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Medicinal fungi research database
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Oncology
Cancer, tumor biology, chemotherapy support, and oncology adjunct literature.
Species records
Species record
Oyster Mushroom
Pleurotus ostreatus
- Studies
- 1,947
- Avg relevance
- 53
- Latest
- 2026
Species record
Reishi · Lingzhi
Ganoderma lucidum
- Studies
- 1,830
- Avg relevance
- 60
- Latest
- 2026
Species record
Turkey Tail · Yun Zhi
Trametes versicolor
- Studies
- 1,828
- Avg relevance
- 41
- Latest
- 2026
Species record
Shiitake · Hua Gu
Lentinula edodes
- Studies
- 1,766
- Avg relevance
- 60
- Latest
- 2026
Species record
Cordyceps · Scarlet Club
Cordyceps militaris
- Studies
- 1,635
- Avg relevance
- 67
- Latest
- 2026
Species record
Cordyceps · Caterpillar Fungus
Ophiocordyceps sinensis
- Studies
- 1,576
- Avg relevance
- 59
- Latest
- 2026
Species record
Almond Mushroom · ABM
Agaricus blazei
- Studies
- 1,441
- Avg relevance
- 54
- Latest
- 2026
Species record
Enoki · Winter Mushroom
Flammulina velutipes
- Studies
- 1,403
- Avg relevance
- 47
- Latest
- 2026
Species record
King Oyster · Eryngii
Pleurotus eryngii
- Studies
- 1,278
- Avg relevance
- 60
- Latest
- 2026
Species record
Maitake · Hen of the Woods
Grifola frondosa
- Studies
- 1,276
- Avg relevance
- 48
- Latest
- 2026
Species record
Snow Fungus · Silver Ear
Tremella fuciformis
- Studies
- 1,052
- Avg relevance
- 29
- Latest
- 2026
Species record
Lion's Mane · Yamabushitake
Hericium erinaceus
- Studies
- 862
- Avg relevance
- 67
- Latest
- 2026
Species record
Chaga
Inonotus obliquus
- Studies
- 738
- Avg relevance
- 65
- Latest
- 2026
Species record
Mesima · Sanghwang
Phellinus linteus
- Studies
- 722
- Avg relevance
- 58
- Latest
- 2026
Species record
Niu-Chang-Chih
Antrodia camphorata
- Studies
- 496
- Avg relevance
- 63
- Latest
- 2026
Species record
Nameko · Nametake
Pholiota microspora
- Studies
- 421
- Avg relevance
- 29
- Latest
- 2026
Species record
Yellow Morel
Morchella esculenta
- Studies
- 392
- Avg relevance
- 42
- Latest
- 2026
Species record
Zhu Ling · Umbrella Polypore
Polyporus umbellatus
- Studies
- 263
- Avg relevance
- 55
- Latest
- 2026
Species record
Wood Ear · Kikurage
Auricularia auricula-judae
- Studies
- 254
- Avg relevance
- 51
- Latest
- 2026
Species record
Agarikon · Quinine Conk
Fomitopsis officinalis
- Studies
- 47
- Avg relevance
- 55
- Latest
- 2026
Articles
4,056 results
Showing 1,251–1,300 of 4,056
Chaga · 2011 · Research Support, Non U.S. Gov'T · Phytochemical analysis: PCA
Rapid isolation and purification of inotodiol and trametenolic acid from Inonotus obliquus by high-speed counter-current chromatography with evaporative light scatting detection.
INTRODUCTION: In Eastern Europe, especially Russia, the fruiting body of Inonotus obliquus has been used as a folk medicine for cancer since the sixteenth or seventeenth century. Inotodiol and trametenolic acid are considered to be the main bioactive compounds of the fruiting body of the mushroom..
Niu-Chang-Chih · 2011 · Patent · journal metadata
USE OF ANTRODIA CAMPHORATA FOR TREATING DISEASES
The present invention relates to the use of antrodia camphorata in the treatment of skin conditions, allergic rhinitis, diabetes mellitus and its complications, cancer cachexia, hypercholesterolemia, gout in a subject in need of such treatment..
Mesima · 2010 · Patent · journal metadata
ANTICANCER HEALTH FOOD CONTAINING PHELLINUS LINTEUS AND VEGETABLE WORMS
The present invention relates to a health food containing extracts of Phellinus linteus and vegetable worms for preventing and relieving cancer. The health food contains ethanol extract of the mixture containing the mycelia of the Phellinus linteus and vegetable worms at a ratio of 1:5 to 5:1..
Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology
Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell.
AIM OF THE STUDY: Antrodia camphorata (niu-chang-chih) is a fungus native to Taiwan which is believed to be effective in preventing diseases. Recent reports demonstrate that Antrodia camphorata products induce the apoptosis of various kinds of tumor cells..
Chaga · 2010 · Comparative Study · Journal of food science
Effects of ultrasonic treatment on the physicochemical properties and DPPH radical scavenging activity of polysaccharides from mushroom Inonotus obliquus.
UNLABELLED: An ultrasonic technique was employed to extract polysaccharides from Inonotus obliquus (UPS). The effects of ultrasonic conditions on the recovery and 1, 1-diphenyl -2-picrylhydrazyl (DPPH) radical scavenging activity of UPS were evaluated..
Niu-Chang-Chih · 2010 · Patent · journal metadata
NEW COMPOUNDS ISOLATED FROM EXTRACT OF ANTRODIA CAMPHORATA
The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells..
Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · International urology and nephrology
Protective effect of Antrodia camphorata on bladder ischemia/reperfusion injury.
INTRODUCTION: Obstructive bladder dysfunction is directly related to ischemia/reperfusion injury characterized by damage to nerves, synapses and smooth muscle cells within the bladder wall. Antrodia Camphorata (AC) has significant antioxidant, antiinflammatory and cell-cycle inhibition properties..
Chaga · 2010 · Research Support, Non U.S. Gov'T · Acta poloniae pharmaceutica
Separation of an aqueous extract Inonotus obliquus (Chaga). A novel look at the efficiency of its influence on proliferation of A549 human lung carcinoma cells.
Aqueous extract of Inonotus obliquus was hydrolyzed in dilute hydrochloric acid. The products were extracted applying organic solvents, and separated chromatographically on a silica gel-packed column.
Mesima · 2010 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology
The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis.
ETHNOPHARMACOLOGICAL RELEVANCE: Phellinus linteus and Panax ginseng have been widely used as traditional herbal medicines to treat various diseases including cancer in East Asia..
Niu-Chang-Chih · 2009 · Patent · journal metadata
AN ANTRODIA CAMPHORATA CYCLOHEXENONE COMPOUND USED FOR INHIBITING HEPATITIS B VIRUS
Antrodia camphoratacyclohexenone compounds which is effective in inhibiting hepatitis B virus, in particular 4-hydroxy-2,3-dimethoxy-6-methy-5 [3,7,11-trimethy-dodeca-2,6,10-trienyl]-cyclohex-2-enone isolated from an extract of Antrodia camphorata..
King Oyster · 2009 · Research Support, Non U.S. Gov'T · Natural product research
Apoptotic cell death of human leukaemia U937 cells by ubiquinone-9 purified from Pleurotus eryngii.
A chloroform extract of the edible mushroom Pleurotus eryngii showed an inhibitory effect on mammalian DNA topoisomerase I. The topoisomerase I inhibitory compound was purified and identified as ubiquinone-9.
Maitake · 2009 · Letter · Experimental dermatology
Augmentation of sebaceous lipogenesis by an ethanol extract of Grifola frondosa (Maitake mushroom) in hamsters in vivo and in vitro.
Grifola frondosa (Maitake mushroom) is an edible and medicinal mushroom with versatile effects such as antitumor and immunomodulating actions. Here, we demonstrated that an ethanol extract of G..
Niu-Chang-Chih · 2009 · Patent · journal metadata
Cyclohexenone extract of Antrodia camphorata
The invention relates to a novel compound as well as purposes thereof, particularly relating to 4-oxhydryl-2, 3-dimethoxy-6-methyl-5(3, 7, 11-trimethyl-2, 6, 10-dodecatriene)-2-cyclohexenone (4-hydroxy-2, 3-dimethoxy-6-methy-5(3, 7, 11-trimethyl-dodeca-2, 6, 10-trienyl)-cyclohex-2-enone) separated from an Antrodia….
Almond Mushroom · 2009 · Research Support, Non U.S. Gov'T · In vivo (Athens, Greece)
Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice.
Agaricus blazei Murill (ABM) has shown particularly strong results in treating and preventing cancer and has also traditionally been used as a food source in Brazil..
Niu-Chang-Chih · 2009 · Patent · journal metadata
NEW COMPOUNDS ISOLATED FROM EXTRACT OF ANTRODIA CAMPHORATA
New compounds and their uses, in particular Antroquinonol B and Antroquinonol C isolated from extract of Antrodia camphorata, said compounds can be used for effectively inhibiting tumor growth..
Chaga · 2008 · Patent · journal metadata
ANTIOXIDANTS FROM MUSHROOM INONOTUS OBLIQUUS AND COMPOSITION CONTAINING THEM
An anti-oxidative compound isolated from Inonotus obliquus is provided to show the antioxidative activity due to superoxide radical scavenging effect, ABTS radical scavenging effect and DPPH radical scavenging effect, thereby being used as a medicine, a cosmetic, a functional food or a food additive for preventing and….
Chaga · 2008 · Research Support, Non U.S. Gov'T · World journal of gastroenterology
Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells.
AIM: To investigate the anti-proliferative and apoptotic effects of Chaga mushroom (Inonotus obliquus) water extract on human hepatoma cell lines, HepG2 and Hep3B cells. METHODS: The cytotoxicity of Chaga extract was screened by 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay..
Niu-Chang-Chih · 2008 · Patent · journal metadata
Compounds from Antrodia camphorata
The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells..
Mesima · 2008 · Patent · journal metadata
DYES FROM PHELLINUS LINTEUS, ITS EXTRACTING METHOD AND CLOTH DYED THE SAME
Dyes from Phellinus linteus are provided to have efficiencies of Phellinus linteus and to produce clothes capable of preventing and treating user's atopic skin diseases and cancers..
Lion's Mane · 2008 · Patent · journal metadata
HERICIUM ERINACEUS MYCELIUM COMPRISING RICE BRAN AND GINSENG STEAMED RED AND CULTIVATION METHOD THEREOF
The present invention relates to a production method of Hericium erinaceus mycelium using rice bran or ginseng steamed red as a substrate and Hericium erinaceus mycelium containing active ingredients of rice bran or ginseng steamed red prepared by the same, aiming at the increase of production of mycelium by using….
Mesima · 2008 · Patent · journal metadata
MIXTURE COMPOSITION OF POLYSACCHARIDE EXTRACTED FROM PHELLINUS LINTEUS HYPHA AND THEANINE
A mixture composition comprising a polysaccharide extracted from phellinus linteus hypha and theanine is provided to promote immunoreaction by promoting differentiation of immune cells and antibody formation capability and be usefully used for preventing and treating immune-related diseases such as cancer..
Niu-Chang-Chih · 2008 · Patent · journal metadata
NOVEL COMPOUNDS FROM ANTRODIA CAMPHORATA
The present invention relates to a novel compound and use thereof, in particular to Antroquinonol B and Antroquinonol C isolated from Antrodia camphorata extracts which can effectively inhibit the growth of cancer cells..
Niu-Chang-Chih · 2008 · Patent · journal metadata
Novel cyclohexenone compounds from antrodia camphorata and application thereof
The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorata, in particular to 4-hydroxy-2,3-dimethoxy-6-methy-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone, and its use in tumor growth inhibition..
Niu-Chang-Chih · 2008 · Patent · journal metadata
NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF
NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorata, in particular to 4- hydroxy-2,3-dimethoxy-6-methy-5(3,7,1 1-trimethyl-dodeca-2,6, 10-trienyl)-….
Niu-Chang-Chih · 2008 · Patent · journal metadata
NOVEL CYCLOHEXENONE COMPOUNDS FROM ANTRODIA CAMPHORATA AND APPLICATION THEREOF
The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorata, in particular to 4-hydroxy--2,3-dimethoxy-6-methy-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)- cyclohex-2-enone, and its use in tumor growth inhibition..
Maitake · 2008 · Research Support, Non U.S. Gov'T · The Journal of pharmacy and pharmacology
Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice.
Grifola frondosa fruiting body (Maitake) has been used as a dietary supplement due to its antitumour and immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of orally administered submerged cultivated G..
Mesima · 2008 · Research Support, Non U.S. Gov'T · British journal of cancer
Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling.
The antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation of immune system or the induction of apoptosis, has been recently described. However, the molecular mechanisms responsible for the inhibition of invasive behaviour of cancer cells remain to be addressed..
Mesima · 2008 · Patent · journal metadata
Process for co-fermentation of phellinus linteus fungus with chinese herbal medicines
The present invention relates to a process of fermenting a strain of Phellinus linteus fungus, in which the fungus is incubated in a medium under the condition for the best yield control with the aim to obtain the best yield of mycelia and polysaccharides, where the best ratio of the medium having potato extract and….
Niu-Chang-Chih · 2008 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology
The adjuvant effects of Antrodia Camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells.
AIM OF THE STUDY: The objectives of this study were to investigate the adjuvant anti-tumor effects of Antrodia camphorate in human hepatoma cells (C3A and PLC/PRF/5) which are resistance to most anti-tumor agents, elucidate the possible regulation pathways, and measure the tumor growth and survival rate in….
Chaga · 2007 · Research Support, Non U.S. Gov'T · Chemical & pharmaceutical bulletin
Antioxidant Small Phenolic Ingredients in Inonotus obliquus (persoon) Pilat (Chaga)
Inonotus obliquus (persoon) Pilat (Chaga, in Russia, kabanoanatake in Japan) is a fungus having been used as a folk medicine in Russia and said to have many health beneficial functions such as immune modulating and anti-cancer activities..
King Oyster · 2007 · Patent · journal metadata
ENDO-BIOPOLYMERS PRODUCED FROM A SUBMERGED MYCELLIM CULTURE OF PLEUROTUS ERYNGII HAVING ANTITUMOR EFFECTS
Endo-biopolymers produced from submerged mycelium culture of Pleurotus eryngii are provided to inhibit proliferation of tumor cancer cells, increase activity of natural killer(NK) cells in the spleen and activity of glutathione S-transferase in the liver..
Chaga · 2007 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters
New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.
The fruiting body of Inonotus obliquus, a medicinal mushroom called chaga, has been used as a traditional medicine for cancer treatment. Although this mushroom has been known to exhibit potent antioxidant activity, the mechanisms responsible for this activity remain unknown..
Niu-Chang-Chih · 2007 · Patent · journal metadata
NOVEL MIXTURE AND COMPOUNDS FROM MYCELIA OF ANTRODIA CAMPHORATA AND USE THEREOF
A novel mixture extracted from mycelia of Antrodia camphorata and compounds isolated therefrom are provided to reduce maximum blood pressure, increase high density lipoprotein, and have central cholinergic agonism, hepatoprotection, antiinflammation and anticancer activities..
Chaga · 2007 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry
Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
Two new lanostane-type triterpenoids, inonotsuoxides A (1) and B (2) along with three known lanostane-type triterpenoids, inotodiol (3), trametenolic acid (4), and lanosterol (5), were isolated from the sclerotia of Inonotus obliquus (Pers.: Fr.) (Japanese name: Kabanoanakake) (Russian name: Chaga)..
Mesima · 2006 · Patent · journal metadata
FUNCTIONAL COMPOSITION WHICH IS CONTAINING THE ANTITUMOR EFFECTS FROM THE EXTRACTS OF PHELLINUS LINTEUS AND PROCESSED GINSENG AND THE PREPARATION METHOD OF FUNCTIONAL TEA USING THE SAME
Provided are a method for preparing a functional composition which is rich in ginsenoside Rg3 and Rg5 and shows an antitumor effect, and a method for preparing a functional tea by using the composition..
Maitake · 2006 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry
Immunomodulatory properties of Grifola frondosa in submerged culture.
Maitake (Grifola frondosa) is a popular mushroom in Asia for its tasty flavor and immune-stimulating property. The aim of the study is to investigate the innate immunity augmentation effects of different extracts of mycelia and culture filtrate from G.
Mesima · 2006 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin
Inhibition of Anaphylaxis-Like Reaction and Mast Cell Activation by Water Extract from the Fruiting Body of Phellinus linteus
Mast cell-mediated anaphylactic reaction is involved in many allergic diseases such as asthma and allergic rhinitis. Phellinus linteus has been used as a traditional herb medicine in oriental countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities..
Niu-Chang-Chih · 2006 · Patent · journal metadata
Liver cancer resistant Antrodia camphorata and preparation method thererof
The invention discloses an Antrodia camphorata capsule for resisting hepatic carcinoma, which comprises the following constituents (by weight portions): Antrodia camphorate mycelium fermentation extract 20-100, protein-free maize starch or medicinal starch gum 200-480..
Maitake · 2006 · Patent · journal metadata
PROCESS FOR CULTIVATING MACROMYCETES OF "GRIFOLA FRONDOSA" SPECIES, FOR PREPARING SOME ANTI-TUMORAL AND ANTI-INFECTIOUS IMMUNOSTIMULATING BIOPREPARATIONS
The invention relates to a process for cultivating macromycetes of the Grifola frondosa species for obtaining fructiferous bodies used for preparing anti-tumoral and anti-infectious immunostimulating biopreparations..
Niu-Chang-Chih · 2006 · Research Support, Non U.S. Gov'T · Proteomics
Proteomic analysis of the effect of Antrodia camphorata extract on human lung cancer A549 cell.
Antrodia camphorata (niu-chang-chih) is a fungus native to Taiwan that is believed to be effective in preventing diseases. This study demonstrates that 0.2-2% v/v ethanol extracts of A..
Chaga · 2006 · Research Support, Non U.S. Gov'T · BioFactors (Oxford, England)
Reversal of the TPA-induced inhibition of gap junctional intercellular communication by Chaga mushroom (Inonotus obliquus) extracts: effects on MAP kinases.
Chaga mushroom (Inonotus obliquus) has continued to receive attention as a folk medicine with indications for the treatment of cancers and digestive diseases. The anticarcinogenic effect of Chaga mushroom extract was investigated using a model system of gap junctional intercellular communication (GJIC) in WB-F344….
Mesima · 2006 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology
The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells.
Phellinus linteus (Berkeley & Curtis) Teng, a well-known fungus of the genus Phellinus in the family of Hymenochaetaceae, is being increasingly used to treat a wide variety of disease processes such as oral ulcer, gastroenteric disorder, inflammation, lymphatic disease, and various cancers..
Maitake · 1990 · Journal Article · CHEMOTHERAPY
ANTITUMOR EFFECT OF ORALLY ADMINISTERED EXTRACTS FROM FRUIT BODY OF GRIFOLA FRONDOSA (MAITAKE)
Metadata-grounded summary: This journal article indexes research on Grifola frondosa in CHEMOTHERAPY in 1990. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..
Reishi · 1989 · Journal Article · Nippon Nōgeikagaku Kaishi
Triterpenoids from the Fungus Ganoderma lucidum (Reishi)
Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Nippon Nōgeikagaku Kaishi in 1989. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..
Maitake · 1988 · Journal Article · Chemical & pharmaceutical bulletin
Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake).
Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Chemical & pharmaceutical bulletin in 1988. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..
Reishi · 1988 · Journal Article · Agricultural and Biological Chemistry
Bitterness and Structure Relationship of the Triterpenoids from Ganoderma lucidum (Reishi)
Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Agricultural and Biological Chemistry in 1988. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..
Maitake · 1987 · Journal Article · Chemical & pharmaceutical bulletin
The Chemical Structure of an Antitumor Polysaccharide in Fruit Bodies of Grifola frondosa (Maitake)
Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Chemical & pharmaceutical bulletin in 1987. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..
Maitake · 1986 · Journal Article · Agricultural and Biological Chemistry
Fractionation and Characterization of Antitumor Polysaccharides from Maitake, Grifola frondosa
Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Agricultural and Biological Chemistry in 1986. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..
Reishi · 1986 · Journal Article · Agricultural and Biological Chemistry
Ganoderiol A and B, New Triterpenoids from the Fungus Ganoderma lucidum (Reishi)
Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Agricultural and Biological Chemistry in 1986. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..
Reishi · 1985 · Journal Article · Agricultural and Biological Chemistry
New Bitter C27 and C30 Terpenoids from the Fungus Ganoderma lucidum (Reishi)
Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Agricultural and Biological Chemistry in 1985. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..