MycoData

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2025 · Review · NPJ science of food

Application of edible fungi in gut microbiota regulation.

The human gut microbiota serves as a critical hub for host metabolic and immune regulation. Disruption of its homeostasis is closely associated with diseases such as Inflammatory Bowel Disease (IBD), metabolic syndrome, and colorectal cancer..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Cordyceps-Fermented Chinese Jujube Ameliorates Oxidative Stress and Restores Gut Microbiome in Alcohol-Induced Liver Injury in Mice.

This research investigated the influence of Chinese jujube fermented with Cordyceps kyushuensis extracts on mice with alcohol-induced liver injury (ALI). Our findings highlighted the antioxidant properties of these extracts through various assays and demonstrated potential biochemical effects in ALI mice..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2025 · Review · Journal of ethnopharmacology

Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderic acid A (GAA, C30H44O7) is one of the most abundant and active components of Ganoderic acids (GAs). GAs are highly oxidized tetracyclic triterpenoid compounds mainly derived from Ganoderma lucidum (Curtis) P.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Macromycete Edible Fungi as a Functional Poultry Feed Additive: Influence on Health, Welfare, Eggs, and Meat Quality-Review.

Over the years, macromycete fungi have been used as a source of food, part of religious rites and rituals, and as a medicinal remedy. Species with strong health-promoting potential include Hericium erinaceus, Cordyceps militaris, Ganoderma lucidum, Pleurotus ostreatus, Flammulina velutipes, and Inonotus obliquus..

Immune supportRespiratory

Oyster Mushroom · 2025 · Randomized Controlled Trial · Advances in therapy

Novel Chewable Pleuran-Based Supplement Decreases Respiratory Tract Infections in Children: A Randomised Controlled Trial.

INTRODUCTION: Recurrent respiratory tract infections (RRTIs) are common in childhood and impose substantial socioeconomic burden. β-Glucans, particularly pleuran from Pleurotus ostreatus, demonstrate immunomodulatory properties through the pathogen-associated molecular pattern receptor interactions..

Immune supportMetabolic healthGut & microbiome

Shiitake · 2025 · Preprint · journal metadata

Valorization of mushroom by-products for sustainability: exploring antioxidant and prebiotic properties

Agaricus bisporus (white button mushroom), Pleurotus ostreatus (oyster mushroom), and Lentinula edodes (shiitake mushroom) are the most cultivated mushrooms in the Spanish region of Castilla-La Mancha..

OncologyImmune supportLiver support

Almond Mushroom · 2024 · Review · Journal of agricultural and food chemistry

Chemical Structures, Biological Activities, and Biosynthetic Analysis of Secondary Metabolites from Agaricus Mushrooms: A Review.

Agaricus mushrooms are an important genus in the Agaricaceae family, belonging to the order Agaricales of the class Basidiomycota. Among them, Agaricus bisporus is a common mushroom for mass consumption, which is not only nutritious but also possesses significant medicinal properties such as anticancer, antibacterial,….

OncologyImmune supportCognition & nervesMetabolic health

King Oyster · 2024 · Preprint · journal metadata

Olive mill solid waste induces beneficial mushroom-specialized metabolite diversity revealed by computational metabolomics strategies

Introduction Mushrooms contain besides proteins a diverse pallet of specialized metabolites bioactive in either beneficial or harmful manner. Therefore, mushrooms have been exploited by humans for centuries for dietary or medical purposes..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

A New Galactoglucomannan from the Mycelium of the Medicinal Parasitic Fungus Cordyceps cicadae and Its Immunomodulatory Activity In Vitro and In Vivo.

A new galactoglucomannan (C-0-1) was purified from the medicinal parasitic fungus of Cordyceps cicadae using an anion-exchange column and gel permeation column. The results of high-performance liquid chromatography and high-performance gel permeation chromatography indicated that C-0-1 consists of galactose, glucose,….

Immune supportGut & microbiome

Reishi · 2023 · Journal Article · Archives of microbiology

Application of Miscanthus substrates in the cultivation of Ganoderma lingzhi.

Ganoderma lingzhi is a traditional Chinese medicine that has been used to improve health and longevity for thousands of years. It is usually cultivated on hardwood log- or sawdust-based formulations.

Shiitake · 2023 · Journal Article · International journal of biological macromolecules

Characterization of an active film prepared with Lentinus edodes (shiitake) polysaccharide and its effect on post-harvest quality and storage of shiitake.

The aim of this study was to prepare a film based on shiitake (Lentinus edodes) stalk polysaccharides (LEP) for mushroom preservation. The effects of different LEP concentrations on physical, mechanical, antioxidant, and antimicrobial properties of the prepared film were evaluated..

Cordyceps · 2023 · Journal Article · Journal of ethnopharmacology

Cordyceps proteins alleviate lupus nephritis through modulation of the STAT3/mTOR/NF-кB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps is a parasitic edible fungus, which is a unique Chinese medicinal material. It has been reported to have immunomodulatory effects and use in kidney disease.

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2023 · Journal Article · Journal of natural medicines

Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity.

Chinese cordyceps, also known as Dong-Chong-Xia-Cao, is widely recognized as a famous precious tonic herb, and used as traditional Chinese medicine for centuries..

Shiitake · 2023 · Journal Article · Foods (Basel, Switzerland)

Effect of Different Cooking Methods on the Bioactive Components, Color, Texture, Microstructure, and Volatiles of Shiitake Mushrooms.

The effects of different cooking methods (steaming, boiling, air frying, and oven baking) and cooking times (0, 5, 10, 15, and 20 min) on the bioactive components (total phenol, total flavonoid, crude polysaccharides, and eritadenine), color, texture, microstructure, and volatiles in shiitake mushrooms were….

OncologyImmune supportEnergy & fatigueSkin & hydration

Cordyceps · 2023 · Research Article · Chinese medicine

Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.

BACKGROUND: Silicosis is an important occupational disease caused by inhalation of free silica and is characterized by persistent pulmonary inflammation, subsequent fibrosis and lung dysfunction. Until now, there has been no effective treatment for the disease due to the complexity of pathogenesis..

Immune supportMetabolic health

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Increased production and anti-senescence activity of exopolysaccharides in Ganoderma lingzhi by co-overexpression of β-1,3-glucan synthase and UDP-glucose pyrophosphorylase.

A β-1,3-glucan synthase gene (gls) was cloned and overexpressed in Ganoderma lingzhi. The content of intracellular polysaccharides (IPS) in G.

Immune supportMetabolic healthLiver supportSkin & hydration

Chaga · 2023 · Research Article · Antioxidants (Basel, Switzerland)

Isolation, Physicochemical Characterization, and Biological Properties of Inotodiol, the Potent Pharmaceutical Oxysterol from Chaga Mushroom.

Inotodiol, an oxysterol found only in Chaga mushroom, has received attention from the pharmaceutical industry due to its strong antioxidant and anti-allergic activities. However, the production of inotodiol is still challenging, and its fundamental properties have yet to be investigated..

OncologyImmune supportSkin & hydration

Chaga · 2023 · Research Article · International journal of molecular sciences

Protective Effects of Lanostane Triterpenoids from Chaga Mushroom in Human Keratinocytes, HaCaT Cells, against Inflammatory and Oxidative Stresses.

Inotodiol, a lanostane-type triterpenoid, and many phytochemicals from Chaga mushrooms have been investigated for various allergic diseases. However, the anti-aging and anti-inflammatory activities of inotodiol under different types of oxidative stress and the impact of inotodiol on collagen and hyaluronan synthesis….

Immune supportMetabolic healthLiver support

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

Structural Characterization and Hypoglycemic Function of Polysaccharides from Cordyceps cicadae.

The polysaccharides isolated and purified from different parts of the medicinal fungus Cordyceps cicadae were identified, and three extracts displaying significant biological activities were selected for further study..

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2023 · Research Article · Antioxidants (Basel, Switzerland)

The Addition of Reishi and Lion's Mane Mushroom Powder to Pasta Influences the Content of Bioactive Compounds and the Antioxidant, Potential Anti-Inflammatory, and Anticancer Properties of Pasta.

The influence of a 2.5% and 5% addition of dried Reishi and Lion's Mane mushrooms on the content of bioactive compounds and some pro-health properties of pasta was studied..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice.

Cordyceps has anti-cancer effects; however, the bioactive substance and its effect are still unclear. Polysaccharides extracted from Cordyceps sinensis, the fugus of Cordyceps, have been reported to have anti-cancer properties..

Shiitake · 2022 · Research Article · Nutrients

Astragalus Shiitake-A Novel Functional Food with High Polysaccharide Content and Anti-Proliferative Activity in a Colorectal Carcinoma Cell Line.

The chemical and nutritional constituents of mushrooms can alter significantly when grown on different substrates. Based on this fact, an approach was made to cultivate a new type of mushroom, Hengshan Astragalus Shiitake, by growing Shiitake mushrooms on beds supplemented with the roots of an edible herbal plant,….

Cordyceps · 2022 · Research Article · Frontiers in pharmacology

Bidirectional regulatory effects of Cordyceps on arrhythmia: Clinical evaluations and network pharmacology.

Background: Cordyceps is a precious Chinese herbal medicine with rich bio-active ingredients and is used for regulating arrhythmia alongside routine treatments. However, the efficacy and potential mechanisms of Cordyceps on patients with arrhythmia remain unclear..

Immune supportCognition & nervesEnergy & fatigue

Nameko · 2022 · Journal Article · Journal of food biochemistry

Chemical properties and anti‐fatigue effect of polysaccharide from Pholiota nameko

The aim of this study was to explore the primary chemical properties and anti‐fatigue effect in vivo of Pholiota nameko polysaccharide (PNP). Through UV‐visible spectrum, the absorption peaks of proteins, nucleic acids and pigments were not found..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2022 · Journal Article · The American journal of Chinese medicine

Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism.

Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of Cordyceps sinensis (BerK.) Sacc.

Immune supportEnergy & fatigueSkin & hydration

Shiitake · 2022 · Research Article · Foods (Basel, Switzerland)

Effect of Electrohydrodynamic (EHD) on Drying Kinetics and Quality Characteristics of Shiitake Mushroom.

The effect of an electrohydrodynamic (EHD) drying system on the drying kinetics, microstructure and nutritional composition of shiitake mushrooms was studied. Shiitake mushroom slices were dried at 0, 18, 22, 26, 30 and 34 kV..

Cordyceps · 2022 · Research Article · Journal of oncology

Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps sinensis in the Treatment of Oral Lichen Planus.

OBJECTIVE: Oral lichen planus (OLP) is the most common potentially malignant disorder of the oral cavity. This study aimed to investigate the mechanism of action of Cordyceps sinensis in the treatment of OLP and provides a theoretical support for improving current treatment regimens for OLP..

Cordyceps · 2022 · Research Article · Frontiers in nutrition

Optimisation of the production of a selenium-enriched polysaccharide from Cordyceps cicadae S1 and its structure and antioxidant activity.

The fermentation medium of a newly identified Cordyceps cicadae S1 was optimized by response surface methodology, with the optimal medium containing sucrose (80 g/L), yeast powder (60 g/L), KH2PO4 (5 g/L), MgSO4·7H2O (1 g/L) and Na2SeO3 (0. 1 g/L)..

Shiitake · 2022 · Journal Article · Journal of the science of food and agriculture

Role of thermal and non‐thermal drying techniques on drying kinetics and the physicochemical properties of shiitake mushroom

BACKGROUND: Fresh shiitake mushrooms are rich in nutrients, but have high water content, a fast metabolism after harvest, and deteriorate extremely easily. Therefore, the drying of shiitake mushrooms has become a research direction..

Immune supportSkin & hydration

Shiitake · 2022 · Journal Article · Clinical toxicology (Philadelphia, Pa.)

Shiitake dermatitis: experience of the Poison Control Centre Network in France from 2014 to 2019.

OBJECTIVE: Shiitake mushrooms (Lentinus edodes) are an edible fungus, initially grown in Japan and China that are increasingly marketed in Europe. We previously presented 15 shiitake dermatitis cases reported to Poison Control Centres (PCCs) in France from January 2000 to December 2013..

Nameko · 2022 · Journal Article · Journal of food biochemistry

Structure characterization and antioxidant activity of carboxymethylated polysaccharide from Pholiota nameko

The objective of this paper was to prepare the carboxymethyl polysaccharide of Pholiota nameko (CPPN) and further evaluate its structural characteristics, water solubility, and antioxidant activities..

Cordyceps · 2021 · Journal Article · Carbohydrate polymers

A specific and bioactive polysaccharide marker for Cordyceps

Cordyceps is one of the most expensive and widely used functional foods. But the authenticity is still a concern due to the lack of appropriate markers.

Cordyceps · 2021 · Journal Article · Carbohydrate polymers

A specific and bioactive polysaccharide marker for Cordyceps.

Cordyceps is one of the most expensive and widely used functional foods. But the authenticity is still a concern due to the lack of appropriate markers.

Shiitake · 2021 · Research Article · Foods (Basel, Switzerland)

An Insight by Molecular Sensory Science Approaches to Contributions and Variations of the Key Odorants in Shiitake Mushrooms.

An insight using molecular sensory science approaches to the contributions and variations of the key odorants in shiitake mushrooms is revealed in this study. Odorants were extracted by headspace solid phase microextraction (HS-SPME) and direct solvent extraction combined with solvent-assisted flavor evaporation….

OncologyImmune supportMetabolic health

Cordyceps · 2021 · Research Article · Journal of diabetes research

Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy.

BACKGROUND: Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus and is a major cause of end-stage kidney disease. Cordyceps sinensis (Cordyceps, Dong Chong Xia Cao) is a widely applied ingredient for treating patients with DN in China, while the molecular mechanisms remain unclear..

Shiitake · 2021 · Journal Article · Food chemistry

Coating shiitake mushrooms (Lentinus edodes) with a polysaccharide from Oudemansiella radicata improves product quality and flavor during postharvest storage.

In this work, we investigated whether coating fresh shiitake mushrooms with a polysaccharide isolated from Oudemansiella radicata (ORWP) would impact key quality characteristics after 18 d of storage at 4 °C..

Cordyceps · 2021 · Journal Article · Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association

Cordyceps cicadae polysaccharides inhibit human cervical cancer hela cells proliferation via apoptosis and cell cycle arrest.

The present study presented the extraction and purification of polysaccharides from artificially cultured Cordyceps cicadae and wild Cordyceps cicadae by pre-soaking ultrasonic water extraction..

Cordyceps · 2021 · Journal Article · Carbohydrate polymers

Cordyceps polysaccharide marker CCP modulates immune responses via highly selective TLR4/MyD88/p38 axis.

Cordyceps, one of the most expensive natural health supplements, is popularly used to modulate immune function. However, little is known regarding the underlying mechanism of its immunomodulatory activity..

OncologyImmune supportMetabolic healthSkin & hydration

Nameko · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Effect of Pholiota nameko Polysaccharides Inhibiting Methylglyoxal-Induced Glycation Damage In Vitro.

Advanced glycation end products (AGEs) can induce oxidative stress and inflammation. AGEs are major risk factors for the development of many aging-related diseases, such as cancer and diabetes.

Immune supportMetabolic healthLiver support

Shiitake · 2021 · Journal Article · Foods (Basel, Switzerland)

Efficacy and Safety of Aronia, Red Ginseng, Shiitake Mushroom, and Nattokinase Mixture on Insulin Resistance in Prediabetic Adults: A Randomized, Double-Blinded, Placebo-Controlled Trial.

We determined whether oral consumption of Aronia, red ginseng, shiitake mushroom, and nattokinase mixture (3.4: 4.1: 2.4: 0.1 w/w; AGM) improved glucose metabolism and insulin resistance in prediabetic adults in a 12-week randomized, double-blinded clinical trial..

Immune supportEnergy & fatigue

Shiitake · 2021 · Journal Article · Journal of the science of food and agriculture

Intensive pulsed light pretreatment combined with controlled temperature and humidity for convection drying to reduce browning and improve quality of dried shiitake mushrooms

BACKGROUND: The change of surface color caused by browning during the drying process of shiitake mushrooms seriously affects its market circulation. Intensive pulsed light (IPL) as a non‐heat‐treatment method can reduce enzyme activity by changing the enzyme structure..

Immune supportEnergy & fatigueRespiratory

Chaga · 2021 · Research Article · Food science & nutrition

Targeting SARS-CoV-2 with Chaga mushroom: An in silico study toward developing a natural antiviral compound.

The novel coronavirus (SARS-CoV-2) has caused large-scale global outbreaks and mainly mediates host cell entry through the interaction of its spike (S) protein with the human angiotensin-converting enzyme-2 (ACE-2) receptor..

Immune supportSkin & hydration

Shiitake · 2020 · Case Reports · The American journal of emergency medicine

Not a fungi to be with: Shiitake mushroom flagellate dermatitis.

Shiitake dermatitis is a rare adverse cutaneous reaction to the ingestion of raw or undercooked shiitake mushrooms (Lentinula edodes). We report the case of a patient who developed a striking linear flagellate dermatitis without urticaria three days after returning from a trip from Tokyo where he had eaten shiitake….

Immune supportSkin & hydration

Shiitake · 2014 · Journal Article · Clinical toxicology (Philadelphia, Pa.)

Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations.

CONTEXT: Shiitake (Lentinula edodes) is an edible mushroom which was initially grown in Japan and China and is now sold on the European market. Flagellate erythema may arise following shiitake consumption and was first described in Japan in 1974.

Chaga · 2013 · Journal Article · International immunopharmacology

Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice.

Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity..

OncologyImmune supportGut & microbiome

Maitake · 2009 · Journal Article · International immunopharmacology

Maitake beta-glucan enhances granulopoiesis and mobilization of granulocytes by increasing G-CSF production and modulating CXCR4/SDF-1 expression.

Previous studies have presented that Maitake beta-glucan (MD-Fraction) extracted from the fruit body of Grifola frondosa has an anti-tumor effect by activating the immune system..

Immune supportRespiratory

Enoki · 2007 · Journal Article · American journal of industrial medicine

Hypersensitivity pneumonitis caused by Penicillium citrinum, not Enoki spores.

BACKGROUND: Flammulina velutipes is called the Enoki mushroom in Japanese and is cultivated indoors. Mushroom workers face occupational exposure to a tremendous number of fungi and organic antigens capable of causing hypersensitivity pneumonitis (HP)..

Chaga · 2026 · Journal Article · Journal of ethnopharmacology

Lanostane-type triterpenoids from ethnomedicinal fungi inhibit endothelial cell proliferation.

ETHNOPHARMACOLOGICAL RELEVANCE: Ethnomedicinal fungi have a long history of use in the treatment of tumors and inflammatory disorders, pathologies often associated with dysregulated angiogenesis and immune-vascular interactions..

Cordyceps · 2025 · Research Article · MedComm

Cordycepin Targets HRD1 to Promote Cancer Cell PD-L1 Ubiquitin-Proteasome Degradation and Increase Antitumor Immunity.

Immune checkpoint blockade has become an effective strategy for inhibiting tumor growth, especially immune checkpoint inhibitors that target the programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway, which have shown significant effects in tumor immunotherapy..