MycoData

Cordyceps · 2020 · Research Article · BMC genomics

Changes in transcriptomic and metabolomic profiles of morphotypes of Ophiocordyceps sinensis within the hemocoel of its host larvae, Thitarodes xiaojinensis.

BACKGROUND: Ophiocordyceps sinensis (Berk.) is a well-known entomopathogenic and medicinal fungus. It parasitizes and mummifies the underground ghost moth larvae to produce a fruiting body named Chinese cordyceps.

Cognition & nervesMetabolic healthGut & microbiome

Lion's Mane · 2020 · Journal Article · Journal of ethnopharmacology

Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus).

ETHNOPHARMACOLOGICAL RELEVANCE: Hericium erinaceus, commonly called lion's mane mushroom, is an edible and medicinal mushroom that has been traditionally used for the treatment of metabolic disorders, gastrointestinal diseases and memory impairment..

Cordyceps · 2020 · Journal Article · International journal of biological macromolecules

Chemical structure and mechanism of polysaccharide on Pb2+ tolerance of Cordyceps militaris after Pb2+ domestication.

In this study, the purified polysaccharide (DCP-I) was extracted from Cordyceps militaris domesticated with Pb2+. After that, the structural feature and mechanism of lead resistance of DCP-I were investigated using novel approaches..

Reishi · 2020 · Journal Article · International journal of medicinal mushrooms

Effect of Cultured Substrates on the Chemical Composition and Biological Activities of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes).

A systematic study was carried out to compare the chemical composition and biological activities of wood-cultured and sack-cultured Ganoderma lucidum (WG and SG, respectively). The proximate composition, microelement content, and functional compounds of the two different cultivated mushrooms were investigated..

Immune supportMetabolic healthGut & microbiomeLiver support

King Oyster · 2020 · Journal Article · European journal of nutrition

Effect of mushroom polysaccharides from Pleurotus eryngii on obesity and gut microbiota in mice fed a high-fat diet.

PURPOSE: Mushrooms are reported to have a variety of health-promoting activities. However, little information is available on the effects of intake of polysaccharides from Pleurotus eryngii on obesity.

Cognition & nervesMetabolic healthLiver support

King Oyster · 2020 · Journal Article · International journal of medicinal mushrooms

Effect of the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Basidiocarps Powder to Ameliorate Memory and Learning Deficit in Ability in Aβ-Induced Alzheimer's Disease C57BL/6J Mice Model.

One of the major causes of Alzheimer's disease (AD) is oxidative stress, which accelerates β-amyloid peptide (AP) plaque and neurofibrillary tangle accumulation in the brain..

Immune supportMetabolic healthGut & microbiomeLiver support

Almond Mushroom · 2020 · Research Article · Food science & nutrition

Effects of Agaricus blazei Murrill polysaccharides on hyperlipidemic rats by regulation of intestinal microflora.

The present research envisaged the effects of Agaricus blazei Murrill polysaccharides (ABPs) on blood lipids and its role in regulation of the intestinal microflora in hyperlipidemic rats. The acidic polysaccharide fraction of Agaricus blazei Murrill was obtained by DEAE-cellulose ion exchange column chromatography..

Turkey Tail · 2020 · Journal Article · International journal of medicinal mushrooms

Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus.

The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been reported to increase cellular glucose uptake in HepG2 cells in an insulin-independent manner..

Immune supportEnergy & fatigueMetabolic health

King Oyster · 2020 · Journal Article · International journal of food science & technology

Extraction, isolation, characterisation, antioxidant and anti‐fatigue activities of Pleurotus eryngii polysaccharides

Pleurotus eryngii polysaccharide (PEP) was obtained using hot water extraction and ethanol precipitation. Three purified polysaccharide fractions (namely PEP1‐A, PEP2‐A and PEP3‐A) were obtained from PEP using DEAE‐cellulose‐52 chromatography and a gel permeation Sephadex G‐100 column..

OncologyImmune supportEnergy & fatigueMetabolic health

Lion's Mane · 2020 · Journal Article · Food & function

Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways.

The fruiting bodies of Hericium erinaceus (Bull.) Pers. are commonly used in China in the treatment of digestive system diseases.

Reishi · 2020 · Research Article · Biology

Ganoderma Lucidum from Red Mushroom Attenuates Formaldehyde-Induced Liver Damage in Experimental Male Rat Model.

The majority of liver-related illnesses are caused by occupational and domestic exposure to toxic chemicals like formaldehyde (FA), which is widely common in Africa and the world at large. Hence, measures should be taken to protect humans from its hazardous effects..

Cognition & nervesMetabolic health

Cordyceps · 2020 · Journal Article · Journal of biotechnology

Genome mining and biosynthesis of the Acyl-CoA:cholesterol acyltransferase inhibitor beauveriolide I and III in Cordyceps militaris.

Ascomycete fungi Cordyceps are widely used in traditional Chinese medicine, and numerous investigations have been carried out to uncover their biological activities. However, primary researches on the physiological effects of Cordyceps were committed using crude extracts..

OncologyCognition & nervesMetabolic health

King Oyster · 2020 · Research Article · Applied microbiology and biotechnology

High-level expression of aryl-alcohol oxidase 2 from Pleurotus eryngii in Pichia pastoris for production of fragrances and bioactive precursors.

The fungal secretome comprises various oxidative enzymes participating in the degradation of lignocellulosic biomass as a central step in carbon recycling. Among the secreted enzymes, aryl-alcohol oxidases (AAOs) are of interest for biotechnological applications including production of bio-based precursors for….

Metabolic healthGut & microbiome

Lion's Mane · 2020 · Journal Article · Planta medica

Identification and α-Glucosidase Inhibitory Activity of Meroterpenoids from Hericium erinaceus.

Hericium erinaceus is a very popular edible and medicinal mushroom used for the treatment of enervation and gastrointestinal diseases in Eastern Asia. Chemical investigation on the fruiting body of Hericium erinaceus led to the isolation of 4 new (1: - 4: ) and 10 known meroterpenoids (5: - 14: )..

Cordyceps · 2020 · Journal Article · International journal of medicinal mushrooms

Immunomodulatory Properties of Water-Soluble Polysaccharides Extracted from the Fruiting Body of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis Cultivar OCS02® (Ascomycetes).

Ophiocordyceps sinensis (=Cordyceps sinensis) has been known for its various medicinal properties, in particular immunomodulatory activities associated with its polysaccharides. In this study, the fruiting body of O.

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2020 · Research Article · Frontiers in pharmacology

Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome.

Inonotus obliquus polysaccharide (IOP), the primary constituent of the parasitic fungus Inonotus obliquus, has anti-tumor, anti-inflammatory, anti-oxidation effects. However, the roles of IOP on colitis-associated cancer (CAC) are still unclear..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2020 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides induces apoptosis of lung cancer cells and alters energy metabolism via the LKB1/AMPK axis.

The present study explores the mechanisms underlying the anti-cancer action of Inonotus obliquus polysaccharides (IOP). Thus, we characterized the IOP components extracted from Chaga sclerotium and, found that the extracts contained 70% polysaccharides with an average molecular weight of 4.5 × 104 Da consisting of 75%….

OncologyImmune supportMetabolic health

Shiitake · 2020 · Journal Article · Carbohydrate polymers

Isolation and comparison of α- and β-D-glucans from shiitake mushrooms (Lentinula edodes) with different biological activities.

A polysaccharide-enriched extract obtained from Lentinula edodes was submitted to several purification steps to separate three different D-glucans with β-(1→6), β-(1→3),(1→6) and α-(1→3) linkages, being characterized through GC-MS, FT-IR, NMR, SEC and colorimetric/fluorimetric determinations..

Almond Mushroom · 2020 · Journal Article · International journal of biological macromolecules

Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid-lowering mechanism.

Polysaccharides are important active constituents of Agaricus blazei Morrill. In the present study, WABM-A was isolated from WABM using DEAE-cellulose, and subsequently purified using sepharose CL-6B to obtain the acidic polysaccharide WABM-A-b..

Energy & fatigueMetabolic health

Oyster Mushroom · 2020 · Journal Article · Applied microbiology and biotechnology

Lactic acid accumulation under heat stress related to accelerated glycolysis and mitochondrial dysfunction inhibits the mycelial growth of Pleurotus ostreatus.

High temperature is a major threat to Pleurotus ostreatus cultivation. In this study, a potential mechanism by which P.

Cognition & nervesEnergy & fatigueMetabolic health

Reishi · 2020 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Ameliorates Spatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease.

Hypercholesterolemia has been implicated as one of the pathomechanistic factors of Alzheimer's disease (AD), the most common neurodegenerative disorder affecting memory and learning abilities..

Cognition & nervesMetabolic health

Reishi · 2020 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Ameliorates Nonspatial Learning and Memory Deficits in Rats with Hypercholesterolemia and Alzheimer's Disease.

Alzheimer's disease (AD) is the leading neurodegenerative disorder affecting memory and learning of aged people. Hypercholesterolemia had been implicated as one of the stark hallmarks of AD.

Reishi · 2020 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Polysaccharides Suppressed Adipogenesis and Stimulated Lipolysis in HPA-v and 3T3-L1 Adipocytes.

Ganoderma lucidum polysaccharides (GLP) are one of the major bioactive components with many beneficial properties. In the present study we aimed to systematically evaluate the effects of GLP on lipid metabolism in human (HPA-v) and murine adipocytes (3T3-L1).

Cordyceps · 2020 · Research Article · Biology

Metabolic Responses of Carotenoid and Cordycepin Biosynthetic Pathways in Cordyceps militaris under Light-Programming Exposure through Genome-Wide Transcriptional Analysis.

Cordyceps militaris is currently exploited for commercial production of specialty products as its biomass constituents are enriched in bioactive compounds, such as cordycepin. The rational process development is important for economically feasible production of high quality bioproducts..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2020 · Research Article · Scientific reports

Molecular insights and cell cycle assessment upon exposure to Chaga (Inonotus obliquus) mushroom polysaccharides in zebrafish (Danio rerio).

Chaga (Inonotus obliquus) mushroom is considered as one of the most powerful antioxidants across the world. Though the therapeutic effects of Chaga components are well characterized in vitro, the in vivo developmental effects are not elucidated in detail..

King Oyster · 2020 · Research Article · RSC advances

Optimization of extraction parameters of Pleurotus eryngii polysaccharides and evaluation of the hypolipidemic effect.

The hot water extraction of polysaccharides from the fruiting body of Pleurotus eryngii was studied. In this paper, according to single-factor experiments, a response surface methodology and the Box-Behnken design were applied to optimize the extraction parameters of Pleurotus eryngii polysaccharides (PEP)..

Cordyceps · 2020 · Research Article · Computational and structural biotechnology journal

Optimizing cultivation of Cordyceps militaris for fast growth and cordycepin overproduction using rational design of synthetic media.

Cordyceps militaris is an entomopathogenic fungus which is often used in Asia as a traditional medicine developed from age-old wisdom. Presently, cordycepin from C.

King Oyster · 2020 · Journal Article · International journal of medicinal mushrooms

Polysaccharides from Pleurotus eryngii var. elaeoselini (Agaricomycetes), a New Potential Culinary-Medicinal Oyster Mushroom from Italy.

Three water-soluble glucans (PELPS-A1, PELPS-A2, and PELPS-A3) purified from the hot water extract of the basidiomata of an edible mushroom Pleurotus eryngii var. elaeoselini by chromatography on DEAE-cellulose 32 and Sephadex G-100 column were found to consist of only D-glucose as monosaccharide constituent..

OncologyImmune supportMetabolic health

King Oyster · 2020 · Journal Article · Journal of food science

Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti-inflammation activities potential.

The anti-inflammatory effects of two newly identified Pleurotus eryngii polysaccharides (WPEP, NPEP) were determined in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in this study..

Immune supportEnergy & fatigueMetabolic health

Snow Fungus · 2020 · Journal Article · International journal of biological macromolecules

Production, structure, and bioactivity of polysaccharide isolated from Tremella fuciformis XY.

Tremella fuciformis polysaccharide (TFP) is an important bioactive substance in Tremella, that contributes to its use as medicine and food. In this study, a novel fungus Tremella fuciformis XY was isolated and introduced to produce macromolecule polysaccharides (TFPB)..

Cordyceps · 2020 · Research Article · BMC genomics

Proteome sequencing and analysis of Ophiocordyceps sinensis at different culture periods.

BACKGROUND: Ophiocordyceps sinensis is an important traditional Chinese medicine for its comprehensive active ingredients, such as cordycepin, cordycepic acid, and Cordyceps polysaccharide. O.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Chaga · 2020 · Journal Article · International journal of biological macromolecules

Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus.

The aim of this study was to evaluate the spatial structure and potential antifatigue activity of polysaccharide fractions which was extracted from Inonotus obliquus..

Reishi · 2020 · Journal Article · International journal of medicinal mushrooms

Statistical Optimization of Polysaccharides Production by the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) in Solid-State Fermentation Using Highland Barley Grains.

Ganoderma lucidum is a widely used medicinal mushroom in traditional Chinese medicine that creates a diverse set of bioactive compounds. Highland barley, a typical nutrition-balanced crop, is not convenient for direct consumption but its nutritional characteristics meet the modern requirements of health food..

Oyster Mushroom · 2020 · Journal Article · International journal of biological macromolecules

Structural characterization of phosphorylated Pleurotus ostreatus polysaccharide and its hepatoprotective effect on carbon tetrachloride-induced liver injury in mice.

This study aimed to explore the basic structural features of phosphorylated Pleurotus ostreatus polysaccharide (PPOP) and study the protective effect of PPOP on liver injury induced by carbon tetrachloride in male Kunming mice..

Cordyceps · 2020 · Journal Article · Carbohydrate polymers

Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley

A water-soluble neutral polysaccharide (SDQCP-1) was isolated from fruit bodies of Cordyceps militaris cultivated on hull-less barley. SDQCP-1 was composed of mannose, glucose and galactose in the mole ratio of 13.3:1.0:9.7, with an average molecular weight of 19.3 kDa..

Cordyceps · 2020 · Journal Article · Carbohydrate polymers

Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley.

Almond Mushroom · 2020 · Journal Article · Journal of food biochemistry

The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin‐induced diabetic rats

Agaricus blazei Murrill (ABM), is a medicinal mushroom, has beneficial effects on diabetes mellitus. In this study, ABM extracts (ethanol extract, EE and ethyl acetate extract, EA) were evaluated to explore the beneficial effect on hepatic antioxidant activity and recovery of the pancreatic tissue in….

King Oyster · 2020 · Journal Article · Acta scientiarum polonorum. Technologia alimentaria

Therapeutic effects of chitin from Pleurotus eryngii on high-fat diet induced obesity in rats.

BACKGROUND: Recent shifts in lifestyles and diets have caused the incidence of obesity to increase rapidly, resulting in a serious threat to modern human health. There is a growing interest the use of plant or fungi derived supplements as a safe and effective means to treat obesity..

Turkey Tail · 2020 · Journal Article · International journal of medicinal mushrooms

Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Crude Exopolysaccharides with Antioxidative Activity.

Crude Trametes versicolor exopolysaccharides (cEPS) were used for antioxidative activity testing. Obtained results revealed high ability of cEPS for DPPH free radical scavenging and high chelating ability at the highest tested concentration (20 mg/mL), while the reducing power was significantly lower..

OncologyMetabolic healthLiver support

Cordyceps · 2019 · Journal Article · Journal of microbiology and biotechnology

1H-NMR-Based Metabolic Profiling of Cordyceps militaris to Correlate the Development Process and Anti-Cancer Effect.

The study of metabolomics in natural products using the diverse analytical instruments including GC-MS, LC-MS, and NMR is useful for the exploration of physiological and biological effects and the investigation of drug discovery and health functional foods..

King Oyster · 2019 · Journal Article · Carbohydrate polymers

A 3-O-methylated heterogalactan from Pleurotus eryngii activates macrophages.

Mushroom-derived polysaccharides exhibit various biological activities owing to their diverse structural features. Here, we purified a 3-O-methylated heterogalactan (WPEP-N-b, Mw 21.4 kDa) from the fruiting bodies of Pleurotus eryngii..

Immune supportCognition & nervesMetabolic health

Maitake · 2019 · Research Article · RSC advances

A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance.

Alzheimer's disease (AD) is characterized by the deposition of amyloid-β (Aβ) plaques, neuronal loss and neurofibrillary tangles. In addition, neuroinflammatory processes are thought to contribute to AD pathophysiology..

OncologyEnergy & fatigueMetabolic health

Cordyceps · 2019 · Journal Article · Fitoterapia

A new cerebroside from cordyceps militaris with anti-PTP1B activity.

Cordyceps militaris (L.) Link (C. militaris) has been used as a folk medicine for treatment of various diseases in China and some other countries.

Cordyceps · 2019 · Research Article · Experimental and therapeutic medicine

Anti-obesity effect in high-fat-diet-induced obese C57BL/6 mice: Study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris.

The therapeutic effects of mulberry (Morus alba) leaves on lipid metabolism, including lipogenesis, lipolysis and hyperlipidemia are widely known, although their fermented products are yet to be applied..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2019 · Research Article · Botanical studies

Comparative transcriptome analysis reveals the genetic basis underlying the biosynthesis of polysaccharides in Hericium erinaceus.

BACKGROUND: Hericium erinaceus, also known as lion's mane mushroom, is a widely distributed edible and medicinal fungus in Asian countries. H.

Cordyceps · 2019 · Journal Article · Food & function

Cordyceps militaris polysaccharides exerted protective effects on diabetic nephropathy in mice via regulation of autophagy.

The present study was designed to investigate the protective effects of Cordyceps militaris polysaccharides (CMP) on STZ-treated DN mice. CMP were identified by FT-IR and HPLC..

Energy & fatigueMetabolic health

Cordyceps · 2019 · Journal Article · Journal of AOAC International

Dynamic Analysis of Nucleosides and Carbohydrates during Developmental Stages of Cordyceps militaris in Silkworm (Bombyxmori).

Background: Cultured Cordyceps militaris is very popular. Objective: To gain dynamic insight into activity markers in fruiting body of Cordyceps militaris (C.

Reishi · 2019 · Journal Article · International journal of medicinal mushrooms

Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats.

Ganoderma lucidum is a hard, bitter mushroom with many ethnomedicinal uses, including conditions similar to lead (Pb) toxicity. The aim of this study was to evaluate the protective effects of a G.

Oyster Mushroom · 2019 · Journal Article · International journal of medicinal mushrooms

Evaluation of Antiarthritic Effect of Culinary-Medicinal Oyster Mushroom Pleurotus ostreatus cv. Florida (Agaricomycetes) on Complete Freund's Adjuvant Induced Arthritis in Rats.

The present study evaluates the antiarthritic effect of hydroethanolic extract of Pleurotus ostreatus cv. Florida, which was tested against adjuvant induced arthritis in rat models.