MycoData

Reishi · 2025 · Journal Article · Microbiological research

Nitrogen-dependent regulation of extracellular and intracellular polysaccharide content in Ganoderma lucidum via the transcription factor AreA.

Fungal polysaccharides serve as vital components and hold significant value in food and medicinal applications. Nitrogen plays a crucial role in the biosynthesis of fungal polysaccharides, yet our comprehension of its specific influence on fungal polysaccharides biosynthesis remains limited..

Cordyceps · 2025 · Research Article · BMC biology

Ophiocordyceps sinensis-induced changes in Thitarodes xiaojinensis: from intestinal barrier destruction, microbiome dysbiosis to immune responses at the molecular level.

BACKGROUND: The entomopathogenic fungus (EPF) Ophiocordyceps sinensis has a long-term coexistence with its host insect, Thitarodes xiaojinensis, making it a unique model for host-pathogen interactions..

Immune supportLiver support

Oyster Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Optimization and Hepatoprotective Potential of Sulfated Polysaccharide From Pleurotus ostreatus.

In this study, we explored an efficient method for synthesizing sulfated Pleurotus ostreatus polysaccharides (SPOP) with a higher degree of substitution. The structure conformation was characterized and confirmed by the Fourier transform infrared (FT-IR) spectroscopy analysis..

Oyster Mushroom · 2025 · Journal Article · Journal of food composition and analysis

Optimization of selenium biofortification by liquid fermentation based on 2,4-dichlorophenoxyacetic acid and its effect on nutritional value of Pleurotus ostreatus

Pleurotus ostreatus is one of the most popular edible mushrooms worldwide and has been proposed as a candidate for human selenium (Se) supplementation. The objective of this study is to develop a Se-biofortification method by liquid fermentation and evaluate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D),….

Immune supportLiver supportRespiratory

Wood Ear · 2025 · Journal Article · International journal of biological macromolecules

Oral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.

Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications..

Snow Fungus · 2025 · Journal Article · Food chemistry

Phased characterization of soy protein gel modified by lactobacillus plantarum JYLP-326 in cooperation with acidic tremella fuciformis fruiting body polysaccharide: Focus on structural network, interaction and gel properties.

Soybean protein isolate (SPI) and acidic tremella fuciformis fruiting body polysaccharide (AP) were used to prepare phased products "sterilized soft gel (SPI-AP)" and "fermented strong gel (FSPI-AP)" to study the structural network, interaction and gel characteristics..

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Journal Article · International journal of medicinal mushrooms

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.

Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph.

Immune supportRespiratory

Mesima · 2025 · Research Article · Foods (Basel, Switzerland)

Phellinus linteus Mycelia Extracts Show Potent Antiviral and Immunomodulatory Effects in H1N1 Influenza Virus-Infected Mice.

Phellinus linteus, a medicinal mushroom with an ancient history in traditional medicine, serves as a valuable raw material for functional foods. While previous studies have shown promising antiviral effects, the present work is the most comprehensive investigation of P..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Enoki · 2025 · Journal Article · ACS applied materials & interfaces

Photo-Cross-Linked and Photothermal Flammulina velutipes Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing.

Diabetic ulcers remain a persistent global health challenge. Developing therapeutic systems with antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic properties presents a promising strategy for effectively and rapidly treating diabetic wounds and preventing the development of diabetic ulcers..

Immune supportGut & microbiomeSkin & hydration

Zhu Ling · 2025 · Journal Article · International journal of biological macromolecules

Polyporus Umbellatus polysaccharide ameliorates rheumatoid arthritis via inhibiting inflammation and regulating gut microbiota.

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can cause cartilage and bone damage as well as a disability. Polyporus Umbellatus polysaccharide (PUP) as a β-glucan exhibit remarkable anti-inflammatory activity..

Cordyceps · 2025 · Journal Article · Journal of functional foods

Polysaccharide from natural Ophiocordyceps sinensis alleviated dextran sulfate sodium-induced colitis through modulating sIgA formation and gut microbiota

Polysaccharide from natural Ophiocordyceps sinensis (NCSP-50) significantly modulated the gut microbiota composition and elevated the levels of sIgA in dextran sodium sulfate (DSS)-induced colitis mice. However, the in-depth mechanism remains unknown..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Reishi · 2025 · Journal Article · Metabolic brain disease

Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation.

Oxidative stress and mitochondrial dynamics imbalance are key contributors to AD pathogenesis. GLPS, an extract from Ganoderma lucidum spores, exhibits anti-inflammatory, antioxidant, and immunomodulatory properties..

Immune supportMetabolic healthLiver support

Snow Fungus · 2025 · Journal Article · Chemistry & biodiversity

Polysaccharides from Tremella Fuciformis Enhance Glucose and Lipid Metabolism in HepG2 Cells Through Activating the AMPK Signaling Pathway.

Polysaccharides have gained substantial attention for their diverse biological activities. The present study was conucted to elucidate the effects and molecular mechanisms of Tremella fuciformis-derived polysaccharides (PTP-3a) on glucose and lipid metabolism in palmitic acid (PA) - treated HepG2 cells..

Oyster Mushroom · 2025 · Research Article · Scientific reports

Prebiotic properties and antioxidant effect of crude extracts and polysaccharides from Agaricus bisporus and Pleurotus ostreatus mushrooms.

Modifying the gut microbiome, also known as bacteriotherapy, is a key strategy that uses probiotics, prebiotics, or synbiotics to reduce inflammation and fight infection and colonization by pathogenic bacteria..

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy

Cancer remains a significant global health challenge. Given the limitations of conventional single-treatment modalities and the potential benefits of combination therapies, this study aimed to develop a multifunctional nanoplatform integrating immunotherapy, chemotherapy, and photothermal therapy for cancer treatment..

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy.

Maitake · 2025 · Journal Article · Chemistry & biodiversity

Preparation and Characterization of Polysaccharides From Grifola frondosa and Their Human Intestinal Flora-modulating Effect.

A novel and efficient hydrogen peroxide/ascorbic acid-assisted extraction method for the preparation of Grifola frondosa polysaccharide (GFP) was developed, and two GFP fractions (GFP-H and GFP-L) with different molecular weights (Mws) were obtained by separation with ultrafiltration..

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Preparation, Structural Characterization, and In Vitro Modulation of the Gut Microbiota Activity of a Novel α-Glucan in Hericium erinaceus.

Hericium erinaceus (H. erinaceus) is a kind of medicinal and edible fungus that contains polysaccharide as the most studied effective component at present.

Maitake · 2025 · Journal Article · Biotechnology and applied biochemistry

Protective Effect and Gut Microbiota Modulation of Grifola frondosa Antioxidant Peptides in Sodium Dextran Sulfate-Induced Ulcerative Colitis Mice.

Grifola frondosa antioxidant peptides (GFAP) were prepared through trypsin enzymolysis and characterized. This study conducted a comprehensive assessment of clinical symptoms, colon pathological injuries, levels of inflammatory factors, expression of inflammation-related proteins, and alterations in gut microbiota….

Immune supportMetabolic health

Shiitake · 2025 · Journal Article · Biological & pharmaceutical bulletin

Protective Effects of Maternal Administration of a Standardized Extract of Cultured Lentinula edodes Mycelia against Radiation-Induced Fetal Morphological Abnormalities

Exposure to ionizing radiation during early pregnancy poses serious risks to fetal development, particularly during organogenesis. In this study, we evaluated the protective effects of AHCC®, a standardized extract of Lentinula edodes mycelia with known immunomodulatory and metabolic properties, using an ICR mouse….

OncologyImmune supportEnergy & fatigue

Mesima · 2025 · Research Article · BMC research notes

Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation.

OBJECTIVE: This study aimed to explore the protective mechanism of Phellinus linteus polysaccharides (Phps) against hypoxia/reoxygenation (H/R)-induced injury in H9c2 cardiomyocytes, focusing on oxidative stress, apoptosis, and PI3K-AKT pathway regulation..

Oyster Mushroom · 2025 · Journal Article · Fungal genetics and biology: FG & B

Putative transcription factor Nrg1 is involved in the hyphal branching and the cell wall structure formation in the filamentous fungus Pleurotus ostreatus.

Nrg1 is a C2H2 zinc finger transcription factor that functions in various cellular processes related to environmental responses and cell wall synthesis in yeast. The present study investigated the function of Nrg1 in filamentous development in the white-rot fungus Pleurotus ostreatus for the first time..

Immune supportCognition & nervesGut & microbiomeLiver support

Lion's Mane · 2025 · Journal Article · International Journal of Biological Macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Restoring Mitochondrial Function and Remodeling Gut Microbiota by Low-Molecular-Weight β-Glucan of Hericium erinaceus in Alcohol-Induced Gastrointestinal Injury.

Excessive alcohol consumption poses significant risks for gastrointestinal injury; β-glucans from Hericium erinaceus are known for gastroprotective properties; however, the efficacy of its high-molecular-weight β-glucan is often limited by poor solubility and bioavailability, leaving its protective mechanisms against….

Chaga · 2025 · Research Article · Journal of microbiology and biotechnology

Revitalization of the Endophytic Fungus Acremonium sp. MEP2000 and Its Impact on the Growth and Accumulation of Bioactive Compounds in Inonotus obliquus.

Inonotus obliquus is a large, medicinal and edible fungus known for its extremely slow growth. It has garnered significant attention due to its high socioeconomic and pharmaceutical value.

OncologyImmune supportMetabolic health

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Screening of Lentinula edodes Strains for High Polysaccharide Production and In Vitro Antioxidant Activities.

Lentinan is one of the main metabolites of Lentinula edodes and exhibits numerous biological properties, such as antitumor and antioxidant activity. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates

In the study, Grifola frondosa polysaccharides (GFPs) and gallic acid (GA) were utilized to synthesize selenium nanoparticles (GFPs-GA-SeNPs) through a redox reaction involving sodium selenite and ascorbic acid..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

Immune supportMetabolic health

Shiitake · 2025 · Research Article · Polymers

Selenium-Enriched Polysaccharides from Lentinula edodes Mycelium: Biosynthesis, Chemical Characterisation, and Assessment of Antioxidant Properties.

Selenium-polysaccharides possess antioxidant properties, making them promising materials for functional foods, pharmaceuticals, and clinical applications. This study examines the incorporation of selenium into polysaccharides via mycelial biosynthesis and its effects on structure and antioxidant activity..

Lion's Mane · 2025 · Journal Article · Carbohydrate polymers

Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing

Bacterial infection severely hinders skin wound healing, highlighting the critical application value of developing antibacterial and anti-inflammatory hydrogel dressings..

Lion's Mane · 2025 · Journal Article · Carbohydrate polymers

Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing.

Bacterial infection severely hinders skin wound healing, highlighting the critical application value of developing antibacterial and anti-inflammatory hydrogel dressings..

Snow Fungus · 2025 · Journal Article · Journal of agricultural and food chemistry

Simulated Digestion and Metabolic Outcomes of Tremella fuciformis Polysaccharides and Their Effects on the Gut Microbiota.

Tremella fuciformis polysaccharides (TFP) were evaluated for their gastrointestinal stability and microbiota-modulating effects using in vitro digestion and fecal fermentation..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Simulated gut microbiota fermentation of polysaccharide extracts from Ganoderma lucidum and Ganoderma neo-japonicum.

This study compared the chemical composition and effects on the gut microbiota of hot-water extracts from two Ganoderma species: Ganoderma lucidum (GL), a well-studied medicinal mushroom, and Ganoderma neo-japonicum (GN), a lesser-known counterpart..

Reishi · 2025 · Journal Article · Fitoterapia

Six new metabolites from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and their anti-inflammatory activities.

Six undescribed trichophthalides A-F (1-6) and a known phthalide derivative (7) were isolated from Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02.

Immune supportGut & microbiomeLiver supportSkin & hydration

Snow Fungus · 2025 · Journal Article · Langmuir: the ACS journal of surfaces and colloids

Soy Protein Isolate/Tremella Fuciformis Polysaccharide Complex-Stabilized High Internal Phase Pickering Emulsions: Andrographolide Delivery, Digestive Behavior, and 3D Printability.

The development of advanced bioactive delivery systems is critical for enhancing nutraceutical stability, controlled release, and functional food design. This study presented the fabrication of high internal phase Pickering emulsions (HIPPEs) stabilized by soy protein isolate (SPI) and Tremella fuciformis….

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance

Sporoderm-Broken Ganoderma lucidum spore polysaccharides (BGLSPs) have demonstrated therapeutic potential in inflammatory bowel disease (IBD), however, their mechanisms of action in colitis remain unclear..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Sporoderm-broken of Ganoderma lucidum spore polysaccharides alleviate dextran sulfate sodium-induced colon inflammation in mice by regulating Th17/Treg homeostasis and restore gut microbiota balance.

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Structural Characterization and Gastrointestinal Fate of a High-Molecular-Weight Hericium erinaceus Polysaccharide during Digestion and Fermentation.

This study systematically isolated a high-molecular-weight polysaccharide (HHEP; 9.14 × 103 kDa) from Hericium erinaceus, consisting predominantly of glucose (59.16% ± 0.09%), galactose (26.29% ± 0.59%), and mannose (5.69% ± 0.58%)..

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Structural Characterization of Polysaccharide from Flammulina velutipes and Its Impact on Hyperlipidemia Through Modulation of Hepatic Cholesterol Metabolism and Gut Microbiota.

FVPB1, a novel heteropolysaccharide, was extracted from the Flammulina velutipes fruiting body, and its structure was determined by methylation analysis, nuclear magnetic resonance (NMR) spectroscopy..

Lion's Mane · 2025 · Journal Article · Food chemistry

Structural characterization of β-glucan in Hericium erinaceus pretreated by steam explosion and its effects on human gut microbiota in vitro.

To investigate the impact of steam explosion on the structure of β-glucan and its regulation human gut microbiota (GM), two polysaccharides were prepared from Hericium erinaceus fruit bodies treated by steam explosion and conventional crushing, respectively..

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural insights into polysaccharides in Ganoderma lucidum cell walls by solid-state NMR

Ganoderma lucidum is a medicinal mushroom long esteemed in Asian traditional medicine for its health-promoting and longevity-enhancing properties. It contains over 400 bioactive compounds, among which its polysaccharides (GLPs) are especially significant due to their diverse biological functions..

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural insights into polysaccharides in Ganoderma lucidum cell walls by solid-state NMR.

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota

Sweet potato residue (SPR), a by-product of sweet potato processing, is rich in dietary fiber and other is rich in dietary fiber and other essential nutrients; however, its industrial utilization remains limited..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota.

Maitake · 2025 · Research Article · NPJ science of food

Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice.

Polysaccharide extracted from Grifola frondosa (GFP) was selected in this study. After preliminary separation, four factions were collected, named GFP-F1, GFP-F2, GFP-F3 and GFP-F4.

Oyster Mushroom · 2025 · Journal Article · Food Chemistry

Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides

Edible mushrooms polysaccharides are widely recognized for their biological activities, yet the prebiotic potential of Pleurotus ostreatus polysaccharides (POP) remains underexplored. In this study, POP was isolated, structurally characterized, and evaluated for digestibility and impact on gut microbiota..

Oyster Mushroom · 2025 · Journal Article · Food chemistry

Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides.

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2025 · Journal Article · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory‐enhancing, anti‐inflammatory,….