MycoData

OncologyImmune supportLiver support

Maitake · 2021 · Journal Article · International journal of biological macromolecules

The effects of quorum sensing molecule farnesol on the yield and activity of extracellular polysaccharide from Grifola frondosa in liquid fermentation.

A strategy by exogenous addition of quorum sensing molecule farnesol to improve the production, antioxidant activity and antitumor activity of extracellular polysaccharide (EPS) of Grifola frondosa by liquid fermentation was proposed in the study..

Niu-Chang-Chih · 2021 · Journal Article · The American journal of Chinese medicine

The NF- κB Signaling and Wnt/ β-catenin Signaling in MCF-7 Breast Cancer Cells in Response to Bioactive Components from Mushroom Antrodia Camphorata.

Breast cancer is the leading cancer, accounting for approximately 15% cancer deaths in women worldwide. This study investigated the anti-inflammation and anticancer properties of two bioactive components from Antrodia camphorata(AC), a rare medicinal mushroom natively grown in Taiwan and commonly used in Chinese….

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2021 · Research Article · Polymers

WSG, a Glucose-Rich Polysaccharide from Ganoderma lucidum, Combined with Cisplatin Potentiates Inhibition of Lung Cancer In Vitro and In Vivo.

Lung cancer has the highest global mortality rate of any cancer. Although targeted therapeutic drugs are commercially available, the common drug resistance and insensitivity to cisplatin-based chemotherapy, a common clinical treatment for lung cancer, have prompted active research on alternative lung cancer therapies….

Maitake · 2007 · Clinical Trial · Journal of veterinary internal medicine

Mushroom-derived maitake PETfraction as single agent for the treatment of lymphoma in dogs.

BACKGROUND: Maitake PETfraction is a standardized essence extracted from the mushroom Maitake (Grifola frondosa) that has antitumor activity in tumor-bearing mice..

OncologyMetabolic health

OncologyImmune supportCognition & nerves

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · Amyotrophic lateral sclerosis & frontotemporal degeneration

ALSUntangled #73: Lion's Mane.

Lion's Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer..

Chaga · 2024 · Research Support, Non U.S. Gov'T · Scientific reports

Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism.

Oral cancer stands as a prevalent maligancy worldwide; however, its therapeutic potential is limited by undesired effects and complications. As a medicinal edible fungus, Chaga mushroom (Inonotus obliquus) exhibits anticancer effects across diverse cancers..

OncologyEnergy & fatigue

Chaga · 2023 · Research Article · Current research in toxicology

Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review.

Cancer has become the second leading cause of death in the world. Integrative cancer therapy management is continuously evolving to enhance treatment outcomes.

OncologyGut & microbiomeRespiratory

Oyster Mushroom · 2023 · Research Article · Molecules (Basel, Switzerland)

Effect of Oyster Mushroom Addition on Improving the Sensory Properties, Nutritional Value and Increasing the Antioxidant Potential of Carp Meat Burgers.

The growing interest in functional food makes looking for new possibilities of enriching products with health-promoting ingredients necessary. One raw material with a very high potential for the food industry is the oyster mushroom (Pleurotus ostreatus), which has a strong antioxidant, antiviral, and anticancer….

Reishi · 2022 · Research Article · Pharmaceuticals (Basel, Switzerland)

Discovery of a Multifunctional Octapeptide from Lingzhi with Antioxidant and Tyrosinase Inhibitory Activity.

Ganoderma lucidum or Lingzhi is a fungus species widely known as a traditional medicine. Exploring the beneficial peptides by hydrolysis using pepsin and trypsin has been extensively performed to identify new bioactive natural products..

OncologySkin & hydration

OncologyImmune supportGut & microbiome

Reishi · 2022 · Research Article · Heliyon

Investigating the cellular antioxidant and anti-inflammatory effects of the novel peptides in lingzhi mushrooms.

The lingzhi mushroom (Ganoderma lucidum) is well known for its medicinal properties and has long played a role in traditional oriental medicine due to its health-giving benefits and potential to extend life expectancy..

Cordyceps · 2021 · Research Article · PeerJ

Arsenic transfer along the soil-sclerotium-stroma chain in Chinese cordyceps and the related health risk assessment.

BACKGROUND: Chinese cordyceps (Lepidoptera: Ophiocordyceps sinensis)is a larval-fungus complex. The concentration and distribution of arsenic (As) may vary during the stroma (ST) germination process and between the sclerotium (SC) and the ST..

OncologySkin & hydration

Chaga · 2021 · Journal Article · Journal of ethnopharmacology

Chaga mushroom extract induces autophagy via the AMPK-mTOR signaling pathway in breast cancer cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Chaga mushrooms (Inonotus obliquus) are commonly used in traditional treatments in Eastern Europe and Asia due to their diverse pharmacological effects, including anti-tumor and immunologic effects..

OncologyEnergy & fatigueGut & microbiome

Maitake · 2021 · Research Article · Foods (Basel, Switzerland)

Prebiotic Effect of Maitake Extract on a Probiotic Consortium and Its Action after Microbial Fermentation on Colorectal Cell Lines.

Maitake (Grifola frondosa) is a medicinal mushroom known for its peculiar biological activities due to the presence of functional components, including dietary fibers and glucans, that can improve human health through the modulation of the gut microbiota..

OncologyImmune supportGut & microbiome

Maitake · 2020 · Journal Article · Milk Science

Dietary milk and maitake mushroom (Grifola frondosa) modulate inflammation-related cytokines and apoptosis related-proteins in colon of 1,2-dimethylhydrazine-treated mice

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Milk Science in 2020. MycoData maps the paper to oncology, immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2020 · Research Article · Animals: an open access journal from MDPI

Effect of Spent Mushroom (Cordyceps militaris) on Growth Performance, Immunity, and Intestinal Microflora in Weaning Pigs.

There are limited published reports regarding the optimal dosage of spent mushroom. This study investigated the effect of various levels of spent mushroom derived from C..

Cordyceps · 2019 · Research Article · RSC advances

Tussah silkmoth pupae improve anti-tumor properties of Cordyceps militaris (L.) Link by increasing the levels of major metabolite cordycepin.

Silkworms have been reported to promote the growth and production of the stromata of C. militaris (L.) Link as a parasite insect medium and may improve its metabolites.

OncologyMetabolic health

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2016 · Research Article · Experimental and therapeutic medicine

Separation of cordycepin from Cordyceps militaris fermentation supernatant using preparative HPLC and evaluation of its antibacterial activity as an NAD+-dependent DNA ligase inhibitor.

Cordycepin exhibits various bio-activities, including anticancer, antibacterial, antiviral and immune regulation activities, and is a significant focus of research. However, the preparation of high-purity cordycepin remains challenging..

OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Review · Journal of natural medicines

The emerging role of fatty acids as key bioactive components of Ganoderma lucidum spore oil in alleviating tumor progression.

Ganoderma lucidum, long revered as a divine fungus in traditional medicine, has garnered significant attention for its therapeutic potential. Ganoderma lucidum spore oil (GLSO) is an oil-like substance extracted from cracked Ganoderma lucidum spores using supercritical CO₂ extraction technology..

OncologyImmune supportEnergy & fatigueMetabolic health

King Oyster · 2025 · Journal Article · Chemistry & biodiversity

Composition Analysis and In Vitro Investigation on Antioxidant, α-Amylase, and Pancreatic Lipase Inhibitory Activities of Major Mushrooms in Qinling Mountains.

Edible mushrooms exhibit a range of pharmacological activities, including anticancer, antimicrobial, antioxidant, anti-obesity, and hepatoprotective effects, thereby holding significant potential for applications in the development of functional foods..

Agarikon · 2020 · Review · Chemistry & biodiversity

Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties.

Medicinal mushrooms of the order Polyporales have a long history of use, which is evidenced by the finding of dissected fruiting bodies with Ötzi, who lived over 5000 years ago..

OncologyImmune supportSkin & hydration

Maitake · 2020 · Review · Carbohydrate polymers

Preparation and activities of selenium polysaccharide from plant such as Grifola frondosa.

Selenium polysaccharide is an organic selenium compound formed by the combination of polysaccharide and selenium. The biological activity of selenium polysaccharide from plant such as Grifola frondosa is generally higher than that of selenium and polysaccharide, and it is more easily absorbed and utilized by human….

Turkey Tail · 2020 · Review · Biomedicines

Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy.

Coriolus versicolor (L.) Quél. is a higher fungi or mushroom which is now known by its accepted scientific name as Trametes versicolor (L.) Lloyd (family Polyporaceae)..

OncologyImmune supportCognition & nervesMetabolic health

Mesima · 2019 · Review · Molecules (Basel, Switzerland)

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus.

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P.

OncologyImmune supportCognition & nervesMetabolic health

Niu-Chang-Chih · 2019 · Review · Applied microbiology and biotechnology

Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata.

Antrodia camphorata, also known as A. cinnamomea, is a precious medicinal basidiomycete fungus endemic to Taiwan.

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2019 · Review · International journal of biological macromolecules

Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review.

Tremella fuciformis is an important edible mushroom that has been widely cultivated and used as food and medicinal ingredient in traditional Chinese medicine. In the past decades, many researchers have reported that T..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2019 · Review · Phytotherapy research: PTR

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies.

The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties..

OncologyImmune supportGut & microbiome

Maitake · 2018 · Review · Oncotarget

B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.

Culinary and medicinal mushrooms are widely used in Asian countries, both as dietary supplements and as nutraceutical foods. They have recently become popular in Europe, as well, for their nutritional and health benefits..

OncologyImmune supportMetabolic healthRespiratory

Maitake · 2018 · Review · Discovery medicine

Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China.

Grifola frondosa, a species of Basidiomycotina, is an edible medicinal mushroom with a large fruiting body characterized by overlapping caps. The β-glucan is the major biologically active component in G.

OncologyImmune supportMetabolic health

Zhu Ling · 2017 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Correlative analysis advance of chemical constituents of Polyporus umbellatus and Armillaria mellea].

Medicinal Polyporus umbellatus is the dry sclerotia of P. umbellatus, with the effect of diuresis; Armillaria mellea is a parasitic fungus which can infect plants up to 300 genera, with sedative, anticonvulsant and some other biological activities.

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2017 · Review · Current pharmaceutical design

Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies.

BACKGROUND: The mushroom Agaricus blazei has evoked considerable scientific and practical interest in several fields, especially those linked to its medicinal properties. This review aims to summarize and evaluate the past decade findings related to nutritional and therapeutic uses of A..

OncologyImmune supportMetabolic healthLiver support

Maitake · 2017 · Review · International journal of biological macromolecules

Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review.

Grifola frondosa (Dicks.) Gray is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers.

Cordyceps · 2026 · Review · Journal of Asian natural products research

Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action.

Over the past decade, species of Cordyceps, particularly C. sinensis, C.

OncologyImmune supportMetabolic health

Nameko · 2026 · Review · RSC advances

Extraction, purification, structural characterization, bioactivities, and applications of Pholiota nameko polysaccharide: a review.

Pholiota nameko, an edible mushroom, is recognized for its significant medicinal properties and broad application potential. Pholiota nameko polysaccharide (PNP), a major bioactive component derived from this fungus, exhibits diverse biological activities, including anti-inflammatory, antioxidant, antitumor,….

OncologyImmune supportCognition & nerves

Cordyceps · 2025 · Review · International journal of molecular sciences

Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease.

Alzheimer's disease (AD) is considered one of the main pathologies of our time, whose incidence and prevalence are suggested to be strongly underestimated. AD presents as a complex neurodegenerative condition characterized by marked neuroinflammation and a significant decline in the cognitive and mnemonic functions of….

Cordyceps · 2024 · Review · Critical reviews in biotechnology

Bioactive compounds from Cordyceps and their therapeutic potential.

The Clavicipitaceae family's largest and most diverse genus is Cordyceps. They are most abundant and diverse in humid temperate and tropical forests and have a wide distribution in: Europe, North America, and East and Southeast Asian countries, particularly: Bhutan, China, Japan, Nepal, Korea, Thailand, Vietnam,….

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2024 · Review · Journal of ethnopharmacology

Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular injury - A comprehensive review.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps has a long medicinal history as a nourishing herb in traditional Chinese medicine (TCM). Ischemic cardio-cerebrovascular diseases (CCVDs), including cerebral ischemic/reperfusion injury (CI/RI) and myocardial ischemic/reperfusion injury (MI/RI), are major contributors to….

OncologySkin & hydrationRespiratory

Shiitake · 2016 · Review · Pharmacognosy reviews

The Unexplored Anticaries Potential of Shiitake Mushroom.

Keeping an eye the escalating costs of dental services, the treatment cost of the consequences of dental caries can be reduced to manageable proportions by preventive measures aimed at decreasing the prevalence. One such measure is by increasing the consumption of caries preventive foods..

OncologyEnergy & fatigueSkin & hydration

Maitake · 2026 · Journal Article · Journal of complementary & integrative medicine

Evaluating the anticancer potential of black maitake extract in A375 human malignant melanoma cells.

UNLABELLED: Melanoma is one of the deadliest skin cancers, characterized by high metastatic potential and poor prognosis in advanced stages. While chemotherapeutic agent temozolomide (TMZ) is the standard treatment, its clinical utility is hindered by toxicity and limited specificity..

OncologyImmune supportRespiratory

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

Exploring the Therapeutic Potential of Cordyceps Mushroom on SARS-CoV-2 Using Virtual Screening against Mpro and In Vitro Validation of Cordycepin.

Pathogenic coronavirus, including COVID-19, threatens human health, and there have been strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects.

Maitake · 2024 · Journal Article · Biological & pharmaceutical bulletin

Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity

Trastuzumab, an anti-HER2 monoclonal antibody, is the mainstay treatment for of HER2-positive breast cancer. However, trastuzumab resistance is often observed during treatment.

Chaga · 2024 · Research Article · Oxidative medicine and cellular longevity

Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro.

Chaga mushroom (Inonotus obliquus) contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties..

Reishi · 2020 · Comparative Study · International journal of medicinal mushrooms

Comparative Study on Bioactivities from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Gives an Insight into the Fermentation Broth Showing Greater Antioxidative Activities.

Ganoderma lucidum is one of the most famous mushrooms in traditional Chinese medicine. At present, the fully utilized parts of G.

OncologySkin & hydration

OncologyImmune supportRespiratory

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Cordyceps militaris Exerts Anticancer Effect on Non-Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3.

This study aimed to investigate the effect of Cordyceps militaris extract on the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and determine the underlying mechanisms..

OncologyEnergy & fatigueMetabolic healthLiver support

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses.

This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity..

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Biomolecules

Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak.

This study was designed to assess the nephroprotective effects of Pleurotus ostreatus and Agaricus bisporus aqueous extracts and carvedilol on hyperoxaluria-induced urolithiasis and to scrutinize the possible roles of NF-κB, p53, Bcl-2, Bax and Bak..

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Glycobiology

Structure and properties of the oyster mushroom (Pleurotus ostreatus) lectin.

Pleurotus ostreatus Lectin (POL) is a 353 amino acid chain lectin that can be purified from the fruiting bodies of the very well-known and widely diffused edible oyster mushrooms (P. ostreatus)..

Cordyceps · 2019 · Abstract · Current developments in nutrition

Anticancer Effects of Cordyceps Militaris Extract in Human Ovarian Cancer Cells via ADORA2B (P05-012-19)

Abstract Objectives The study was aimed to determine anticancer effects of Cordyceps militaris extract (CME) and its major bioactive compound, cordycepin, in human ovarian cancer cells, and to identify their putative molecular mechanism mediated by adenosine receptors (ADORAs)..

OncologyImmune supportRespiratory

Cordyceps · 2019 · Comparative Study · International journal of biological macromolecules

Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro.

A comparison of the anti-tumor activity of CMPS-II and CBPS-II polysaccharides, respectively is obtained from the fermented mycelium and cultivated fruiting bodies of Cordyceps militaris..