MycoData

To improve the pentose fermentation rate in Flammulina velutipes, the putative xylose isomerase (XI) gene from Arabidopsis thaliana was cloned and introduced into F. velutipes and the gene expression was evaluated in transformants..

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of biotechnology

Functional expression of FIP-fve, a fungal immunomodulatory protein from the edible mushroom Flammulina velutipes in Pichia pastoris GS115.

FIP-fve is a bioactive protein isolated from the mushroom Flammulina velutipes, which belongs to the fungal immunomodulatory protein (FIP) family and demonstrates several kinds of biological activities including anti-allergy, anti-tumor and immunomodulation..

OncologyImmune support

Medium relevance

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · PloS one

Genetic diversity and evolution of Chinese traditional medicinal fungus Polyporus umbellatus (Polyporales, Basidiomycota).

BACKGROUND: Polyporus umbellatus is an important medicinal fungus distributed throughout most area of China. Its wide distribution may have resulted in substantial intraspecific genetic diversity for the fungus, potentially creating variation in its medical value..

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Food chemistry

Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Mesima · 2013 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.

Hispolon (a phenolic compound isolated from Phellinus linteus) has been shown to possess strong antioxidant, anti-inflammatory, anticancer, and antidiabetic properties..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Mesima · 2013 · Research Support, Non U.S. Gov'T · Asian Pacific journal of tropical biomedicine

Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice.

OBJECTIVE: To isolate and identify the anticancer compound against proliferation of human colon cancer cells from ethyl acetate (EtOAc) extract of Phellinus linteus grown on germinated brown rice (PB). METHODS: EtOAc extract of PB was partitioned with n-hexane, EtOAc, and water-saturated n-butanol..

OncologyGut & microbiome

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Journal of industrial microbiology & biotechnology

Immobilization of Trametes versicolor cultures for improving laccase production in bubble column reactor intensified by sonication.

The mycelia of Trametes versicolor immobilized in alginate beads provided higher laccase production than that in pelleted form. An efficient ultrasonic treatment enhanced laccase production from the immobilized T.

Medium relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent.

Grifola frondosa (GF), a high value medicinal mushroom in China and Japan, is popularly consumed as traditional medicines and health foods, especially for enhancing immune functions..

Immune support

Medium relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa, through dectin-1 in macrophages.

Polysaccharides, especially β-glucans isolated from various species of mushrooms, are considered as biological response modifiers (BRMs) to be widely used in the treatment of cancer, especially due to their immunostimulatory activity..

OncologyImmune support

Medium relevance

Yellow Morel · 2013 · Research Support, Non U.S. Gov'T · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta.

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation.

Low molecular weight (LMW) polyphenolics containing a polyhydroxylated benzyl moiety are abundant in medicinal plants. In the present study, we report on the activities of seven LMW polyphenolics isolated from Inonotus obliquus, a medicinal mushroom..

OncologyMetabolic healthGut & microbiome

Medium relevance

Maitake · 2013 · Research Support, Non U.S. Gov'T · Biotechnology and applied biochemistry

Inhibitory potential of Grifola frondosa bioactive fractions on α-amylase and α-glucosidase for management of hyperglycemia.

This study examined the inhibitory effects of Grifola frondosa (GF), a medicinal mushroom popularly consumed in traditional medicine and health food, on digestive enzymes related to type 2 diabetes; chemical profiles and inhibitory kinetics of its bioactive fractions were also analyzed..

Metabolic healthGut & microbiome

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes.

FIP-fve is an immunomodulatory protein isolated from Flammulina velutipes that possesses anti-inflammatory and immunomodulatory activities. However, little is known about its anticancer effects.

OncologyImmune supportSkin & hydrationRespiratory

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

Isolation and synthesis of a bioactive benzenoid derivative from the fruiting bodies of Antrodia camphorata.

A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'-methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus)..

OncologyGut & microbiome

Medium relevance

Turkey Tail · 2013 · Comparative Study · Bioprocess and biosystems engineering

Laccase production by free and immobilized mycelia of Peniophora cinerea and Trametes versicolor: a comparative study.

The production of laccase by immobilized mycelia of Peniophora cinerea and Trametes versicolor was studied. In an initial stage, experimental assays were performed in Erlenmeyer flasks using free and immobilized mycelium, and the performance of the fungal strains to produce the enzyme was compared..

Energy & fatigue

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Environmental technology

Laccase production by Trametes versicolor under limited-growth conditions using dyes as inducers.

Laccase production by pre-growth pellets of Trametes versicolor using two types of textile dyes as inducers was studied. By decoupling the enzyme production phase from the growth phase, it is possible to reduce the time and nutrients required for laccase production..

Metabolic health

Medium relevance

Snow Fungus · 2013 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Mechanical Wounding of Yeast-Like Conidium Cells of Tremella fuciformis Makes Them Susceptible to Agrobacterium-Mediated Transformation

We developed an efficient protocol that makes possible the practical use of Agrobacterium to transform the yeast-like conidia of Tremella fuciformis. Mechanical wounding of fungal cells prior to co-cultivation with Agrobacterium cells greatly improved transformation efficiency..

Skin & hydration

Medium relevance

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

Nox gene expression and cytochemical localization of hydrogen peroxide in Polyporus umbellatus sclerotial formation.

The effect of temperature shift on Polyporus umbellatus sclerotial development was investigated. Micromorphology of the sclerotia was observed by using scanning electron microscopy (SEM)..

Medium relevance

Mesima · 2013 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells.

Tacrine (THA) was the first drug licensed for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity is evident in about 30% of patients and limits its clinical use.

OncologyCognition & nervesEnergy & fatigueLiver support

Medium relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties.

Physical modification of polysaccharides exerted better biological properties because of the change of physicochemical properties. Polysaccharides from Inonotus obliquus (IOPS) were modified by acid, alkali hydrolysis, thermal and ultrasonic treatment in this study..

Immune support

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Bioprocess and biosystems engineering

Production of laccase from Trametes versicolor by solid-state fermentation using olive leaves as a phenolic substrate.

The aim of the present study was to investigate whether olive leaves were feasible as a substrate for laccase production by the white-rot fungus Trametes versicolor FPRL 28A INI under solid-state fermentation conditions..

Medium relevance

Mesima · 2013 · Research Support, Non U.S. Gov'T · Prikladnaia biokhimiia i mikrobiologiia

Purification and characterization of laccase secreted by Phellinus linteus MTCC-1175 and its role in the selective oxidation of aromatic methyl group.

A laccase from the culture filtrate of Phellinus linteus MTCC-1175 has been purified to homogeneity. The method involved concentration of the culture filtrate by ammonium sulphate precipitation and an anion exchange chro- matography on DEAE-cellulose..

Energy & fatigue

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of environmental biology

Removal of Cu2+ ions from aqueous solution by the abandoned mushroom compost of Flammulina velutipes.

The abandoned mushroom compost of Flammulina velutipes, a cheap and easy by-product to get, was used as biosorbent for removing copper ions from aqueous solution..

Medium relevance

Turkey Tail · 2013 · Comparative Study · Water science and technology: a journal of the International Association on Water Pollution Research

Removal of trace organic contaminants by nitrifying activated sludge and whole-cell and crude enzyme extract of Trametes versicolor.

The resistance of certain anthropogenic trace organic contaminants (TrOCs) to conventional wastewater treatment and their potential adverse effects on human and ecological health raise significant concerns and have prompted research on their bioremediation by white-rot fungi..

Energy & fatigue

Medium relevance

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · PloS one

Sclerotial formation of Polyporus umbellatus by low temperature treatment under artificial conditions.

BACKGROUND: Polyporus umbellatus sclerotia have been used as a diuretic agent in China for over two thousand years. A shortage of the natural P.

Immune supportEnergy & fatigue

Medium relevance

Chaga · 2013 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Stimulatory effect of different lignocellulosic materials for phenolic compound production and antioxidant activity from Inonotus obliquus in submerged fermentation.

White-rot fungus Inonotus obliquus grown in submerged culture produces antioxidative phenolic compounds. In this study, addition of lignocellulosic materials into the liquid culture increased the production and antioxidant activity of extra- and intra-cellular phenolic compounds (EPC and IPC, respectively)..

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Successive transformation of benzo[a]pyrene by laccase of Trametes versicolor and pyrene-degrading Mycobacterium strains.

We previously hypothesized that polycyclic aromatic hydrocarbon (PAH)-degrading bacteria that produce laccase may enhance the degree of benzo[a]pyrene mineralization. However, whether the metabolites of benzo[a]pyrene oxidized by laccase can be further transformed by PAH degraders remains unknown..

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicinal fungus. However, the anticancer activity of AC against human HER-2/neu-overexpressing ovarian cancers is poorly understood..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Journal of biotechnology

The secretome of Trametes versicolor grown on tomato juice medium and purification of the secreted oxidoreductases including a versatile peroxidase.

The present work was carried out with the aim to analyze the secretome of Trametes versicolor BAFC 2234 grown on tomato juice medium supplemented with copper and manganese. T..

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · PloS one

Trametes versicolor protein YZP activates regulatory B lymphocytes - gene identification through de novo assembly and function analysis in a murine acute colitis model.

BACKGROUND: Trametes versicolor (Yun-Zhi) is a medicinal fungus used as a chemotherapy co-treatment to enhance anti-tumor immunity. Although the efficacies of T.

OncologyImmune supportGut & microbiome

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Ultrasonics sonochemistry

Ultrasound-intensified laccase production from Trametes versicolor.

An efficient intermittent ultrasonic treatment strategy was developed to improve laccase production from Trametes versicolor mycelia cultures. The optimized strategy consisted of exposing 2-day-old mycelia cultures to 5-min ultrasonic treatments for two times with a 12-h interval at the fixed ultrasonic power and….

Medium relevance

Lion's Mane · 2012 · English Abstract · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

[Submerged cultivation and chemical composition of Hericium erinaceus mycelium].

Submerged cultivation of Hericium erinaceus in various media was studied. The yield of the biomass was shown to depend mainly on the carbon source, whereas the content of water soluble polysaccharides depended mainly on the nitrogen source..

Immune supportMetabolic health

Medium relevance

Chaga · 2012 · English Abstract · Yao xue xue bao = Acta pharmaceutica Sinica

[Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4].

To investigate the effects of lanosterol (1), inotodiol (2) and trametenolic acid (3) from Inonotus obliquus against oxidative damage induced by CCl4 in mice, 1, 2 and 3 (20, 10 and 5 mg x kg(-1)) were respectively administered to mice, once a day for 3 days..

Immune supportLiver support

Medium relevance

Snow Fungus · 2012 · Research Support, Non U.S. Gov'T · Bioresource technology

A three-stage culture process for improved exopolysaccharide production by Tremella fuciformis.

Tremella fuciformis produces several bioactive secondary metabolites including exopolysaccharides. Cultivation of the fungus was carried out in a three-stage process consisting of a 1.5-day cultivation with orbital shaking at 200 rpm, a 1.5-day cultivation with reciprocal shaking at 200 strokes, and a 1.5-day….

Immune support

Medium relevance

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Analytical chemistry

An electrochemical method for investigation of conformational flexibility of active sites of Trametes versicolor laccase based on sensitive determination of copper ion with cysteine-modified electrodes.

This study demonstrates a facile yet effective electrochemical method to investigate the conformational flexibility of the active sites of Trametes versicolor (Tv) laccase based on sensitive determination of copper ions (Cu(2+)) dissociated from the enzyme with the cysteine-modified Au electrodes..

Medium relevance

Mesima · 2012 · Research Support, Non U.S. Gov'T · PloS one

Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

Inotilone was isolated from Phellinus linteus. The anti-inflammatory effects of inotilone were studied by using lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells and λ-carrageenan (Carr)-induced hind mouse paw edema model..

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Anticancer research

Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.

Eleven derivatives from Antrodia camphorata were isolated in order to evaluate their selective cytotoxicity toward 14 types of human cancer cell and two non-transformed cell types..

OncologyEnergy & fatigueLiver support

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.

Antrodia camphorata (AC) is a native Taiwanese mushroom which is used in Asian folk medicine as a chemopreventive agent. The triterpenoid-rich fraction (FEA) was obtained from the ethanolic extract of AC and characterized by high performance liquid chromatography (HPLC)..

OncologyEnergy & fatigueMetabolic health

Medium relevance

Chaga · 2012 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Antioxidant activities of five polysaccharides from Inonotus obliquus.

Five polysaccharides (IOP1b, IOP2a, IOP2c, IOP3a and IOP4) were isolated and purified from Inonotus obliquus by DEAE-Sepharose fast flow and SepharoseCL-6B column chromatography..

Immune support

Medium relevance

Lion's Mane · 2012 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Antioxidant and hepatoprotective potential of endo-polysaccharides from Hericium erinaceus grown on tofu whey.

Three fractions of the endo-polysaccharides from the mycelium of Hericium erinaceus (HEP) grown on tofu whey were obtained by the fractional precipitation with gradient concentrations of ethanol (HEP40, HEP60 and HEP80)..

Immune supportLiver support

Medium relevance

Chaga · 2012 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

Antioxidative properties of crude polysaccharides from Inonotus obliquus.

The mushroom Inonotus obliquus has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. In this study, water-soluble and alkali-soluble crude polysaccharides (IOW and IOA) were isolated from I..

Immune support

Medium relevance

Chaga · 2012 · Evaluation Study · Carbohydrate polymers

Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.

The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology

Batch production of Pyranose 2-oxidase from Trametes versicolor (ATCC 11235) in medium with a lignocellulosic substrate and enzymatic bleaching of cotton fabrics.

The aim of this work was to determine new, different and low-cost substrates that can be used for enzyme production from the white rot fungus Trametes versicolor (ATCC 11235) by taking advantage of the broad substrate specificity of pyranose 2-oxidase..

Metabolic health

Medium relevance

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Environmental science & technology

Bioaugmentation of sewage sludge with Trametes versicolor in solid-phase biopiles produces degradation of pharmaceuticals and affects microbial communities.

The use of sludge (biosolids) in land application may contribute to the spread of organic micropollutants as wastewater treatments do not completely remove these compounds. Therefore, the development of alternative strategies for sludge treatment is a matter of recent concern..

Gut & microbiome

Medium relevance

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Environmental technology

Biodegradation of organics in landfill leachate by immobilized white rot fungi, Trametes versicolor BCC 8725.

Immobilized Trametes versicolor BCC 8725 was evaluated for the biodegradation of the organic components of four different types of landfill leachate collected at different time periods and locations from the Nonthaburi landfill site of Thailand in batch treatment..

Energy & fatigue

Medium relevance

Turkey Tail · 2012 · Evaluation Study · Journal of environmental science & engineering

Biological decolourisation of pulp mill effluent using white rot fungus Trametes versicolor.

The conventional biological treatment methods employed in the pulp and paper industries are not effective in reducing the colour and chemical oxygen demand (COD). The white-rot fungi are reported to have the ability to biodegrade the lignin and its derivatives..

Energy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · BMC biotechnology

Characterization of purified and xerogel immobilized novel lignin peroxidase produced from Trametes versicolor IBL-04 using solid state medium of corncobs.

BACKGROUND: Cost-effective production of industrially important enzymes is a key for their successful exploitation on industrial scale. Keeping in view the extensive industrial applications of lignin peroxidase (LiP), this study was performed to purify and characterize the LiP from an indigenous strain of Trametes….

Medium relevance

Chaga · 2012 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Chemical modification and antioxidant activities of polysaccharide from mushroom Inonotus obliquus.

Chemical modification polysaccharides exerted potent biological property which was related to the physicochemical properties. In the present study, polysaccharides from Inonotus obliquus were modified by suflation, acetylation and carboxymethylation.

Immune support

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Journal of pharmaceutical and biomedical analysis

Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata.

Antrodia camphorata (AC), also known as Antrodia cinnamomea, an endemic species in Taiwan, is one of the treasured medicinal mushrooms. AC is traditionally used for its chemopreventive biofunctions..

OncologyEnergy & fatigue

Medium relevance

Chaga · 2012 · Research Support, Non U.S. Gov'T · Food chemistry

Chemical properties and antioxidant activity of exopolysaccharides fractions from mycelial culture of Inonotus obliquus in a ground corn stover medium.

The medicinal mushroom Inonotus obliquus has been a folk remedy for a long time in East-European and Asian countries. We first reported the enhancement in production and antioxidant activity of exopolysaccharides by I.

Immune support