MycoData

Ophiocordyceps sinensis, a fungus revered in traditional Asian medicine, is critically endangered due to climate change and overharvesting. Artificial cultivation is thus essential to meet demand and promote conservation.

High relevance

Lion's Mane · 2025 · Review · Psychopharmacology bulletin

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia.

Schizophrenia is a serious mental illness that is a leading cause of disability worldwide. While antipsychotic agents are the most effective medications, up to one-third of patients experience treatment resistance, and approximately one-sixth of patients experience ultra-resistant illness..

Immune supportCognition & nervesGut & microbiome

High relevance

Reishi · 2025 · Review · Chinese herbal medicines

Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling.

Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics..

OncologyImmune supportCognition & nerves

High relevance

Almond Mushroom · 2024 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on structures, activities, and biosynthesis of blazeispirol compounds from Agaricus blazei].

Agaricus blazei is a rare medicinal and edible fungus with a crispy taste and delicious flavor. Both fruiting body and mycelium are rich in polysaccharides, sterols, terpenoids, peptides, lipids, polyphenols, and other active ingredients, which have strong pharmacological activities such as anti-tumor, lipid-lowering,….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2024 · Review · Fungal biology and biotechnology

A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus.

Medicinal mushrooms, such as Taiwanofungus camphoratus, Inonotus obliquus, and Tropicoporus linteus, have been used in traditional medicine for therapeutic purposes and promotion of overall health in China and many East Asian countries for centuries..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2024 · Review · Chinese herbal medicines

Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review.

Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Reishi · 2024 · Review · Heliyon

Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review.

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Review · Trends in biotechnology

Developing Ganoderma lucidum as a next-generation cell factory for food and nutraceuticals.

Ganoderma lucidum holds a colossal reservoir of hydrolytic enzymes and therapeutic compounds and can be a sustainable source of proteins and bioactive compounds. Its metabolic versatility, propelled by its rich genome content, provides excellent biosynthetic machinery for innovation-driven pathway engineering..

Metabolic health

High relevance

Turkey Tail · 2024 · Review · Steroids

Ergostanes from the mushroom Trametes versicolor and their cancer cell inhibition: In vitro and in silico evaluation.

In this study, five steroid compounds were isolated from the fruiting bodies mushroom Trametes versicolor. The compounds, 9,19-cyclolanostane-3,29-diol (3), ergosta-7,22-dien-3-acetate (4), and ergosta-8(14),22-dien-3β,5α,6β,7α-tetrol (5), were identified from T.

Oncology

High relevance

Reishi · 2024 · Review · World journal of microbiology & biotechnology

Exploring Ganoderma lucidum: morphology, cultivation and market potential.

Ganoderma lucidum, known as the "mushroom of immortality," is a white rot fungus renowned for its medicinal properties, attributed to its bioactive compounds. Although species with similar morphological traits to G..

High relevance

Reishi · 2024 · Review · The Journal of pharmacy and pharmacology

Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection.

OBJECTIVES: Ganoderma lucidum (GL) is a white rot fungus widely used for its pharmacological properties and health benefits. GL consists of several biological components, including polysaccharides, sterols, and triterpenoids..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2024 · Review · Heliyon

Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites.

Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times.

OncologyImmune supportMetabolic health

High relevance

Reishi · 2024 · Review · Journal of basic microbiology

Ganoderma lucidum: Insights on host range, diagnosis, and management strategies.

Forest ecosystems play an important role in upholding life on our planet. However, the onslaught of fungal pathogens like Ganoderma lucidum, poses a threat by decimating numerous tree species.

High relevance

Reishi · 2024 · Review · International journal of biological macromolecules

Ganoderma lucidum: Multifaceted mechanisms to combat diabetes through polysaccharides and triterpenoids: A comprehensive review.

Diabetes is a chronic metabolic disorder. Diabetes complications can affect many organs and systems in the body.

Immune supportMetabolic health

High relevance

Maitake · 2024 · Review · International journal of biological macromolecules

Grifola frondosa polysaccharides: A review on structure/activity, biosynthesis and engineering strategies.

Polysaccharides are the main polymers in edible fungi Grifola frondosa, playing a crucial role in the physiology and representing the healthy benefits for humans. Recent efforts have well elucidated the fine structures and biological functions of G.

Immune support

High relevance

Oyster Mushroom · 2024 · Review · International journal of biological macromolecules

Is Laccase derived from Pleurotus ostreatus effective in microplastic degradation? A critical review of current progress, challenges, and future prospects.

Exploration of Pleurotus ostreatus as a biological agent in the degradation of persistent plastics like polyethylene, polystyrene, polyvinyl chloride, and polyethylene terephthalate, revealing a promising avenue toward mitigating the environmental impacts of plastic pollution..

High relevance

Mesima · 2024 · Review · International journal of biological macromolecules

Phellinus linteus polysaccharides: A review on their preparation, structure-activity relationships, and drug delivery systems.

Phellinus linteus polysaccharides exhibit antitumor, immunomodulatory, anti-inflammatory, and antioxidant properties, mitigate insulin resistance, and enhance the diversity and abundance of gut microbiota. However, the bioactivities of P..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Review · Frontiers in microbiology

Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases.

Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal and nutritional health care values. Among them, polysaccharides, triterpenoids, oligosaccharides, trace elements, etc.

Immune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2024 · Review · International journal of biological macromolecules

Research progress and future development potential of Flammulina velutipes polysaccharides in the preparation process, structure analysis, biology, and pharmacology: A review.

In recent years, Flammulina velutipes (F. velutipes) has attracted consequential attention in various research fields due to its rich composition of proteins, vitamins, amino acids, polysaccharides, and polyphenols.

Immune supportSkin & hydration

High relevance

Reishi · 2024 · Review · Life (Basel, Switzerland)

Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years.

Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China.

OncologyImmune supportCognition & nervesLiver support

High relevance

Reishi · 2024 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease.

Alzheimer's disease (AD) is a high-incidence neurodegenerative disorder, characterized by cognitive impairment, memory loss, and psychiatric abnormalities. Ganoderma lucidum is a famous medicinal fungus with a long history of dietary intake, containing various bioactive components, and have been documented to exhibit….

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Snow Fungus · 2018 · Randomized Controlled Trial · Journal of medicinal food

Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial.

The efficacy and safety of Tremella fuciformis (TF) as a nutritional supplement were assessed in individuals with subjective cognitive impairment (SCI). Seventy-five individuals with SCI were enrolled in an 8-week, randomized, double-blind, placebo-controlled trial of TF (600 mg/day, n = 30 or 1200 mg/day, n = 30) or….

Cognition & nervesEnergy & fatigue

High relevance

Almond Mushroom · 2026 · Randomized Controlled Trial · Spine

Cost-Effectiveness of ABM/P-15 Versus Allograft in Degenerative Spondylolisthesis Surgery: Ten-Year Follow-Up on a Randomized Controlled Trial.

STUDY DESIGN: Randomized controlled trial. OBJECTIVE: The aim of this study was to investigate whether ABM/P-15 was cost-effective compared with allograft as a bone graft extender for uninstrumented posterolateral fusion for degenerative spondylolisthesis with spinal stenosis in elderly patients..

High relevance

Almond Mushroom · 2025 · Randomized Controlled Trial · Spine

ABM/P-15 Versus Allograft in Non-Instrumented Lumbar Fusion: Ten-Year Follow-Up of a Double Blind Randomized Controlled Trial.

STUDY DESIGN: Double blind randomized clinical controlled trial. OBJECTIVE: To compare long-term outcomes and reoperation rates in patients who underwent decompression and non-instrumented fusion for lumbar degenerative spondylolisthesis with either ABM/P-15 or allograft..

High relevance

Enoki · 2025 · Randomized Controlled Trial · Nutrients

Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study.

With the increase in average life expectancy, age-related male menopause has become a cause of decreased quality of life in men. The present study investigated the efficacy and safety of powdered enoki mushroom extract containing adenosine (test food) for menopausal symptoms in middle-aged and elderly men based on an….

High relevance

Shiitake · 2025 · Journal Article · Industrial Crops & Products

Comparative extraction of bioactive compounds from spent mushroom substrates of Lentinula edodes and Pleurotus ostreatus using subcritical water and pressurized ethanol

This study aimed to assess subcritical water extraction (SWE) and pressurized ethanol extraction (PEE) for recovering bioactive compounds from spent mushroom substrate (SMS) derived from shiitake and oyster mushrooms..

High relevance

Cordyceps · 2025 · Review · Molecular biotechnology

Conservation of Endangered Cordyceps sinensis Through Artificial Cultivation Strategies of C. militaris, an Alternate.

Cordyceps, an entomopathogenic fungus belonging to the Ascomycota phylum, is a familiar remedial mushroom that is extensively used in the traditional medicinal system, especially in South Asian nations..

High relevance

Cordyceps · 2025 · Randomized Controlled Trial · Journal of cosmetic dermatology

Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial.

BACKGROUND: Cordyceps is a valuable Chinese herbal medicine known for its various components with antioxidant properties, which may theoretically improve melasma..

Metabolic healthSkin & hydration

High relevance

Shiitake · 2025 · Journal Article · Anais da Academia Brasileira de Ciencias

Nutritional value and antioxidant activity of Agaricus bisporus, Lentinula edodes and Pleurotus ostreatus mushrooms.

The increase in mushroom production is driven by the versatility of these fungi to develop in various substrates. This study compared the macronutrients, micronutrients, total phenolic content, flavonoid content and antioxidant activity of Button, Portobello, Shiitake, and Oyster mushrooms cultivated on different….

High relevance

Shiitake · 2025 · Research Article · Mycology

Seasonal discrepancy of airborne fungal diversity and community structure in Lentinula edodes factory.

Understanding the composition and community of airborne mycobiota associated with fungal diseases was critical for mushroom production and disease control. In this study, we first investigated airborne fungi concentrations in different function areas of a Chinese shiitake factory..

High relevance

Cordyceps · 2024 · Review · Journal of integrative medicine

Cordyceps as potential therapeutic agents for atherosclerosis.

Atherosclerosis is a leading cause of mortality and morbidity worldwide. Despite the challenges in managing atherosclerosis, researchers continue to investigate new treatments and complementary therapies..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2024 · Review · Molecules (Basel, Switzerland)

Cordyceps Polysaccharides: A Review of Their Immunomodulatory Effects.

Cordyceps primarily consists of ascomycetes, a parasitic fungus that infects insects and arthropods. Recently, Cordyceps has been shown to manifest a diverse range of pharmacological activities, rendering it applicable for the treatment and mitigation of various diseases, such as diabetes, acute liver injury, and….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Randomized Controlled Trial · Food & function

Cordyceps sinensis accelerates stem cell recruitment to human skeletal muscle after exercise.

Cordyceps sinensis is a parasitic fungus known to induce immune responses. The impact of Cordyceps supplementation on stem cell homing and expansion to human skeletal muscle after exercise remains unexplored..

Immune supportEnergy & fatigue

High relevance

Oyster Mushroom · 2024 · Research Article · Life (Basel, Switzerland)

Microbial Inoculation during the Short-Term Composting Process Enhances the Nutritional and Functional Properties of Oyster Mushrooms (Pleurotus ostreatus).

In recent years, short-term composting techniques have been widely applied in oyster mushroom cultivation, but there is still a lack of systematic research on their impact on the nutritional and functional properties of fruiting bodies..

Immune support

High relevance

Cordyceps · 2024 · Review · Cellular and molecular biology (Noisy-le-Grand, France)

Pharmacological and economical aspects of important species of Cordyceps sensu lato: A review.

Cordyceps is a well-known endo-parasitic fungus commonly used in traditional Chinese medicine for a long time. The demand for Cordyceps is increasing daily because it is commonly used as a nutritional food, medicine, and supplement owing to its natural source..

Skin & hydration

High relevance

Maitake · 2024 · Review · Heliyon

Unveiling the full spectrum of maitake mushrooms: A comprehensive review of their medicinal, therapeutic, nutraceutical, and cosmetic potential.

This literature review provides an up-to-date exploration of the multifaceted attributes of maitake mushrooms (Grifola frondosa), elucidating their bioactive phytochemicals and diverse health advantages, including their substantial role in supporting human health and potential incorporation into the medicinal….

Skin & hydration

High relevance

Cordyceps · 2023 · Preprint · journal metadata

A Novel Complementary Pathway of Cordycepin Biosynthesis in Cordyceps militaris

We determined whether there exists a complementary pathway of cordycepin biosynthesis in wild-type Cordyceps militaris, cordycepin-high-producing strain C. militaris GYS60, and cordycepin-low-producing strain C.

High relevance

Reishi · 2023 · Preprint · journal metadata

A Review of the Application of Ganoderma lucidum (Curtis) P. Karst. In Nanotechnology for the Treatment of Cancer

Ganoderma lucidum, commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits, and medicinal properties in traditional Chinese medicine..

OncologyImmune supportLiver support

High relevance

Oyster Mushroom · 2023 · Preprint · journal metadata

Active compound test: ethanolic extract of White Oyster Mushroom (Pleurotus ostreatus) Using HPLC and LC-MS

Background: The use of herbs as traditional medicine in Indonesia is increasing, with more than 40% of Indonesia's population utilizing them. White oyster mushroom ( Pleurotus Ostreatus ) is a fungus that has various therapeutic effects including antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, and….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2023 · Preprint · journal metadata

Biodegradation of malachite green by Pleurotus eryngii: A study on decolorization, mechanism, toxicity, and enzyme

Abstract The purpose of this study was to investigate the biodegradation capability of Pleurotus eryngii through decolorizing malachite green (MG), explore the possible mechanism, and test the toxicity. The results indicated that this strain possessed a high decolorizing ability..

High relevance

King Oyster · 2023 · Preprint · journal metadata

Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies

Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the Sarcin-Ricin Loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk)..

OncologyCognition & nerves

High relevance

Oyster Mushroom · 2023 · Preprint · journal metadata

Comparison of low cost substrates and Spawn levels for Oyster mushroom (Pleurotus ostreatus) cultivation in Afghanistan

There is a significant interest in cultivation of oyster mushroom ( Pleurotus ostreatus ) as nutritious food, with the rise in its consumption. Thus, there is a need to compare different low-cost available substrates for its productivity in Afghanistan..

High relevance

Reishi · 2023 · Preprint · journal metadata

Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer

The Ganoderma Lucidum is known as a promising medicine that contains a high amount of antioxidants and calcium. The selection of appropriate drying process methods in food science has a chief role to reach the best final characteristics..

Energy & fatigue

High relevance

Turkey Tail · 2023 · Preprint · journal metadata

Comprehending and Domesticating of Wild Growing Turkey Tail Mushroom (Trametes versicolor) from Ethiopia on augmented agro-industrial byproducts

Abstract Despite being one of the most studied white-rot fungi, nothing has been done to discover and domesticate Ethiopia's high-yielding wild Trametes versicolor. Thus, this study was initiated to evaluate the growth performance of T.

Energy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2023 · Preprint · journal metadata

Cultivation of Pleurotus ostreatus (oyster mushroom) using Sawdust supplemented with Waste Human Hair

Abstract Waste human hair (WHH) is a part of municipal solid waste generated from salons that may lead to clogging of drainage pipes ensued with flooding. Pleurotus ostreatus (mushroom) is capable of utilizing several organic substrate types due to its enzyme secretions..

High relevance

Shiitake · 2023 · Preprint · journal metadata

Extracellular enzymes secreted in the mycelial block of Lentinula edodes during hyphal growth

Abstract Lentinula edodes (shiitake mushroom) is one of the most widely cultivated edible mushrooms and is primarily cultivated using sawdust medium. While there have been improvements in the cultivation technology, the mechanism of mycelial block cultivation, such as mycelial growth and enzymatic sawdust degradation,….

Gut & microbiome

High relevance

Cordyceps · 2023 · Preprint · journal metadata

Extracts from Cordyceps militaris: Novel, potential, and efficiently bioactive natural materials used for skin-care products

Extracts of Cordyceps militaris which possess the bioactive capacity such as antimicrobial activity and DPPH-free radical scavenging capacity, are applied to the serum product..

Skin & hydration

High relevance

Chaga · 2023 · Preprint · journal metadata

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism

Abstract Background Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2023 · Preprint · journal metadata

Molecular characterization of a novel deltaflexivirus infecting the edible fungus Pleurotus ostreatus

Abstract A novel positive single-stranded RNA virus, Pleurotus ostreatus deltaflexivirus 1 (PoDFV1), was isolated from an edible fungus Pleurotus ostreatus strain ZP6. The complete genome of PoDFV1 is 7706 nucleotides (nt) longand contains a short poly(A) tail..

Respiratory

High relevance

Cordyceps · 2023 · Preprint · journal metadata

Molecular Mechanisms Underlying Phenotypic Degeneration in Cordyceps militaris: Insights from Transcriptome Reanalysis and Osmotic Stress Studies

Phenotypic degeneration is a well-known phenomenon in fungi, yet the underlying mechanisms remain poorly understood. Cordyceps militaris, a valuable medicinal fungus with therapeutic potential and known bioactive compounds, is vulnerable to degeneration, which is a concern for producers..