MycoData

BACKGROUND: Natural products, especially those with high contents of phytochemicals, are promising alternative medicines owing to their antitumor properties and few side effects..

OncologyImmune support

Medium relevance

Lion's Mane · 2021 · Journal Article · Food & function

Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL.

Erinacine S, the new bioactive diterpenoid compound isolated from the ethanol extract of the mycelia of Hericium erinaceus, displays great health-promoting properties. However, the effects of erinacine S on inductive apoptosis in cancer cells such as gastric cancer and its molecular mechanisms remain unclear..

OncologyImmune supportCognition & nerves

Medium relevance

Agarikon · 2021 · Journal Article · International journal of medicinal mushrooms

Effect of Cytokinin-Containing Extracts from Some Medicinal Mushroom Mycelia on HepG2 Cells In Vitro.

Endogenous cytokinins in mycelia of medicinal mushrooms Hericium coralloides and Fomitopsis officinalis grown in vitro were identified using high-performance liquid chromatography coupled with mass spectrometry. High amounts of zeatin-type cytokinins and isopentenyladenine were found..

OncologyEnergy & fatigueMetabolic health

Medium relevance

Shiitake · 2021 · Journal Article · Food & function

Effects of fungal beta-glucans on health - a systematic review of randomized controlled trials.

INTRODUCTION: Beta-glucans are polysaccharides that exhibit a wide range of biological properties as a result of their varying chemical composition. Like all dietary fibers, they avoid catabolism in the upper gastrointestinal tract, and they reach the large intestine undigested..

OncologyImmune supportGut & microbiomeRespiratory

Medium relevance

Shiitake · 2021 · Journal Article · Clinical nutrition (Edinburgh, Scotland)

Fungal beta-glucans as adjuvants for treating cancer patients - A systematic review of clinical trials.

BACKGROUND & AIMS: Fungal β-glucans have been considered as biological response modifiers (BRMs) promoting stimulation of immune system according to numerous scientific publications performed in vitro and in vivo. Some clinical trials involving such compounds started to be published since 1980's..

OncologyImmune supportCognition & nerves

Medium relevance

Mesima · 2021 · Research Article · Experimental and therapeutic medicine

Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling.

Neuroinflammation is associated with many neurodegenerative diseases. Abnormal activation of microglial cells in the central nervous system (CNS) is a major characteristic of neuroinflammation..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Mesima · 2021 · Research Article · Molecules (Basel, Switzerland)

Hispolon Induces Apoptosis, Suppresses Migration and Invasion of Glioblastoma Cells and Inhibits GBM Xenograft Tumor Growth In Vivo.

Hispolon, a polyphenol compound isolated from Phellinus linteus, has been reported to exhibit antioxidant, antiproliferative, and antitumor activities. This study aimed to explore the antitumor effects of hispolon on glioblastoma multiforme (GBM) cells in vitro and in vivo..

OncologySkin & hydration

Medium relevance

Zhu Ling · 2021 · Research Article · BMC complementary medicine and therapies

Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment.

BACKGROUND: Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activities..

OncologyImmune supportLiver support

Medium relevance

Chaga · 2021 · Journal Article · International immunopharmacology

Inonotsuoxide B regulates M1 to M2 macrophage polarization through sirtuin-1/endoplasmic reticulum stress axis.

We explored the effect of tetracyclic triterpenoid inonotsuoxide B (IB) extracts of Inonotus obliquus on M1 to M2 macrophage polarization and its possible underlying mechanism..

OncologyImmune support

Medium relevance

Turkey Tail · 2021 · Research Article · Polymers

Laccase-Mediator System Using a Natural Mediator as a Whitening Agent for the Decolorization of Melanin.

In this study, a laccase-mediator system (LMS) using a natural mediator was developed as a whitening agent for melanin decolorization. Seven natural mediators were used to replace synthetic mediators and successfully overcome the low redox potential of laccase and limited access of melanin to the active site of….

OncologySkin & hydration

Medium relevance

Turkey Tail · 2021 · Research Article · Journal of environmental health science & engineering

Removal of two cytostatic drugs: bleomycin and vincristine by white-rot fungi - a sorption study.

PURPOSE: Cytostatic drugs cannot be easily removed by conventional sewage treatment plants, resulting in their ultimate release into aquatic systems where they become a threat..

Oncology

Medium relevance

Shiitake · 2021 · Research Article · Pharmaceuticals (Basel, Switzerland)

The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine.

The AHCC standardized extract of cultured Lentinula edodes mycelia, and the standardized extract of Asparagus officinalis stem, trademarked as ETAS, are well known supplements with immunomodulatory and anticancer potential..

OncologyImmune supportGut & microbiome

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Journal of hazardous materials

White-rot fungi-mediated biodegradation of cytostatic drugs - bleomycin and vincristine.

The contamination of the environment with anticancer drugs, which show recalcitrance to conventional wastewater treatment, has become a significant ecological threat. Fungi represent a promising non-conventional biological alternative for water conditioning..

Oncology

Medium relevance

Enoki · 2007 · Research Article · Nutrition research and practice

Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2).

Cytoprotective ability of polysaccharides isolated from different edible mushrooms was investigated on the 7-ketocholesterol-induced damaged cell line. Polysaccharide extracts from six different edible mushrooms-Flammulina velutipes, Peurotus ostreatus, Lentinus edodes, Agrocybe aegerita, Agaricus blazei, and….

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Enoki · 2006 · Journal Article · Oncology reports

In vitro effects on proliferation, apoptosis and colony inhibition in ER-dependent and ER-independent human breast cancer cells by selected mushroom species.

Breast cancer is the most commonly diagnosed cancer among women in Western countries. Currently, there is no effective therapy for malignant estrogen-independent breast cancer..

OncologyGut & microbiome

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · PLoS computational biology

Calibrating agent-based models to tumor images using representation learning.

Agent-based models (ABMs) have enabled great advances in the study of tumor development and therapeutic response, allowing researchers to explore the spatiotemporal evolution of the tumor and its microenvironment..

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Cancer communications (London, England)

Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.

BACKGROUND: Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2 (HER2)-positive gastric cancer. However, the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit, and there is currently no effective reversal measure..

OncologyImmune supportMetabolic healthSkin & hydration

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Toxicology

Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis.

Indiscriminate use of pesticides not only leads to environmental pollution problems, but also causes poisoning of non-target organisms. Abamectin (ABM), a widely used insecticide worldwide, is of wide concern due to its persistence in the environment and its high toxicity to fish..

OncologyImmune supportEnergy & fatigue

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · PLoS computational biology

Quantification of spatial and phenotypic heterogeneity in an agent-based model of tumour-macrophage interactions.

We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial relationships between points marked with combinations of discrete and continuous labels..

OncologyImmune support

Medium relevance

Almond Mushroom · 2023 · Research Support, N.I.H., Intramural · British journal of cancer

Radiation exposure and leukaemia risk among cohorts of persons exposed to low and moderate doses of external ionising radiation in childhood.

BACKGROUND: Many high-dose groups demonstrate increased leukaemia risks, with risk greatest following childhood exposure; risks at low/moderate doses are less clear..

Oncology

Medium relevance

Almond Mushroom · 2022 · Research Support, Non U.S. Gov'T · Journal of urban health: bulletin of the New York Academy of Medicine

Patient Navigation Can Improve Breast Cancer Outcomes among African American Women in Chicago: Insights from a Modeling Study.

African American (AA) women experience much greater mortality due to breast cancer (BC) than non-Latino Whites (NLW). Clinical patient navigation is an evidence-based strategy used by healthcare institutions to improve AA women's breast cancer outcomes..

Oncology

Medium relevance

Almond Mushroom · 2022 · Research Support, Non U.S. Gov'T · PLoS computational biology

Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model.

Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM) are powerful and efficient approaches for the analysis of biological systems and for clinical applications..

OncologyImmune support

Medium relevance

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · PLoS computational biology

Bayesian calibration of a stochastic, multiscale agent-based model for predicting in vitro tumor growth.

Hybrid multiscale agent-based models (ABMs) are unique in their ability to simulate individual cell interactions and microenvironmental dynamics. Unfortunately, the high computational cost of modeling individual cells, the inherent stochasticity of cell dynamics, and numerous model parameters are fundamental….

OncologyMetabolic health

Medium relevance

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · BMC immunology

Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma.

BACKGROUND: This study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL). METHODS: A total of 32 patients with ARL participated in this study..

OncologyImmune support

Medium relevance

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · Journal of comparative effectiveness research

Matching-adjusted indirect comparison of palbociclib versus ribociclib and abemaciclib in hormone receptor-positive/HER2-negative advanced breast cancer.

Aim: Palbociclib (PAL), ribociclib (RIB) and abemaciclib (ABM), in combination with fulvestrant (FUL), are approved for the treatment of hormone receptor-positive, HER2-negative advanced breast cancer..

Oncology

Medium relevance

Almond Mushroom · 2020 · Journal Article · Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine

ABM Clinical Protocol #34: Breast Cancer and Breastfeeding.

A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success..

Oncology

Medium relevance

Shiitake · 2020 · Journal Article · The Science of the total environment

β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies.

Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death..

OncologyImmune supportRespiratory

Medium relevance

Wood Ear · 2019 · Journal Article · International journal of medicinal mushrooms

Aqueous Extract of Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), Demonstrated Antiepileptic Activity against Seizure Induced by Maximal Electroshock and Isoniazid in Experimental Animals.

Auricularia polytricha is a popular mushroom found all over the world. This article describes a study of the antiepileptic effect of A.

OncologyMetabolic healthRespiratory

Medium relevance

Shiitake · 2019 · Journal Article · International journal of biological macromolecules

Mycelial polysaccharides of Lentinus edodes (shiitake mushroom) in submerged culture exert immunoenhancing effect on macrophage cells via MAPK pathway.

A crude polysaccharide fraction (termed cLEP) and two derived fractions (termed LEP1 and LEP2) from Lentinus edodes mycelia were purified and characterized. LEP1/-2 were classified as α-type heteropolysaccharides with 1 → 2, 1 → 3, 1 → 4, 1 → 6 linkages..

OncologyImmune support

Medium relevance

Shiitake · 2018 · Journal Article · International journal of medicinal mushrooms

Expression and Antitumor Function of Latcripin-4 RCC1 and ANK Domain Protein on HepG2 from the Shiitake Medicinal Mushroom, Lentinus edodes C91-3 (Agaricomycetes), Transcriptome.

The recombinant protein of Latcripin-4 regulator of chromosome condensation 1 (RCC1) and ankyrin (ANK) domains were expressed and the antitumor activity of Latcripin-4 on HepG2 cells was studied..

OncologyLiver support

Medium relevance

Reishi · 2018 · Journal Article · IEICE Transactions on Communications

Smart Farm: Applying the Use of NodeMCU, IOT, NETPIE and LINE API for a Lingzhi Mushroom Farm in Thailand

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in IEICE Transactions on Communications in 2018. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Shiitake · 2017 · Journal Article · International journal of medicinal mushrooms

Characterization and Antiproliferative Effect of Novel Acid Polysaccharides from the Spent Substrate of Shiitake Culinary-Medicinal Mushroom Lentinus edodes (Agaricomycetes) Cultivation.

In this study, a high yield of crude polysaccharide (16.73 ± 0.756%) was extracted from the spent mushroom substrate of Lentinus edodes using a hot alkali extraction method..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Shiitake · 2017 · Journal Article · International journal of medicinal mushrooms

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats.

Lentinus edodes is a culinary-medicinal mushroom that has an established history of use in Asian therapies. The mushroom offers well-documented beneficial health effects such as antihypercholesterolemic, antitumor, and antibacterial activities.

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Shiitake · 2017 · Journal Article · International journal of medicinal mushrooms

Turmeric Bioprocessed with Mycelia from the Shiitake Culinary-Medicinal Mushroom Lentinus edodes (Agaricomycetes) Protects Mice Against Salmonellosis.

This study investigated the suppressive mechanisms of an extract from bioprocessed Lentinus edodes mycelial liquid culture supplemented with turmeric (bioprocessed Curcuma longa extract [BPCLE]) against murine salmonellosis..

OncologyImmune supportGut & microbiomeLiver support

Medium relevance

Shiitake · 2016 · Journal Article · International journal of medicinal mushrooms

Assessment of the Safety of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), in Rats: Biochemical, Hematological, and Antioxidative Parameters.

Lentinus edodes is an edible mushroom studied for use, or as an adjunct, in the prevention of illnesses such as hypertension, hypercholesterolemia, diabetes, and cancer. Despite the functional properties of L.

OncologyMetabolic healthLiver support

Medium relevance

Reishi · 2016 · Journal Article · Mycoscience

The identification of microRNAs in Ganoderma lingzhi sporocarp

Ganoderma lingzhi is a kind of precious medicinal mushroom. MicroRNAs (miRNAs) play an important role in the regulation of a broad range of biological processes.

Oncology

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · Journal of cellular biochemistry

3,4-dihydroxybenzalacetone protects against Parkinson's disease-related neurotoxin 6-OHDA through Akt/Nrf2/glutathione pathway.

UNLABELLED: Oxidative stress is implicated in the pathogenesis of various neurodegenerative diseases including Parkinson's disease (PD). 3,4-Dihydroxybenzalacetone (DBL) is a small catechol-containing compound isolated from Chaga (Inonotus obliquus [persoon] Pilat), and has been reported to have beneficial….

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Maitake · 2010 · Patent · journal metadata

Adonis amurensis edible fungus preparation and preparation method thereof

The invention relates to a special dietary preparation and a preparation method thereof, wherein the special dietary preparation can improve human immunity and has a better food therapy action on the aspects of preventing and curing tumors..

OncologyImmune supportGut & microbiome

Medium relevance

Maitake · 2009 · Patent · journal metadata

Anti-tumor pharmaceutical composition and preparation method thereof

The invention relates to an anti-tumor pharmaceutical composition and a preparation method thereof, and belongs to the technical field of bio-pharmaceuticals. The pharmaceutical composition comprises the following components: 20 to 60 percent of extract of brown heart rot of cinnamomum kanehirai, 5 to 30 percent of….

OncologyImmune support

Medium relevance

Enoki · 2009 · Patent · journal metadata

Preparation and use of recombinant gold needle mushroom immunomodulatory protein

The invention discloses a preparation method and application of a recombinant flammulina velutipes immunomodulatory protein that is expressed by Pasteur pichia pastoris, and the preparation method comprises following steps: (1) an encoding FIP-fve gene is cloned (2) a recombinant Pasteur pichia pastoris expression….

OncologyImmune support

Medium relevance

Maitake · 2009 · Patent · journal metadata

Traditional Chinese composition for treating tumor and production method thereof

The invention relates to a traditional Chinese medicine composition for treating tumors, the traditional Chinese medicine composition comprises ganoderma lucidum, ganoderma sinensis, coriolus versicolor, antrodia camphorate, agaricus blazei, grifola frondosa, ginseng and ganoderma lucidum spore oil or the traditional….

OncologyImmune support

Medium relevance

Mesima · 2008 · Patent · journal metadata

BREWING KOJI WITH IMPROVED ANTIOXIDANT ACTIVITY AND METHOD OF PRODUCING SAKE THEREOF

A brewing koji having improved antioxidant activity is provided to improve antioxidant activity of liquor without affecting flavors, so that the liquor having improved antioxidant activity is useful for prevention of aging, adult diseases and cancer caused by accumulation of reactive oxygen..

OncologyEnergy & fatigueMetabolic health

Medium relevance

Mesima · 2008 · Patent · journal metadata

FUNCTIONAL BREAD MANUFACTURING METHOD

A method of manufacturing functional bread by fermenting Phellinus linteus mycelium and brown rice flour and kneading with bread material is provided to ensure the efficacy of Phellinus linteus mycelium and brown rice such as anticancer effect and immune function..

OncologyImmune support

Medium relevance

Chaga · 2008 · Research Support, Non U.S. Gov'T · Molecular cancer therapeutics

Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.

3,4-dihydroxybenzalacetone (DBL) is a polyphenol derived from the medicinal plant Chaga [Inonotus obliquus (persoon) Pilat]. Although Chaga is used in Russia folk medicine to treat tumors, very little is known about its mechanism of action..

OncologyImmune supportSkin & hydration

Medium relevance

Mesima · 2006 · Patent · journal metadata

HERB SOY SAUCE AND PRODUCING METHOD THEREOF

Provided are a soy sauce of traditional oriental medicine having anticancer effect, fatigue recovery, immunity augmentation, and a method for preparing the soy sauce by heating medicinal herbs including a young antlers of the deer, ginseng steamed red, Phellinus linteus, and vegetable worms in water, and extracting….

OncologyImmune supportEnergy & fatigue

Medium relevance

Maitake · 2004 · Journal Article · Veterinary therapeutics: research in applied veterinary medicine

Potential growth inhibitory effect of maitake D-fraction on canine cancer cells.

The postulated anticancer effect of D-fraction, the bioactive extract of maitake mushroom, on three types (CF33, CF21, and CL-1) of canine cancer cells was evaluated. The effect of D-fraction on several human cancer cells was also investigated.

OncologyImmune support

Medium relevance

Maitake · 2002 · Journal Article · Journal of alternative and complementary medicine (New York, N.Y.)

Chemosensitization of carmustine with maitake beta-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I.

OBJECTIVE: To improve the poor efficacy (< 10%) of chemotherapy for patients with hormone-refractory prostate cancer, we investigated a possible cytotoxic effect of carmustine/beta-glucan combination on prostatic cancer PC-3 cells, focusing on a glutathione-dependent detoxifying enzyme, glyoxalase I (Gly-I)..

OncologyImmune support

Medium relevance

Lion's Mane · 2020 · Review · Pharmacological research

Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities.

The presence of a fused 5/6/7 tricyclic core characterizes the group of cyathane diterpene natural products, that include more than 170 compounds, isolated from fungi such as Cyathus africanus and Hericium erinaceus..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Mesima · 2020 · Review · Environmental research

Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways.

Nature as an infinite treasure of chemotypes and pharmacophores will continue to play an imperative role in the drug discovery. Natural products (NPs) such as plant and fungal metabolites have emerged as leads in drug discovery during recent years due to their efficacy, safety and selectivity..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Almond Mushroom · 2020 · Review · Frontiers in pharmacology

Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review.

Medicinal mushrooms are widely used in East Asia for the treatment of various diseases, especially in complementary cancer care. While there is a growing interest in medicinal mushrooms in Western countries and an increasing number of pre-clinical studies indicate distinct anti-cancer and regenerative properties,….

OncologyImmune supportGut & microbiome