MycoData

Cordyceps · 2022 · Research Article · Mycobiology

Cordycepin from Medicinal Fungi Cordyceps militaris Mitigates Inflammaging-Associated Testicular Damage via Regulating NF-κB/MAPKs Signaling in Naturally Aged Rats.

Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum biochemical changes in….

Immune supportEnergy & fatigueMetabolic healthLiver support

Wood Ear · 2022 · Research Article · Foods (Basel, Switzerland)

Dietary Supplementation of Auricularia auricula-judae Polysaccharides Alleviate Nutritional Obesity in Mice via Regulating Inflammatory Response and Lipid Metabolism.

The incidence of lipid metabolism disorder and obesity that is caused by high-calorie diets is increasing year by year, which has become an urgent global health problem..

Reishi · 2022 · Journal Article · Food & function

Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters.

Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that Ganoderma lucidum extract lowered HUA in animals.

King Oyster · 2022 · Research Article · Frontiers in nutrition

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota.

Pleurotus eryngii mushrooms are commercially cultivated and widely consumed due to their organoleptic properties, and the low caloric and high nutritional value. In addition, they contain various biologically active and health-promoting compounds; very recently, their genoprotective effect in Caco-2 cells after their….

OncologyImmune supportMetabolic healthLiver support

Cordyceps · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris.

BACKGROUND: Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD)..

Metabolic healthGut & microbiomeLiver support

Shiitake · 2022 · Journal Article · International journal of medicinal mushrooms

In Vivo Evaluation and Nutritional Quality of By-Products Subjected to Solid-State Fermentation Using Shiitake Culinary-Medicinal Mushroom, Lentinula edodes (Agaricomycetes).

This study evaluates the nutritional quality and in vivo biological activity of a peach palm by-product food ingredient processed via solid-state fermentation by shiitake culinary-medicinal mushroom, Lentinula edodes..

OncologyImmune supportMetabolic healthLiver support

Cordyceps · 2022 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)

Oral administration of human FGF21 expressed by mycelium of Cordyceps militaris improves blood glucose and lipid in type II diabetes mellitus.

The purpose of this study was to express human FGF21 (hFGF21) using Cordyceps militaris (C. militaris) as a bioreactor and to observe its hypoglycemic and lipid-lowering effects on type II diabetes.

Metabolic healthLiver support

Niu-Chang-Chih · 2022 · Research Article · EFSA journal. European Food Safety Authority

Safety of freeze-dried mycelia of Antrodia camphorata as a novel food pursuant to regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on freeze-dried mycelia of Antrodia camphorata as a novel food (NF) pursuant to Regulation (EU) 2015/2283..

Gut & microbiomeLiver support

Shiitake · 2022 · Research Article · EFSA journal. European Food Safety Authority

Safety of pea and rice protein fermented by Shiitake (Lentinula edodes) mycelia as a Novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on pea and rice protein fermented by Shiitake mushroom (Lentinula edodes) mycelia as a novel food (NF) pursuant to Regulation (EU) 2015/2283..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2022 · Research Article · Food & nutrition research

Sporoderm-broken spore powder of Ganoderma lucidum ameliorate obesity and inflammation process in high-fat diet-induced obese mice.

OBJECTIVE: This study examined the anti-obesity and anti-inflammatory effects of sporoderm-broken spore powder of Ganoderma lucidum (SSPL) against obese mice fed with a high-fat diet..

OncologyEnergy & fatigueMetabolic healthLiver support

Cordyceps · 2022 · Research Article · BMC complementary medicine and therapies

System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats.

BACKGROUND: Cordyceps species have been used as tonics to enhance energy, stamina, and libido in traditional Asian medicine for more than 1600 years, indicating their potential for improving reproductive hormone disorders and energy metabolic diseases..

Cordyceps · 2022 · Journal Article · Journal of agricultural and food chemistry

The in Vitro Fermentation of Cordyceps militaris Polysaccharides Changed the Simulated Gut Condition and Influenced Gut Bacterial Motility and Translocation.

The motility ability of intestinal lipopolysaccharide (LPS)-producing bacteria determines their translocation to the enterohepatic circulation and works as an infectious complication..

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

The Potential Activity of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), to Alleviate Liver Injury in Adults with Acute Mushroom Poisoning: A Retrospective Study.

In the study, we retrospectively reviewed cases of patients with acute mushroom poisoning admitted to seven hospitals from May 2016 to May 2021. In total, we analyzed 153 acute mushroom poisoning cases..

Liver support

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Chaga · 2022 · Journal Article · Journal of food biochemistry

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed..

Oyster Mushroom · 2021 · Research Article · AMB Express

Anti-tumor effect of polysaccharide from Pleurotus ostreatus on H22 mouse Hepatoma ascites in-vivo and hepatocellular carcinoma in-vitro model.

Hepatocellular carcinoma is one of the leading causes of cancer-associated death across the globe. Malignant ascites are the major clinical attributes in cancer patients..

Immune supportCognition & nervesLiver supportSkin & hydration

King Oyster · 2021 · Journal Article · International journal of biological macromolecules

Antioxidant and anti-ageing effects of enzymatic polysaccharide from Pleurotus eryngii residue.

The wide industrial cultivation of Pleurotus eryngii (P. eryngii) has resulted in the massive production of mushroom residues (MR) with low-efficiency utilization.

Metabolic healthLiver support

Chaga · 2021 · Journal Article · Journal of ethnopharmacology

Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus (Fr.) Pilat is a mushroom belonging to the family Hymenochaetaceae. It is popularly called the Chaga mushroom in Russian folk medicine and has been used as a traditional medicine to treat diabetes mellitus in Eastern European and Asian countries..

Immune supportCognition & nervesLiver support

Lion's Mane · 2021 · Journal Article · International journal of medicinal mushrooms

Liver and Brain Protective Effect of Sulfated Polysaccharides from Residue of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), on D-Galactose-Induced Aging Mice.

This work describes the preparation of sulfated Hericium erinaceus residue polysaccharides (SHRPs) and investigates their antioxidant and antiaging effects on D-galactose-induced aging mice. The results indicated that the degree of SO42- substitution was 0.47 ± 0.22 for SHRPs..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2021 · Research Article · Lipids in health and disease

Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR(+/-) hamsters.

BACKGROUND: Cordyceps militaris is cultured widely as an edible mushroom and accumulating evidence in mice have demonstrated that the polysaccharides of Cordyceps species have lipid-lowering effects..

Yellow Morel · 2021 · Journal Article · Food & function

Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.

The pharmaceutical application of fungal polysaccharides has been extensively studied based on their multiple biological activities. However, the effect of Morchella esculenta polysaccharides on the development of atherosclerosis remains unknown..

OncologyImmune supportLiver supportRespiratory

Maitake · 2021 · Journal Article · Food & function

The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.

Polysaccharides can be used as a potential hepatoprotective agent in the treatment of acute liver injury. However, the underlying mechanism governing how polysaccharides protect against acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/d-GalN) remains unclear..

OncologyLiver supportRespiratory

Oyster Mushroom · 2026 · Preprint · journal metadata

Integrated in silico pharmacology of Pleurotus ostreatus derived bioactive compounds targeting EGFR using network pharmacology and molecular simulations

Abstract Cancer remains a most important worldwide health burden, demanding the progress of pioneering and mechanism-driven therapeutic strategies. In this study, we employed an consolidative in silico pharmacology approach combination network pharmacology, molecular docking, ADMET profiling, and molecular dynamics….

Cordyceps · 2025 · Published Erratum · Frontiers in pharmacology

Corrigendum: Protective effects of Cordyceps militaris against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet.

[This corrects the article DOI: 10.3389/fphar.2024.1438997.]..

OncologyLiver support

Yellow Morel · 2025 · Preprint · journal metadata

Morchella esculenta Intensifies Testosterone Production and Spermatogenesis in Male Mice with High-Fat Diet-Induced Obesity by Enhancing Antioxidant Capacity

Obesity has become a major health concern worldwide and is strongly correlated with various comorbidities including reproductive dysfunction. Therefore, this study aimed to explore the ef-fects of Morchella esculenta (ME) in improving reproductive dysfunction caused by high-fat di-et-induced obesity..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2025 · Preprint · journal metadata

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid (IAA) govern thermotolerance in Lentinula edodes mycelia subjected to heat stress

ABSTRACT Heat stress poses a significant constraint on the annual production of Lentinula edodes(L. edodes), a challenge that has been intensified by global warming.

Maitake · 2024 · Preprint · journal metadata

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 diabetes mellitus Rats

Type 2 diabetes mellitus (T2DM) is a common metabolic disease characterized by a lack of insulin secretion, insulin resistance (IR), and hyperglycemia. Given its high prevalence and multifarious complications, diabetes is globally ranked as the third leading cause of mortality..

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Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.

One novel alkali-extracted polysaccharide, CM3-SII, was obtained from the fruiting body of C. militaris via column chromatography.

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Cordyceps · 2021 · Research Article · Frontiers in molecular biosciences

The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia.

Atherosclerotic cardiovascular disease has a high mortality worldwide. Our lab previously purified a polysaccharide designated as CM1 with (1→4)-β-D-Glcp and (1→2)-α-D-Manp glycosyls as the backbone..

OncologyImmune supportLiver supportRespiratory

Zhu Ling · 2019 · Review · Progress in molecular biology and translational science

The efficacy of Polyporus Umbellatus polysaccharide in treating hepatitis B in China.

Polyporus umbellatus polysaccharide (PUPS) has been identified as the major bioactive component in the mushroom Polyporus umbellatus that has immuno-enhancing, anti-tumor, anti-inflammatory, and hepatoprotective activities..

Cognition & nervesMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2026 · Journal Article · Food Research International

A novel Fucose-specific lectin from Morchella esculenta modulates gut-liver Axis to alleviate non-alcoholic fatty liver disease

Morchella esculenta is an underexplored source of lectins with diverse bioactivities. In this study, a novel fucose-specific lectin (MEP5) was isolated from M.

Cognition & nervesMetabolic healthGut & microbiomeLiver support

Yellow Morel · 2026 · Journal Article · Food research international (Ottawa, Ont.)

A novel Fucose-specific lectin from Morchella esculenta modulates gut-liver Axis to alleviate non-alcoholic fatty liver disease.

Morchella esculenta is an underexplored source of lectins with diverse bioactivities. In this study, a novel fucose-specific lectin (MEP5) was isolated from M.

OncologyImmune supportGut & microbiomeLiver support

Snow Fungus · 2026 · Research Article · Foods (Basel, Switzerland)

Absorption, Stability, and Bioactivity of Fungal-Derived Hyaluronic Acid from Tremella fuciformis in a Sequential In Vitro Multi-Barrier Model.

Hyaluronic acid (HA) is widely used in medical, cosmetic, and nutraceutical applications, yet the systemic fate of orally administered HA, particularly non-animal forms, remains poorly characterised..

Reishi · 2026 · Journal Article · BMC complementary medicine and therapies

An integrated strategy for screening Q-markers and elucidating anti-fibrotic mechanisms of Ganoderma lucidum.

BACKGROUND: Ganoderma lucidum (G. lucidum) is a medicinal mushroom known for its hepatoprotective effects against various liver diseases.

Reishi · 2026 · Journal Article · Carbohydrate polymers

Design of functional hydrogel beads based on polysaccharide-encapsulated Ganoderma lucidum spores for stability and targeted gastrointestinal delivery of protein-spore complex.

Oral delivery of protein-based therapeutics and nutraceuticals is often limited by enzymatic degradation and structural instability in gastrointestinal environments, underscoring the need for safe and biocompatible carriers with tailored release profiles..

Reishi · 2026 · Journal Article · Carbohydrate polymers

Design of functional hydrogel beads based on polysaccharide-encapsulated Ganoderma lucidum spores for stability and targeted gastrointestinal delivery of protein–spore complex

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Enoki · 2026 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Dual-crosslinked Flammulina velutipes protein-polysaccharide emulsion gels: Structural enhancement for bioactive delivery and 3D food printing

Emulsion gels face challenges in practical application due to insufficient structural robustness, which limits both bioactive protection and 3D printing precision..

Immune supportEnergy & fatigueGut & microbiomeLiver support

Mesima · 2026 · Research Article · Poultry science

Effects of dietary Phellinus linteus polysaccharides supplementation on productive performance, egg quality, antioxidant status, immune function, cecal microbiota, jejunal morphology, and metabolism in laying hens under lipopolysaccharide challenge.

The effects of Phellinus linteus polysaccharides (PLP) on the immune responses of laying hens remain unclear. This study systematically investigated the impacts of PLP on productive performance, antioxidant status, immune response, cecal microbiota, short-chain fatty acids (SCFAs), jejunal morphology, and metabolism….

Energy & fatigueLiver support

Reishi · 2026 · Research Article · Poultry science

Effects of hot water extract of Juncao-substrate Ganoderma lucidum residue on meat quality and antioxidant capacity of Liancheng white ducks.

The present study explored the effects of dietary supplementation with hot water extract of Juncao-substrate Ganoderma lucidum residue (HWE-JGLR) on growth performance, carcass traits, meat quality, and antioxidant capacity of Liancheng white ducks..

Gut & microbiomeLiver support

Enoki · 2026 · Journal Article · Journal of food engineering

Flammulina velutipes protein-stabilized Pickering high internal phase emulsions for bioactive substance co-delivery

This study pioneered the utilization of Flammulina velutipes protein (FVP) as a sole natural stabilizer for oil-in-water high internal phase Pickering emulsions (O/W HIPPEs), addressing a significant knowledge gap in its interfacial behavior..

Energy & fatigueLiver support

Cordyceps · 2026 · Preprint · journal metadata

From Grow Room to Market: A Technical and Economic Assessment of Family-Operated Small-Scale Cordyceps Production

Cordyceps militaris is a high-value medicinal mushroom with rapidly growing demand in functional food and nutraceutical markets, yet practical frameworks for small-scale household cultivation remain limited..

Reishi · 2026 · Research Article · Pharmaceutics

Ganoderma lucidum Polysaccharide Potentiates mRNA-LNP Efficacy: Synergizing Oxidative Stress Mitigation with Innate Immune Modulation.

Background/Objectives: As a primary mRNA delivery platform, lipid nanoparticles (LNPs) often induce oxidative stress that compromises mRNA translation efficiency. Natural polysaccharides are known for their antioxidant properties..

OncologyImmune supportLiver supportRespiratory

Reishi · 2026 · Research Article · Materials today. Bio

Ganoderma lucidum polysaccharide-decorated extracellular vesicle enables synergistical antitumor immunotherapy.

Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharides alleviate non-alcoholic fatty liver disease by modulating gut microbiota against TLR4/NF-κB/MAPK pathway and activating AMPK pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Leyss. ex Fr.) Karst has been a revered traditional Chinese medicinal herb, widely used in folk medicine to treat various metabolic diseases due to its remarkable bioactivities.

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Research Article · International journal of molecular medicine

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice.

The morbidity of cardiovascular disease in postmenopausal patients increases due to the lack of estrogen protection. One of the most common conditions is hyperlipidemia characterized by abnormally elevated low‑density lipoprotein cholesterol (LDL‑C) and total cholesterol (TC)..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2026 · Journal Article · Molecular pharmaceutics

Ganoderma lucidum-Derived Nanovesicles Attenuate Multiorgan Senescence via Modulation of Oxidative Stress and Inflammation.

Aging is a complex and multifactorial biological process characterized by cellular senescence and is a major risk factor for numerous age-related diseases. Developing safe and effective anti-aging interventions remains a significant challenge..

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Chaga · 2026 · Research Article · Foods (Basel, Switzerland)

Inonotus obliquus Polysaccharides Prevent High-Fat Diet-Induced Obesity in Mice Related to Reshaping Gut Microbiota.

Obesity development is linked to disturbances in the gut microbiota. Inonotus obliquus polysaccharides (IOPs) have potential therapeutic efficacy in alleviating metabolic disorders.

Gut & microbiomeLiver support

Shiitake · 2026 · Journal Article · Food chemistry

Lentinula edodes-derived exosome-like nanoparticles improve curcumin stability and biotransformation via gut microbiota interactions.

Exosome-like nanoparticles (ELNs) from edible sources are emerging as natural carriers for stabilizing bioactive compounds. This study investigated Lentinula edodes-derived ELNs (LeELNs) as a delivery system for curcumin..

OncologyImmune supportEnergy & fatigueLiver support

Mesima · 2026 · Research Article · American journal of cancer research

Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation.

Castration-resistant prostate cancer (CRPC) remains a major challenge due to limited treatment options and frequent therapeutic resistance. This study demonstrates that Phellinus linteus polysaccharides (PLP), both in the form of drug-loaded serum and as a purified extract, exhibit potent anti-CRPC activity through a….

Lion's Mane · 2026 · Journal Article · Colloids and surfaces. B, Biointerfaces

Physicochemical properties and immunological effects of macrophage membrane-coated PLGA nanoparticles loaded with Hericium erinaceus polysaccharides.

In this study, we developed biomimetic Hericium erinaceus polysaccharides PLGA nanoparticles (NPs) coated with macrophage membrane (MM-PLGA-HEP) and examined their immune activity in vitro and in vivo..