MycoData

Polysaccharides isolated from the fruiting body of Inonotus obliquus (PFIO) are known to possess various pharmacological properties including antitumor activity. However, the anti-metastatic effect and its underlying mechanistic signaling pathway involved these polysaccharides in human non-small cell lung carcinoma….

OncologyImmune supportRespiratory

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

Insulin-sensitizing and beneficial lipid-metabolic effects of the water-soluble melanin complex extracted from Inonotus obliquus.

Inonotus obliquus has been traditionally used for treatment of metabolic diseases; however, the mechanism remains to be elucidated. In this study, we found that the water-soluble melanin complex extracted from I.

Metabolic healthSkin & hydration

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of industrial microbiology & biotechnology

Integrated strategy of pH-shift and glucose feeding for enhanced production of bioactive Antrodin C in submerged fermentation of Antrodia camphorata.

Antrodin C is one of the most potent bioactive components produced by the medicinal mushroom Antrodia camphorata. However, almost all studies in this field have focused on the biological activity of Antrodin C and relatively rare information has been reported regarding the biosynthetic process of Antrodin C..

Metabolic health

Medium relevance

Mesima · 2014 · Research Support, Non U.S. Gov'T · Journal of food science

Isolation, purification, and structural features of a polysaccharide from Phellinus linteus and its hypoglycemic effect in alloxan-induced diabetic mice.

Phellinus linteus is a medicinal mushroom that has been used in Oriental countries for centuries for its antitumor, antioxidant, immunomodulatory, and biological activity on hyperglycemia. A water-soluble crude polysaccharide was extracted using hot water from P.

OncologyImmune supportMetabolic health

Medium relevance

Zhu Ling · 2014 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus umbellatus mycelia (Khz). It inhibits the growth of cancer cells.

OncologyImmune supportEnergy & fatigue

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Journal of microbiology and biotechnology

Kinetic evidence for the interactive inhibition of laccase from Trametes versicolor by pH and chloride.

The interactive inhibitory effects of pH and chloride on the catalysis of laccase from Trametes versicolor were investigated by studying the alteration of inhibition characteristics of sodium chloride at different pHs for the oxidation of 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid)..

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

Metabolite secretion, Fe(3+)-reducing activity and wood degradation by the white-rot fungus Trametes versicolor ATCC 20869.

Trametes versicolor is a promising white-rot fungus for the biological pretreatment of lignocellulosic biomass. In the present work, T.

Immune support

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.

Antrodia camphorata (AC) has been used as a herbal medicine for drug intoxication for the treatment of inflammation syndromes and liver-related diseases in Taiwan. This study demonstrates the protective effect of the methanol extract of AC (MAC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Multiple-fingerprint analysis for investigating quality control of Flammulina velutipes fruiting body polysaccharides.

Quality control issues overshadow potential health benefits of the edible mushroom Flammulina velutipes, with the detection and isolation of polysaccharides posing particular problems..

Immune supportEnergy & fatigue

Medium relevance

Mesima · 2014 · Brief Report · Mycobiology

Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus.

During a search for neuraminidase inhibitors derived from medicinal fungi, we found that the fermentation broth of Phellinus linteus exhibited potent neuraminidase inhibitory activity..

Respiratory

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

New and Cytotoxic Components from Antrodia camphorata.

The solid-state cultured products of Antrodia camphorata as health foods has been blooming for the past few decades in Taiwan. In continuing our studies on the chemical constituents of the solid-state cultured products of this fungus, 6-methoxy-4-methyl-2,3-(methylenedioxy)phenol (1) and….

Oncology

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Optimization of enzyme-assisted extraction and characterization of polysaccharides from Hericium erinaceus.

The enzyme-assisted extraction (EAE) of polysaccharides from the fruits of Hericium erinaceus was studied. In this study, response surface methodology and the Box-Behnken design based on single-factor and orthogonal experiments were applied to optimize the EAE conditions..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Prikladnaia biokhimiia i mikrobiologiia

Overexpression and characterization of laccase from Trametes versicolor in Pichia pastoris.

A laccase-encoding gene of Trametes versicolor, lccA, was cloned and expressed in Pichia pastoris X33. The lccA gene consists ofa 1560 bp open reading frame encoding 519 amino acids, which was classified into family copper blue oxidase.

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Pb tolerance and bioaccumulation by the mycelia of Flammulina velutipes in artificial enrichment medium.

Mushrooms have the ability to accumulate high concentrations of heavy metals, which gives them potential for use as bioremediators of environmental contamination. The Pb(2+) tolerance and accumulation ability of living mycelia of Flammulina velutipes were studied in this work..

Gut & microbiome

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Oncology reports

Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway.

Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown..

OncologyImmune supportEnergy & fatigue

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · International immunopharmacology

Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization.

Inonotus obliquus is an edible and medicinal mushroom to treat many diseases. In the present study, polysaccharides and fractions were isolated and purified by DEAE-52 and Sephadex G-200 chromatography from I.

Immune supportMetabolic health

Medium relevance

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex.

Two new Bi3+-Hericium erinaceus polysaccharide (BiHEP) complexes were prepared using Bi3+ and two purified polysaccharides from H. erinaceus (HEPs), respectively.

Immune support

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Foodborne pathogens and disease

Prevalence and contamination patterns of Listeria monocytogenes in Flammulina velutipes plants.

Four mushroom (Flammulina velutipes) production plants were sampled to investigate the prevalence and contamination source of Listeria monocytogenes. Among 295 samples, the prevalence of L..

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Bioprocess and biosystems engineering

Production of bioactive polysaccharides by Inonotus obliquus under submerged fermentation supplemented with lignocellulosic biomass and their antioxidant activity.

The effect of lignocellulose degradation in wheat straw, rice straw, and sugarcane bagasse on the accumulation and antioxidant activity of extra- (EPS) and intracellular polysaccharides (IPS) of Inonotus obliquus under submerged fermentation were first evaluated..

Immune support

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Responses of antioxidant defenses and membrane damage to drought stress in fruit bodies of Auricularia auricula-judae.

Fruit bodies of Auricularia auricula-judae are often subjected to drought stress and became dormant. The responses of antioxidant defenses and membrane damage to drought stress were investigated in this study..

Energy & fatigue

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of chromatography. A

Separation of 25R/S-ergostane triterpenoids in the medicinal mushroom Antrodia camphorata using analytical supercritical-fluid chromatography.

Ergostanes are major bioactive constituents of the medicinal mushroom Antrodia camphorata. These tetracyclic triterpenoids usually occur as 25R/S epimeric pairs, which renders their chromatographic separation difficult..

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of chromatographic science

Simultaneous determination of 10 nucleosides and nucleobases in Antrodia camphorata using QTRAP LC-MS/MS.

A liquid chromatography-triple-quadrupole linear ion trap mass spectrometry (LC-QTrap-MS) analysis has been developed for the identiﬁcation and quantiﬁcation of 10 nucleosides and nucleobases in extracts of Antrodia camphorata..

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Biomedical chromatography: BMC

Simultaneous HPLC determination of ergosterol and 22,23-dihydroergosterol in Flammulina velutipes sterol-loaded microemulsion.

An efficient HPLC method was developed and validated for the simultaneous determination of ergosterol and 22,23-dihydroergosterol in Flammulina velutipes sterol-loaded microemulsions (FVSMs)..

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Stimulated production of steroids in Inonotus obliquus by host factors from birch.

Steroids was considered as one of the bioactive components in Inonotus obliquus, while this kind of secondary metabolites are less accumulated in cultured mycelia. In this study, effect of extracts from bark and core of host-related species, birch (Betula platyphylla Suk.), on steroid production of I..

Energy & fatigueMetabolic health

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

Stipe wall extension of Flammulina velutipes could be induced by an expansin-like protein from Helix aspersa.

Expansin proteins extend plant cell walls by a hydrolysis-free process that disrupts hydrogen bonding between cell wall polysaccharides. However, it is unknown if this mechanism is operative in mushrooms..

Immune support

Medium relevance

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Enzyme and microbial technology

The use of Trametes versicolor laccase for the polymerization of aniline in the presence of vesicles as templates.

The enzymatic polymerization of aniline to polyaniline (PANI) with Trametes versicolor laccase (TvL) as catalyst and dioxygen (O₂) as oxidant was investigated in an aqueous medium containing unilamellar vesicles with an average diameter of about 80 nm formed from AOT (=sodium bis(2-ethylhexyl) sulfosuccinate)..

Energy & fatigue

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Organic & biomolecular chemistry

Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus Flammulina velutipes.

The first total synthesis of a norsesquiterpene alkaloid (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione, isolated from the mushroom-forming fungus Flammulina velutipes, in both racemic and enantiomeric pure forms, is reported..

Oncology

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · PloS one

Whole genome and global gene expression analyses of the model mushroom Flammulina velutipes reveal a high capacity for lignocellulose degradation.

Flammulina velutipes is a fungus with health and medicinal benefits that has been used for consumption and cultivation in East Asia. F.

Energy & fatigue

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Fungal biology

A novel serine protease with caspase- and legumain-like activities from edible basidiomycete Flammulina velutipes.

A serine protease with caspase- and legumain-like activities from basidiocarps of the edible basidiomycete Flammulina velutipes was characterized. The protease was purified to near homogeneity by three steps of chromatography using acetyl-Tyr-Val-Ala-Asp-4-methylcoumaryl-7-amide (Ac-YVAD-MCA) as a substrate..

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Carcinogenesis

A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.

Lung cancer is the leading cause of cancer deaths worldwide and current therapies fail to treat this disease in majority of cases. Antrodia camphorata is a medicinal mushroom being widely used as food dietary supplement for cancer prevention..

OncologyImmune supportGut & microbiomeSkin & hydration

Medium relevance

Mesima · 2013 · Research Support, Non U.S. Gov'T · Chemico-biological interactions

Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.

Our previous study showed that polysaccharide (P1) from Phellinus linteus exhibits a significant inhibitive activity on human colorectal carcinoma cells (HT-29). However its novel molecular mechanism remains unknown..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.

Eburicoic acid (TR1) and dehydroeburicoic acid (TR2), an active ingredient from Antrodia camphorata (AC) solid-state culture, were evaluated for analgesic and anti-inflammatory effects..

OncologyImmune support

Medium relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · Food chemistry

Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus.

Mushroom Inonotus obliquus (I. obliquus) has been used as functional food and traditional Chinese herbs for long time.

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of natural products

Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.

Four new lanostanoids, ethyl lucidenate A (1), ethyl lucidenate F (2), 15-O-acetylganolucidate A (3), and 3,11,15,23-tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid (4), and two new lactone derivatives, 5-hydroxy-5-(methoxymethyl)-4-methylfuran-2(5H)-one (5) and 3-(4-methoxy-2-oxo-2H-pyran-6-yl)propanoic acid (6), together….

Immune support

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Antrodia camphorata ATCC 200183 sporulates asexually in submerged culture.

Antrodia camphorata is a well-known Chinese medicinal mushroom that protects against diverse health-related conditions. Submerged fermentation of A.

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Antrodia camphorata grown on germinated brown rice inhibits HT-29 human colon carcinoma proliferation through inducing G0/G1 phase arrest and apoptosis by targeting the β-catenin signaling.

Antrodia camphorata (AC) has been used as a traditional medicine to treat food and drug intoxication, diarrhea, abdominal pain, hypertension, pruritis (skin itch), and liver cancer in East Asia..

OncologyEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

Antrodia camphorata is a unique fungus in Taiwan; the submerged fermentation product is used as the functional food for liver protection. Deep ocean water (DOW) containing rich metals and trace elements is proven to stimulate the production of functional metabolites and health function of functional fungus product in….

Immune supportEnergy & fatigueLiver supportSkin & hydration

Medium relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Bioassay-guided isolation of DPP-4 inhibitory fractions from extracts of submerged cultured of Inonotus obliquus.

Inonotus obliquus is a medicinal mushroom used in Russian and Eastern European folk medicine for the treatment of gastrointestinal cancer, cardiovascular disease and diabetes. Previous studies in our laboratory have demonstrated that the mycelium powders of I..

OncologyMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Protein and peptide letters

Characterization and decolorization applicability of xerogel matrix immobilized manganese peroxidase produced from Trametes versicolor IBL-04.

A novel manganese peroxidase (MnP) isolated from solid state culture of Trametes versicolor IBL-04 was immobilized using xerogel matrix composed of trimethoxysilane (TMOS) and propyltetramethoxysilane (PTMS). FTIR spectroscopy confirmed the successful entrapment of MnP into the xerogel matrix..

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Characterization of a gene coding for a putative adenosine deaminase-related growth factor by RNA interference in the basidiomycete Flammulina velutipes.

A full-length cDNA coding for a putative adenosine deaminase (Fv-ada) was isolated from the basidiomycete Flammulina velutipes. Fv-ada encodes a polypeptide consisting of 537 amino acid residues, which has a consensus sequence conserved among adenosine deaminase-related growth factors (ADGF) found in several metazoa,….

Medium relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Chemical analysis and antioxidant activity of polysaccharides extracted from Inonotus obliquus sclerotia.

Three water-soluble polysaccharide fractions (IOP40, IOP60 and IOP80) were isolated by using different concentrations of alcohol precipitation from Inonotus obliquus sclerotia. Their physicochemical properties, including total sugar content, protein content, monosaccharide composition and percentage were analyzed..

Immune support

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Cytotoxic effect and induction of apoptosis in human cervical cancer cells by Antrodia camphorata.

Antrodia camphorata is a Chinese herb indigenous to Taiwan. Previous reports demonstrated that it could induce apoptosis in some cancer cells.

Oncology

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · International journal of pharmaceutics

Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation.

The aim of this study was to investigate the anti-tumor effect of sterols initially separated from Flammulina velutipes and the pharmacokinetics and tissue distribution after oral administration of F. velutipes sterol nanomicelles (FVSNs).

OncologyLiver support

Medium relevance

Almond Mushroom · 2013 · Research Support, Non U.S. Gov'T · BioMed research international

Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.

The action of an Agaricus blazei aqueous extract pretreatment on paracetamol injury in rats was examined not only in terms of the classical indicators (e.g., levels of hepatic enzymes in the plasma) but also in terms of functional and metabolic parameters (e.g., gluconeogenesis)..

Immune supportCognition & nervesMetabolic healthLiver support

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Effects of extraction methods on the antioxidant activities of polysaccharides obtained from Flammulina velutipes.

Four polysaccharides (CFP, UFP, MFP and EFP) were extracted from Flammulina velutipes using hot water, ultrasonic, microwave or enzymatic methods optimized by orthogonal test. Preliminary structural characterizations were conducted using physicochemical properties..

Immune support

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor affect differently the proliferation rate of HepG2 cells.

Fungi have been used for medicinal purposes for long time by Asian countries, being a putative source of powerful new phytopharmaceuticals such as polysaccharides..

Immune support

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation.

This study innovatively investigated the anticancer effect of Flammulina velutipes sterols (FVSs), the in vivo pharmacokinetics, and the tissue distribution of FVS-loaded liposomes..

OncologyLiver supportRespiratory

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Enzymatic removal of estrogenic activity of nonylphenol and octylphenol aqueous solutions by immobilized laccase from Trametes versicolor.

A fluidized bed reactor, filled with laccase-based beads, has been employed to bioremediate aqueous solutions polluted by endocrine disruptors belonging to the alkylphenols (APs) class. In particular Octylphenol and Nonylphenol have been studied..

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Fungal biology

Ethanol production from high cellulose concentration by the basidiomycete fungus Flammulina velutipes.

Ethanol production by Flammulina velutipes from high substrate concentrations was evaluated. F.

Metabolic health

Medium relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · Archives of pharmacal research

Experimental analysis on the main contents of Rhizoma gastrodiae extract and inter-transformation throughout the fermentation process of Grifola frondosa.

Gastrodin (GA), p-hydroxylbenzaldehyde (HBA), p-hydroxybenzyl alcohol (gastrodigenin, HA) and parishin not only are the major active ingredients of Rhizoma gastrodiae, but exist transformed relations from each other throughout the fermentation process of Grifola frondosa in this work..