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Immune supportGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum sporoderm-broken spore powder alleviates kidney aging by modulating gut microbiota.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum), a revered medicinal mushroom in traditional Chinese medicine (TCM), has been historically documented for its anti-aging properties and nephroprotective effects..

Oyster Mushroom · 2025 · Randomized Controlled Trial · Molecular nutrition & food research

GLP-1 Responses to a Single Meal Fortified With Oyster Mushroom Powder in Adults With Impaired Glucose Tolerance Depend on the Gut Microbiota Composition Before the Meal.

Fortification of a single meal with β-glucan-rich oyster mushroom (Pleurotus ostreatus) powder has been shown to increase the response of glucagon-like peptide 1 (GLP-1) and reduce concentrations of non-esterified fatty acids (NEFAs) in adults with impaired glucose tolerance (IGT)..

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharide F2 Ameliorates Disordered Glucose and Lipid Metabolism in Prediabetic Mice by Modulating Bile Acids.

Prediabetes (pre-DM) is the buffer period before developing overt type 2 diabetes (T2DM), and the search for novel food agents to protect against pre-DM is in high demand..

King Oyster · 2025 · Journal Article · Animal science journal =

Growth Performance, Apparent Digestibility, Serum Indices, and Fecal Bacterial Community Diversity in Yanbian Cattle Fed Diets With Fermented Spent Mushroom Substrate From Pleurotus Eryngii Instead of Brewers Spent Grain

This experiment was to evaluate the effect of fermented spent mushroom substrate from Pleurotus eryngii (FSMPE) instead of brewers spent grain (BSG) on growth performance, apparent digestibility, serum indices, and fecal bacterial community of Yanbian cattle..

King Oyster · 2025 · Journal Article · Animal science journal = Nihon chikusan Gakkaiho

Growth Performance, Apparent Digestibility, Serum Indices, and Fecal Bacterial Community Diversity in Yanbian Cattle Fed Diets With Fermented Spent Mushroom Substrate From Pleurotus Eryngii Instead of Brewers Spent Grain.

Immune supportGut & microbiomeRespiratory

Shiitake · 2025 · Journal Article · Biocatalysis and Agricultural Biotechnology

Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes

Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived….

Cordyceps · 2025 · Journal Article · International Journal of Biological Macromolecules

Impact of cell disruption technologies on the structure, functionality, and digestibility of Cordyceps militaris protein isolates

Cell disruption is essential for extracting intracellular proteins from fungal biomass. However, its effects on the structural and functional properties of proteins remain insufficiently understood..

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Impact of cell disruption technologies on the structure, functionality, and digestibility of Cordyceps militaris protein isolates.

Cell disruption is essential for extracting intracellular proteins from fungal biomass. However, its effects on the structural and functional properties of proteins remain insufficiently understood..

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Impact of the sterol O-acyltransferase gene (Cmare2) on morphology and stability of the mushroom Cordyceps militaris.

Strain degeneration in mushroom cultivation can lead to significant commercial losses, yet the genetic factors remain elusive. This study identified the sterol O-acyltransferase gene, Cmare2, which is associated with colony sectorization in Cordyceps militaris, using a T-DNA insertion-mutant library..

OncologyImmune supportGut & microbiome

Reishi · 2025 · Journal Article · Heliyon

In vitro evaluation of antioxidant, probiotic, and antiproliferative activity of Ganoderma lucidum-extracted polysaccharides for the prevention of complication associated with gastrointestinal inflammatory diseases

Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are associated with increased oxidative stress, chronic inflammation, and in some cases, abnormal cell proliferation, which can lead to serious complications such as cancer..

Maitake · 2025 · Research Article · Nutrients

In Vitro Gastrointestinal Digestion of Grifola frondosa Polysaccharides and Their Enhancement of GABA Production via Gut Microbiota Modulation.

Background: The water-soluble Grifola frondosa polysaccharides (GFPs) are the primary bioactive component of the edible and medicinal fungus Grifola frondosa. However, the digestive behavior of GFPs in the human gastrointestinal (GI) tract and their subsequent interaction with gut microbiota (GM) to exert health….

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Incorporating Fresh Durum Wheat Semolina Pasta Fortified with Cardoncello (Pleurotus eryngii) Mushroom Powder as a Mediterranean Diet Staple.

Pasta made from durum wheat semolina has a medium-high glycemic index score, high starch digestibility, and limited nutritional value due to its low fiber, vitamin, and bioactive compound content..

Reishi · 2025 · Research Article · Journal of food science and technology

Incorporating Ganoderma lucidum extract and powder with probiotic cultures (Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis) enhanced the functional, textural, and sensory qualities of yogurt.

In this study, the extract and powder obtained from the Reishi mushroom (Ganoderma lucidum) were used in the production of yogurt, and also Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis bacteria were also inoculated..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · International Journal of Biological Macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation.

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

OncologyGut & microbiomeRespiratory

Cordyceps · 2025 · Journal Article · Anticancer research

Integrating Network Pharmacology and Optimization of Preparation Methods to Enhance the Anticancer Effect of Cordyceps militaris on Lung Cancer.

BACKGROUND/AIM: Cordyceps militaris, a medicinal fungus, is renowned for its anticancer properties. To maximize its therapeutic efficacy, this study aimed to optimize the extraction and preparation methods of Cordyceps militaris and evaluate its effects on non-small cell lung cancer (NSCLC)..

Cordyceps · 2025 · Research Article · Food chemistry: X

Low-glycemic index cookies supplemented with Cordyceps militaris substrate: Nutritional values, physicochemical properties, antioxidant activity, bioactive constituents, and bioaccessibility.

Cordyceps militaris substrate (CMS) is a novel ingredient rich in dietary fibers and bioactive compounds; however, its application in food products remains largely unexplored..

Yellow Morel · 2025 · Research Article · Scientific reports

Medicinal potential of Morchella esculenta oil inhibits cancer cell proliferation, metabolite characterization through GCMS, GC×GC-TOF-MS and UHPLC-QTOF-MS.

The current study investigated comprehensive phytochemical profile through high resolution techniques like GCMS, GC×GC-TOF-MS, UHPLC-QTOF-MS, total phenolic content, total flavonoid content, antioxidant, and anticancer activities of Morchella esculenta oil using in vitro approaches..

OncologyGut & microbiome

Cordyceps · 2025 · Journal Article · Food chemistry

Metabolomics analysis reveals the changes of metabolites in Cordyceps militaris during subculture.

Cordyceps militaris (C. militaris) strain is highly prone to degeneration during subculture.

Snow Fungus · 2025 · Research Article · Microorganisms

Microbiota Involved in the Degradation of Tremella fuciformis Polysaccharide and Microbial Enzymatic Potential Revealed by Microbiome and Metagenome.

Tremella fuciformis, as a traditional edible fungus in Asian countries, is rich in polysaccharides with a variety of bioactivities. Nevertheless, its high molecular weight and complex structure have caused limitations in its application and structural analysis..

Energy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Research Article · Veterinary world

Microencapsulated Ganoderma lucidum extract improves antioxidant capacity, intestinal morphology, and nutrient digestibility in free-range laying hens under tropical conditions.

BACKGROUND AND AIM: Free-range laying hens raised under tropical climates are susceptible to heat stress (HS), which compromises intestinal integrity, nutrient absorption, and egg quality..

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Molecular and functional modulation of mycoprotein extract from edible Trametes versicolor via pH cycling and ultrasound-enhanced transglutaminase treatment.

This study investigates the structural and functional modification of mycoprotein extract from Trametes versicolor through ultrasound (US) processing combined with either pH cycling treatment or transglutaminase (TGase) cross-linking..

Shiitake · 2025 · Journal Article · Biocatalysis and Agricultural Biotechnology

Mycelial vigor, growth, physicochemical and sensory characteristics of Lentinula edodes produced from agroindustrial residues and their anaerobic digestates

In some Latin American countries, agro-industrial wastes (AIW) are put aside in significant quantities, as it is treated as common garbage without a specific management plan. A viable alternative would be to use AIW as substrates for further valorization processes..

OncologyGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Food and Bioproducts Processing

Novel advanced nanoliposomes incorporating adenosine, cordycepin from riched-Cordyceps militaris extract, and curcumin: Formulation, stability, in vitro digestion, and enhanced biological activities

This study details the development and evaluation of novel nanoliposomes for the co-delivery of adenosine and cordycepin from Cordyceps militaris extract, alongside curcumin..

Oyster Mushroom · 2025 · Journal Article · World J Microbiol Biotechnol

Novel chia (Salvia Hispanica L.) residue-based substrate formulations for oyster mushroom (Pleurotus ostreatus) cultivation

Chia (Salvia hispanica) and mushrooms represent valuable natural resources with numerous beneficial attributes as functional food ingredient with potential health benefits that support human health..

Oyster Mushroom · 2025 · Research Article · World journal of microbiology & biotechnology

Novel chia (Salvia Hispanica L.) residue-based substrate formulations for oyster mushroom (Pleurotus ostreatus) cultivation.

Chia (Salvia hispanica) and mushrooms represent valuable natural resources with numerous beneficial attributes as functional food ingredient with potential health benefits that support human health..

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Food & function

Novel double nanoemulsion loading of Cordyceps militaris extract: formulation, stability, in vitro digestion, and in vivo evaluation for regulation of acute lipid disorders.

This study explores a novel approach for addressing acute lipid disorders using a double nanoemulsion system (NCMs) loading Cordyceps militaris extract. Cordyceps militaris, a medicinal mushroom, is valued for its bioactive compounds, particularly adenosine (ADE) and cordycepin (COR), which possess lipid-regulating….

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities

Galactose-rich polysaccharides from Ganoderma lucidum have emerged as promising immunomodulatory agents, yet their structural characteristics and mechanisms of action remain poorly understood. Here, we isolated and characterized a novel galactose-rich polysaccharide (GLP-1b, 16.79 kDa) from Ganoderma lucidum..

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities.

Shiitake · 2025 · Research Article · Food science & nutrition

Novel Insights Into Peptide-Calcium Chelates From Lentinula edodes: Preparation and Its Structure, Stability, and Calcium Transport Analysis.

Peptide-Ca chelates are innovative calcium supplements. Lentinula edodes possesses nutritional advantages for preparing calcium-binding peptides (CBPs), although there are limited studies on this subject..

Reishi · 2025 · Research Article · Scientific reports

Phytochemical analysis and antimicrobial activity of Ganoderma lucidum against selected bacteria and fungi of medical importance.

Ganoderma lucidum is a rapidly growing mushroom, wood-colonizing fungus belonging to the phylum Basidiomycota. G.

OncologyGut & microbiome

Immune supportGut & microbiomeLiver support

King Oyster · 2025 · Research Article · Food science & nutrition

Pleurotus eryngii Culture Filtrate and Aqueous Extracts Alleviate Aflatoxin B1 Synthesis.

Mycotoxins in food and feed are a significant health risk, even more so than pesticides and synthetic waste. These toxic secondary metabolites are produced by various fungal species, particularly after fungal colonization of crops..

King Oyster · 2025 · Research Article · Nutrients

Pleurotus eryngii Mushrooms Fermented with Human Fecal Microbiota Protect Intestinal Barrier Integrity: Immune Modulation and Signalling Pathways Counter Deoxycholic Acid-Induced Disruption in Healthy Colonic Tissue.

Background: This study explores the potential of the Pleurotus eryngii mushroom fermentation supernatant (FS-PEWS) as an intervention for mitigating sodium deoxycholate (SDC)-induced intestinal barrier dysfunction and inflammation..

King Oyster · 2025 · Journal Article · Food & function

Positive effect of a novel protein from Pleurotus eryngii on improving colitis: exploring potential mechanisms from the perspective of intestinal metabolism.

Pleurotus eryngii (P. eryngii) protein has demonstrated potential anti-inflammatory effects, but the specific mechanism has not been reported.

Immune supportGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Food Bioscience

Preparation of novel Ganoderma lucidum protein-derived bioactive peptides and their oxidation resistance, melanin synthesis inhibition and anti-inflammatory functions

As a key active component in Ganoderma lucidum, the preparation and biological activities of Ganoderma lucidum immunomodulatory protein (rFIP-glu) have been reported, but its deep utilization, such as the preparation of bioactive peptides, has not been explored..

Cordyceps · 2025 · Research Article · Current research in food science

Probiotic Levilactobacillus brevis GH1 from baijiu Daqu enhanced γ-aminobutyric acid and antioxidant ability in Cordyceps militaris fruiting body extract and brown rice beverage.

γ-Aminobutyric acid (GABA) is a functional amino acid with various physiological activities. Increasing the concentration of GABA in foods and enhancing dietary supplementation are important for health benefits.

Cognition & nervesEnergy & fatigueMetabolic healthGut & microbiome

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Production and Optimization of Anti-Aging Peptides from Pleurotus eryngii Mushroom Feet: Mechanistic Insights via Integrated Transcriptomics and Metabolomics.

This study established an optimized process for obtaining anti-aging peptides from Pleurotus eryngii mushroom feet (PEMFPeps). Using response surface methodology, high yields of protein (51.31 ± 3.00%) and peptides (48.71 ± 0.17% hydrolysis degree) were achieved..

Metabolic healthGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Applied and environmental microbiology

Puerarin combined with Hericium erinaceus insoluble dietary fiber alleviates obesity induced by high-fat diet through regulating the glycerophospholipid metabolism pathway influenced by gut microbiota.

The purpose of this study was to evaluate the combined effects of puerarin (Pue) and insoluble dietary fiber from Hericium erinaceus (HEIDF) on obesity induced by a high-fat diet (HFD) in mice, focusing on their effects on lipid and glucose metabolism, gut microbiota (GM), and serum metabolites..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

Ganoderma lucidum is a traditional Chinese medicine used to treat Alzheimer's disease (AD), whose main active ingredient is polysaccharides. A heteropolysaccharide named GLPZ-1 was isolated from Ganoderma lucidum.

OncologyImmune supportMetabolic healthGut & microbiome

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of Pleurotus eryngii polysaccharide and its protective mechanisms against mastitis in mice.

Mastitis, a common inflammatory condition in female mammals, increases the risk of breast cancer and causes substantial economic losses. Although antibiotics effectively treat mastitis, their overuse poses a threat to public health and safety..

Energy & fatigueGut & microbiomeSkin & hydration

Turkey Tail · 2025 · Research Article · Microbial cell factories

Studies on the treatment of anaerobically digested sludge by white-rot fungi: evaluation of the effect of Phanerochaete chrysosporium and Trametes versicolor.

BACKGROUND: The composition of anaerobically digested sludge is inherently complex, enriched with structurally complex organic compounds and nitrogenous constituents, which are refractory to biodegradation. These characteristics limit the subsequent rational utilization of resources from anaerobically digested sludge..

Oyster Mushroom · 2025 · Preprint · journal metadata

Substrate Formulation Effects on Pleurotus ostreatus Production and Nutritional Profile

This study compared the effects of using different lignocellulosic substrates on the growth, yield, and nutritional composition of Pleurotus ostreatus mushrooms. Three substrate formulas were investigated: a commercial/standard oyster formula (S), willow chips with cottonseed hulls (W+C), and willow chips alone (W)..

Enoki · 2025 · Journal Article · Food Research International

Superiority of ultrasound-extracted Flammulina velutipes polysaccharides over hot water-extracted ones in mitigating colonic cell pyroptosis: Discoveries into modulation of NLRP3 pathway

Flammulina velutipes is a major edible fungus with abundant yield and mature industrial production technology. Its main functional component, Flammulina velutipes polysaccharide, has huge development and utilization value..

Enoki · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Superiority of ultrasound-extracted Flammulina velutipes polysaccharides over hot water-extracted ones in mitigating colonic cell pyroptosis: Discoveries into modulation of NLRP3 pathway.

OncologyCognition & nervesGut & microbiomeSkin & hydration

Reishi · 2025 · Research Article · Discover oncology

Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.

BACKGROUND: Glioma is the most common and lethal primary brain tumor with limited therapeutic options and poor prognosis. Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases..

OncologyMetabolic healthGut & microbiome

Oyster Mushroom · 2025 · Journal Article · Bulletin of experimental biology and medicine

The Effect of β-D-Glucans of Pleurotus ostreatus (Oyster Mushroom) on the Development of Myelosuppression and Colitis Induced by 5-Fluorouracil in Mice.

We studied the effect of the water-soluble fraction of the extract containing β-glucans from Pleurotus ostreatus (oyster mushroom) on myelosuppression and colitis induced by 5-fluorouracil (5-FU) in male BALB/c mice..

Cordyceps · 2025 · Journal Article · Animal feed science and technology

The effects of dietary Cordyceps militaris substrate on growth, immunity, gonadal quality, and gut microbiota of the sea urchin Strongylocentrotus intermedius

Sea urchin Strongylocentrotus intermedius is a commercially valuable marine species in China. Cordyceps militaris culture (CMC), containing cordycepin, polysaccharides, cordycepic acid, amino acids, trace elements, and vitamins, was tested in varying concentrations (0.5 %, 1.0 %, and 1.5 %) in sea urchin feed to….

Immune supportGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Journal of food science

The fermentation of Cordyceps militaris polysaccharide influenced gut bacterial LPS structure formation and changed its antigenicity.

Gut bacterial lipopolysaccharide (LPS) could be released into the circulatory system via the gut-liver axis and cause inflammatory immune response, while Cordyceps militaris polysaccharide (CMP40) has been reported to be effective in alleviating this inflammatory response..

Oyster Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

The Impact of Oyster Mushrooms (Pleurotus ostreatus) on the Baking Quality of Rye Flour and Nutrition Composition and Antioxidant Potential of Rye Bread.

This study aimed to evaluate the use of oyster mushroom (Pleurotus ostreatus) powder (OMP) for producing rye bread. The raw materials were low-extract rye flour and OMP, which were analyzed in terms of their nutritional and health-promoting qualities..