MycoData

Oyster Mushroom · 2025 · Journal Article · Journal of agricultural and food chemistry

Discovery and Characterization of Two Novel Sesquiterpene Synthases Producing Pleostene in Oyster and Honey Mushrooms.

Basidiomycetous fungi are prolific producers of terpenoids, yet many biosynthetic pathways remain unexplored. Here, we report the discovery of two novel terpene synthases: PoTS6 from the oyster mushroom (Pleurotus ostreatus) and AgTS2 from the bulbous honey fungus (Armillaria gallica)..

Oncology

Cordyceps · 2025 · Journal Article · International Journal of Biological Macromolecules

Editing a mushroom with high-digestibility using a novel endo-N-acetyl-β-D-glucosaminidase

Fungi comprise approximately 2 % of the Earth's biomass; however, the human gastrointestinal tract has a limited capacity to digest fungal biomass. In this study, a novel endo-N-acetyl-β-D-glucosaminidase, Endo CM, was characterized in the mushroom-forming fungus Cordyceps militaris, where it plays a role in….

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Editing a mushroom with high-digestibility using a novel endo-N-acetyl-β-D-glucosaminidase.

King Oyster · 2025 · Journal Article · Food Chemistry

Effects of three edible mushroom polysaccharides on the freeze-thaw stability of silver carp (Hypophthalmichthys molitrix) surimi gels: Water retention, gel quality, and structural properties

In this study, the effects of three edible mushroom crude polysaccharides, including Tremella polysaccharide (TP), Flammulina velutipes polysaccharide (FVP), and Pleurotus eryngii polysaccharide (PEP) on the freeze-thaw stability of silver surimi were investigated..

Immune support

Cordyceps · 2025 · Journal Article · Journal of agricultural and food chemistry

Enhancing Cordycepin Biosynthesis in Yarrowia lipolytica via Lipid Droplets Compartmentalization Engineering and Optimized Fermentation Strategies.

Cordycepin, a physiologically active nucleoside compound with broad applications in healthcare, is biosynthesized in Cordyceps militaris through a protein complex formed by CmCns1 and CmCns2..

Metabolic health

Immune supportCognition & nerves

Cordyceps · 2025 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Evaluation of antidepressant and sleep-promoting effects of cordycepin in a menopause-like stress model.

The menopausal transition is often accompanied by mood disturbances and sleep disorders, exacerbated by estrogen deficiency and chronic stress. Although hormone replacement therapy (HRT) is effective, its use is limited by safety concerns, underscoring the need for non-hormonal alternatives..

Immune supportSkin & hydration

King Oyster · 2025 · Research Article · Journal of applied glycoscience

Evaluation of Antifreeze Activity of Enzyme-Treated Extract from Mushroom Cell Wall.

Ice formation and growth during freezing in processed foods containing water can deteriorate food quality. Naturally derived antifreeze proteins and antifreeze polysaccharides are an attractive solution to this problem..

Cordyceps · 2025 · Journal Article · Current biology: CB

Fungal pathogen promotes caterpillar feeding and weight gain using a host-like trehalase.

Parasite-mediated extended phenotypes in hosts are of particular interest in biology. However, few parasite genes have been characterized for their selfish role in altering host behaviors to benefit parasite transmission or reproduction..

Metabolic health

OncologyImmune supportLiver support

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Identification and Nutrient Composition of a Wild Pleurotus pulmonarius Strain from Tibet, and the Antioxidant and Cytotoxic Activities of Polysaccharides from This Fungus.

The selection and breeding of high-quality wild edible fungal strains can bring significant economic and social benefits. A wild fungal strain (X21185) from the Tibetan Plateau was isolated and identified as a novel Pleurotus pulmonarius (P.

Shiitake · 2025 · Journal Article · Industrial crops and products

Mild thermal treatment assists fungal preprocessing of softwood sawdust for production of fermentable sugar

Preheating with hot air at 85 – 125 °C was evaluated for its effectiveness in removing terpenes and terpenoids in softwood sawdust, thereby enhancing fungal preprocessing and subsequent saccharification of softwood-based mushroom substrates. Sawdust from pine (Pinus sylvestris L.) and spruce (Picea abies (L.) H..

Reishi · 2025 · Journal Article · Physical chemistry chemical physics: PCCP

Molecular dynamics simulations reveal a strong binding capacity of colossolactone H to the EGFR inactive conformation.

The major side effects of in-use drugs, such as gefitinib, erlotinib and osimetinib, have led to inherent limitations and considerable concerns regarding the use of tyrosine kinase inhibitors (TKIs) in cancer treatment..

OncologySkin & hydration

Shiitake · 2025 · Journal Article · Fungal Genetics and Biology

Nearly telomere-to-telomere genome assembly of the L. edodes diploid genome

Lentinula edodes (shiitake mushroom) possesses substantial nutritional and medicinal value. Even though the genomes of several strains have been reported, some essential observations, including the exact chromosome number, still need validation..

Cordyceps · 2025 · Journal Article · Current biology: CB

Neuroparasitology: Fungal effectors induce feeding in zombie silkworms.

Some entomopathogenic fungi hijack host behavior to increase their pathogenicity, but how they do so has largely remained a mystery. A recent paper shows that Cordyceps militaris fungi produce insect-like trehalase enzymes to induce perceived starvation in silkworms, leading to increased feeding and greater production….

Cognition & nerves

Cordyceps · 2025 · Journal Article · Journal of food composition and analysis

Novel eco-friendly method for pesticide residue detection in tap water: Menthol-based hydrophobic deep eutectic solvent extraction coupled with GC-MS/MS

A novel, rapid, sensitive, and green dispersive liquid-liquid microextraction method using menthol-based hydrophobic deep eutectic solvent (MHDES) drops coupled with gas chromatography-tandem mass spectrometry (MHDES-DLLME-GC-MS/MS) was developed for the extraction and detection of 57 pesticides (organochlorine….

Shiitake · 2025 · Journal Article · Food Packaging and Shelf Life

Preparation and characterization of a novel polyvinyl alcohol/pectin film containing bromocresol green-alizarin mixed indicator label for monitoring mushroom freshness

Intelligent indicator labels offer significant potential for real-time shelf-life assessment and quality preservation during perishable food logistics. This study developed a novel bromocresol green-alizarin (BGA) indicator-embedded polyvinyl alcohol (PVA)/pectin (P) composite film for visual freshness monitoring of….

King Oyster · 2025 · Journal Article · Journal of agricultural and food chemistry

Rational Screening of Four Peroxidases with High Aflatoxin B1 Degradation Efficiency via Integrated Computational Simulations.

Aflatoxin B1 (AFB1) degradation remains a critical challenge due to limitations of conventional methods. This study proposed a computational screening strategy to screen the AFB1-degrading enzymes, and four peroxidases derived from Agrocybe pediades (ApeLip), Klebsiella pneumoniae (KpDyp), Trametopsis cervina….

Respiratory

King Oyster · 2025 · Research Article · Chemistry & biodiversity

Selective Oxidation of α,β-Unsaturated Alcohols With Lyophilisates of Bjerkandera adusta.

The biocatalytic aerobic production of (E)-2-allylic aldehydes from their corresponding alcohols using lyophilisates of the basidiomycetous fungus Bjerkandera adusta is reported..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Food Research International

Study on the intervention mechanism of Ganodermalucidum polysaccharides in mice with atopic dermatitis

Taishan Red Reishi Mushroom, also known as Taishan Ganoderma lucidum, is a medicinal and edible mushroom. Polysaccharides from Taishan Ganodermalucidum (GLP) represent its most significant bioactive component..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Study on the intervention mechanism of Ganodermalucidum polysaccharides in mice with atopic dermatitis.

King Oyster · 2025 · Journal Article · Food Chemistry

Successive fungal solid-state fermentation and UV-B irradiation: A novel strategy to boost bioactive potential and vitamin D2 levels of corn flour

This study introduces a novel biofortification strategy that combines solid-state fermentation (SSF) using edible fungi Pleurotus eryngii and Hericium erinaceus, followed by UV-B irradiation of colonized corn flour, to enhance its vitamin D₂ content and functional properties..

Cordyceps · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Synergistic improvement of hydrolyzed vegetable protein quality and flavor enhancement through multi-microbial fermentation and acid hydrolysis

Three optimized strains SA (Bacillus subtilis), CM17 (Cordyceps militaris), and MI (Aspergillus oryzae) were empioyed to prepare hydrolyzed vegetable protein (HVP) seasoning and fermentation conditions were optimized to maximize yield..

Oyster Mushroom · 2025 · Research Article · Fungal biology and biotechnology

Valorization of bourbon stillage through production of tunable pure mycelium materials.

Stillage is a byproduct of distilleries which is rich in organic matter, minerals, and acidic components. It is commonly used as animal feed and has high potential for use as an alternative substrate for microorganisms.

Liver support

Immune supportCognition & nerves

Cordyceps · 2024 · Research Article · Neural regeneration research

3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.

JOURNAL/nrgr/04.03/01300535-202410000-00028/figure1/v/2024-02-06T055622Z/r/image-tiff Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity..

Shiitake · 2024 · Journal Article · Talanta

Anodic stripping voltammetry of arsenic determination with edible mushroom-nafion-modified glassy carbon electrode.

An edible Mushroom-Nafion modified glassy carbon electrode (M2N5-GCE) was prepared using a homogeneous mixture varying the concentrations of these, in addition to the origin of the mushroom (Shiitake, Lentinula edodes, M1 and Abrantes, Agariscus bisporus, M2) and applied to the As(III) determination by anodic….

King Oyster · 2024 · Research Article · Applied microbiology and biotechnology

Basidiomycota strains as whole-cell biocatalysts for the synthesis of high-value natural benzaldehydes.

Substituted benzaldehydes are the most commonly used natural-occurring flavours in the world. The consumer's preference for 'natural or organic' aromas has increased the request for flavours possessing the 'natural' status..

King Oyster · 2024 · Research Article · AMB Express

Bioconversion efficiency and chemical composition of Hermetia illucens larvae fed spent mushroom substrates.

Spent mushroom substrate (SMS) is a by-product remaining after harvesting mushrooms. We evaluated the effect of substituting chicken feed with 0-100% of Pleurotus eryngii and Lentinula edodes SMS at different stocking densities (200-1000 larvae/box) on development, composition, and substrate reduction of black soldier….

OncologyImmune supportLiver support

Cordyceps · 2024 · Research Article · Bioactive materials

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease.

Radiation-induced heart disease (RIHD), characterized by severe oxidative stress and immune dysregulation, is a serious condition affecting cancer patients undergoing thoracic radiation. Unfortunately, clinical interventions for RIHD are lacking..

Cordyceps · 2024 · Journal Article · South African journal of botany

Biotic elicitors influence boeravinone B production from cell suspension cultures of Boerhavia diffusa Linn.

Boerhavia diffusa L., (punarnava) is known for its rich, secondary metabolite content and potential pharmacological properties. Boeravinone B, a flavonoid, is a significant plant secondary metabolite found in punarnava, exhibiting various pharmacological properties that translate into anticancer, antioxidant,….

OncologyImmune support

King Oyster · 2024 · Research Article · Frontiers in microbiology

Changes in soil organic carbon components and microbial community following spent mushroom substrate application.

While spent mushroom substrate (SMS) has shown promise in increasing soil organic carbon (SOC) and improving soil quality, research on the interplay between SOC components and microbial community following the application of diverse SMS types remains scant..

Cordyceps · 2024 · Journal Article · Physiologia Plantarum

Complete mitochondrial genomes of edible mushrooms: features, evolution, and phylogeny

Edible mushrooms are an important food source with high nutritional and medicinal value. They are a useful source for studying phylogenetic evolution and species divergence..

Immune supportLiver support

Cordyceps · 2024 · Journal Article · International immunopharmacology

Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence.

Cordycepin (CRD) is an active component derived from Cordyceps militaris, which possesses multiple biological activities and uses in liver disease. However, whether CRD improves liver fibrosis by regulating hepatic stellate cell (HSC) activation has remained unknown..

Cordyceps · 2024 · Research Article · Biomolecules & therapeutics

Cordycepin Enhanced Therapeutic Potential of Gemcitabine against Cholangiocarcinoma via Downregulating Cancer Stem-Like Properties.

Cordycepin, a valuable bioactive component isolated from Cordyceps militaris, has been reported to possess anti-cancer potential and the property to enhance the effects of chemotherapeutic agents in various types of cancers..

OncologySkin & hydration

Immune supportRespiratory

Cordyceps · 2024 · Research Article · iScience

Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection.

Cordycepin, a natural derivative of adenosine from Cordyceps militaris, can inhibit the replication of the dengue virus (DENV). Here, we investigated its antiviral and anti-inflammatory effects in DENV infected cells.

Immune supportEnergy & fatigue

Cordyceps · 2024 · Research Article · Reproductive biology and endocrinology: RB&E

Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro.

BACKGROUND: Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte..

Immune supportEnergy & fatigueMetabolic health

Shiitake · 2024 · Journal Article · Aquaculture

Dietary lentinan improves growth, haemato-biochemical indices, resistance to Streptococcus agalactiae infection and expression of immune genes in Asian seabass, Lates calcarifer

Disease outbreak is the single major factor that causes high mortality and substantial economic losses in the farming of Asian seabass, Lates calcarifer. Strategies to improve the health of fishes using prophylactics is considered effective and safe over the use of chemicals and antibiotics..

King Oyster · 2024 · Research Article · Foods (Basel, Switzerland)

Differences in the Physical Properties of Plant-Based Meat Alternatives Containing Root Vegetables.

We investigated the textural characteristics of plant-based meat alternatives based on root vegetables, including Platycodon grandiflorum, Codonopsis lanceolata root, Gastrodia elata blume, and Panax ginseng..

King Oyster · 2024 · Research Article · Global challenges (Hoboken, NJ)

Fungal Carbon: A Cost-Effective Tunable Network Template for Creating Supercapacitors.

Carbons form critical components in biogas purification and energy storage systems and are used to modify polymer matrices. The environmental impact of producing carbons has driven research interest in biomass-derived carbons, although these have yield, processing, and resource competition limitations..

King Oyster · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Intraspecies Variation Offers Potential to Improve White Rot Fungi for Increasing Degradability of Lignocellulose for Ruminants.

The aim of fungal treatment of organic matter for ruminants is the improvement of its degradability. So far, such treatment appears to be time-consuming and improvement has been modest..

Cordyceps · 2024 · Journal Article · Bioresource technology

Low-carbon and overproduction of cordycepin from methanol using engineered Pichia pastoris cell factory.

Cordycepin, a nucleoside analog, is widely used in medicine and health products. However, the production of cordycepin from Cordyceps militaris faces the challenges of low productivity and high rate of greenhouse gas emissions..

OncologyImmune supportCognition & nervesEnergy & fatigue

Maitake · 2024 · Research Article · NeuroImmune pharmacology and therapeutics

Neuroprotective Mushrooms.

Alternative medicines commonly supplement or, at times, replace standard medical treatment. One area of increasing attention is disease-modifying medicines for neurodegenerative diseases..

King Oyster · 2024 · Research Article · Scientific reports

Paramixta manurensis gen. nov., sp. nov., a novel member of the family Erwiniaceae producing indole-3-acetic acid isolated from mushroom compost.

There are numerous species in the Erwiniaceae family that are important for agricultural and clinical purposes. Here we described the Erwiniaceae bacterium PD-1 isolated from mushroom (Pleurotus eryngii) compost..

Immune support

King Oyster · 2024 · Journal Article · Biology and fertility of soils

Spent mushroom substrate as a substitute for chemical fertilizer changes N-cycling genes and reduces N2O emission in different textured soils

Spent mushroom substrate (SMS) is a by-product of mushroom production, which can be used as an organic fertilizer. However, studies on the effect of SMS as a substitute for chemical fertilizer on soil N₂O emissions and relative mechanisms are scarce..

Cordyceps · 2024 · Journal Article · The Science of the total environment

Sustainable treatment of aquaculture water employing fungi-microalgae consortium: Nutrients removal enhancement, bacterial communities optimization, emerging contaminants elimination, and mechanism analysis.

Fungi-microalgae consortium (FMC) has emerged as a promising system for advanced wastewater treatment due to its high biomass yield and environmental sustainability..

Cordyceps · 2024 · Research Article · International journal of molecular sciences

Translation of Mutant Repetitive Genomic Sequences in Hirsutella sinensis and Changes in the Secondary Structures and Functional Specifications of the Encoded Proteins.

Multiple repetitive sequences of authentic genes commonly exist in fungal genomes. AT-biased genotypes of Ophiocordyceps sinensis have been hypothesized as repetitive pseudogenes in the genome of Hirsutella sinensis (GC-biased Genotype #1 of O..

Immune supportMetabolic health

Reishi · 2023 · Review · Integrative medicine (Encinitas, Calif.)

A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.

CONTEXT: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some patients experience persistent symptoms for months to years.

Cordyceps · 2023 · Review · Frontiers in microbiology

Application progress of CRISPR/Cas9 genome-editing technology in edible fungi.

Edible fungi are not only delicious but are also rich in nutritional and medicinal value, which is highly sought after by consumers. As the edible fungi industry continues to rapidly advance worldwide, particularly in China, the cultivation of superior and innovative edible fungi strains has become increasingly….

Cordyceps · 2023 · Review · Phytotherapy research: PTR

Cordycepin: A review of strategies to improve the bioavailability and efficacy.

Cordycepin is a bioactive compound extracted from Cordyceps militaris. As a natural antibiotic, cordycepin has a wide variety of pharmacological effects.

Liver support

Immune supportCognition & nerves

Reishi · 2023 · Review · Ageing research reviews

Fungi as a source of bioactive molecules for the development of longevity medicines.

Age-related loss of function brings age-related disease, and therefore it is of primary importance to search for interventions that can help minimize detrimental symptoms people deal with in old age..