MycoData

To optimize the continuous reflux extraction process of triterpenes from Ganoderma lingzhi using an orthogonal test and to lay a foundation for its industrial application, an orthogonal experiment was carried out for optimization. The optimal conditions were obtained and verified..

Metabolic health

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Purification, structural characterization, and in vitro immunomodulatory activity of a low-molecular-weight polysaccharide from cultivated Chinese cordyceps.

Cultivated Chinese cordyceps, an optimal substitute for the endangered wild resource, has recently been produced on a large scale. This work sought to explore the structural features and immunomodulatory activity of a novel low-molecular-weight polysaccharide (CSP1a, 15.7 kDa) isolated from cultivated Chinese….

OncologyImmune supportMetabolic health

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Cordyceps · 2025 · Journal Article · Analytical and bioanalytical chemistry

Rapid metabolic profiling and authentication of Cordyceps using ambient ionization mass spectrometry and machine learning.

Cordyceps sinensis, a symbiotic organism formed between a fungus and an insect, is celebrated for its substantial medicinal benefits and economic significance in traditional Chinese medicine..

Cognition & nervesMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Frontiers in nutrition

Uncovering proteome variations and concomitant quality changes of different drying methods Cordyceps sinensis by 4D-DIA structural proteomics.

INTRODUCTION: Cordyceps sinensis is a fungus, serves dual purposes as both a medicinal herb and a food source. Due to its high water content, fresh Cordyceps sinensis is difficult to preserve, necessitating the drying necessary to process Cordyceps sinensis..

Metabolic health

High relevance

Shiitake · 2025 · Journal Article · Postharvest Biology and Technology

Unveiling the spore discharge molecular dynamics driven by osmotic substances in postharvest shiitake mushrooms through cross-omics and establishment of prediction model

Spore discharge, a critical quality change indicator in postharvest shiitake mushrooms, is challenging to monitor in practice, necessitating predictive modeling. This study established a strong link between osmotic substances and spore discharge intensity through physiological, transcriptomic, and metabolomic….

Metabolic health

High relevance

Cordyceps · 2025 · Journal Article · Journal of medicinal food

Wild Cordyceps Polysaccharides Alleviate Atherosclerosis by Attenuating Macrophage Cholesterol Accumulation Through the PPARγ-LXRα-ABCA1/ABCG1 Pathway.

Cordyceps has been clinically used to treat atherosclerosis (AS) since the 1980s. However, the active components responsible for its effects and the underlying mechanisms remain poorly understood.

Immune supportMetabolic healthLiver support

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Cordyceps · 2025 · Research Article · Frontiers in pharmacology

Wild Cordyceps sinensis exhibits far lower arsenic accumulation and hepatorenal toxicity in mice compared to equivalent dose of inorganic arsenic.

INTRODUCTION: Wild Cordyceps sinensis (C. sinensis) is a Chinese medicinal material known for its renal and pulmonary benefits.

Metabolic healthLiver supportRespiratory

High relevance

Nameko · 2024 · Research Article · Frontiers in microbiology

Analysis of microbial community evolution, autolysis phenomena, and energy metabolism pathways in Pholiota nameko endophytes.

INTRODUCTION: Pholiota nameko is a widely consumed edible fungus. This study focuses on two crucial developmental stages of Pholiota nameko, namely, mycelium and ascospores..

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2024 · Research Article · Journal of diabetes investigation

Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR-30a-3p/TRIM16 axis.

OBJECTIVE: The molecular mechanism of the protective effect of Cordyceps cicadae polysaccharides (CCPs) on renal tubulointerstitial fibrosis in diabetic nephropathy (DN) is still unclear. This study aims to further understand the molecular mechanisms behind the therapeutic benefits of CCP on diabetic nephropathy..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance.

Polycystic ovary syndrome (PCOS) is an endocrine disorder marked by aberrant glucose metabolism and reproductive dysfunction. It is characterized by polycystic ovaries, ovulatory dysfunction, and hyperandrogenemia..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Maitake · 2024 · Journal Article · Basic & clinical pharmacology & toxicology

Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles.

In this study, the impact of chitosan (CS) and maitake (GF) nanoparticles towards the renal toxicity induced by Ehrlich ascites carcinoma (EAC) in vivo model was conducted. Besides benchmark negative control group, EAC model was constructed by intraperitoneal injection (i.p.) of 2.5 × 106 cells..

OncologyImmune supportMetabolic health

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Cordyceps · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Evaluation of Lipid Changes During the Drying Process of Cordyceps sinensis by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS)-Based Lipidomics Technique.

Comprehensive analysis of the lipid content in Cordyceps sinensis samples is essential for optimizing their effective use. Understanding the lipid profile can significantly enhance the application of this valuable fungus across various fields, including nutrition and medicine..

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2024 · Research Article · Frontiers in microbiology

Exploiting the roles of nitrogen sources for HEA increment in Cordyceps cicadae.

Cordyceps cicadae, as a new food ingredient, is a valuable edible and medicinal fungi. However, its resources are severely depleted due to environmental limitations and excessive harvesting practices..

Metabolic health

High relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism.

Cordyceps sinensis, a traditionally prized medicinal fungus, contains polysaccharides as one of its main bioactive constituents, known for their significant immunomodulatory properties..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Journal Article · Archives of microbiology

Improvement of nucleotide content of Cordyceps tenuipes by Schisandra chinensis: fermentation process optimization and application prospects.

Nucleotides are important components and the main indicators for judging Cordyceps quality. In this paper, the mixed fermentation process of Schisandra chinensis and Cordyceps tenuipes was systematically studied, and it was proposed that the fermentation products aqueous extract (S-ZAE) had antioxidant activity and….

Metabolic health

High relevance

Chaga · 2024 · Journal Article · Journal of biomolecular structure & dynamics

In silico targeting of SARS-CoV-2 spike receptor-binding domain from different variants with chaga mushroom terpenoids.

Terpenoids from the chaga mushroom have been identified as potential antiviral agents against SARS-CoV-2. This is because it can firmly bind to the viral spike receptor binding domain (RBD) and the auxiliary host cell receptor glucose-regulated protein 78 (GRP78)..

Metabolic healthRespiratory

High relevance

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Metabolomic differences between non-hydrothermal treated water-soluble (WSPs) and hydrothermally treated water-insoluble (WIPs) Maitake polysaccharides fermented by Lactobacillus acidophilus and L. plantarum.

Bacterial Metabolite through a fermentation process is a growing trend and a promising alternative for use as functional components. Non-hydrothermal water-soluble (WSPs) and hydrothermally treated water-insoluble (WIPs) Maitake polysaccharides were fermented with Lactobacillus acidophilus (LA) and Lactobacillus….

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2024 · Research Article · Frontiers in veterinary science

Shiitake mushroom powder supplementation increase antioxidative activity in dogs.

INTRODUCTION: The prevalence of age-related diseases, including obesity (a lipid metabolism disorder), increases with the increase in a dog's lifespan. Most of age-related diseases are associated with oxidative stress by excessive production of reactive oxygen species (ROS) from impaired mitochondrial functions..

Immune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2024 · Research Article · Journal of diabetes research

The Intricate Mechanisms of Functional Foods Oyster Mushroom and Fenugreek on Type 2 Diabetic Animal Model.

Mushrooms and fenugreek are widely used to reduce hyperglycemia, and fenugreek is also used as a culinary ingredient to enhance flavor and aroma. This study is aimed at investigating the underlying mechanisms of the hypoglycemic effects of mushrooms and fenugreek in a Type 2 diabetic rat model..

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2022 · Review · Frontiers in pharmacology

Mechanism of Cordyceps sinensis and its Extracts in the Treatment of Diabetic Kidney Disease: A Review.

Diabetic kidney disease (DKD) is the major reason of chronic kidney disease (CKD)-caused end-stage renal failure (ESRF), and leads to high mortality worldwide. At present, the treatment of DKD is mainly focused on controlling the hyperglycemia, proteinuria, and hypertension, but is insufficient on the effective delay….

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Oyster Mushroom · 2021 · Review · International journal of biological macromolecules

Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review.

Cancer dominates among many causes of mortality worldwide. Traditional chemotherapeutic agents are powerful anti-cancer agents employed for treatment of this deadly disease.

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2021 · Review · Medicinal chemistry (Shariqah (United Arab Emirates))

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy.

BACKGROUND: Some species of Cordyceps sensu lato are famous Chinese herbs with significant biological activities, often used as edible food and traditional medicine in China..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Shiitake · 2019 · Journal Article · Journal of dietary supplements

Effects of Shiitake Intake on Serum Lipids in Rats Fed Different High-Oil or High-Fat Diets.

Shiitake (Lentinula edodes) extract, eritadenine, has been shown to reduce cholesterol levels, and its hypocholesterolemic actions are involved in the metabolism of methionine..

Metabolic health

High relevance

Shiitake · 2019 · Research Article · Journal of Indian Society of Periodontology

To detect the minimum inhibitory concentration and time-kill curve of shiitake mushroom on periodontal pathogens: An in vitro study.

INTRODUCTION: Shiitake (Lentinula edodes) is an Asian edible mushroom with the second-largest cultivation percentages among edible mushrooms in the world. Previous studies have shown its nutritional richness such as high quantities of proteins, minerals, and vitamins..

OncologyMetabolic healthRespiratory

High relevance

Cordyceps · 2017 · Research Article · PloS one

Metabolomic profile and nucleoside composition of Cordyceps nidus sp. nov. (Cordycipitaceae): A new source of active compounds.

Cordyceps sensu lato is a genus of arthropod-pathogenic fungi, which have been used traditionally as medicinal in Asia. Within the genus, Ophiocordyceps sinensis is the most coveted and expensive species in China..

Metabolic health

High relevance

Cordyceps · 2014 · Review Article · Journal of functional foods

Recent advances in Cordyceps sinensis polysaccharides: Mycelial fermentation, isolation, structure, and bioactivities: A review.

Cordyceps (Ophiocordyceps sinensis) sinensis, the Chinese caterpillar fungus, is a unique and precious medicinal fungus in traditional Chinese medicine which has been used as a prestigious tonic and therapeutic herb in China for centuries. Polysaccharides are bioactive constituents of C..

OncologyImmune supportMetabolic health

High relevance

Niu-Chang-Chih · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

Unlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application.

Antrodia camphorata is a valued and scarce parasitic mushroom that exclusively proliferates on the inner cavity wall of the endangered tree Cinnamomum kanehirai Hay (Lauraceae), endemic to Taiwan..

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2024 · Review · Mycology

Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review.

Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma neo-japonicum (synonym Ganoderma bambusicola), also known as purple Lingzhi, is a species that is currently underutilised when compared to Ganoderma lucidum (Lingzhi)..

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2019 · Review Article · Molecules (Basel, Switzerland)

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi.

Cordycepin(3'-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12.

Cordyceps militaris has been artificially cultivated in China, and the great amounts of produced medium residue were discarded after the harvest. The aims of this work were to analyze the structure of the residue polysaccharide (RPS) of C..

Immune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Molecular medicine reports

Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.

Oligosaccharide are carbohydrate molecules, comprising repeating units joined together by glycosidic bonds. In recent years, an increasing number of oligosaccharides have been reported to exhibit various biological activities, including antitumor, immune-stimulation and antioxidation effects..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Malaria journal

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria.

BACKGROUND: Cerebral malaria (CM) is debilitating and sometimes fatal. Disease severity has been associated with poor treatment access, therapeutic complexity and drug resistance and, thus, alternative therapies are increasingly necessary..

Immune supportCognition & nervesMetabolic health

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Poultry science

Effects of co-fermented Pleurotus eryngii stalk residues and soybean hulls by Aureobasidium pullulans on performance and intestinal morphology in broiler chickens.

Soybean hulls are a by-product of soybean processing for oil and meal production; Pleurotus eryngii stalk residues (PESR) are by-products of the edible portion of the fruiting body enriched in bioactive metabolites..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · Food & function

Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats.

Our laboratory has previously demonstrated that Grifola frondosa polysaccharides (GFPs) showed hypoglycemic effects. This study aimed to investigate which polysaccharide-enriched fractions of GFPs were the main active constituents, and to disclose their hypoglycemic mechanism..

Immune supportMetabolic healthLiver support

High relevance

Wood Ear · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Hypolipidemic and Hepatic Steatosis Preventing Activities of the Wood Ear Medicinal Mushroom Auricularia auricula-judae (Higher Basidiomycetes) Ethanol Extract In Vivo and In Vitro.

Obesity, a rapidly growing threat to human health worldwide, is responsible for a large proportion of the total burden of disease. Therefore, obesity control could be a vital scheme to prevent many diseases..

OncologyMetabolic healthLiver support

High relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Asian Pacific journal of cancer prevention: APJCP

Inhibition of Azoxymethane-induced Colorectal Aberrant Crypt Foci in Mice Fed a High-fat Diet by Pleurotus eryngii (Eringi) and Hypsizygus marmoreus (Bunashimeji).

Obesity markedly increases the risk of colorectal cancer. Recently, the preventive effects of edible mushrooms on triglyceride elevation and visceral fat accumulation have been reported..

OncologyMetabolic healthGut & microbiomeLiver support

High relevance

Turkey Tail · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Mycochemical Investigation of the Turkey Tail Medicinal Mushroom Trametes versicolor (Higher Basidiomycetes): A Potential Application of the Isolated Compounds in Documented Pharmacological Studies.

The purpose of this study was to elucidate the chemical properties of the n-hexane, chloroform, and ethyl acetate extracts of the fruiting body of the medicinal mushroom Trametes versicolor..

Metabolic health

High relevance

Maitake · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

Type 2 Diabetes mellitus (T2DM), a disease with impaired glucose, protein and lipid metabolism, low-grade chronic inflammation, and immune dysfunction, is a global public health crisis. We previously demonstrated that Grifola frondosa has bioactivities in improving glycemic responses in diabetic rats..

OncologyImmune supportMetabolic health

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

The Anti-Inflammatory Effects of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages.

Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation.

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2015 · Research Support, Non U.S. Gov'T · Journal of medicinal food

The polar high molecular weight fraction of the Agaricus blazei Murill extract, AndoSan™, reduces the activity of the tumor-associated protease, legumain, in RAW 264.7 cells.

AndoSan™ is an extract of Agaricus blazei Murill (AbM; 82.4%), Hericium erinaceum (14.7%), and Grifola frondosa (2.9%). The main ingredient of AndoSan, AbM, is rich in different forms of β-glucans..

OncologyImmune supportMetabolic health

High relevance

Chaga · 2014 · English Abstract · Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine

[Prevention of Inonotus obliquus polysaccharides for high power microwave radiation induced testicular injury in rats: an experimental research].

OBJECTIVE: To investigate the effect of Inonotus obliquus polysaccharides on testicular injury induced by exposure to high power microwave (HPM) in rats. METHODS: A total of 30 male Wistar rats were randomly divided into 5 groups, i.e., the normal control group, the microwave radiation model group, the treatment….

Immune supportEnergy & fatigueMetabolic health

High relevance

Maitake · 2014 · Research Support, Non U.S. Gov'T · Glycoconjugate journal

A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.

Grifola frondosa is an important fungal research resource. However, there was little report about hyperglycemic activity of Grifola frondosa polysaccharide on insulin resistance in vitro..

Immune supportMetabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Biotechnology and applied biochemistry

Biosorption and biotransformation of fluoranthene by the white-rot fungus Pleurotus eryngii F032.

Major concern about the presence of fluoranthene, which consists of four fused benzene rings, in the environment has been raised in the past few years due to its toxic, mutagenic, and persistent organic pollutant properties..

Metabolic health

High relevance

King Oyster · 2014 · Research Support, Non U.S. Gov'T · Food & function

Chemical composition of Pleurotus eryngii polysaccharides and their inhibitory effects on high-fructose diet-induced insulin resistance and oxidative stress in mice.

High intake of dietary fructose exerts a number of adverse metabolic effects. The present study investigates the preventive effects of Pleurotus eryngii polysaccharides (PEP), which showed powerful antioxidant activity in vitro, on insulin resistance and oxidative stress in mice fed a high-fructose diet..

Immune supportMetabolic healthLiver support

High relevance

Shiitake · 2014 · Brief Report · Mycobiology

Determination of Glucan Contents in the Fruiting Bodies and Mycelia of Lentinula edodes Cultivars.

Shiitake mushrooms (Lentinula edodes) containing β-glucans may be beneficial for human health; they have been used in the treatment of cancer, hypertension, and high cholesterol levels..

OncologyMetabolic health

High relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Effect of Antrodia camphorata on inflammatory arterial thrombosis-mediated platelet activation: the pivotal role of protein kinase C.

Antrodia camphorata is a rare Taiwanese medicinal mushroom. Antrodia camphorata extract has been reported to exhibit antioxidant, anti-inflammation, antimetastasis, and anticancer activities and plays a role in liver fibrosis, vasorelaxation, and immunomodulation..

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL/6J mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps species which is well-known as 'winter worm summer grass' has long been used as tonics and stimulants to enhance energy, exhibiting a potential for energy metabolism. Clinical trials have suggested their beneficial effect on lipid metabolic disorders such as hyperlipidemia..

Energy & fatigueMetabolic healthLiver support

High relevance

Almond Mushroom · 2014 · Comparative Study · Biological trace element research

Effects of selenium-enriched Agaricus blazei Murill on liver metabolic dysfunction in mice, a comparison with selenium-deficient Agaricus blazei Murill and sodium selenite.

In the present study, we investigated the effects of Se-enriched Agaricus blazei Murill (Se-AbM) on liver injury in mice induced by acute alcohol administration. Mice received ethanol (5 g/kg body weight (BW)) by gavage every 12 h for a total of 3 doses.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · BioMed research international

Hypolipidemic and antioxidant activity of enoki mushrooms (Flammulina velutipes).

According to the literatures, Flammulina velutipes contains biologically active components such as dietary fiber, polysaccharide, and mycosterol, whose effects in reducing blood sugar, blood pressure, and cholesterol have been proven..

Immune supportMetabolic healthLiver support