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OncologyImmune supportMetabolic healthSkin & hydration

Reishi · 2026 · Review · Journal of natural medicines

The emerging role of fatty acids as key bioactive components of Ganoderma lucidum spore oil in alleviating tumor progression.

Ganoderma lucidum, long revered as a divine fungus in traditional medicine, has garnered significant attention for its therapeutic potential. Ganoderma lucidum spore oil (GLSO) is an oil-like substance extracted from cracked Ganoderma lucidum spores using supercritical CO₂ extraction technology..

OncologyImmune supportEnergy & fatigueMetabolic health

King Oyster · 2025 · Journal Article · Chemistry & biodiversity

Composition Analysis and In Vitro Investigation on Antioxidant, α-Amylase, and Pancreatic Lipase Inhibitory Activities of Major Mushrooms in Qinling Mountains.

Edible mushrooms exhibit a range of pharmacological activities, including anticancer, antimicrobial, antioxidant, anti-obesity, and hepatoprotective effects, thereby holding significant potential for applications in the development of functional foods..

King Oyster · 2025 · Journal Article · Journal of food science

Evaluation of natural polysaccharides from edible mushrooms for the treatment of male testicular injury caused by X-ray.

Radiation exposure can lead to reproductive damage (RD), for which there is currently no effective treatment. Natural compounds, particularly fungal polysaccharides, have shown promising therapeutic potential for RD..

Immune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Current issues in molecular biology

Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR.

Cellular senescence plays a crucial role in skin aging, with senescent dermal fibroblasts contributing to reduced skin elasticity and increased inflammation. This study investigated the potential of Ganoderma lucidum (Reishi) ethanol extract to modulate the senescent phenotype of human dermal fibroblasts..

Agarikon · 2020 · Review · Chemistry & biodiversity

Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties.

Medicinal mushrooms of the order Polyporales have a long history of use, which is evidenced by the finding of dissected fruiting bodies with Ötzi, who lived over 5000 years ago..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Lion's Mane · 2020 · Review · Antioxidants (Basel, Switzerland)

Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea.

Recent studies focused on the pharmacology and feasibility of herbal compounds as a potential strategy to target a variety of human diseases ranging from metabolic to brain disorders..

OncologyImmune supportSkin & hydration

Maitake · 2020 · Review · Carbohydrate polymers

Preparation and activities of selenium polysaccharide from plant such as Grifola frondosa.

Selenium polysaccharide is an organic selenium compound formed by the combination of polysaccharide and selenium. The biological activity of selenium polysaccharide from plant such as Grifola frondosa is generally higher than that of selenium and polysaccharide, and it is more easily absorbed and utilized by human….

Turkey Tail · 2020 · Review · Biomedicines

Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy.

Coriolus versicolor (L.) Quél. is a higher fungi or mushroom which is now known by its accepted scientific name as Trametes versicolor (L.) Lloyd (family Polyporaceae)..

OncologyImmune supportCognition & nervesMetabolic health

Mesima · 2019 · Review · Molecules (Basel, Switzerland)

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus.

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P.

OncologyImmune supportCognition & nervesMetabolic health

Niu-Chang-Chih · 2019 · Review · Applied microbiology and biotechnology

Diversity of potentially exploitable pharmacological activities of the highly prized edible medicinal fungus Antrodia camphorata.

Antrodia camphorata, also known as A. cinnamomea, is a precious medicinal basidiomycete fungus endemic to Taiwan.

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2019 · Review · International journal of biological macromolecules

Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: A review.

Tremella fuciformis is an important edible mushroom that has been widely cultivated and used as food and medicinal ingredient in traditional Chinese medicine. In the past decades, many researchers have reported that T..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2019 · Review · Phytotherapy research: PTR

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies.

The use of mushrooms as functional foods and in the treatment of diseases has a long history. Inonotus obliquus is a mushroom belonging to the Hymenochaetaceae family and has possible anticancer, antiviral, and hypoglycemic properties..

OncologyImmune supportGut & microbiome

Maitake · 2018 · Review · Oncotarget

B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine.

Culinary and medicinal mushrooms are widely used in Asian countries, both as dietary supplements and as nutraceutical foods. They have recently become popular in Europe, as well, for their nutritional and health benefits..

OncologyImmune supportMetabolic healthRespiratory

Maitake · 2018 · Review · Discovery medicine

Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China.

Grifola frondosa, a species of Basidiomycotina, is an edible medicinal mushroom with a large fruiting body characterized by overlapping caps. The β-glucan is the major biologically active component in G.

OncologyImmune supportMetabolic health

Zhu Ling · 2017 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Correlative analysis advance of chemical constituents of Polyporus umbellatus and Armillaria mellea].

Medicinal Polyporus umbellatus is the dry sclerotia of P. umbellatus, with the effect of diuresis; Armillaria mellea is a parasitic fungus which can infect plants up to 300 genera, with sedative, anticonvulsant and some other biological activities.

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2017 · Review · Current pharmaceutical design

Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies.

BACKGROUND: The mushroom Agaricus blazei has evoked considerable scientific and practical interest in several fields, especially those linked to its medicinal properties. This review aims to summarize and evaluate the past decade findings related to nutritional and therapeutic uses of A..

OncologyImmune supportMetabolic healthLiver support

Maitake · 2017 · Review · International journal of biological macromolecules

Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review.

Grifola frondosa (Dicks.) Gray is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers.

Immune supportRespiratory

King Oyster · 2004 · Review · Shi yong jun xue bao (Online)

Advances in the research of Pleurotus eryngii

Macrophages were prepared from the lung, peritoneal cavity and blood of normal, unstimulated rats from a number of strains. The macrophages were purified by adherence, and characterized via surface markers, enzyme activity and phagocytic capacity, and subsequently tested for activity in cultures of mitogen-stimulated….

Maitake · 2004 · Review · Pharmaceutical Biotechnology

Progress on the studies of grifolan from Grifola frondosa

Metadata-grounded summary: This review indexes research on Grifola frondosa in Pharmaceutical Biotechnology in 2004. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune supportRespiratory

King Oyster · 2003 · Review · Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society

[Hypersensitivity pneumonitis induced by Pleurotus eryngii spores--a case report].

A 52-year-old man was hospitalized because of recurrent fever, dyspnea and cough in February 2002. He had worked in a Eringi (Pleurotus eryngii) mushroom factory since 1996.

Maitake · 2003 · Review · Natural Product Research and Development

Recent pharmacological studies on polysaccharide from Grifola frondosa

Metadata-grounded summary: This review indexes research on Grifola frondosa in Natural Product Research and Development in 2003. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Cordyceps · 2026 · Review · Journal of Asian natural products research

Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action.

Over the past decade, species of Cordyceps, particularly C. sinensis, C.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Cordyceps · 2026 · Review · Journal of inflammation research

Anti-Inflammatory Mechanisms and Translational Relevance of Cordyceps sinensis and Its Bioactive Constituents.

Cordyceps sinensis, an important medicinal fungus in traditional Chinese medicine, has gained increasing attention for its diverse pharmacological activities, particularly its anti-inflammatory properties..

Immune supportRespiratory

Cordyceps · 2026 · Review · Phytotherapy research: PTR

Biologically Active Ingredients and Underlying Mechanisms of Cordyceps in Treating Respiratory Diseases: A Comprehensive Review With Future Perspectives.

The incidence of respiratory diseases is increasing worldwide and imposes a significant health burden. Due to the complex etiology and diverse inducements of these diseases, existing therapies often struggle to control disease progression and reduce recurrence rates..

OncologyImmune supportMetabolic health

Nameko · 2026 · Review · RSC advances

Extraction, purification, structural characterization, bioactivities, and applications of Pholiota nameko polysaccharide: a review.

Pholiota nameko, an edible mushroom, is recognized for its significant medicinal properties and broad application potential. Pholiota nameko polysaccharide (PNP), a major bioactive component derived from this fungus, exhibits diverse biological activities, including anti-inflammatory, antioxidant, antitumor,….

Immune supportEnergy & fatigue

Cordyceps · 2025 · Review · Current nutrition reports

Ergogenic Aid by Cordyceps: Does It Work??

PURPOSE OF REVIEW: Supplements for exercise have gained significant attention among athletes and sports practitioners. Herbs with high bioactive content are commonly used to enhance exercise performance..

Immune supportMetabolic health

Nameko · 2025 · Review · Food science and biotechnology

Extraction, structure and bioactivities of polysaccharides from Pholiota nameko: a review.

Pholiota nameko, a famous edible mushroom, has broad application prospects in the field of health food development because of its high nutritional value, complex structure, and diverse biological activities..

Immune supportCognition & nervesLiver supportRespiratory

Cordyceps · 2025 · Review · Current pharmaceutical design

Immunopharmacological Insights into Cordyceps spp.: Harnessing Therapeutic Potential for Sepsis.

Cordyceps spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas.

OncologyImmune supportCognition & nerves

Cordyceps · 2025 · Review · International journal of molecular sciences

Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease.

Alzheimer's disease (AD) is considered one of the main pathologies of our time, whose incidence and prevalence are suggested to be strongly underestimated. AD presents as a complex neurodegenerative condition characterized by marked neuroinflammation and a significant decline in the cognitive and mnemonic functions of….

Immune supportSkin & hydrationRespiratory

Cordyceps · 2025 · Review · Life (Basel, Switzerland)

The Genus Cordyceps Sensu Lato: Their Chemical Constituents, Biological Activities, and Therapeutic Effects on Air Pollutants Related to Lung and Vascular Diseases.

Air pollutants are significant environmental factors that contribute to the exacerbation of respiratory, cardiopulmonary, and skin diseases in East Asia, and their impact is based on particle size..

Cordyceps · 2024 · Review · Critical reviews in biotechnology

Bioactive compounds from Cordyceps and their therapeutic potential.

The Clavicipitaceae family's largest and most diverse genus is Cordyceps. They are most abundant and diverse in humid temperate and tropical forests and have a wide distribution in: Europe, North America, and East and Southeast Asian countries, particularly: Bhutan, China, Japan, Nepal, Korea, Thailand, Vietnam,….

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2024 · Review · Journal of ethnopharmacology

Cordyceps: Alleviating ischemic cardiovascular and cerebrovascular injury - A comprehensive review.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps has a long medicinal history as a nourishing herb in traditional Chinese medicine (TCM). Ischemic cardio-cerebrovascular diseases (CCVDs), including cerebral ischemic/reperfusion injury (CI/RI) and myocardial ischemic/reperfusion injury (MI/RI), are major contributors to….

OncologyImmune supportRespiratory

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

Exploring the Therapeutic Potential of Cordyceps Mushroom on SARS-CoV-2 Using Virtual Screening against Mpro and In Vitro Validation of Cordycepin.

Pathogenic coronavirus, including COVID-19, threatens human health, and there have been strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects.

Maitake · 2024 · Journal Article · Biological & pharmaceutical bulletin

Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity

Trastuzumab, an anti-HER2 monoclonal antibody, is the mainstay treatment for of HER2-positive breast cancer. However, trastuzumab resistance is often observed during treatment.

Immune supportMetabolic health

Chaga · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts.

The mushroom industry should implement green extraction technologies; however, there is not enough information on the differences between these techniques expressed as the chemical composition of the resulting extract..

Immune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2024 · Research Article · Poultry science

The influence of dietary supplementation with oyster mushroom waste on laying hens' performance, egg quality and immune parameters.

The objective of the present study was to evaluate the effects of dietary supplementation with oyster mushroom (Pleurotus ostreatus) waste (OMW) on performance, egg quality, fatty acid (FA) profile and oxidative stability, serum and yolk cholesterol and immune parameters of laying hens..

Cordyceps · 2022 · Randomized Controlled Trial · International journal of medicinal mushrooms

Efficacy of Cordyceps cicadae (Ascomycota) Mycelium Supplementation for Amelioration of Dry Eye Symptoms: A Randomized, Double-Blind Clinical Pilot Study.

Dry eye disease (DED), a multifactorial inflammatory ocular surface disorder, affects up to 50% of individuals over 50 years old worldwide and is one of the most common reasons for seeking ophthalmologic care..

Immune supportSkin & hydration

Oyster Mushroom · 2021 · Journal Article · International journal of food science & technology

Effects of ultraviolet‐C irradiation on the physicochemical properties of polysaccharide films prepared from the stalk base of oyster mushrooms (Pleurotus ostreatus)

The effects of ultraviolet (UV)‐C irradiation on the physicochemical properties of oyster mushroom polysaccharide (OMP) films were investigated. The prepared OMP films were subjected to UV‐C treatment (5.4 kJ m⁻²)..

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Environmental microbiology

CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue-light receptors in edible fungus Cordyceps militaris.

Fruiting body development and carotenoid production are light-induced in Cordyceps militaris. Our previous studies have shown that two blue-light receptors, CmWC-1 and CmCRY-DASH, regulate fruiting body development and secondary metabolism.

Immune supportCognition & nerves

King Oyster · 2020 · Comparative Study · International journal of medicinal mushrooms

Comparative Neuroprotective, Anti-Inflammatory and Neurite Outgrowth Activities of Extracts of King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes).

Pleurotus eryngii (king oyster mushroom) is a renowned culinary mushroom with various medicinal properties that may be beneficial for health maintenance and disease prevention. However, its effect on the nervous system remains elusive.

Reishi · 2020 · Comparative Study · International journal of medicinal mushrooms

Comparative Studies on Bioactive Compounds, Ganoderic Acid Biosynthesis, and Antioxidant Activity of Pileus and Stipes of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes) Fruiting Body at Different Growth Stages.

Total phenolics, flavonoids, and polysaccharides, and individual ganoderic acid (GA) contents, antioxidant capacity, and transcription levels of key enzyme genes involved in GA biosynthesis in pileus and stipes of Ganoderma lucidum fruiting body at different growth stages were investigated in this study..

Immune supportSkin & hydration

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Journal of invertebrate pathology

Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects.

Hypocrealean entomopathogenic fungi (EPF) (Sordariomycetes, Ascomycota) are natural regulators of insect populations in terrestrial environments. Their obligately-killing life-cycle means that there is likely to be strong selection pressure for traits that allow them to evade the effects of the host immune system..

OncologyImmune supportRespiratory

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Cordyceps militaris Exerts Anticancer Effect on Non-Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3.

This study aimed to investigate the effect of Cordyceps militaris extract on the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and determine the underlying mechanisms..

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Biomolecules

Nephroprotective Effect of Pleurotus ostreatus and Agaricus bisporus Extracts and Carvedilol on Ethylene Glycol-Induced Urolithiasis: Roles of NF-κB, p53, Bcl-2, Bax and Bak.

This study was designed to assess the nephroprotective effects of Pleurotus ostreatus and Agaricus bisporus aqueous extracts and carvedilol on hyperoxaluria-induced urolithiasis and to scrutinize the possible roles of NF-κB, p53, Bcl-2, Bax and Bak..

Reishi · 2020 · Research Support, Non U.S. Gov'T · PloS one

Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities.

Ganoderma lucidum (Fr.) Krast, commonly known as "Lingzhi" in Chinese, is a medicinal mushroom that is rich in biologically active substances. Polysaccharides and triterpenoids are the two major components responsible for the bioactivity of this fungus..

Immune supportCognition & nervesMetabolic health

Cordyceps · 2020 · Abstract · Current developments in nutrition

The Antidepressive and Anxiolytic Effects of Formula Consisted of Poria cocos and Cordyceps militaris Waster Medium Extract in Unpredictable Chronic Mild Stress Animal Model

Abstract Objectives According to the WHO report, depression will be the first of the global burden of diseases in 2030. There is more than fifty % of people suffered from depression and anxiety..

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Journal of invertebrate pathology

Vegetative development and host immune interaction of Ophiocordyceps sinensis within the hemocoel of the ghost moth larva, Thitarodes xiaojinensis.

Ophiocordyceps sinensis is an entomopathogenic fungus that infects ghost moth larva, forming the most valuable and rare traditional Chinese medicine, Chinese cordyceps. Our knowledge of the basic morphology and developmental biology of Chinese cordyceps is limited..

OncologyImmune supportRespiratory

Cordyceps · 2019 · Comparative Study · International journal of biological macromolecules

Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro.

A comparison of the anti-tumor activity of CMPS-II and CBPS-II polysaccharides, respectively is obtained from the fermented mycelium and cultivated fruiting bodies of Cordyceps militaris..