceraldehyde-3-phosphate dehydrogenase genes in Auricularia auricula-judae.

Two allelic variants of the gpd gene, Gpd(a) and Gpd(b), were isolated based on a putative glyceraldehyde-3-phosphate dehydrogenase encoding sequence from the transcriptome of Auricularia auricula-judae strain Au916. The two alleles were found to have a 73 bp length discrepancy and 39 SNP variations..

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · Microbiological research

Cloning, expression and phylogenetic analysis of a divergent laccase multigene family in Auricularia auricula-judae.

Laccases (p-diphenol: oxygen oxidoreductase; EC 1.10.3.2) are multi-copper oxidases encoded by gene family in white rot fungi. Auricularia auricula-judae is one kind of white rot fungi with a soft, jelly-like texture and an ear-like shape..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2014 · Comparative Study · Phytomedicine: international journal of phytotherapy and phytopharmacology

Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.

PURPOSE: Antrodia camphorata (AC), a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for the treatment of food and drug intoxication, diarrhea, abdominal pain, hypertension, skin itching, and cancer..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Food chemistry

Compositional analysis of the fruiting body of transgenic Flammulina velutipes producing resveratrol.

Two strains of transgenic Flammulina velutipes TF71 and TF7H with 4cl and rs genes with the capability to produce resveratrol were obtained. In the nutrition assessment and analysis of transgenic strain and original strain (F7), the amino acid composition and proximate compositions of fruiting bodies were determined….

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · The Science of the total environment

Degradation of selected agrochemicals by the white rot fungus Trametes versicolor.

Use of agrochemicals is a worldwide practice that exerts an important effect on the environment; therefore the search of approaches for the elimination of such pollutants should be encouraged..

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Dichlormethane extract of the jelly ear mushroom Auricularia auricula-judae (higher Basidiomycetes) inhibits tumor cell growth in vitro.

In this study, a dichloromethane fraction (DCMF) from 70% Auricularia auricula-judae ethanol extract showed the highest level of antitumor activity compared to other solvent fractions (ethyl acetate, butanol, and water)..

OncologyRespiratory

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Biotechnology and applied biochemistry

Effect of cultural conditions on antrodin C production by basidiomycete Antrodia camphorata in solid-state fermentation.

Antrodia camphorata is a medicinal fungus and antrodin C is one of the main bioactive components of A. camphorata in the submerged fermentation (SmF).

Medium relevance

Mesima · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Effect of extraction media on preliminary characterizations and antioxidant activities of Phellinus linteus polysaccharides.

Three partially purified polysaccharides were extracted from Phellinus linteus mycelia using hot water, 1% (NH4)2C2O4, and 1.25M NaOH/0.05% NaBH4, and the extracts were named PL-W, PL-A, and, PL-N respectively..

Immune supportMetabolic health

Medium relevance

Mesima · 2014 · Comparative Study · International journal of food sciences and nutrition

Effects of polysaccharide from fruiting bodies of Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus on alcoholic liver injury.

In the present study, the curative effects of crude polysaccharides (PSs) from mushrooms on the symptoms of alcoholic liver injury were investigated. PSs from Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus fruiting bodies were administered by gavage at levels of 100 mg per kg body weight per day for 7….

Immune supportEnergy & fatigueMetabolic healthLiver support

Medium relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Effects of the continuous administration of an Agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging.

An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract.

Cognition & nervesLiver support

Medium relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Oxidative medicine and cellular longevity

Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria.

Dysfunction of the mitochondrial respiratory chain and increased oxidative stress is a striking phenomenon in the brain of aged individuals. For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems..

Cognition & nervesEnergy & fatigueRespiratory

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Bioresource technology

Enhanced laccase production by Trametes versicolor using corn steep liquor as both nitrogen source and inducer.

A highly efficient strategy for laccase production by Trametes versicolor was developed using corn steep liquor (CSL) as both a nitrogen source and a laccase inducer. At the optimal CSL concentration of 20 gL(-1), an extracellular laccase activity of 633.3 UL(-1) was produced after a culture period of only 5 days..

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence.

In this study, the neuroprotective effect of an extract of Antrodia camphorata (A. camphorata), a fungus commonly used in Chinese folk medicine for treatment of viral hepatitis and cancer, alone or in combination with aspirin was investigated in a rat embolic stroke model..

OncologyCognition & nervesLiver supportRespiratory

Medium relevance

Snow Fungus · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Free-radical degradation by Fe2+/Vc/H2O2 and antioxidant activity of polysaccharide from Tremella fuciformis.

The free-radical degradation and antioxidant activity of polysaccharide from Tremella fuciformis was investigated. In present study, the combination of Fe(2+), ascorbic acid and H2O2 was used as degradation regents in order to obtain the lower molecular weight product..

Immune support

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Food & function

Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways.

Hericium erinaceus (Bull.: Fr.) Pers. is an edible and medicinal mushroom used traditionally to improve memory.

Cognition & nervesEnergy & fatigue

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · Protein expression and purification

Heterologous expression and physicochemical characterization of a fungal dye-decolorizing peroxidase from Auricularia auricula-judae.

An efficient heterologous expression system for Auricularia auricula-judae dye-decolorizing peroxidase (DyP) has been constructed. DNA coding for the mature protein sequence was cloned into the pET23a vector and expressed in Escherichia coli BL21(DE3)pLysS..

Medium relevance

Mesima · 2014 · Research Support, Non U.S. Gov'T · Chemico-biological interactions

Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells.

Acrylamide (AA), a well-known toxicant, has attracted numerous attentions for its presumably carcinogenesis, neurotoxicity and cytotoxicity. Oxidative stress was considered to be associated with acrylamide cytotoxicity, but the link between oxidative stress and acrylamide cytotoxicity is still unclear..

OncologyCognition & nervesEnergy & fatigue

Medium relevance

Mesima · 2014 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway.

Hispolon, a phenol compound isolated from Phellinus linteus (PL), possesses anti-inflammatory, antiproliferative, and antioxidant effects. However, the effects of hispolon on human nasopharyngeal carcinomas have yet to be evaluated..

OncologyImmune support

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · PloS one

Identification of degenerate nuclei and development of a SCAR marker for Flammulina velutipes.

Flammulina velutipes is one of the major edible mushrooms in the world. Recently, abnormalities that have a negative impact on crop production have been reported in this mushroom.

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Image analysis technique as a tool to identify morphological changes in Trametes versicolor pellets according to exopolysaccharide or laccase production.

Image analysis technique was applied to identify morphological changes of pellets from white-rot fungus Trametes versicolor on agitated submerged cultures during the production of exopolysaccharide (EPS) or ligninolytic enzymes. Batch tests with four different experimental conditions were carried out..

Immune supportMetabolic health

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Immunomodulatory effect of polysaccharides extracted from the medicinal mushroom Antrodia camphorata (higher Basidiomycetes) in specific pathogen-free chickens.

The immunomodulatory effect of polysaccharides extracted from mycelia of the medicinal mushroom Antrodia camphorata in submerged culture was studied in 100 specific pathogen-free (SPF) chickens. The chickens were randomly divided into 2 groups (50 per group)..

Immune support

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Induction of laccases in Trametes versicolor by aqueous wood extracts.

The induction of laccase isoforms in Trametes versicolor HEMIM-9 by aqueous extracts (AE) from softwood and hardwood was studied. Samples of sawdust of Pinus sp., Cedrela sp., and Quercus sp.