MycoData

Laccases have wide range of substrate specificity and find applications from pulp industry to waste water remediation. Laccases have also been used in combined pretreatment of biomass hydrolyzates to remove enzymatic and fermentation inhibitors..

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Aroma Characterization and Safety Assessment of a Beverage Fermented by Trametes versicolor.

A cereal-based beverage was developed by fermentation of wort with the basidiomycete Trametes versicolor. The beverage possessed a fruity, fresh, and slightly floral aroma.

Medium relevance

Snow Fungus · 2015 · Research Support, Non U.S. Gov'T · Molecular biotechnology

Biosynthesis of Resveratrol in Blastospore of the Macrofungus Tremella fuciformis.

Tremella fuciformis is a known edible macrofungus that has medicinal value. It is widely cultivated in China and its products are distributed worldwide.

Medium relevance

Snow Fungus · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Carboxymethylation of polysaccharides from Tremella fuciformis for antioxidant and moisture-preserving activities.

The carboxymethylated polysaccharide (CATP), which derived from water-insoluble crude Tremella fuciformis polysaccharide (ATP), was prepared. And then the antioxidant and moisture-preserving activities of the samples were investigated..

Immune support

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Journal of microbiology and biotechnology

Characterization of β-glucosidase produced by the white rot fungus Flammulina velutipes.

β-Glucosidase production by the white rot fungus Flammulina velutipes CFK 3111 was evaluated using different carbon and nitrogen sources under submerged fermentation. Maximal extracellular enzyme production was 1.6 U/ml, corresponding to a culture grown in sucrose 40 g/l and asparagine 10 g/l..

Metabolic health

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Chemical Compositions and Macrophage Activation of Polysaccharides from Leon's Mane Culinary-Medicinal Mushroom Hericium erinaceus (Higher Basidiomycetes) in Different Maturation Stages.

We studied the effect of the maturation stage on the chemical compositions and macrophage activation activity of polysaccharides from the culinary-medicinal mushroom Hericium erinaceus..

Immune support

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters

Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells.

One new meroterpenoid, named hericenone K (11), along with 10 known compounds (1-10), ergosterol peroxide (1), cerevisterol (2), 3β,5α,9α-trihydroxy-ergosta-7,22-dien-6-one (3), inoterpene A (4), astradoric acid C (5), betulin (6), oleanolic acid (7), ursolic acid (8), hemisceramide (9), and….

Cognition & nerves

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Bioprocess and biosystems engineering

Chitosan multiple addition enhances laccase production from Trametes versicolor.

Chitosan multiple addition strategy was developed to improve laccase production from Trametes versicolor cultures. The optimized multiple addition strategy was carried out by two-time addition of 0.1 g L(-1) chitosan to a 2-day-old culture media, with 24-h interval between the treatments..

Energy & fatigueMetabolic health

Medium relevance

Enoki · 2015 · Brief Report · Mycobiology

Cloning and Expression Analysis of Phenylalanine Ammonia-Lyase Gene in the Mycelium and Fruit Body of the Edible Mushroom Flammulina velutipes.

Phenylalanine ammonia-lyase (PAL) gene is known to be expressed in plants, and is involved in the differentiation, growth and synthesis of secondary metabolites. However, its expression in fungi remains to be explored..

Medium relevance

Snow Fungus · 2015 · Comparative Study · The American journal of Chinese medicine

Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk.

Tremella fuciformis Berk (TF) is a common edible and medicinal mushroom, and has long been used in food and in Chinese medicine. It possesses anticancer, anti-inflammation, anti-oxidative, and neuroprotective abilities..

OncologyImmune supportCognition & nerves

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Journal of environmental management

Correlation between mesopore volume of carbon supports and the immobilization of laccase from Trametes versicolor for the decolorization of Acid Orange 7.

Immobilization of laccase from Trametes versicolor was carried out using carbon supports prepared from different lignocellulosic wastes. Enzymes were immobilized by physical adsorption..

Medium relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Correlation of nitric oxide produced by an inducible nitric oxide synthase-like protein with enhanced expression of the phenylpropanoid pathway in Inonotus obliquus cocultured with Phellinus morii.

Fungal interspecific interactions enhance biosynthesis of phenylpropanoid metabolites (PM), and production of nitric oxide (NO) is known to be involved in this process. However, it remains unknown which signaling pathway(s) or regulator(s) mediate fungal PM biosynthesis..

Medium relevance

Shiitake · 2015 · Brief Report · Toxicology reports

Deficiency of macro- and micronutrients induced by Lentinula edodes.

Mushroom Lentinula edodes has been widely studied therapeutically. However, there is no data regarding its daily intake level safety.

Liver support

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Environmental science. Processes & impacts

Degradation of pharmaceuticals from membrane biological reactor sludge with Trametes versicolor.

Emerging contaminants are a wide group of chemical products that are found at low concentrations in the environment. These contaminants can be either natural, e.g., estrogens, or synthetics, such as pesticides and pharmaceuticals, which can enter the environment through the water and sludge from wastewater treatment….

Metabolic health

Medium relevance

Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · BioMed research international

Development of Microsatellite Markers Derived from Expressed Sequence Tags of Polyporales for Genetic Diversity Analysis of Endangered Polyporus umbellatus.

A large scale of EST sequences of Polyporales was screened in this investigation in order to identify EST-SSR markers for various applications. The distribution of EST sequences and SSRs in five families of Polyporales was analyzed, respectively.

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Phytochemistry

Diacylglyceryltrimethylhomoserine content and gene expression changes triggered by phosphate deprivation in the mycelium of the basidiomycete Flammulina velutipes.

Diacylglyceryltrimethylhomoserines (DGTS) are betaine-type lipids that are phosphate-free analogs of phosphatidylcholines (PC). DGTS are abundant in some bacteria, algae, primitive vascular plants and fungi..

Medium relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Effect of chemicals on production, composition and antioxidant activity of polysaccharides of Inonotus obliquus.

Polysaccharides are important secondary metabolites from the medicinal mushroom Inonotus obliquus. Various fatty acids, surfactants and organic solvents as cell membrane-reorganizing chemicals were investigated for their stimulatory effects on the growth of fungal mycelium and production of exopolysaccharides (EPS)….

Immune supportMetabolic health

Medium relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Genetics and molecular research: GMR

Effect of different compounds on the induction of laccase production by Agaricus blazei.

Laccases are polyphenol oxidases produced by many fungi and have many applications in textile, food and beverage, and pulp and paper industries. Laccase production can be induced using aromatic or phenolic compounds that mostly affect the transcription of laccase-encoding genes..

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Effect of the replacement of aspartic acid/glutamic acid residues with asparagine/glutamine residues in RNase He1 from Hericium erinaceus on inhibition of human leukemia cell line proliferation.

RNase He1 from Hericium erinaceus, a member of the RNase T1 family, has high identity with RNase Po1 from Pleurotus ostreatus with complete conservation of the catalytic sequence..

Oncology

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Effects of Antrodia camphorata extracts on anti-oxidation, anti-mutagenesis and protection of DNA against hydroxyl radical damage.

BACKGROUND: Antrodia camphorata is a geographically special fungus and is one of the precious traditional medicines of Taiwan. A lot of reports have addressed its antioxidant activities and anticancer activities..

Oncology

Medium relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Pharmaceutical biology

Effects of Grifola frondosa non-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice.

CONTEXT: Consumption of medicinal mushrooms for disease prevention and maintaining health has a very long history in Asia. Grifola frondosa (Fr) S.F.

Immune supportCognition & nervesMetabolic health

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Bioresource technology

Efficient production of bioactive metabolites from Antrodia camphorata ATCC 200183 by asexual reproduction-based repeated batch fermentation.

Large-scale submerged fermentation (SmF) of Antrodia camphorata (A. camphorata) usually encounters challenges including tedious preparation of mycelial inoculum, long fermentation period (10-14 d), and poor repeatability..

Energy & fatigue

Medium relevance

Turkey Tail · 2015 · Research Support, U.S. Gov'T, Non P.H.S. · Environmental toxicology and chemistry

Environmental biodegradability of [¹⁴C] single-walled carbon nanotubes by Trametes versicolor and natural microbial cultures found in New Bedford Harbor sediment and aerated wastewater treatment plant sludge.

Little is known about environmental biodegradability or biotransformations of single-walled carbon nanotubes (SWNT). Because of their strong association with aquatic organic matter, detailed knowledge of the ultimate fate and persistence of SWNT requires investigation of possible biotransformations (i.e.,….

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Enzymatic and acidic degradation effect on intracellular polysaccharide of Flammulina velutipes SF-08.

The intracellular polysaccharide (IPS) from Flammulina velutipes SF-08 mycelia was isolated and degraded by enzyme and acid. IPS and its derivative were purified by DEAE-52 cellulose chromatography, and five fractions were obtained..

Immune supportSkin & hydration

Medium relevance

Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Ergostatrien-3β-ol from Antrodia camphorata inhibits diabetes and hyperlipidemia in high-fat-diet treated mice via regulation of hepatic related genes, glucose transporter 4, and AMP-activated protein kinase phosphorylation.

This study was designed to explore the effects and mechanism of ergostatrien-3β-ol (EK100) from the submerged whole broth of Antrodia camphorata on diabetes and dyslipidemia in high fat diet (HFD)-fed mice for 12 weeks..

Energy & fatigueMetabolic healthLiver support

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Journal of natural products

Erinaceolactones A to C, from the culture broth of Hericium erinaceus.

Three novel compounds, erinaceolactones A to C (1-3), and a known compound (4) were isolated from the culture broth of Hericium erinaceus. The planar structures of 1-3 were determined by the interpretation of spectroscopic data.

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Journal of natural products

Erinacerins C-L, isoindolin-1-ones with α-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus.

The well-known edible and medicinal mushroom Hericium erinaceus produces various bioactive secondary metabolites. Ten new isoindolin-1-ones, named erinacerins C-L (1-10), together with (E)-5-(3,7-dimethylocta-2,6-dien-1-yl)-4-hydroxy-6-methoxy-2-phenethylisoindolin-1-one (11) were isolated from the solid culture of H..

Oncology

Medium relevance

Lion's Mane · 2015 · Evaluation Study · Fungal biology

Erinacine C: A novel approach to produce the secondary metabolite by submerged cultivation of Hericium erinaceus.

Erinacine C is a cyathane scaffold-based secondary metabolite, which is naturally produced by the filamentous fungus Hericium erinaceus and has a high potential to treat nervous diseases such as Alzheimer's disease. The investigated approach consists of combining an optimised precultivation of H..

Cognition & nerves

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Fitoterapia

Four new spiroaxane sesquiterpenes and one new rosenonolactone derivative from cultures of Basidiomycete Trametes versicolor.

Four new spiroaxane sesquiterpenes, tramspiroins A-D (1-4), one new rosenonolactone 15,16-acetonide (5), and the known drimane sesquiterpenes isodrimenediol (6) and funatrol D (7) have been isolated from the cultures of Basidiomycete Trametes versicolor..

Oncology

Medium relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice.

Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body..

Immune supportSkin & hydration

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Hericium erinaceus polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest and apoptosis.

HEG-5 is a novel polysaccharide-protein purified from the fermented mycelia of Hericium erinaceus CZ-2. The present study aims to investigate the effects of HEG-5 on proliferation, cell cycle and apoptosis of human gastric cancer cells SGC-7901..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Current microbiology

Homocitrate synthase expression and lysine content in fruiting body of different developmental stages in Flammulina velutipes.

Homocitrate synthase (EC 2.3.3.14) regulates the first step of fungal lysine biosynthesis. The gene encoding homocitrate synthase was identified in whole genomic sequencing of Flammulina velutipes and contains seven introns.

Medium relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Chinese journal of natural medicines

Immunomodulatory activity of macromolecular polysaccharide isolated from Grifola frondosa.

The present study was designed to evaluate the immune-modulating effects of the polysaccharide from Grifola frondosa (GFP) by using mouse peritoneal macrophage and cytoxan (CTX) induced immunosuppression models..

Immune support

Medium relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · BioMed research international

Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study.

Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy with autologous stem cell support were randomized in a double blinded fashion to receive adjuvant treatment with the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients)..

OncologyImmune support

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Laccase production and metabolic diversity among Flammulina velutipes strains.

Twelve Flammulina velutipes strains originating from Poland were identified using internal transcribed spacer (ITS) region sequencing. Based on the sequences obtained, the genomic relationship of the analyzed strains was determined.

Energy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2015 · Evaluation Study · Fungal biology

Long term storage of Pleurotus ostreatus and Trametes versicolor isolates using different cryopreservation techniques and its impact on laccase activity.

The strain Pleurotus ostreatus Florida f6, its 45 basidiospore-derived isolates (both monokaryons and dikaryons prepared in our laboratory), Trametes versicolor strain CCBAS 614 and 22 other T..

Gut & microbiome

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of nanomedicine

Neurite outgrowth stimulatory effects of myco synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells.

BACKGROUND: Hericium erinaceus has been reported to have a wide range of medicinal properties such as stimulation of neurite outgrowth, promotion of functional recovery of axonotmetic peroneal nerve injury, antioxidant, antihypertensive, and antidiabetic properties..

Cognition & nervesEnergy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Chemosphere

Non conventional biological treatment based on Trametes versicolor for the elimination of recalcitrant anticancer drugs in hospital wastewater.

This work presents a study about the elimination of anticancer drugs, a group of pollutants considered recalcitrant during conventional activated sludge wastewater treatment, using a biological treatment based on the fungus Trametes versicolor..

OncologyEnergy & fatigue

Medium relevance

Snow Fungus · 2015 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Optimal codons in Tremella fuciformis end in C/G, a strong difference with known Tremella species.

Tremella fuciformis is a popular edible fungus with fruiting bodies that can be produced in large quantities at low costs, while it is easy to transform and cultivate as yeast. This makes it an attractive potential bioreactor..

Cognition & nerves

Medium relevance

Snow Fungus · 2015 · Research Support, Non U.S. Gov'T · Biotechnology letters

Oral vaccination of mice with Tremella fuciformis yeast-like conidium cells expressing HBsAg.

Tremella fuciformis yeast-like conidium (YLC) cells were transformed by co-cultivation with Agrobacterium cells harboring the hepatitis B surface antigen (HBsAg) gene construct under the control of the CaMV35S promoter. Integration of HBsAg DNA into the YLC genome was confirmed by PCR and dot-blot hybridization..

Immune supportLiver support

Medium relevance

Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · Scientific reports

Oxalic acid and sclerotial differentiation of Polyporus umbellatus.

The present investigation aimed to uncover the effects of exogenous oxalic acid during the sclerotial formation of Polyporus umbellatus, with an emphasis on determining the content of the endogenic oxalic acid in the fungus..

Energy & fatigue

Medium relevance

Mesima · 2015 · Research Support, Non U.S. Gov'T · Nutrition and cancer

Phellinus linteus extract induces autophagy and synergizes with 5-fluorouracil to inhibit breast cancer cell growth.

Phellinus linteus (PL) is a medicinal mushroom due to its several biological properties, including anticancer activity. However, the mechanisms of its anticancer effect remain to be elucidated..

Oncology

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Polysaccharides of Trametes versicolor Improve Bone Properties in Diabetic Rats.

This study investigates the effects of Trametes versicolor (L.:Fr.) Pilát (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five male Wistar rats (8 weeks old) were fed either a chow diet (control) or a high-fat diet throughout the study period of 28 days..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Materials science & engineering. C, Materials for biological applications

Potential of extracellular enzymes from Trametes versicolor F21a in Microcystis spp. degradation.

Studies have shown that microorganisms may be used to eliminate cyanobacteria in aquatic environments. The present study showed that the white-rot fungus Trametes versicolor F21a could degrade Microcystis aeruginosa.

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Preparation of the oligosaccharides derived from Flammulina velutipes and their antioxidant activities.

The oligosaccharides were prepared from Flammulina velutipes by hydrolysis of F. velutipes polysaccharides with hydrogen peroxide (H2O2).

Immune support

Medium relevance

Lion's Mane · 2015 · Case Reports · Fungal biology and biotechnology

Production of cyathane type secondary metabolites by submerged cultures of Hericium erinaceus and evaluation of their antibacterial activity by direct bioautography.

BACKGROUND: Fungi of the phylum Basidiomycota are well-known to form a broad spectrum of biologically active secondary metabolites, especially low molecular weight compounds such as terpenoids. Hericium erinaceus produces various cyathane type diterpenoids including erinacines..

Cognition & nervesEnergy & fatigue

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Biotechnology letters

Production, purification and biochemical characterization of two laccase isoforms produced by Trametes versicolor grown on oak sawdust.

Two laccase isoforms (lcc1 and lcc2) produced by Trametes versicolor, grown on oak sawdust under solid-state fermentation conditions, were purified and characterized. The two isoforms showed significant biochemical differences.

Medium relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Proteomics investigation reveals cell death-associated proteins of basidiomycete fungus Trametes versicolor treated with Ferruginol.

Ferruginol has antifungal activity against wood-rot fungi (basidiomycetes). However, specific research on the antifungal mechanisms of ferruginol is scarce.

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Antonie van Leeuwenhoek

Purification, characterization, antioxidant activity and anti-aging of exopolysaccharides by Flammulina velutipes SF-06.

The main objective of this work was to purify the exopolysaccharides (EPS) of Flammulina velutipes SF-06 and investigate the relationship between the different purified fractions and bioactive activity..

Immune supportSkin & hydration

Medium relevance

Wood Ear · 2015 · Research Support, Non U.S. Gov'T · The journal of physical chemistry. B

Redox-Active Sites in Auricularia auricula-judae Dye-Decolorizing Peroxidase and Several Directed Variants: A Multifrequency EPR Study.

Peroxide-activated Auricularia auricula-judae dye-decolorizing peroxidase (DyP) forms a mixed Trp377 and Tyr337 radical, the former being responsible for oxidation of the typical DyP substrates (Linde et al. Biochem..