MycoData

A new enynyl-benzenoid, antrocamphin O (1,4,7-dimethoxy-5-methyl-6-(3'-methylbut-3-en-1-ynyl)benzo[d][1,3]dioxide), and the known benzenoids antrocamphin A and 7-dimethoxy-5-methyl-1,3-benzodioxole, were isolated from the fruiting bodies of Antrodia camphorata (Taiwanofungus camphoratus)..

OncologyGut & microbiome

Medium relevance

Mesima · 2013 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells.

Tacrine (THA) was the first drug licensed for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity is evident in about 30% of patients and limits its clinical use.

OncologyCognition & nervesEnergy & fatigueLiver support

Medium relevance

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicinal fungus. However, the anticancer activity of AC against human HER-2/neu-overexpressing ovarian cancers is poorly understood..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · PloS one

Trametes versicolor protein YZP activates regulatory B lymphocytes - gene identification through de novo assembly and function analysis in a murine acute colitis model.

BACKGROUND: Trametes versicolor (Yun-Zhi) is a medicinal fungus used as a chemotherapy co-treatment to enhance anti-tumor immunity. Although the efficacies of T.

OncologyImmune supportGut & microbiome

Medium relevance

Mesima · 2012 · Research Support, Non U.S. Gov'T · PloS one

Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

Inotilone was isolated from Phellinus linteus. The anti-inflammatory effects of inotilone were studied by using lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells and λ-carrageenan (Carr)-induced hind mouse paw edema model..

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Anticancer research

Anticancer effects of eleven triterpenoids derived from Antrodia camphorata.

Eleven derivatives from Antrodia camphorata were isolated in order to evaluate their selective cytotoxicity toward 14 types of human cancer cell and two non-transformed cell types..

OncologyEnergy & fatigueLiver support

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Antileukemia component, dehydroeburicoic acid from Antrodia camphorata induces DNA damage and apoptosis in vitro and in vivo models.

Antrodia camphorata (AC) is a native Taiwanese mushroom which is used in Asian folk medicine as a chemopreventive agent. The triterpenoid-rich fraction (FEA) was obtained from the ethanolic extract of AC and characterized by high performance liquid chromatography (HPLC)..

OncologyEnergy & fatigueMetabolic health

Medium relevance

Chaga · 2012 · Evaluation Study · Carbohydrate polymers

Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.

The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Journal of pharmaceutical and biomedical analysis

Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata.

Antrodia camphorata (AC), also known as Antrodia cinnamomea, an endemic species in Taiwan, is one of the treasured medicinal mushrooms. AC is traditionally used for its chemopreventive biofunctions..

OncologyEnergy & fatigue

Medium relevance

Enoki · 2012 · Research Support, Non U.S. Gov'T · International journal of nanomedicine

Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes, a potential antitumor drug.

PURPOSE: To investigate the growth inhibition activity of Flammulina velutipes sterol (FVS) against certain human cancer cell lines (gastric SGC and colon LoVo) and to evaluate the optimum microemulsion prescription, as well as the pharmacokinetics of encapsulated FVS..

OncologyMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2012 · Research Support, Non U.S. Gov'T · Protein expression and purification

Gene cloning and recombinant expression of a novel fungal immunomodulatory protein from Trametes versicolor.

Homology-based cloning was used to obtain a new gene (named FIP-tvc) from the genomic DNA of the Chinese traditional medicinal mushroom Trametes versicolor. FIP-tvc is a member of the fungal immunomodulatory protein family, is composed of 336bp encoding 111 amino acids, and is highly homologous with other fungal….

OncologyImmune support

Medium relevance

Zhu Ling · 2012 · Research Support, Non U.S. Gov'T · Genetics and molecular research: GMR

Genetic diversity of endangered Polyporus umbellatus from China assessed using a sequence-related amplified polymorphism technique.

Polyporus umbellatus (Pers.) Fries is an endangered medicinal fungus in China with in vivo anticancer activity, but its genetic information is lacking. Eight natural P..

Oncology

Medium relevance

Mesima · 2012 · Research Support, Non U.S. Gov'T · Chemico-biological interactions

Hispidin produced from Phellinus linteus protects against peroxynitrite-mediated DNA damage and hydroxyl radical generation.

Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders..

OncologyCognition & nervesMetabolic health

Medium relevance

Mesima · 2012 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis.

BACKGROUND: Complementary and alternative medicine (CAM) is becoming a popular treatment for modulating diverse immune disorders. Phellinus linteus (P.

OncologyImmune supportSkin & hydration

Medium relevance

Niu-Chang-Chih · 2012 · Comparative Study · Applied microbiology and biotechnology

In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment.

Antrodia camphorata is a particular and precious medicinal mushroom, and its fruiting body was found to provide more efficient protection from oxidative stress and inflammation than its mycelium because of its higher content of triterpenoids, total phenols, and so on..

OncologyImmune supportCognition & nerves

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

In vivo antitumor effects of 4,7-dimethoxy-5-methyl-1,3-benzodioxole isolated from the fruiting body of Antrodia camphorata through activation of the p53-mediated p27/Kip1 signaling pathway.

In this study, 4,7-dimethoxy-5-methyl-1,3-benzodioxole (SY-1) was isolated from three different sources of dried Antrodia camphorata (AC) fruiting bodies. AC is a medicinal mushroom that grows on the inner heartwood wall of Cinnamomum kanehirai Hay (Lauraceae), which is an endemic species that is used in Chinese….

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Phytochemistry

Lanostane triterpenoids and sterols from Antrodia camphorata.

Four lanostane triterpenes, 3,7,11-trioxo-5α-lanosta-8,24(E)-dien-26-oic acid, methyl 11α-3,7-dioxo-5α-lanosta-8,24(E)-dien-26-oate, methyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, and ethyl 3,7,11,12,15,23-hexaoxo-5α-lanost-8-en-26-oate, two sterols, (14α,22E)-14-hydroxyergosta-7,22-diene-3,6-dione and a….

Oncology

Medium relevance

Maitake · 2012 · Research Support, Non U.S. Gov'T · Inflammation

Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation.

The objective of the present study was to demonstrate the anti-inflammatory and antinociceptive properties of agaricoglycerides of the fermented mushroom of Grifola frondosa (AGF)..

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Nutrition (Burbank, Los Angeles County, Calif.)

Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis.

OBJECTIVES: Antrodia camphorata (AC) is a traditional Chinese medicine, and the polysaccharides contained within AC (AC-PSs) are reported to possess various biological functions..

OncologyImmune supportRespiratory

Medium relevance

Maitake · 2012 · Research Support, Non U.S. Gov'T · Glycoconjugate journal

Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling.

A soluble homogeneous β-glucan, GFPBW1, with a molecular mass of 300 kDa was purified from the fraction of the fruit bodies of Grifola frondosa extracted with 5% NaOH..

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM

A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging.

This study was carried out to provide a platform for the pre-clinical evaluation of anti-cancer properties of a unique CAM (complementary and alternative medicine) agent, Antrodia camphorata alcohol extract (ACAE), in a mouse model with the advantageous non-invasive in vivo bioluminescence molecular imaging….

OncologyImmune supportRespiratory

Medium relevance

Niu-Chang-Chih · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM

An Extract of Antrodia camphorata Mycelia Attenuates the Progression of Nephritis in Systemic Lupus Erythematosus-Prone NZB/W F1 Mice.

Antrodia camphorata is used in folk medicine for the treatment of inflammation syndromes and liver-related diseases in Taiwan. The goal of this study was to evaluate the efficacy of the mycelial extract of A.

OncologyImmune supportLiver support

Medium relevance

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.

The triterpenoids methylantcinate B (MAB) and antcin B (AB), isolated from the medicinal mushroom Antrodia camphorata, have been identified as strong cytotoxic agents against various type of cancer cells; however, the mechanisms of MAB- and AB-induced cytotoxicity have not been adequately explored..

OncologyEnergy & fatigueLiver support

Medium relevance

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway.

The fermented culture broth of Antrodia camphorata (A. camphorata) has been shown to promote cell cycle arrest and apoptosis of human estrogen-nonresponsive MDA-MB-231 cells.

OncologySkin & hydration

Medium relevance

Mesima · 2011 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma.

Proteoglycan (P1) purified from Phellinus linteus has been reported to have anti-disease activities. The objectives of our research were to determine the anti-tumor effect and possible mechanisms of P1 on human cancer cells..

OncologyImmune supportGut & microbiome

Medium relevance

Yellow Morel · 2011 · Research Support, Non U.S. Gov'T · Natural product research

Antioxidant and NF-κB inhibitory constituents isolated from Morchella esculenta.

Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells..

OncologyEnergy & fatigueGut & microbiome

Medium relevance

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · International journal of gynecological cancer: official journal of the International Gynecological Cancer Society

Antrodia camphorata induces apoptosis and enhances the cytotoxic effect of paclitaxel in human ovarian cancer cells.

INTRODUCTION: Antrodia camphorata is a Chinese herb. Recently, several reports demonstrated that it had growth-inhibiting effects on some cancer cells.

OncologyEnergy & fatigue

Medium relevance

Mesima · 2011 · Patent · journal metadata

COMPOSITION CONTAINING EXTRACTS OF FUSCOPORIA OBLIQUA, GANODERMA LUCIDUM AND PHELLINUS LINTEUS FOR PROMOTING THE PROLIFERATION OF HEMATOPOIETIC STEM CELLS

A composition for promoting the proliferation of hematopoietic stem cells, which contains mushroom extracts, and more particularly to a composition and functional food for promoting the proliferation of hematopoietic stem cells, which contain, as active ingredients, an Inonotus Obliquus extract, a Ganoderma Luciderm….

OncologyImmune support

Medium relevance

Mesima · 2011 · Patent · journal metadata

COMPOSITION CONTAINING EXTRACTS OF FUSCOPORIA OBLIQUA, GANODERMA LUCIDUM AND PHELLINUS LINTEUS FOR PROMOTING THE PROLIFERATION OF HEMATOPOIETIC STEM CELLS

The present invention relates to a composition for promoting the proliferation of hematopoietic stem cells, which contains mushroom extracts, and more particularly to a composition and functional food for promoting the proliferation of hematopoietic stem cells, which contain, as active ingredients, an Inonotus….

OncologyImmune support

Medium relevance

Turkey Tail · 2011 · Dissertation · journal metadata

Effects of volatiles and stress on growth, enzyme activity and gene expression of trametes versicolor

Metadata-grounded summary: This dissertation indexes research on Trametes versicolor in 2011. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune support

Medium relevance

Mesima · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM

Filtrate of Phellinus linteus Broth Culture Reduces Infarct Size Significantly in a Rat Model of Permanent Focal Cerebral Ischemia.

Phellinus linteus, a natural growing mushroom, has been known to exhibit anti-tumor, anti-inflammatory, anti-allergic and anti-oxidant effects. Aiming to exploit the neuroprotective effects of P.

OncologyImmune supportCognition & nerves

Medium relevance

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Chemical research in toxicology

Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells.

The PI3K/Akt/mTOR pathway is considered to be an attractive target for the development of novel anticancer molecules. This paper reports for the first time that a small molecule, antrocin (MW = 234), from Antrodia camphorata was a potent antagonist in various cancer types, being highest in metastatic breast cancer….

OncologyGut & microbiome

Medium relevance