MycoData

Immune supportMetabolic healthLiver support

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

Structural Characterization and Hypoglycemic Function of Polysaccharides from Cordyceps cicadae.

The polysaccharides isolated and purified from different parts of the medicinal fungus Cordyceps cicadae were identified, and three extracts displaying significant biological activities were selected for further study..

Reishi · 2023 · Journal Article · Communications biology

The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi.

Ganoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice.

Cordyceps has anti-cancer effects; however, the bioactive substance and its effect are still unclear. Polysaccharides extracted from Cordyceps sinensis, the fugus of Cordyceps, have been reported to have anti-cancer properties..

Reishi · 2023 · Research Article · Frontiers in microbiology

Transcriptome analysis of Ganoderma lingzhi (Agaricomycetes) response to Trichoderma hengshanicum infection.

Green mold caused by Trichoderma spp. has become one of the most serious diseases which threatening the production of Ganoderma lingzhi.

Cognition & nervesMetabolic health

Reishi · 2022 · Journal Article · Journal of fungi (Basel, Switzerland)

Characteristics of the Genome, Transcriptome and Ganoderic Acid of the Medicinal Fungus Ganoderma lingzhi.

Ganoderma (Ganodermaceae) is a genus of edible and medicinal mushrooms that create a diverse set of bioactive compounds. Ganoderma lingzhi has been famous in China for more than 2000 years for its medicinal properties.

Cognition & nervesMetabolic healthSkin & hydration

Almond Mushroom · 2022 · Research Article · Journal of Korean Neurosurgical Society

Comparative Analysis of ABM/P-15, Bone Morphogenic Protein and Demineralized Bone Matrix after Instrumented Lumbar Interbody Fusion.

OBJECTIVE: ABM/P-15 (anorganic bone matrix/15-amino acid peptide fragment) is a commercially available synthetically manufactured P-15 collagen peptide fragment, that is adsorbed on ABM..

Cordyceps · 2022 · Journal Article · Journal of economic entomology

Comparing Production and Efficacy of Cordyceps javanica With Cordyceps fumosorosea.

A newly discovered entomopathogenic fungus Cordyceps javanica (Friedrichs & Bally) Samson & Hywel-Jones (Hypocreales: Cordycipitaceae) strain Wf GA17 was compared with the commercial Cordyceps fumosorosea Wize (Hypocreales: Cordycipitaceae) Apopka 97 strain for liquid-culture production, formulation, insecticidal….

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2022 · Journal Article · The American journal of Chinese medicine

Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism.

Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of Cordyceps sinensis (BerK.) Sacc.

OncologyCognition & nervesMetabolic healthRespiratory

Chaga · 2022 · Research Article · Computers in biology and medicine

Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective.

Finding a potent inhibitor to the pandemic SARS-CoV-2 is indispensable nowadays. Currently, in-silico methods work as expeditious investigators to screen drugs for possible repurposing or design new ones..

Cordyceps · 2022 · Journal Article · Current microbiology

Microbial Diversity Analyses of Fertilized Thitarodes Eggs and Soil Provide New Clues About the Occurrence of Chinese Cordyceps.

Chinese cordyceps is a well-known fungus-larva complex with medicinal and economic importance. At present the occurrence of Chinese cordyceps has not been fully illuminated..

Cognition & nervesEnergy & fatigueMetabolic health

Lion's Mane · 2022 · Research Article · Frontiers in nutrition

Potential antidepressant effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice.

Since the 1990s, the prevalence of mental illnesses, such as depression, has been increasing annually and has become a major burden on society. Due to the many side effects of antidepressant drugs, the development of a complementary therapy from natural materials is an urgent need..

Metabolic healthLiver support

Maitake · 2021 · Journal Article · Polski merkuriusz lekarski: organ Polskiego Towarzystwa Lekarskiego

Application of the thick extract from Maitake mushrooms for correction of metabolic disorders under the paracetamol hepatitis in rats.

UNLABELLED: It is known that the violation of one or more functions of the liver, where the basic biochemical processes take place, is reflected in the functional state of many organs and systems, causing severe consequences..

OncologyImmune supportMetabolic health

Cordyceps · 2021 · Research Article · Journal of diabetes research

Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy.

BACKGROUND: Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus and is a major cause of end-stage kidney disease. Cordyceps sinensis (Cordyceps, Dong Chong Xia Cao) is a widely applied ingredient for treating patients with DN in China, while the molecular mechanisms remain unclear..

OncologyImmune supportMetabolic healthSkin & hydration

Nameko · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Effect of Pholiota nameko Polysaccharides Inhibiting Methylglyoxal-Induced Glycation Damage In Vitro.

Advanced glycation end products (AGEs) can induce oxidative stress and inflammation. AGEs are major risk factors for the development of many aging-related diseases, such as cancer and diabetes.

Immune supportMetabolic healthLiver support

Shiitake · 2021 · Journal Article · Foods (Basel, Switzerland)

Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial.

We determined whether oral consumption of Aronia, red ginseng, shiitake mushroom, and nattokinase mixture (3.4: 4.1: 2.4: 0.1 w/w; AGM) improved glucose metabolism and insulin resistance in prediabetic adults in a 12-week randomized, double-blinded clinical trial..

Cordyceps · 2021 · Research Article · Journal of diabetes research

Mechanism of Cordyceps Cicadae in Treating Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking Analysis.

OBJECTIVE: To systematically study the mechanism of cordyceps cicadae in the treatment of diabetic nephropathy (DN) with the method of network pharmacology and molecular docking analysis, so as to provide theoretical basis for the development of new drugs for the treatment of DN..

Metabolic healthGut & microbiome

Enoki · 2021 · Journal Article · Food chemistry

No mutagenicity and oral toxicity of winter mushroom powder treated with atmospheric non-thermal plasma.

This study aimed to evaluate the mutagenicity and oral acute toxicity of winter mushroom powder (PW) treated by atmospheric non-thermal plasma (ANP). Winter mushroom powder without plasma treatment (CW) containing an equivalent amount of sodium nitrite as PW was used as a control..

Cordyceps · 2020 · Preprint · journal metadata

Production of diverse beauveriolide analogs in closely related fungi: a rare case of fungal chemodiversity

ABSTRACT Fungal chemodiversity is well known in part due to the production of diverse analogous compounds by a single biosynthetic gene cluster (BGCs). Usually, similar metabolites are produced by closely related fungal species..

Cordyceps · 2019 · Comparative Study · Scientific reports

Metabolic profiling of natural and cultured Cordyceps by NMR spectroscopy.

Cordyceps, a type of Chinese herbal medicine that exhibits anti-angiogenesis and tumor growth suppression effects, has recently gained increasing popularity. However, high-quality, natural Cordyceps, such as Ophiocordyceps sinensis, is very rare and difficult to obtain in large amounts..

OncologyMetabolic health

Energy & fatigueMetabolic healthGut & microbiome

Shiitake · 2026 · Journal Article · Environmental microbiology

Edible Fungi Are a Hidden Source of Carbon Monoxide and Carbon Dioxide.

This study provides the first clear evidence that edible mushrooms, such as Lentinula edodes (shiitake), Pleurotus ostreatus and Pleurotus eryngii, can generate carbon monoxide (CO) as part of their metabolic activity-independent of bacteria, illumination or oxygen limitation..

Turkey Tail · 2025 · Journal Article · Environmental technology

Evaluation of mixed culture fungal strains for degradation of paraquat.

ABSTRACTThe potential of fungal mixed culture CI (Aspergillus niger + Phanerochaete chrysosporium), CII (Aspergillus niger AN400 + Trametes versicolor), and CIII (Phanerochaete chrysosporium + Trametes versicolor) was evaluated for paraquat removal, along with the individual potential of each fungus..

Immune supportMetabolic health

Reishi · 2025 · Research Article · Food science & nutrition

Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway.

Osteoporosis is a disorder of decreased bone mass, microarchitectural deterioration, and fragility fractures. Ganoderma lucidum has been reported to have a variety of pharmacological activities, including immune regulation, anti-inflammation, antioxidation, sedative hypnosis, blood sugar and lipid regulation, and so….

Cognition & nervesMetabolic health

King Oyster · 2025 · Research Article · Metabolomics: Official journal of the Metabolomic Society

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies.

INTRODUCTION: Mushrooms contain besides proteins a diverse pallet of specialized metabolites bioactive in either beneficial or harmful manner. Therefore, mushrooms have been exploited by humans for centuries for dietary or medical purposes..

Cordyceps · 2025 · Research Article · International journal of molecular sciences

Reconstruction of a Genome-Scale Metabolic Model for Aspergillus oryzae Engineered Strain: A Potent Computational Tool for Enhancing Cordycepin Production.

Cordycepin, a bioactive adenosine analog, holds promise in pharmaceutical and health product development. However, large-scale production remains constrained by the limitations of natural producers, Cordyceps spp..

Energy & fatigueMetabolic healthLiver support

Oyster Mushroom · 2025 · Journal Article · Water research

Sticky or thrifty: Divergence in extracellular glycometabolic architecture underpins contrasting fungal bioflocculation strategies.

Fungal-assisted bioflocculation is attracting attention as a chemical-free route for algal bloom mitigation and pollutants sequestration, but its species-specific traits that govern performance remain poorly quantified, hindering rational strain selection and scale-up..

Oyster Mushroom · 2025 · Journal Article · Journal of hazardous materials

Study on the degradation efficiency and mechanism of polystyrene microplastics by five kinds of edible fungi.

The harm caused by microplastics to the environment and human body has become a hot issue, and screening for microorganisms that potentially degrade microplastics is urgently needed..

King Oyster · 2024 · Research Article · Frontiers in bioengineering and biotechnology

Unveiling the kinetic versatility of aryl-alcohol oxidases with different electron acceptors.

Introduction: Aryl-alcohol oxidase (AAO) shows a pronounced duality as oxidase and dehydrogenase similar to that described for other glucose-methanol-choline (GMC) oxidase/dehydrogenase superfamily proteins involved in lignocellulose decomposition..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2023 · Review · International journal of molecular sciences

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.

Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits..

OncologyImmune supportCognition & nervesMetabolic health

Almond Mushroom · 2022 · Randomized Controlled Trial · Cytotherapy

Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow: a pilot randomized controlled open-label clinical study with 8-year follow-up.

BACKGROUND AIMS: To explore the long-term safety and benefit of umbilical cord mesenchymal stromal cell (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem cell transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D)..

OncologyImmune supportMetabolic health

Almond Mushroom · 2021 · Review · International journal of biological macromolecules

Polysaccharides and extracts from Agaricus brasiliensis Murill - A comprehensive review.

Edible mushrooms have been increasingly introduced into the human diet, which has driven research into their functional properties. Thus, Agaricus brasiliensis Murill or Agaricus blazei Murill (ABM) is a species native to the Brazilian biome, whose fruiting body has been used not only for dietary purposes, but also in….

Cognition & nervesEnergy & fatigueMetabolic health

Chaga · 2025 · Preprint · journal metadata

Impact of a CoQ10, Alpha-Lipoic Acid, and Chaga Extract Formulation on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy and Neurotransmission

Objectives: The aim of this study was to evaluate the impact of a novel antioxidant formulation (RP-25) con-taining CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress..

Cordyceps · 2024 · Preprint · journal metadata

Application of UHPLC-MS/MS-Based on Metabonomic Techniques to Analyze the Cordyceps cicadae Metabolic Profile Changes on Urea Response Mechanism in the Process of Ergosterol Synthesis

Nitrogen source is a necessary nutrient factor in the process of mycelial growth and metabolite synthesis. In the previous study, we have explored the differentially expressed genes resulted from urea by transcriptome analysis..

Immune supportMetabolic health

Nameko · 2017 · Review · Carbohydrate polymers

Structural characterization and rheological properties of a gel-like β-d-glucan from Pholiota nameko.

A crude fraction (SCW) was extracted with cold water from Pholiota nameko and showed mannose (24.1%), galactose (44.9%) and glucose (31%). Purification procedures resulted in a polysaccharide fraction (bG-PN), that showed only glucose..

Shiitake · 2010 · Journal Article · EFSA journal. European Food Safety Authority

Scientific Opinion on the safety of "Lentinus edodes extract" (Lentinex®) as a Novel Food ingredient.

Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies was asked to carry out the additional safety assessment for Lentinex®, an aqueous mycelial extract of Lentinula edodes (Shiitake mushroom), as a novel food ingredient in the context of Regulation (EC) No….

Lion's Mane · 2005 · Journal Article · Journal of the science of food and agriculture

Hypoglycemic effect of extract of Hericium erinaceus

Recent studies have determined that many types of mushroom (eg Hericium spp), may have important physiological functions in humans, including antioxidant activities, the regulation of blood lipid levels and reduction of blood glucose levels..

OncologyImmune supportMetabolic healthSkin & hydration

Maitake · 2005 · Journal Article · FEMS microbiology letters

Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts.

Exopolysaccharide (EPS) was prepared by submerged mycelial culture of a newly isolated mushroom Grifola frondosa HB0071 in a 5-l stirred-tank fermenter. This fungus produced a high concentration of biomass (24.8 gl(-1) at day 4), thereby achieving high EPS concentration (7.2 gl(-1) at day 4)..

Turkey Tail · 2004 · Journal Article · Environmental technology

Decolorization of dyes from textile wastewater by Trametes versicolor.

The white rot fungus Trametes versicolor was applied to the decolourisation of three synthetic textile dyes in the presence and absence of glucose. Different initial dye concentrations were tested and approximately 97% decolourisation was achieved..

Wood Ear · 2004 · Journal Article · Journal of nutritional science and vitaminology

Reductive Effect of Hot-Water Extracts from Woody Ear (Auricularia auricula-judae Quel.) on Food Intake and Blood Glucose Concentration in Genetically Diabetic KK-Ay Mice

Genetically diabetic (type II) KK-Ay mice, male and 5 wk of age, were divided into four groups and fed test diets containing 2 (2F), 5 (5F), 10 (10F), or 20 (20F)% fat for 4 wk, and then the 5F group and one-half of the 20F group continued to be fed the corresponding diet and the other half of the latter group was….

Immune supportMetabolic health

Lion's Mane · 2004 · Journal Article · Carbohydrate research

Structural investigation of a novel rhamnoglucogalactan isolated from the fruiting bodies of the fungus Hericium erinaceus.

A new heteropolysaccharide (HEP-1) was isolated from the fruiting bodies of Hericium erinaceus. It was estimated to have a molecular weight of 1.8x10(4) da and showed [alpha](D)(20) +129 (c 0.295, H(2)O).

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2002 · Research Article · Cytotechnology

Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells.

It was found that an exo-biopolymer (M.W. 1,000,000, molar ratio of 1.5:1.7:1.2:0.6:0.9, glucose:galactose:xylose:mannose:fructose, purity 99%) purified from the liquid culture broth of Hericium erinaceus mycelium enhanced the growth of rat adrenal nerve cells..

Metabolic healthGut & microbiomeLiver support

Snow Fungus · 2002 · Journal Article · Journal of agricultural and food chemistry

Interactions of lipid metabolism and intestinal physiology with Tremella fuciformis Berk edible mushroom in rats fed a high-cholesterol diet with or without Nebacitin.

Male adult Wistar rats were randomly divided into six groups in a 2 x 3 factorial design and fed diets containing different levels of Tremella fuciformis Berk (TFB) dietary fiber (0, 5, or 10%) and 1 g of cholesterol/100 g of diet with or without 0.7% Nebacitin for 4 weeks..

Niu-Chang-Chih · 2001 · Journal Article · Food chemistry

Non-volatile taste components of Agaricus blazei, Antrodia camphorata and Cordyceps militaris mycelia

Three non-Ganoderma medicinal mushrooms are currently popular in Taiwan, including Brazilian mushroom (Agaricus blazei), chang-chih (Antrodia camphorata) and northern caterpillar fungus (Cordyceps militaris). The moisture contents of three dry mycelia ranged widely from 6.65 to 14.91%..

Immune supportMetabolic healthLiver support

Wood Ear · 1998 · Journal Article · Bioscience, biotechnology, and biochemistry

Hypoglycemic Effect of Water-soluble Polysaccharide from Auricularia auricula-judae Quel. on Genetically Diabetic KK-Ay Mice

The hypoglycemic effect of water-soluble polysaccharide(FA) from fruiting bodies of Auricularia auricula-judae Quel. was investigated on genetically diabetic mice (KK-Ay) from 10 to 14 weeks of age..

Maitake · 1998 · Journal Article · Applied microbiology and biotechnology

Production of trehalose synthase from a basidiomycete, Grifola frondosa, in Escherichia coli.

The genomic DNA and cDNA for a gene encoding a novel trehalose synthase (TSase) catalyzing trehalose synthesis from alpha-D-glucose 1-phosphate and D-glucose were cloned from a basidiomycete, Grifola frondosa. Nucleotide sequencing showed that the 732-amino-acid TSase-encoding region was separated by eight introns..

Maitake · 1998 · Research Article · Applied and environmental microbiology

Purification and characterization of a trehalose synthase from the basidiomycete grifola frondosa.

A trehalose synthase (TSase) that catalyzes the synthesis of trehalose from D-glucose and alpha-D-glucose 1-phosphate (alpha-D-glucose 1-P) was detected in a basidiomycete, Grifola frondosa..

Maitake · 1995 · Journal Article · Journal of biochemistry

Characterization of a thermostable lysine-specific metalloendopeptidase from the fruiting bodies of a basidiomycete, Grifola frondosa.

A zinc-metalloendopeptidase, MEP, capable of catalyzing specific cleavage of acyl-lysine bonds (-X-Lys-) in polypeptides has been purified 212-fold in a yield of 24.7% from the fruiting bodies of Grifola frondosa, which is a popular edible mushroom called "MAITA-KE" in Japan..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2026 · Journal Article · Industrial crops and products

An active polysaccharide isolated from cultivated Cordyceps Chanhua: Structural elucidation and anti-inflammatory/antioxidant effects on human intestinal Caco-2 cells

Artificially cultivated Cordyceps chanhua is commonly used in medicinal and edible applications, with polysaccharides serve as the primary bioactive compounds and critical indicators for quality control..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2026 · Research Article · Scientific reports

Cordyceps sinensis enhances the efficacy of anti-PD-1 immunotherapy in Lewis lung adenocarcinoma.

Lung cancer, primarily non-small cell lung cancer (NSCLC), causes the highest cancer-related mortality. Although PD-1/PD-L1 inhibitors have improved survival in advanced NSCLC, they can cause immune-related adverse events.