MycoData

Glucuronoxylomannan (AAPS) from the edible wood ear mushroom Auricularia auricula-judae has been demonstrated to exhibit immunostimulatory properties through its binding to TLR4. However, the mechanisms of immune modulation by AAPS in mammalian cells remains unclear..

Immune supportEnergy & fatigue

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Shiitake · 2020 · Journal Article · International journal of biological macromolecules

Physicochemical properties and bioactivities of Lentinula edodes polysaccharides at different development stages.

Lentinula edodes polysaccharides from at four different development stages (referred to L1, L2, L3 and L4, respectively) were extracted by hot water method, and graded ethanol precipitation to final concentration of 20%, 50% and 70%, then12 crude polysaccharide fractions (referred to L1P20, L2P20, L3P20; L4P20, L1P50,….

Immune support

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King Oyster · 2020 · Journal Article · International journal of medicinal mushrooms

Polysaccharides from Pleurotus eryngii var. elaeoselini (Agaricomycetes), a New Potential Culinary-Medicinal Oyster Mushroom from Italy.

Three water-soluble glucans (PELPS-A1, PELPS-A2, and PELPS-A3) purified from the hot water extract of the basidiomata of an edible mushroom Pleurotus eryngii var. elaeoselini by chromatography on DEAE-cellulose 32 and Sephadex G-100 column were found to consist of only D-glucose as monosaccharide constituent..

Immune supportMetabolic health

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King Oyster · 2020 · Journal Article · Journal of food science

Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti-inflammation activities potential.

The anti-inflammatory effects of two newly identified Pleurotus eryngii polysaccharides (WPEP, NPEP) were determined in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in this study..

OncologyImmune supportMetabolic health

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Snow Fungus · 2020 · Journal Article · International journal of biological macromolecules

Production, structure, and bioactivity of polysaccharide isolated from Tremella fuciformis XY.

Tremella fuciformis polysaccharide (TFP) is an important bioactive substance in Tremella, that contributes to its use as medicine and food. In this study, a novel fungus Tremella fuciformis XY was isolated and introduced to produce macromolecule polysaccharides (TFPB)..

Immune supportEnergy & fatigueMetabolic health

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King Oyster · 2020 · Journal Article · International journal of medicinal mushrooms

Protective Effects of the King Oyster Culinary-Medicinal Mushroom, Pleurotus eryngii (Agaricomycetes), Polysaccharides on β-Amyloid-Induced Neurotoxicity in PC12 Cells and Aging Rats, In Vitro and In Vivo Studies.

Pleurotus eryngii (PE) contains polysaccharides and vitamins, and has been reported to have antidepression properties. P.

OncologyImmune supportCognition & nerves

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Cordyceps · 2020 · Research Article · BMC genomics

Proteome sequencing and analysis of Ophiocordyceps sinensis at different culture periods.

BACKGROUND: Ophiocordyceps sinensis is an important traditional Chinese medicine for its comprehensive active ingredients, such as cordycepin, cordycepic acid, and Cordyceps polysaccharide. O.

Immune supportMetabolic health

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Reishi · 2020 · Research Article · Frontiers in pharmacology

Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia.

Ganoderma lucidum, also known as LINGZHI, has a long tradition of use in folk medicine of the Far East, which is documented in the oldest Chinese pharmacopoeia, declaring it a superior medicine. LINGZHI-8 (LZ-8) is an immunoregulatory fungal protein isolated from the fruiting body of Ganoderma lucidum..

OncologyImmune supportGut & microbiome

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Maitake · 2020 · Journal Article · Glycoconjugate journal

Relationship between heat treatment on structural properties and antitumor activity of the cold-water soluble polysaccharides from Grifola frondosa.

Grifola frondosa is a basidiomycete fungus with potential biomedical applications owing to the presence of bioactive polysaccharides. The activities of polysaccharides are influenced by many factors, particularly temperature; however, the optimal temperature and conditions for preparation of polysaccharides from this….

OncologyImmune supportEnergy & fatigue

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Shiitake · 2020 · Research Article · Frontiers in microbiology

RNA-seq Profiling Showed Divergent Carbohydrate-Active Enzymes (CAZymes) Expression Patterns in Lentinula edodes at Brown Film Formation Stage Under Blue Light Induction.

Lentinula edodes (shiitake mushroom) is one of the most important edible mushrooms worldwide. The L.

Immune support

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Chaga · 2020 · Journal Article · International journal of biological macromolecules

Spatial structure and anti-fatigue of polysaccharide from Inonotus obliquus.

The aim of this study was to evaluate the spatial structure and potential antifatigue activity of polysaccharide fractions which was extracted from Inonotus obliquus..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

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Reishi · 2020 · Journal Article · International journal of medicinal mushrooms

Statistical Optimization of Polysaccharides Production by the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) in Solid-State Fermentation Using Highland Barley Grains.

Ganoderma lucidum is a widely used medicinal mushroom in traditional Chinese medicine that creates a diverse set of bioactive compounds. Highland barley, a typical nutrition-balanced crop, is not convenient for direct consumption but its nutritional characteristics meet the modern requirements of health food..

Immune supportMetabolic health

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King Oyster · 2020 · Journal Article · International journal of biological macromolecules

Structural characterization and inhibition on α-glucosidase of the polysaccharides from fruiting bodies and mycelia of Pleurotus eryngii.

The Pleurotus eryngii was chose as research subject to study the similarity and discrepancy of polysaccharides from fruiting body and mycelia, which were named as PEBP-II and PEMP-II, respectively. The purpose is to expand the production and application of Pleurotus eryngii polysaccharide..

Immune support

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Oyster Mushroom · 2020 · Journal Article · International journal of biological macromolecules

Structural characterization of phosphorylated Pleurotus ostreatus polysaccharide and its hepatoprotective effect on carbon tetrachloride-induced liver injury in mice.

This study aimed to explore the basic structural features of phosphorylated Pleurotus ostreatus polysaccharide (PPOP) and study the protective effect of PPOP on liver injury induced by carbon tetrachloride in male Kunming mice..

Immune supportMetabolic healthLiver support

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Cordyceps · 2020 · Journal Article · Carbohydrate polymers

Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley

A water-soluble neutral polysaccharide (SDQCP-1) was isolated from fruit bodies of Cordyceps militaris cultivated on hull-less barley. SDQCP-1 was composed of mannose, glucose and galactose in the mole ratio of 13.3:1.0:9.7, with an average molecular weight of 19.3 kDa..

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Cordyceps · 2020 · Journal Article · Carbohydrate polymers

Structural characterization, antioxidant and immunomodulatory activities of a neutral polysaccharide from Cordyceps militaris cultivated on hull-less barley.

Immune supportMetabolic health

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Cordyceps · 2020 · Journal Article · Food & function

Study on the effect of regulation of Cordyceps militaris polypeptide on the immune function of mice based on a transcription factor regulatory network.

BACKGROUND: The pathogenesis of the abnormality of the immune system is still not clear at present. Chemosynthetic drugs, human or animal immune products and microbiological drugs are used as the main drugs in clinics currently, but these drugs have different side effects..

OncologyImmune support

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Enoki · 2020 · Journal Article · International journal of medicinal mushrooms

The Biosynthetic Pathway of Ergothioneine in Culinary-Medicinal Winter Mushroom, Flammulina velutipes (Agaricomycetes).

Ergothioneine is a natural 2-thiol-amidazole amino acid that plays an important role in inflammation, depression, and cardiovascular disease. Flammulina velutipes is a common basidiomycete mushroom rich in ergothioneine (EGT).

Immune supportCognition & nerves

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Maitake · 2020 · Journal Article · International journal of biological macromolecules

The caspases-dependent apoptosis of hepatoma cells induced by an acid-soluble polysaccharide from Grifola frondosa.

The edible mushroom Grifola frondosa has been used as a functional food for diseases prevention and therapy in Asian countries. In the present work, an acid-soluble polysaccharide (GFAP) was prepared from Grifola frondosa under room temperature and hydrochloric acid solution treatment, and its inhibitory effects on….

OncologyImmune supportEnergy & fatigueLiver support

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Turkey Tail · 2020 · Journal Article · International journal of medicinal mushrooms

Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Crude Exopolysaccharides with Antioxidative Activity.

Crude Trametes versicolor exopolysaccharides (cEPS) were used for antioxidative activity testing. Obtained results revealed high ability of cEPS for DPPH free radical scavenging and high chelating ability at the highest tested concentration (20 mg/mL), while the reducing power was significantly lower..

Immune supportMetabolic health

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Cordyceps · 2020 · Journal Article · Food & function

Using Cordyceps militaris extracellular polysaccharides to prevent Pb2+-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota.

In this study, we investigated the protective efficacy of extracellular polysaccharide from Cordyceps militaris (CEP-I) in liver and kidney and their regulating effect on gut microbiota against Pb-induced toxicity in vivo..

Immune supportEnergy & fatigueGut & microbiomeLiver support

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Mesima · 2020 · Research Article · Molecules (Basel, Switzerland)

Vasodilatory Effect of Phellinus linteus Extract in Rat Mesenteric Arteries.

Phellinus linteus is a well-known medicinal mushroom that is widely used in Asian countries. In several experimental models, Phellinus linteus extracts were reported to have various biological effects, including anti-inflammatory, anti-cancer, hepatoprotective, anti-diabetic, neuroprotective, and anti-angiogenic….

OncologyImmune supportCognition & nervesEnergy & fatigue

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Cordyceps · 2019 · Journal Article · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Production of antioxidative exopolysaccharides of Cordyceps militaris with Vernonia amygdalina leaves in substrate].

Cordyceps militaris exopolysaccharides (EPS) have many pharmacological activities such as boosting immunity and antifatigue. To obtain EPS efficiently, we added moderate Vernonia amygdalina leaf powder as inducer to the fermentation medium to promote the production of Cordyceps militaris EPS and studied the infrared….

Immune supportEnergy & fatigue

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King Oyster · 2019 · Journal Article · Carbohydrate polymers

A 3-O-methylated heterogalactan from Pleurotus eryngii activates macrophages.

Mushroom-derived polysaccharides exhibit various biological activities owing to their diverse structural features. Here, we purified a 3-O-methylated heterogalactan (WPEP-N-b, Mw 21.4 kDa) from the fruiting bodies of Pleurotus eryngii..

Immune supportMetabolic health

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Maitake · 2019 · Journal Article · International journal of biological macromolecules

A cold-water soluble polysaccharide isolated from Grifola frondosa induces the apoptosis of HepG2 cells through mitochondrial passway.

Grifola frondosa is a widely eaten and medicinal fungus. In this study, we extracted a cold-water-soluble polysaccharide from Grifola frondosa (cGFP) and investigated its effects on the proliferation and apoptosis of human hepatoma HepG2 cells..

OncologyImmune supportEnergy & fatigueLiver support

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Maitake · 2019 · Research Article · RSC advances

A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance.

Alzheimer's disease (AD) is characterized by the deposition of amyloid-β (Aβ) plaques, neuronal loss and neurofibrillary tangles. In addition, neuroinflammatory processes are thought to contribute to AD pathophysiology..

Immune supportCognition & nervesMetabolic health

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Maitake · 2019 · Journal Article · International journal of medicinal mushrooms

A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice.

Maitake (Grifola frondosa) is an edible mushroom exhibiting high nutritional value in terms of containing health-beneficial bioactive compounds. Previously, we reported that a protein-bound polysaccharide bioactive component of G..

Immune supportCognition & nerves

High relevance

Cordyceps · 2019 · Journal Article · International journal of food science & technology

A simple and effective method using macroporous resins for the simultaneous decoloration and deproteinisation of Cordyceps militaris polysaccharides

The aim of this study was to develop an effective one‐step decoloration and deproteinisation method using macroporous resin for Cordyceps militaris polysaccharide (CMP) extraction..

Immune supportEnergy & fatigue

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Cordyceps · 2019 · Journal Article · International journal of medicinal mushrooms

Antioxidant-Rich Peptide Fractions Derived from High-Altitude Chinese Caterpillar Medicinal Mushroom Ophiocordyceps sinensis (Ascomycetes) Inhibit Bacterial Pathogens.

Ophiocordyceps sinensis (=Cordyceps sinensis), a medicinal mushroom native to the Orient, has been extensively used for the past few centuries in traditional Chinese medicine because of its immunomodulatory, antiinflammatory, and nutraceutical properties..

Immune supportEnergy & fatigue

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Maitake · 2019 · Journal Article · International journal of medicinal mushrooms

Antioxidative and Immunomodulatory Activities of the Exopolysaccharides from Submerged Culture of Hen of the Woods or Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) by Addition of Rhizoma gastrodiae Extract and Its Main Components.

Grifola frondosa (hen of the woods or maitake) is a famous culinary-medicinal mushroom, and its exopolysaccharides (EPSs) have biological activities with or without supplementation with exogenous additives. In this study, a Rhizoma gastrodiae extract was added to a G.

Immune support

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Shiitake · 2019 · Journal Article · International journal of biological macromolecules

Application of near infrared spectroscopy for rapid determination the geographical regions and polysaccharides contents of Lentinula edodes.

In this study, a calibration model based on Near-infrared spectroscopy (NIR) technique and chemometrics method was developed for rapid and non-destructive detecting the polysaccharide contents of lentinula edodes samples collected from different regions..

Immune support

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Chaga · 2019 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes) Polysaccharides Suppress Tacrine-induced Apoptosis by ROS-scavenging and Mitochondrial Pathway in HepG2 Cells.

Tacrine is the first drug licensed for the treatment of Alzheimer disease. Unfortunately, reversible hepatotoxicity limits its clinical use.

OncologyImmune supportCognition & nervesEnergy & fatigue

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Lion's Mane · 2019 · Research Article · Botanical studies

Comparative transcriptome analysis reveals the genetic basis underlying the biosynthesis of polysaccharides in Hericium erinaceus.

BACKGROUND: Hericium erinaceus, also known as lion's mane mushroom, is a widely distributed edible and medicinal fungus in Asian countries. H.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2019 · Journal Article · Food & function

Cordyceps militaris polysaccharides exerted protective effects on diabetic nephropathy in mice via regulation of autophagy.

The present study was designed to investigate the protective effects of Cordyceps militaris polysaccharides (CMP) on STZ-treated DN mice. CMP were identified by FT-IR and HPLC..

Immune supportMetabolic health

High relevance

Snow Fungus · 2019 · Research Article · Molecules (Basel, Switzerland)

Differences in the Moisture Capacity and Thermal Stability of Tremella fuciformis Polysaccharides Obtained by Various Drying Processes.

We compared the proportions and differences in the polysaccharides of Tremella fuciformis (Berkeley) after drying them by various processes, such as 18 °C cold air, 50 °C hot air, and freeze-drying..

Immune support

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Cordyceps · 2019 · Research Article · The journal of poultry science

Effect of Cordyceps militaris Hot Water Extract on Immunomodulation-associated Gene Expression in Broilers, Gallus gallus.

Cordyceps militaris is a well-known Chinese medicinal fungus that has been used as a nutraceutical food in several Asian countries. Cordycepin (3'-deoxyadenosine), a secondary metabolite produced from Cordyceps militaris, has been demonstrated to exert a wide spectrum of pharmacological activities, such as….

OncologyImmune supportEnergy & fatigue

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Cordyceps · 2019 · Journal Article · International journal of medicinal mushrooms

Effect of Culture Time on the Bioactive Components in the Fruit Bodies of Caterpillar Mushroom, Cordyceps militaris CM-H0810 (Ascomycetes).

Cordyceps militaris are widely cultivated in China for an important raw material for health foods. CM-H0810 is a C.

Immune support

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Lion's Mane · 2019 · Journal Article · International journal of medicinal mushrooms

Effects of Extraction Conditions on Crude Polysaccharides and Antioxidant Activities of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).

Dietary supplements are important to sustain an adequate level of antioxidants to balance reactive oxygen species (ROS) in vivo. Hericium erinaceus is one of the rare wood-rotting mushrooms with polysaccharides, which play antioxidant roles in multiple physiological systems of the organism..

Immune supportEnergy & fatigue

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Maitake · 2019 · Journal Article · Applied biochemistry and biotechnology

Effects of Heat Treatment on the Structural Characteristics and Antitumor Activity of Polysaccharides from Grifola frondosa.

This study investigated the effects of heat treatment on structural characteristics and in vitro antitumor activity of polysaccharides from Grifola frondosa. GFP-4 (extracted at 4 °C), GFP-4-80 (80 °C treatment on GFP-4) and GFP-80 (extracted at 80 °C) were prepared, and the chemical composition analysis showed that….

OncologyImmune supportEnergy & fatigue

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King Oyster · 2019 · Research Article · Food science & nutrition

Effects of Pleurotus eryngii (mushroom) powder and soluble polysaccharide addition on the rheological and microstructural properties of dough.

Adding a certain proportion of Pleurotus eryngii can improve the nutritional value of wheat-flour foods and enhance the utilization of this mushroom. In this research, partial wheat flour was substituted with P..

Immune support

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Oyster Mushroom · 2019 · Journal Article · Journal of the science of food and agriculture

Effects of pulverized oyster mushroom (Pleurotus ostreatus) on diarrhea incidence, growth performance, immunity, and microbial composition in piglets

BACKGROUND: Pleurotus ostreatus mushroom (POM) is an edible mushroom with rich nutritional components and vital pharmacological properties. The present study comprised 100 cross‐bred piglets, weaned at 28 days old, who were randomly assigned to four POM diets with five replicates per diet and five piglets per pen..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2019 · Research Article · Journal of the science of food and agriculture

Effects of pulverized oyster mushroom (Pleurotus ostreatus) on diarrhea incidence, growth performance, immunity, and microbial composition in piglets.

BACKGROUND: Pleurotus ostreatus mushroom (POM) is an edible mushroom with rich nutritional components and vital pharmacological properties. The present study comprised 100 cross-bred piglets, weaned at 28 days old, who were randomly assigned to four POM diets with five replicates per diet and five piglets per pen..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Cordyceps · 2019 · Research Article · Veterinary world

Growth performance and hematological changes in growing pigs treated with Cordyceps militaris spent mushroom substrate.

BACKGROUND AND AIM: This study was aimed to compare the efficacy of dietary Cordyceps militaris spent mushroom substrate (CMS) on growth performance, immunity, metabolic profiles, and antioxidant capacity in growing pigs..

Immune supportEnergy & fatigueMetabolic health

High relevance

Lion's Mane · 2019 · Journal Article · Journal of medicinal food

Hericium erinaceus Mycelium and Its Isolated Compound, Erinacine A, Ameliorate High-Fat High-Sucrose Diet-Induced Metabolic Dysfunction and Spatial Learning Deficits in Aging Mice.

Aging and lifestyle factors, including high-sugar and high-fat diets, promote a systemic metabolic imbalance that promotes neurodegeneration. Hericium erinaceus has long been used in traditional Chinese medicine..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Maitake · 2019 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice.

GFP-N, a novel heteropolysaccharide with a molecular weight of 1.26 × 107 Da, was isolated from maitake mushroom and purified by anion-exchange chromatography on a DEAE cellulose-52 column and gel-filtration chromatography on a Sephadex G-100 column..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

King Oyster · 2019 · Journal Article · International journal of medicinal mushrooms

Immunomodulating Effects Exerted by Glucans Extracted from the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Grown in Substrates Containing Various Concentrations of Olive Mill Waste.

We have recently demonstrated that we could enhance glucan content in Pleurotus eryngii following cultivation of the mushrooms on a substrate containing different concentrations of olive mill solid waste (OMSW). These changes are directly related to the content of OMSW in the growing substrate..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2019 · Journal Article · International journal of medicinal mushrooms

In Vitro and In Vivo Inhibition of Helicobacter pylori by Ethanolic Extracts of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).

Natural products are sources for exploratory development of new agents to combat the gastric pathogen Helicobacter pylori. Some edible fungi, such as the lion's mane mushroom, have been used for several thousand years to treat digestive diseases..

Immune supportGut & microbiome

High relevance

Cordyceps · 2019 · Journal Article · International journal of medicinal mushrooms

Increasing of the Contain of Carotenoids in Caterpillar Mushroom, Cordyceps militaris (Ascomycetes) by Using the Fungal Elicitors Cultivation.

As a natural pigment, cordycepic carotenoids have many bioactive functions, such as antiinflammation, anticancer, and antioxidation. In addition, the good coloring of this hydrophilic pigment enables it to have wide application in the food industry..

OncologyImmune support

High relevance

Chaga · 2019 · Journal Article · Artificial cells, nanomedicine, and biotechnology

Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance.

Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4+T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects..

Immune supportGut & microbiome

High relevance

Shiitake · 2019 · Journal Article · Carbohydrate polymers

Isolation and comparison of α- and β-D-glucans from shiitake mushrooms (Lentinula edodes) with different biological activities

A polysaccharide-enriched extract obtained from Lentinula edodes was submitted to several purification steps to separate three different D-glucans with β-(1→6), β-(1→3),(1→6) and α-(1→3) linkages, being characterized through GC–MS, FT-IR, NMR, SEC and colorimetric/fluorimetric determinations..

OncologyImmune supportMetabolic health