MycoData

OncologySkin & hydrationRespiratory

Shiitake · 2016 · Review · Pharmacognosy reviews

The Unexplored Anticaries Potential of Shiitake Mushroom.

Keeping an eye the escalating costs of dental services, the treatment cost of the consequences of dental caries can be reduced to manageable proportions by preventive measures aimed at decreasing the prevalence. One such measure is by increasing the consumption of caries preventive foods..

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

Exploring the Therapeutic Potential of Cordyceps Mushroom on SARS-CoV-2 Using Virtual Screening against Mpro and In Vitro Validation of Cordycepin.

Pathogenic coronavirus, including COVID-19, threatens human health, and there have been strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects.

Oyster Mushroom · 2024 · Research Article · International journal of molecular sciences

Transmission of Oyster Mushroom Spherical Virus to Progeny via Basidiospores and Horizontally to a New Host Pleurotus floridanus.

Mycoviruses are usually transmitted horizontally via hyphal anastomosis and vertically through sporulation in natural settings. Oyster mushroom spherical virus (OMSV) is a mycovirus that infects Pleurotus ostreatus, with horizontal transmission via hyphal anastomosis..

King Oyster · 2020 · Research Support, Non U.S. Gov'T · Genomics

Comparative transcriptomic analysis reveals molecular processes involved in pileus morphogenesis in Pleurotus eryngii under different light conditions.

Light plays an important role in pileus differentiation in Pleurotus eryngii cultivation, and pileus morphology is influenced by light quality. To understand the effects of light quality on pileus morphology at the transcriptional level, we performed a comparative transcriptomic analysis of pilei grown under blue and….

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Cordyceps militaris Exerts Anticancer Effect on Non-Small Cell Lung Cancer by Inhibiting Hedgehog Signaling via Suppression of TCTN3.

This study aimed to investigate the effect of Cordyceps militaris extract on the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and determine the underlying mechanisms..

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · Scientific reports

The PoV mycovirus affects extracellular enzyme expression and fruiting body yield in the oyster mushroom, Pleurotus ostreatus.

Isogenic virus-cured and virus-infected fungal strains were previously obtained and compared to investigate mycoviral diseases and, specifically, the influence of viral infection on the vegetative growth of Pleurotus ostreatus..

Cordyceps · 2019 · Comparative Study · International journal of biological macromolecules

Comparisons of the anti-tumor activity of polysaccharides from fermented mycelia and cultivated fruiting bodies of Cordyceps militaris in vitro.

A comparison of the anti-tumor activity of CMPS-II and CBPS-II polysaccharides, respectively is obtained from the fermented mycelium and cultivated fruiting bodies of Cordyceps militaris..

Shiitake · 2019 · Research Support, Non U.S. Gov'T · Virology

Two novel fungal negative-strand RNA viruses related to mymonaviruses and phenuiviruses in the shiitake mushroom (Lentinula edodes).

There is still limited information on the diversity of (-)ssRNA viruses that infect fungi. Here, we have discovered two novel (-)ssRNA mycoviruses in the shiitake mushroom (Lentinula edodes)..

OncologyEnergy & fatigueRespiratory

Chaga · 2018 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B).

BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems..

King Oyster · 2015 · Journal Article · Journal of food biochemistry

Antitumor and Immunomodulatory Activity of Pleurotus eryngii Extract

Pleurotus eryngii (P. eryngii), also known as the king oyster mushroom, contains many bioactive substances, including polysaccharides, lipids, peptides, sterols and triterpenoids.

Chaga · 2014 · Journal Article · Voprosy virusologii

[A study of the antiherpetic activity of the chaga mushroom (Inonotus obliquus) extracts in the Vero cells infected with the herpes simplex virus].

The chaga mushroom (Inonotus obliquus) contains a wide range of excellent bioactive compounds. However, limited information exists on the antiviral activity of the compounds extracted from chaga.

King Oyster · 2014 · Journal Article · Journal of the science of food and agriculture

Antiproliferative and immunostimulatory activity of a protein from Pleurotus eryngii

BACKGROUND: Currently, the use of mushrooms as functional foods, nutraceuticals or phytopharmaceuticals source has risen. In contrast, the possible cellular cytotoxicity and immunostimulatory activity of Pleurotus eryngii (DC.

OncologyEnergy & fatigueRespiratory

Chaga · 2014 · Journal Article · Journal of photochemistry and photobiology. B, Biology

Mycosynthesis: antibacterial, antioxidant and antiproliferative activities of silver nanoparticles synthesized from Inonotus obliquus (Chaga mushroom) extract.

In the present study, silver nanoparticles (AgNPs) were rapidly synthesized from silver nitrate solution at room temperature using Inonotus obliquus extract. The mycogenic synthesized AgNPs were characterized by UV-Visible absorption spectroscopy, Fourier transform infrared (FTIR), scanning electron microscopy (SEM)….

King Oyster · 2014 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice.

Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects.

Almond Mushroom · 2013 · Journal Article · Clinical journal of gastroenterology

Drug-induced liver injury associated with Agaricus blazei Murill which is very similar to autoimmune hepatitis.

Agaricus blazei Murill (ABM) is one of the most popular complementary alternative medicines (CAM). We experienced a case of a 60-year-old woman with severe hepatitis associated with extract of ABM and extract of Ganoderma lucidum, and a case of a 75-year-old man with drug-induced liver injury (DILI) associated with….

OncologyGut & microbiomeRespiratory

Lion's Mane · 2013 · Journal Article · Journal of agricultural and food chemistry

Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice.

This study investigated the antimetastatic activity of four Hericium erinaceus edible mushroom extracts using CT-26 murine colon carcinoma cells as an indicator of inhibition of cell migration to the lung. Hot water (HWE) and microwaved 50% ethanol (MWE) extracts of H..

Shiitake · 2013 · Research Article · The plant pathology journal

Occurrence of dsRNA Mycovirus (LeV-FMRI0339) in the Edible Mushroom Lentinula edodes and Meiotic Stability of LeV-FMRI0339 among Monokaryotic Progeny.

dsRNA was found in malformed cultures of Lentinula edodes strain FMRI0339, one of the three most popular sawdust cultivated commercial strains of shiitake, and was also found in healthy-looking fruiting bodies and actively growing mycelia..

Immune supportEnergy & fatigueRespiratory

Chaga · 2012 · Journal Article · Aquaculture

Effect of Inonotus obliquus enriched diet on hematology, immune response, and disease protection in kelp grouper, Epinephelus bruneus against Vibrio harveyi

The aim of the present study was to determine the changes in the hematological and immunological response in kelp grouper Epinephelus bruneus against Vibrio harveyi infection after fed with 0%, 0.1%, 1.0%, and 2.0% Chaga mushroom, Inonotus obliquus extract enriched diet..

Shiitake · 2012 · Research Article · Virology journal

Molecular characterization of a novel mycovirus in the cultivated mushroom, Lentinula edodes.

BACKGROUND: In the 1970s, mycoviruses were identified that infected the edible mushroom Lentinula edodes (shiitake), but they were not regarded as causal agents for mushroom diseases. None of their genes has been sequenced..

Chaga · 2011 · Journal Article · Chinese journal of integrative medicine

Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549.

OBJECTIVE: To observe the proliferation inhibition, apoptosis, and cell proliferation cycle of human lung carcinoma cell line A549 treated with Inotodiol extracts from Inonotus obliquus and explore the possibility of Inotodiol extracts from Inonotus obliquus as a new tumor chemopreventive drug..

Chaga · 2010 · Research Article · Nutrition research and practice

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.

The Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat cancers. However, limited information exists on the underlying anticancer effects of the major component of I.

OncologyRespiratory

Mesima · 2009 · Research Article · Mycobiology

Anti-cancer Activities of Ginseng Extract Fermented with Phellinus linteus.

In the present study, the anti-cancer effects of ginseng fermented with Phellinus linteus (GFPL) extract were examined through in vitro and in vivo assays. GFPL was produced by co-cultivating ginseng and Phellinus linteus together..

Gut & microbiomeRespiratory

King Oyster · 2007 · Journal Article · Biotechnology letters

Isolation and characterization of a novel mycovirus, PeSV, in Pleurotus eryngii and the development of a diagnostic system for it

A novel mycovirus was isolated from a cultivated edible mushroom, Pleurotus eryngii, with severe epidemic symptoms. Purification of the virus was carried out by a sequential procedure of polyethylene glycol precipitation, differential centrifugation, and equilibrium centrifugation in a CsCl gradient..

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · PloS one

Isolation and identification of bioactive compounds from Antrodia camphorata against ESKAPE pathogens.

Antimicrobial resistance is a major threat to human health globally. Antrodia camphorata was grown in a malt/yeast extract broth liquid medium for 15 days.

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · Organic & biomolecular chemistry

Regio-specific enzymatic glucosylation of triterpenoids from Antrodia camphorata and their biological activities.

The bacterial glycosyltransferase YjiC1 was used to glycosylate triterpenoids from the medicinal fungus Antrodia camphorata. Eleven new compounds were obtained from enzymatic reactions..

Immune supportEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · PloS one

The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics.

Ophiocordyceps sinensis is a fungus with medicinal value in treating lung diseases, but no study has reported how to prevent acute lung injury using this fungus. The mice were divided into normal, model, positive control, and O..

Reishi · 2022 · Video Audio Media · Journal of visualized experiments: JoVE

Co-Fermentation of Marsdenia tenacissima with Ganoderma lucidum and Anti-Lung Cancer Effect of the Fermentation Products.

Marsdenia tenacissima (Roxb.) Wight et Arn. (MT), as a traditional Chinese and Dai herbal medicine, has anti-inflammatory, antibacterial, and antitumor properties.

OncologyGut & microbiomeRespiratory

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Journal of virological methods

Curing two predominant viruses occurring in Lentinula edodes by chemotherapy and mycelial fragmentation methods.

Previous research has established that Lentinula edodes mycovirus HKB (LeV-HKB) and L. edodes partitivirus 1(LePV1) are major mycoviruses identified in L.edodes germplasm..

Turkey Tail · 2022 · Research Support, Non U.S. Gov'T · Viruses

β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection.

Coriolus versicolor (C. versicolor) is a higher fungi or mushroom which is now known by its accepted scientific names as Trametes versicolor (L.) Lloyd.

Lion's Mane · 2021 · Journal Article · Journal of food biochemistry

Prospecting medicinal properties of Lion's mane mushroom.

Hericium erinaceus (Bull.) Persoon, a popular medicinal edible mushroom, owns a long history of usage in traditional Chinese medicine and also in other oriental countries. Along with this, its several bioactive compounds have been evolved into food supplements..

OncologyRespiratory

Energy & fatigueMetabolic healthRespiratory

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Translational research: the journal of laboratory and clinical medicine

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.

Ophiocordyceps sinensis (OCS), an entomopathogenic fungus, is known to exert antiproliferative and antitissue remodeling effects. Vascular remodeling and vasoconstriction play critical roles in the development of pulmonary hypertension (PH)..

Reishi · 2026 · Journal Article · Journal of natural medicines

Anti-asthmatic effects and ingredient annotation of the active fraction from Ganoderma lucidum.

This research aims to screen the active fraction and explore the action mechanism of Ganoderma lucidum to combat asthma using asthmatic mice induced by OVA. In this study, three Ganoderma lucidum fractions, including GLEF40, GLEF60, and GLEF100, were obtained through the separation of D101 macroporous adsorption….

Nameko · 2025 · Preprint · journal metadata

A novel narnavirus isolated from the edible fungus Pholiota nameko

Abstract A novel positive single-stranded RNA virus, tentatively named “Pholiota nameko narnavirus 1” (PnNV1), has been identified in an edible fungus Pholiota nameko strain N1..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

DCs-targeted full-cell nanovaccine based on chitosan oligosaccharide self-assembled with ganoderma lucidum polysaccharide for enhancing tumor immunotherapy.

Tumor vaccines, designed to deliver immunogenic antigens and initiate tumor-specific immune responses, hold significant promise for cancer prevention and therapy. However, their efficacy remains limited by the inherently low immunogenicity of tumor antigens and inefficient antigen presentation..

OncologyGut & microbiomeSkin & hydrationRespiratory

Yellow Morel · 2025 · Journal Article · International journal of medicinal mushrooms

Methanolic Extract of Morchella esculenta (Ascomycota) Prevents Chemotherapy-Related Cardiotoxicity in Tumor-Bearing Mice.

The quest for bioactives that confer protection against chemotherapy induced cardio toxicity is a front-line area of cardio oncology research. Species of genus Morchella have been used in traditional medicine to treat asthma, wound healing, cough, cold, indigestion, excessive phlegm and breathlessness.

Energy & fatigueRespiratory

Shiitake · 2025 · Preprint · journal metadata

Physical Intervention Strategy for Postharvest Shiitake Mushrooms Quality Improvement: Partial Water Loss-Induced Delay of Spore Discharge via Energy Metabolism Maintenance

Abstract Spore discharge of postharvest shiitake mushrooms represents a critical turning point in quality deterioration, necessitating the development of effective intervention strategies to delay this process..

Cordyceps · 2024 · Preprint · journal metadata

Cordyceps Sinensis Mycelium polysaccharides CP1 display anti-lung cancer activity mediated by inhibiting M2 polarization of tumor-associated macrophages

Cordyceps sinensis mycelium polysaccharide has been reported to regulate immune function, but its anti-lung cancer efficacy and its role in regulating the polarization of TAMs remain unelucidated..

Cordyceps · 2024 · Preprint · journal metadata

Identification of a novel member of the genus Laulavirus (family Phenuiviridae) from the entomopathogenic ascomycete fungus Cordyceps javanica

Abstract The virus family Phenuiviridae (order Bunyavirales, comprising segmented negative-sense single stranded RNA viruses) has highly diverse members that are known to infect animals, plants, protozoans and fungi..

Oyster Mushroom · 2020 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Efficacy of Pleuran (β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection.

One of the highly prevalent viral pathogens among children and adults causing infection, clinically presenting as herpes labialis, is herpes simplex virus type 1 (HSV-1). The long-term administration of acyclovir, a standard regimen for therapy against HSV-1 infections, can cause viral resistance against this drug..

Oyster Mushroom · 2020 · Journal Article · International journal of medicinal mushrooms

Ergosterol Peroxide Isolated from Oyster Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes), Potentially Induces Radiosensitivity in Cervical Cancer.

Every year, more than 500,000 new cases of cervical cancer are reported, making it the fourth leading cause of cancer globally. Although human papillomavirus (HPV) vaccines show promise as a protective measure, HPV-related cancers remain a public health problem since the vaccines, which are only specific to certain….

OncologyCognition & nervesEnergy & fatigueRespiratory

Lion's Mane · 2020 · Research Article · International journal of molecular sciences

Hericium Erinaceus Prevents DEHP-Induced Mitochondrial Dysfunction and Apoptosis in PC12 Cells.

Hericium Erinaceus (HE) is a medicinal plant known to possess anticarcinogenic, antibiotic, and antioxidant activities. It has been shown to have a protective effect against ischemia-injury-induced neuronal cell death in rats..

Turkey Tail · 2020 · Research Article · 3 Biotech

In vitro bioactivity, antimicrobial and anti-inflammatory efficacy of modified solvent evaporation assisted Trametes versicolor extract.

In the present study, modified solvent evaporation assisted methanolic Trametes versicolor extract was evaluated for its antimicrobial and anti-inflammatory efficacy..

Oyster Mushroom · 2020 · Journal Article · PloS one

Interruption of an MSH4 homolog blocks meiosis in metaphase I and eliminates spore formation in Pleurotus ostreatus.

Pleurotus ostreatus, one of the most widely cultivated edible mushrooms, produces high numbers of spores causing severe respiratory health problems for people, clogging of filters and spoilage of produce. A non-sporulating commercial variety (SPOPPO) has been successfully introduced into the market in 2006..

OncologyGut & microbiomeRespiratory

Lion's Mane · 2020 · Journal Article · Food & function

Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans.

This research examined the antioxidant abilities of peptides derived from the Hericium erinaceus mushroom produced via three microbial proteases (Alcalase®, Neutrase®, and Flavourzyme®) at varying concentrations of 10, 25, and 50 mg mL-1. The H..

OncologyImmune supportEnergy & fatigueRespiratory

Yellow Morel · 2019 · Journal Article · International journal of biological macromolecules

Anti-inflammatory effects of Morchella esculenta polysaccharide and its derivatives in fine particulate matter-treated NR8383 cells.

Fine particulate matter (PM2.5) exposure could cause many acute and chronic respiratory diseases. In this study the protective effects of polysaccharide from Morchella esculenta (FMP-1) and its derivatives against PM2.5-induced inflammation were evaluated..

Immune supportLiver supportRespiratory

Enoki · 2019 · Research Article · Food technology and biotechnology

Development of a Transgenic Flammulina velutipes Oral Vaccine for Hepatitis B.

Orally administered fungal vaccines show promise for the prevention of infectious diseases. Edible mushrooms are deemed appropriate hosts to produce oral vaccines due to their low production cost and low risk of gene contamination..

Energy & fatigueRespiratory

Maitake · 2019 · Journal Article · Mycoscience

Mitochondrial DNA dynamics during fruiting body formation in Grifola frondosa

In the present study, the copy number of mitochondrial DNA in Grifola frondosa was estimated at several developmental stages by quantitative real-time PCR, revealing that it decreases gradually during fruiting body development..

Immune supportGut & microbiomeRespiratory

Lion's Mane · 2019 · Journal Article · International journal of biological macromolecules

Transcriptome analysis of the effects of Hericium erinaceus polysaccharide on the lymphocyte homing in Muscovy duck reovirus-infected ducklings.

Hericium erinaceus polysaccharide (HEP) is a bioactive substance present in the fruiting bodies of H. erinaceus.