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OncologyImmune supportEnergy & fatigueMetabolic health

Maitake · 2022 · Journal Article · International journal of biological macromolecules

A cold-water polysaccharide-protein complex from Grifola frondosa exhibited antiproliferative activity via mitochondrial apoptotic and Fas/FasL pathways in HepG2 cells.

Grifola frondosa (G. frondosa) is widely known for its anti-tumor potential, which has been demonstrated by numerous scientific researches.

OncologyImmune supportGut & microbiome

Oyster Mushroom · 2022 · Journal Article · International journal of biological macromolecules

A natural selenium polysaccharide from Pleurotus ostreatus: Structural elucidation, anti-gastric cancer and anti-colon cancer activity in vitro.

The development and application of new natural selenium polysaccharides with relatively clear structure and excellent activity have become hot and difficult issues..

Niu-Chang-Chih · 2022 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus.

BACKGROUND: Diabetes mellitus is a chronic carbohydrate metabolism disorder, which could develop a series of complications and thus lead to poor quality of life or even mortality. Antrodia camphorata is a rare parasitic fungus and has been proven to be effective for treating type II diabetes..

Immune supportMetabolic healthGut & microbiome

Chaga · 2022 · Journal Article · International journal of biological macromolecules

A polysaccharide from Inonotus obliquus ameliorates intestinal barrier dysfunction in mice with type 2 diabetes mellitus.

Type 2 diabetes mellitus is a global disease that endangers human health, and the need for the development of nontoxic treatment candidates is urgent. In the present work, one homogeneous polysaccharide from Inonotus obliquus (IN) was isolated, and the protective effect and mechanism of IN on type 2 diabetes mellitus….

Shiitake · 2022 · Research Article · Frontiers in microbiology

A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms.

The priority pathogen list of the World Health Organization classified Pseudomonas aeruginosa as the second top critical pathogen. Hence, the development of novel antibacterial strategies to tackle this bacterium is highly necessary..

Snow Fungus · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

A standardized method for the quantification of polysaccharides: An example of polysaccharides from Tremella fuciformis

The most widely used colorimetric method based on the phenol-sulfuric acid system generally has problems of poor reproducibilities and large measurement errors. In this study, bioactive Tremella fuciformis polysaccharides (TFPS) were used as the test materials, a systematic investigation was performed to solve these….

Immune supportMetabolic healthGut & microbiome

Snow Fungus · 2022 · Research Article · Polymers

Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid-Rich Polysaccharides Derived from Tremella fuciformis.

Obesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from Tremella fuciformis (TFPS) on high-fat diet (HFD; 34.9% fat)-induced obesity in mice..

Snow Fungus · 2022 · Research Article · International journal of molecular sciences

An Immunological Polysaccharide from Tremella fuciformis: Essential Role of Acetylation in Immunomodulation.

The edible fungus Tremella fuciformis was shown to have a high molecular weight (1.87 × 103 kDa) bioactive polysaccharide, denoted as TFP-F1. Monosaccharide composition and NMR analysis of the polysaccharide and its derivatives indicated it contained fucose (Fucp), xylose (Xylp), mannose (Manp), and glucuronic acid….

OncologyImmune supportRespiratory

Niu-Chang-Chih · 2022 · Research Article · Molecules (Basel, Switzerland)

Anti-Inflammatory Constituents of Antrodia camphorata on RAW 264.7 Cells Induced by Polyinosinic-Polycytidylic Acid.

Antrodia camphorata is an endemic mushroom in Taiwan. This study was designed to screen anti-inflammatory compounds from the methanolic extract of the mycelium of A..

OncologyImmune supportGut & microbiome

Oyster Mushroom · 2022 · Journal Article · International journal of medicinal mushrooms

Anticancer Properties of Selenium-Enriched Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), in Colon Cancer In Vitro.

Mushrooms have become an important way to safely supply the body with the daily needs of organic selenium and they also possess remarkable medicinal properties. In this study, we examined the ability of the Pleurotus ostreatus mushroom to grow in selenium (Se) and its ability to accumulate and convert Se from….

OncologyImmune supportGut & microbiome

Reishi · 2022 · Journal Article · Carbohydrate polymers

Antimelanoma effect of a fucoxylomannan isolated from Ganoderma lucidum fruiting bodies.

A fucoxylomannan (FXM) was isolated from the mushroom Ganoderma lucidum through alkaline extraction followed by dialysis, freeze-thawing, and fractionation by Fehling's solution..

OncologyImmune supportCognition & nervesSkin & hydration

Lion's Mane · 2022 · Journal Article · International journal of medicinal mushrooms

Aqueous Extracts of Pleurotus ostreatus and Hericium erinaceus Protect against Ultraviolet A-Induced Damage in Human Dermal Fibroblasts.

Pleurotus ostreatus (PO) and Hericium erinaceus (HE) have been traditionally used to treat various diseases, owing to their antioxidant, antimicrobial, neuroprotective, and antitumor effects. However, few studies have been reported on their antiaging effects..

Immune supportMetabolic healthGut & microbiome

Turkey Tail · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor.

The aim of this study is to characterize the bioactivity of mycelial biomass and crude exopolysaccharides (EPS) produced by Trametes versicolor NBIMCC 8939 and to reveal its nutraceutical potential. The EPS (1.58 g/L) were isolated from a culture broth..

Immune supportCognition & nervesLiver supportSkin & hydration

Enoki · 2022 · Research Article · Frontiers in bioengineering and biotechnology

Biocompatible and antibacterial Flammulina velutipes-based natural hybrid cryogel to treat noncompressible hemorrhages and skin defects.

Hemorrhage, infection, and frequent replacement of dressings bring great clinical challenges to wound healing. In this work, Flammulina velutipes extract (FV) and hydroxyethyl cellulose (HEC) were chemically cross-linked and freeze-dried to obtain novel HFV cryogels (named HFVn, with n = 10, 40, or 70 corresponding to….

Immune supportEnergy & fatigueMetabolic health

Turkey Tail · 2022 · Journal Article · Water environment research: a research publication of the Water Environment Federation

Bioremediation of bisphenol A found in industrial wastewater using Trametes versicolor (TV) laccase nanoemulsion-based bead organogel in packed bed reactor.

Bisphenol A (BPA) is one of the toxic chemicals, which is widely used for manufacturing epoxy, polyester resin, and polycarbonates. These materials are extensively used in manufacturing of reusable bottles, baby bottles, dental sealants, various medical devices, and so forth..

Maitake · 2022 · Research Article · Polymers

Characterization and Comparison of Bioactive Polysaccharides from Grifola frondosa by HPSEC-MALLS-RID and Saccharide Mapping Based on HPAEC-PAD.

Grifola frondosa polysaccharides (GFPs) from different regions in China were characterized and compared using HPSEC-MALLS-RID and saccharide mapping based on HPAEC-PAD analysis for achieving and improving its quality control..

Yellow Morel · 2022 · Journal Article · Carbohydrate polymers

Characterization and immunomodulatory effect of an alkali-extracted galactomannan from Morchella esculenta

In our continuous exploration for bioactive polysaccharides, a novel polysaccharide FMP-2 was isolated and purified from the fruiting bodies of Morchella esculenta by alkali-assisted extraction..

Yellow Morel · 2022 · Journal Article · Carbohydrate polymers

Characterization and immunomodulatory effect of an alkali-extracted galactomannan from Morchella esculenta.

In our continuous exploration for bioactive polysaccharides, a novel polysaccharide FMP-2 was isolated and purified from the fruiting bodies of Morchella esculenta by alkali-assisted extraction..

Snow Fungus · 2022 · Research Article · Foods (Basel, Switzerland)

Characterization of Physicochemical Properties of Oil-in-Water Emulsions Stabilized by Tremella fuciformis Polysaccharides.

In this paper, emulsions stabilized by Tremella fuciformis polysaccharides (TFP) were prepared and the physiochemical properties were assessed. Results showed that the TFP emulsions illustrated the highest emulsifying activity (EAI) and emulsifying stability (ESI) when the concentration of TFP and oil were 0.8% and….

Immune supportEnergy & fatigueSkin & hydration

Snow Fungus · 2022 · Research Article · Frontiers in nutrition

Chemical profile and antioxidant activity of bidirectional metabolites from Tremella fuciformis and Acanthopanax trifoliatus as assessed using response surface methodology.

This study aimed to establish a bidirectional fermentation system using Tremella fuciformis and Acanthopanax trifoliatus to promote the transformation and utilization of the synthesized antioxidant metabolites from fermentation supernatant..

OncologyImmune supportRespiratory

Shiitake · 2022 · Research Article · BMC genomics

Chromosomal genome and population genetic analyses to reveal genetic architecture, breeding history and genes related to cadmium accumulation in Lentinula edodes.

BACKGROUND: Lentinula edodes (Berk.) is the second most productive mushroom in the world. It contains compounds effective for antiviral, antitumor, antioxidant and immune regulation.

Shiitake · 2022 · Journal Article · Journal of basic microbiology

Cloning and characterization of phosphoglucose isomerase in Lentinula edodes.

Phosphoglucose isomerase (PGI) is a key enzyme that participates in polysaccharide synthesis, which is responsible for the interconversion of glucose-6-phosphate (G-6-P) and fructose-6-phosphate (F-6-P), but there is little research focusing on its role in fungi, especially in higher basidiomycetes..

Immune supportGut & microbiome

Reishi · 2022 · Journal Article · Annals of surgical treatment and research

Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats.

PURPOSE: The etiology and pathogenesis of distal colitis (DC) are poorly understood. Activation of intestinal inflammatory response may lead to intestinal tissue necrosis.

Chaga · 2022 · Journal Article · Journal of bioscience and bioengineering

Effect of alkali-treated birch sawdust on the lignocellulase secretion and exo-polysaccharide production by Inonotus obliquus under submerged fermentation and its lignocellulose degradation patterns.

The objectives of this study were to investigate the medicinal mushroom Inonotus obliquus on the production of polysaccharides and changes of extracellular lignocellulolytic enzymes during submerged fermentation using alkali-treated birch sawdust as substrate..

Maitake · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Effect of low-intensity magnetic field on the growth and metabolite of Grifola frondosa in submerged fermentation and its possible mechanisms

This study aimed to investigate the effects of low intensity alternating magnetic field on the submerged fermentation of Grifola frondosa, and its possible mechanism was also explored..

Immune supportLiver supportRespiratory

Shiitake · 2022 · Research Article · Molecules (Basel, Switzerland)

Effect of Supplementation with the Combination of Se-Enriched Lentinula edodes Mycelium, Exogenous Enzymes, Acidifiers, Sodium Butyrate and Silicon Dioxide Nanoparticle Feed Additives on Selected Parameters in Calves.

During the initial months of calves’ lives, the young animals are exposed to bacterial and viral infections, and during this period, crucial physiological changes take place in their organisms..

Snow Fungus · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effect of surfactants on the production and biofunction of Tremella fuciformis polysaccharide through submerged fermentation

Tremella fuciformis polysaccharide (TFPS) have been widely used in the fields of food and medicine due to their multiple functions. submerged cultivation of mushroom is viewed as a promising alternative for efficient production of TFPS..

OncologyImmune supportMetabolic health

Reishi · 2022 · Journal Article · BioMed research international

Effects and Mechanism of Ganoderma lucidum Polysaccharides in the Treatment of Diabetic Nephropathy in Streptozotocin-Induced Diabetic Rats.

Ganoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This study was designed to investigate its effect and mechanism using a diabetic rat model induced by streptozotocin (50 mg/kg, i.p.)..

Immune supportSkin & hydration

Snow Fungus · 2022 · Journal Article · Food chemistry

Effects of combined drying methods on physicochemical and rheological properties of instant Tremella fuciformis soup.

The textural, rheological and flavor reconstitution behaviors of rehydrated instant Tremella fuciformis soup, treated by combined freeze drying + vacuum drying (FD-VD), freeze drying + far-infrared drying (FD-FIRD) and freeze drying + hot air drying (FD-HAD), were evaluated and compared with fresh soup..

Snow Fungus · 2022 · Research Article · Ultrasonics sonochemistry

Effects of combined ultrasonic and microwave vacuum drying on drying characteristics and physicochemical properties of Tremella fuciformis.

This study analyzes the effects of ultrasonic waves on the drying kinetics of Tremella fuciformis during microwave vacuum drying. The physicochemical properties and structural characteristics of T..

Lion's Mane · 2022 · Journal Article · Animal feed science and technology

Effects of dietary Hericium erinaceus powder on growth, hematology, disease resistance, and expression of genes related immune response against thermal challenge of Nile tilapia (Oreochromis niloticus)

Functional feed additives have been promising possibilities for improving fish immune function. The present study attempts to investigate the effect of dietary Hericium erinaceus (HE) supplementation on growth performance, hematology, disease resistance, and expression of genes related immune response against thermal….

Oyster Mushroom · 2022 · Research Article · Life (Basel, Switzerland)

Effects of Heat Stress and Exogenous Salicylic Acid on Secondary Metabolites Biosynthesis in Pleurotus ostreatus (Jacq.) P. Kumm.

Pleurotus ostreatus (Jacq.) P. Kumm has high medicinal value, but few studies exist on regulating secondary metabolite biosynthesis.

Reishi · 2022 · Journal Article · The Science of the total environment

Effects of microplastics of different sizes on the Chlorella vulgaris - Ganoderma lucidum co-pellets formation processes.

The effects of different sized MPs on the formation process of algal-fungal co-pellets were studied. The results show that a maximum biomass recovery of 70.96% and a minimum Fv/Fm ratio of 0.463 reached with 5.000 μm-microplastics..

Immune supportGut & microbiome

Reishi · 2022 · Research Article · Frontiers in nutrition

Effects of molecular weight on intestinal anti-inflammatory activities of β-D-glucan from Ganoderma lucidum.

To investigate the influence of molecular weight (M w) on the anti-inflammatory activity of β-D-glucan from Ganoderma lucidum, ultrasonic irradiation was applied to treat the β-D-glucan (GLP, 2.42 × 106 g/mol) solution to obtain two degraded fractions with molecular weight of 6.53 × 105 g/mol (GLPC) and 3.49 × 104….

Enoki · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of polysaccharides autoclave extracted from Flammulina velutipes mycelium on freeze-thaw stability of surimi gels

Quality deterioration caused by ice formation and growth is a prevailing problem in frozen food, therefore, exploration of natural cryoprotectants has been attracting more attention..

Oyster Mushroom · 2022 · Research Article · Molecules (Basel, Switzerland)

Effects of Rosa roxburghii Tratt Must on the Growth, Nutrient Composition, and Antioxidant Activity of Pleurotus ostreatus Mycelia.

Rosa roxburghii Tratt, a Rosaceae plant endemic to China, produces fruit with high nutritional and medicinal value. The effects of R.

Immune supportGut & microbiome

Enoki · 2022 · Research Article · Ultrasonics sonochemistry

Effects of ultrasound on the degradation kinetics, physicochemical properties and prebiotic activity of Flammulina velutipes polysaccharide.

The controllable ultrasonic modification was hindered due to the uncertainty of the relationship between ultrasonic parameters and polysaccharide quality. In this study, the ultrasonic degradation process was established with kinetics..

Immune supportEnergy & fatigueMetabolic health

Cordyceps · 2022 · Journal Article · International journal of medicinal mushrooms

Efficacy of Aqueous Extract of Chinese Caterpillar Mushroom Ophiocordyceps sinensis (Ascomycota) Against Simulated Altitude Stress and Subacute Toxicity Studies.

Exposure to high altitude severely impacts performance of unacclimatized individuals and contraindications associated with synthetic drugs ascertain the need for development of herbal drugs..

OncologyImmune supportMetabolic healthRespiratory

Shiitake · 2022 · Research Article · Bioengineering (Basel, Switzerland)

Enhanced Effects of Iron on Mycelial Growth, Metabolism and In Vitro Antioxidant Activity of Polysaccharides from Lentinula edodes.

The polysaccharides found in Lentinula edodes have a variety of medicinal properties, such as anti-tumor and anti-viral effects, but their content in L. edodes sporophores is very low.

OncologyImmune supportSkin & hydration

Mesima · 2022 · Research Article · Journal of nanobiotechnology

Exosome-like nanovesicles derived from Phellinus linteus inhibit Mical2 expression through cross-kingdom regulation and inhibit ultraviolet-induced skin aging.

BACKGROUND: Phellinus linteus (PL), which is a typical medicinal fungus, has been shown to have antitumor and anti-inflammatory activities. However, studies on the effect of anti-photoaging are limited..

Reishi · 2022 · Research Article · Frontiers in nutrition

Extraction, Structural Characterization, and Immunomodulatory Activity of a High Molecular Weight Polysaccharide From Ganoderma lucidum.

Ganoderma lucidum polysaccharides (GLP) exhibited excellent immunomodulatory activity. Unfortunately, the structure and immunomodulatory activity of GLP are still unclear..

Turkey Tail · 2022 · Research Article · Journal of industrial microbiology & biotechnology

Fatty acid secretion by the white-rot fungus, Trametes versicolor.

Fungi can acquire and store nutrients through decomposing and converting organic matter into fatty acids. This research demonstrates for the first time that the white-rot fungus Trametes versicolor has the ability to secrete extracellular droplets which can contain a high concentration of long-chain fatty acids and….

Immune supportMetabolic healthLiver support

Enoki · 2022 · Research Article · Nutrients

Flammulina velutipes Mycorrhizae Attenuate High Fat Diet-Induced Lipid Disorder, Oxidative Stress and Inflammation in the Liver and Perirenal Adipose Tissue of Mice.

Flammulina velutipes (FV) is edible mushroom that has nutritional and medicinal values. FV mycorrhizae, the by-products of FV, are an abundant source and receive less attention..

Wood Ear · 2022 · Research Article · Molecules (Basel, Switzerland)

Formation Optimization, Characterization and Antioxidant Activity of Auricularia auricula-judae Polysaccharide Nanoparticles Obtained via Antisolvent Precipitation.

Auricularia auricula-judae polysaccharide (AAP)-based nanoparticles (NPs) prepared via an anti-solvent precipitation approach were studied. Response surface methodology (RSM) design was carried out on the basis of single factor experiments, using average size and polydispersity index (PDI) as indicators..

Oyster Mushroom · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Functional Roles of LaeA-like Genes in Fungal Growth, Cellulase Activity, and Secondary Metabolism in Pleurotus ostreatus.

The global regulator LaeA plays crucial roles in morphological development and secondary metabolite biosynthesis in filamentous fungi. However, the functions of LaeA in basidiomycetes are less reported..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2022 · Journal Article · Food & function

Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition.

Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It is well known that Ganoderma lucidum has excellent beneficial effects on liver function and lipid metabolism..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2022 · Journal Article · Current research in food science

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake.

Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human health. It is well known that Ganoderma lucidum possesses various excellent beneficial effects on liver function and lipid metabolism..

Reishi · 2022 · Research Article · American journal of cancer research

Ganoderma lucidum enhances carboplatin chemotherapy effect by inhibiting the DNA damage response pathway and stemness.

Inflammatory Breast Cancer (IBC) is a rare and aggressive type of breast cancer with a poor prognosis. Its management is challenging because of a lack of targeted therapies, increased metastatic potential, and high recurrence rates..

OncologyImmune support