MycoData

PURPOSE: This study aims to provide new insights into the potential of oyster mushroom (Pleurotus ostreatus) ethanolic extract in preventing obesity through the inhibition of Pparg expression and modulation of methylation level on Pparg promoter during 3T3-L1 adipocyte differentiation..

Metabolic health

High relevance

Lion's Mane · 2025 · Journal Article · Journal of food science

pH-shifted synergistic ultrasound-modified extraction of Hericium erinaceus protein.

In this paper, we investigated the effects of different conditions on the extraction rate of Hericium erinaceus protein (HEP), determined the optimal extraction process for alkaline extraction of Hericium erinaceus (HE) protein, and explored the effects of ultrasound-assisted pH-shift treatment on HEP activity..

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Pharmacokinetic and tissue distribution analysis of sporoderm-removed Ganoderma lucidum spore powder in rats.

Ganoderma lucidum (Lingzhi), a medicinal mushroom, is recognized for its broad pharmacological activities, including potential health and longevity benefits. Notably, several triterpenoids derived from its spores and fruiting body have demonstrated anti-inflammatory, anti-tumor, and immunomodulatory effects..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2025 · Journal Article · Food & function

Positive effect of a novel protein from Pleurotus eryngii on improving colitis: exploring potential mechanisms from the perspective of intestinal metabolism.

Pleurotus eryngii (P. eryngii) protein has demonstrated potential anti-inflammatory effects, but the specific mechanism has not been reported.

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Production and Optimization of Anti-Aging Peptides from Pleurotus eryngii Mushroom Feet: Mechanistic Insights via Integrated Transcriptomics and Metabolomics.

This study established an optimized process for obtaining anti-aging peptides from Pleurotus eryngii mushroom feet (PEMFPeps). Using response surface methodology, high yields of protein (51.31 ± 3.00%) and peptides (48.71 ± 0.17% hydrolysis degree) were achieved..

Cognition & nervesEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Applied and environmental microbiology

Puerarin combined with Hericium erinaceus insoluble dietary fiber alleviates obesity induced by high-fat diet through regulating the glycerophospholipid metabolism pathway influenced by gut microbiota.

The purpose of this study was to evaluate the combined effects of puerarin (Pue) and insoluble dietary fiber from Hericium erinaceus (HEIDF) on obesity induced by a high-fat diet (HFD) in mice, focusing on their effects on lipid and glucose metabolism, gut microbiota (GM), and serum metabolites..

Metabolic healthGut & microbiomeLiver support

High relevance

Snow Fungus · 2025 · Review · Frontiers in nutrition

Recent advances in polysaccharides from Tremella fuciformis: isolation, structures, bioactivities and application.

Tremella fuciformis, commonly known as snow fungus, is a traditional edible and medicinal fungus widely used in Asian countries for centuries. Its main bioactive constituents, Tremella fuciformis polysaccharides (TFPs), have attracted considerable attention in both food and pharmaceutical industries due to their….

Immune supportMetabolic health

High relevance

Reishi · 2025 · Review · Natural product research

Reishi Mushroom (Ganoderma lucidum): pharmacology of a potent healer in traditional Chinese medicine.

Reishi mushroom, also known as Lingzhi or Ganoderma lucidum, is a widely studied macrofungus in Traditional Chinese Medicine, revered for over two millennia in Asia..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

King Oyster · 2025 · Research Article · Bioresources and bioprocessing

Revitalizing Pleurotus eryngii polysaccharides: gamma irradiation boosts antidiabetic and antioxidant potential.

Polysaccharides derived from Pleurotus eryngii possess various bioactive properties, including antioxidant, antidiabetic, anti-inflammatory, and immunomodulatory effects. In this study, polysaccharides were extracted from P..

Immune supportMetabolic healthLiver support

High relevance

Shiitake · 2025 · Research Article · Scientific reports

Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines.

Medicinal mushrooms offer diverse therapeutic benefits, but proper administration is crucial to avoid long-term health issues linked to fungal toxicity. This study evaluated the safety and in vitro cytotoxic potential of Lentinula edodes (shiitake) mushrooms for broader use in food and health supplements..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Food science & nutrition

Selenium-Enriched Cordyceps militaris Polysaccharides Alleviate Insulin Resistance in HepG2 Cells by Regulating the PI3K/AKT/GLUT4 Signaling Pathway.

Metal ion-rich Cordyceps militaris polysaccharides (CMP) are obtained by biotransformation and chemical synthesis. The physicochemical properties and bioactivity of selenium-enriched CMP (Se-CMP) obtained using biotransformation remain unclear.

Immune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2025 · Journal Article · Journal of food science

Simultaneous extraction and purification of polysaccharides and proteins from Pleurotus ostreatus using an aqueous two-phase system.

Pleurotus ostreatus is a nutrient-dense edible fungus renowned for its delicate texture, appealing flavor, and numerous potential health benefits. Simultaneous extraction within the framework of food resource processing facilitates the concurrent isolation and analysis of multiple target compounds..

Immune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Review · Antonie van Leeuwenhoek

Strain improvement of Cordyceps militaris for optimized bioactive metabolite biosynthesis: current progress and prospective approaches.

Cordyceps militaris is a rare and highly valued medicinal fungus that has attracted considerable attention due to its production of diverse bioactive compounds, including nucleosides such as cordycepin, polysaccharides, lovastatin, carotenoids, etc., all of which exhibit significant nutritional and therapeutic….

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural and functional benefits of Ganoderma lucidum polysaccharides due to space mutagenesis

Ganoderma lucidum samples from space-mutated strains transported by China's “Shenzhou” recoverable satellites, along with traditionally cultivated counterparts, were selected for this study..

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural and functional benefits of Ganoderma lucidum polysaccharides due to space mutagenesis.

Ganoderma lucidum samples from space-mutated strains transported by China's "Shenzhou" recoverable satellites, along with traditionally cultivated counterparts, were selected for this study..

Immune supportMetabolic health

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

Ganoderma lucidum is a traditional Chinese medicine used to treat Alzheimer's disease (AD), whose main active ingredient is polysaccharides. A heteropolysaccharide named GLPZ-1 was isolated from Ganoderma lucidum.

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of Pleurotus eryngii polysaccharide and its protective mechanisms against mastitis in mice.

Mastitis, a common inflammatory condition in female mammals, increases the risk of breast cancer and causes substantial economic losses. Although antibiotics effectively treat mastitis, their overuse poses a threat to public health and safety..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Research Article · Scientific reports

Structural characteristics, sugar metabolizing enzyme activity and biological activity of Ganoderma lucidum polysaccharides at different growth stages.

The Ganoderma lucidum polysaccharides (GLPs) content, monosaccharide composition, molecular weight, sugar metabolism-related enzyme activities and in vitro antioxidant activities of Ganoderma lucidum fruiting body (GLFB) from cassava stalk cultivation at different growth stages (namely, differentiation stage, umbrella….

Immune supportMetabolic health

High relevance

Chaga · 2025 · Journal Article · Journal of Chromatography A

Supercritical fluid-based protocol for the identification and quantitation of triterpenoids in commercial Inonotus obliquus (chaga) samples

Inonotus obliquus is a fungal pathogen that parasitizes the trunks of broadleaved tree species. The sclerotia of this fungus, so-called chaga, show a broad range of traditional and medicinal uses..

Immune supportEnergy & fatigueMetabolic health

High relevance

Chaga · 2025 · Journal Article · Journal of chromatography. A

Supercritical fluid-based protocol for the identification and quantitation of triterpenoids in commercial Inonotus obliquus (chaga) samples.

Inonotus obliquus is a fungal pathogen that parasitizes the trunks of broadleaved tree species. The sclerotia of this fungus, so-called chaga, show a broad range of traditional and medicinal uses..

Immune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Journal Article · Current pharmaceutical design

Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking.

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced insulin sensitivity in the body's cells, leading to persistently high blood glucose levels..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2025 · Journal Article · Bulletin of experimental biology and medicine

The Effect of β-D-Glucans of Pleurotus ostreatus (Oyster Mushroom) on the Development of Myelosuppression and Colitis Induced by 5-Fluorouracil in Mice.

We studied the effect of the water-soluble fraction of the extract containing β-glucans from Pleurotus ostreatus (oyster mushroom) on myelosuppression and colitis induced by 5-fluorouracil (5-FU) in male BALB/c mice..

OncologyMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Review · Food science & nutrition

The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.

This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

The Performance of Pleurotus eryngii β-Glucans on Protein Digestion and the Release of Free Amino Acids in the Bloodstream of Obese Adults.

Pleurotus eryngii is an edible mushroom with previously characterized β-glucans. Its potential to ameliorate postprandial glycemia and regulate appetite at the postprandial state has been previously shown.

Energy & fatigueMetabolic healthGut & microbiome

High relevance

King Oyster · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii.

Background/Objectives: Over the past twenty years, there has been a rapid increase in studies aimed at comprehending how cells communicate with each other via Extracellular Vesicles (EVs), accompanied by a heightened interest in plant-derived extracellular vesicles due to their potential relevance in dietary….

OncologyImmune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2025 · Research Article · Frontiers in pharmacology

Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy.

BACKGROUND: Diabetic nephropathy (DN), a leading cause of chronic kidney disease and end-stage renal disease, is a serious complication of type 2 diabetes mellitus (T2DM). Current therapies primarily slow disease progression but are unable to reverse kidney damage, highlighting the need for novel therapy to treat DN..

Metabolic healthLiver support

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Upcycling Chitin Waste and Aged Rice into Fungi Protein Through Fermentation with Cordyceps militaris.

Microbial protein represents a sustainable alternative to conventional animal protein, yet optimizing substrates for fungal cultivation remains critical. This study demonstrates the successful upcycling of chitin waste and aged rice into fungal protein through fermentation with Cordyceps militaris..

Metabolic health

High relevance

Cordyceps · 2025 · Research Article · BMC genomics

Whole genome sequencing and resequencing provide insight into the genetic structure of wild Ophiocordyceps sinensis.

BACKGROUND: Ophiocordyceps sinensis in the Qinghai-Tibet Plateau parasitizes soil-borne larvae of Thitarodes/Hepialus ghost moths, forming valued Chinese cordyceps..

Metabolic health

High relevance

Chaga · 2024 · Review · Heliyon

A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms.

This literature review offers an extensive exploration of Chaga mushrooms (Inonotus obliquus), focusing on their phytochemical composition, health-promoting attributes, and mechanisms of action..

OncologyImmune supportMetabolic health

High relevance

Maitake · 2024 · Journal Article · International journal of biological macromolecules

A novel angiotensin I-converting enzyme inhibitory peptide APPLRP from Grifola frondosa ameliorated the Ang II-induced vascular modeling in zebrafish model by mediating smooth muscle cells.

Grifola frondosa has garnered significant popularity as an edible mushroom attributable to its exceptional taste and nutritional benefits. This study isolated APPLRP, a potent ACE-inhibitory peptide, from the alcohol-soluble fraction of Grifola frondosa..

Energy & fatigueMetabolic healthGut & microbiomeSkin & hydration

High relevance

Cordyceps · 2024 · Journal Article · Environmental science and pollution research international

A novel approach in valorization of spent mushroom substrate of Cordyceps militaris as in-feed antibiotics in Labeo rohita against Aeromonas hydrophila infection.

The study was carried out to investigate Cordyceps militaris spent mushroom substrate (CMSMS), a renewable biomass, for its effect on fish as an alternative source of in-feed antibiotics..

Immune supportMetabolic health

High relevance

Cordyceps · 2024 · Randomized Controlled Trial · Scientific reports

A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults.

Cordyceps militaris (L.) Link (C. militaris) contains various beneficial substances, including polysaccharides (galactomannan), nucleotides (adenosine and cordycepin), cordycepic acid, amino acids, and sterols (ergosterol and beta-sitosterol)..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2024 · Review · International journal of biological macromolecules

A review on polysaccharide biosynthesis in Cordyceps militaris.

Cordyceps militaris (C. militaris) is an edible parasitic fungus with medicinal properties.

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2024 · Research Article · Heliyon

Adjuvant activity of cordycepin, a natural derivative of adenosine from Cordyceps militaris, on an inactivated rabies vaccine in an animal model.

Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains a major public health concern globally. However, administration of inactivated rabies vaccination without adjuvants is always inefficient and necessitates four to five injections..

Immune supportCognition & nervesMetabolic healthRespiratory

High relevance

Cordyceps · 2024 · Journal Article · Journal of pharmaceutical and biomedical analysis

Amelioration of hyperuricemia by cordycepin and Cordyceps militaris aqueous extract in mice via modulating gut microbiota and restoring metabolic profile.

In this study, we first screened and evaluated the inhibitory effects of seven medicinal fungi on diseases such as hyperuricemia (HUA). Then, using metabolomics and gut microbiome methods, the focus was on analyzing and evaluating the effects of the aqueous extract of Cordyceps..

Metabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Biology

Analysis of Metabolic Profiles and Antioxidant Activity of Chinese Cordyceps, Ophiocordyceps sinensis, and Paecilomyces hepiali Based on Untargeted Metabolomics.

Chinese cordyceps (GL) is a traditional medicinal fungus, with Ophiocordyceps sinensis (O. sinensis, BL) and Paecilomyces hepiali (P.

Metabolic health

High relevance

Cordyceps · 2024 · Research Article · Scientific reports

Analysis of metabolic spectrum characteristics of naturally and cultivated Ophiocordyceps sinensis based on non-targeted metabolomics.

The analysis of the differences in metabolic profiles between naturally Ophiocordyceps sinensis (NO) and cultivated Ophiocordyceps sinensis (CO) is an essential process for the medicinal value mining of Ophiocordyceps sinensis..

Energy & fatigueMetabolic health

High relevance

Chaga · 2024 · Journal Article · Journal of complementary & integrative medicine

Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice.

OBJECTIVES: The Inonotus obliquus is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural Inonotus obliquus….

Metabolic healthLiver support

High relevance

Cordyceps · 2024 · Journal Article · South African journal of botany

Antioxidant potential and cytotoxicity of Cordyceps militaris in vitro culture extracts

Cordyceps militaris is an entomopathogenic fungus with therapeutic potential in humans. The focus is on its hydroalcoholic extracts, which were obtained from biomass cultured in vitro in molasses..

OncologyMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Changes in aggregation properties and the metabolite production of probiotics following treatment with polysaccharides derived from the edible mushroom Cordyceps militaris

Low-molecular-weight exopolysaccharides of Cordyceps militaris (LCMP), obtained by enzymatically digesting the exopolysaccharide produced by C. militaris, were purified and found to be comprised of 77.9% mannose and 22.1% glucose..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2024 · Research Article · Toxicology research

Chitosan and Grifola Frondosa nanoparticles insulate liver dysfunction in EAC-bearing mice.

BACKGROUND: Ehrlich ascites carcinoma (EAC) is a rapidly growing and undifferentiated tumor that can prompt oxidative stress and liver toxicity, whereas chitosan and Grifola Frondosa have widely recognized biological qualities..

OncologyMetabolic healthLiver support

High relevance

Cordyceps · 2024 · Research Article · BMC genomics

Combined metabolome and transcriptome analysis reveal the mechanism of water stress in Ophiocordyceps sinensis.

BACKGROUND: Ophiocordyceps sinensis (O. sinensis) is the dominant bacterium in the asexual stage of Chinese cordyceps, and its growth usually suffers from water stress.

Energy & fatigueMetabolic healthSkin & hydration

High relevance

Cordyceps · 2024 · Review · Biotechnology advances

Cordyceps militaris: A novel mushroom platform for metabolic engineering.

Cordyceps militaris, widely recognized as a medicinal and edible mushroom in East Asia, contains a variety of bioactive compounds, including cordycepin (COR), pentostatin (PTN) and other high-value compounds. This review explores the potential of developing C..

Metabolic health

High relevance

King Oyster · 2024 · Journal Article · Food Research International

Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis

There is a growing interest in employing whole food-based strategies to prevent chronic diseases, owing to the potential synergistic interactions among various bioactive components found within whole foods..

Metabolic healthGut & microbiomeLiver support

High relevance

King Oyster · 2024 · Journal Article · Food research international (Ottawa, Ont.)

Dietary intake of whole king oyster mushroom (Pleurotus eryngii) attenuated obesity via ameliorating lipid metabolism and alleviating gut microbiota dysbiosis.

Metabolic healthGut & microbiomeLiver support

High relevance

Enoki · 2024 · Research Article · Scientific reports

Effect of Flammulina velutipes polysaccharide on mitochondrial apoptosis in lung adenocarcinoma A549 cells.

FVP is a polysaccharide extracted from Flammulina velutipes with immunomodulatory, anti-tumor, and anti-oxidation activities. In this study, we obtained the crude polysaccharide FVP-C from the water extract of Flammulina velutipes, and its main component FVP-S1 was obtained after further purification..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2024 · Research Article · Food science and biotechnology

Effect of steam cooking and particle size on the nutritional composition, phytochemicals and antioxidant activities of oyster mushroom (Pleurotus ostreatus) powder.

In this study raw and steamed Pleurotus ostreatus were dried and ground and fractionated by sieving into four granulometric classes ( 355 µm) and unsieved powders..

Metabolic healthLiver support

High relevance

Wood Ear · 2024 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Effects of Auricularia auricula-judae (Bull.) Quél. polysaccharide acid hydrolysate on glucose metabolism in diabetic mice under oxidative stress.

BACKGROUND: Oxidative stress can lead to uncontrolled glucose metabolism and, thus, diabetes. Auricularia auricula-judae (Bull.) Quél.

Immune supportEnergy & fatigueMetabolic health

High relevance

Shiitake · 2024 · Research Article · Foods (Basel, Switzerland)

Effects of Balsa Fish Skin Gelatin, Lentinula edodes Mushrooms, Soy Protein Isolate, and Starch on the Sensory Quality and Characterization of Physicochemical and Antioxidant Properties of New Sausage.

Sausages are loved by people for their unique texture, satisfying chewiness, and pleasant flavor. However, in the production of sausages, red meat and a large amount of fat are mainly used, and long-term consumption will increase the risk of diseases such as obesity, heart disease, hypertension, and cancer..

OncologyEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Reishi · 2024 · Journal Article · Aquaculture

Effects of dietary reishi mushroom (Ganoderma lucidum) on the growth performance of Nile tilapia, Oreochromis niloticus juveniles

In aquaculture, several medicinal mushrooms have been successfully used as prebiotics, with attractive growth-stimulant, immune-modulatory, and antioxidant functions for several finfish species..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome