MycoData

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Food & function

Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-D-glucan derived from the fruiting body of Antrodia camphorata.

Antrodia camphorata is a fungus native to Taiwan, and it is considered a precious medicinal agent. We analyzed triterpenoids, polysaccharides and 1,3-β-D-glucan, three major effective components in A.

OncologyImmune supportEnergy & fatigueMetabolic health

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers.

ETHNOPHARMACOLOGICAL RELEVANCE: Hericium is a genus of mushrooms (fungus) in the Hericiaceae family. Hericium erinaceus (HE) has been used for the treatment of digestive diseases for over 2000 years in China..

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · PloS one

Antimicrobial activity of Antrodia camphorata extracts against oral bacteria.

Antrodia camphorata (A. camphorata) is a unique, endemic and extremely rare mushroom species native to Taiwan, and both crude extracts of and purified chemical compounds from A.

Snow Fungus · 2014 · Research Support, Non U.S. Gov'T · Journal of food science

Antioxidant and anti-inflammatory activities of methanol extracts of Tremella fuciformis and its major phenolic acids.

Methanol extract subfractions of the edible white jelly mushroom (Tremella fuciformis), were assessed for the following antioxidant properties: ABTS(+) radical scavenging activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and inhibitory activity of human low-density lipoprotein (LDL)….

Mesima · 2014 · Research Support, Non U.S. Gov'T · Journal of bioscience and bioengineering

Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents.

Phellinus linteus and its constituent hispolon induce potent anti-inflammatory activity in macrophages. Efficient production of the effective constituent and the biological function of P.

OncologyImmune supportEnergy & fatigueMetabolic health

Niu-Chang-Chih · 2014 · Comparative Study · Phytomedicine: international journal of phytotherapy and phytopharmacology

Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice.

PURPOSE: Antrodia camphorata (AC), a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine for the treatment of food and drug intoxication, diarrhea, abdominal pain, hypertension, skin itching, and cancer..

Mesima · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Effect of extraction media on preliminary characterizations and antioxidant activities of Phellinus linteus polysaccharides.

Three partially purified polysaccharides were extracted from Phellinus linteus mycelia using hot water, 1% (NH4)2C2O4, and 1.25M NaOH/0.05% NaBH4, and the extracts were named PL-W, PL-A, and, PL-N respectively..

Immune supportEnergy & fatigueMetabolic healthLiver support

Mesima · 2014 · Comparative Study · International journal of food sciences and nutrition

Effects of polysaccharide from fruiting bodies of Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus on alcoholic liver injury.

In the present study, the curative effects of crude polysaccharides (PSs) from mushrooms on the symptoms of alcoholic liver injury were investigated. PSs from Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus fruiting bodies were administered by gavage at levels of 100 mg per kg body weight per day for 7….

Snow Fungus · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Free-radical degradation by Fe2+/Vc/H2O2 and antioxidant activity of polysaccharide from Tremella fuciformis.

The free-radical degradation and antioxidant activity of polysaccharide from Tremella fuciformis was investigated. In present study, the combination of Fe(2+), ascorbic acid and H2O2 was used as degradation regents in order to obtain the lower molecular weight product..

Mesima · 2014 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology

Hispolon from Phellinus linteus possesses mediate caspases activation and induces human nasopharyngeal carcinomas cells apoptosis through ERK1/2, JNK1/2 and p38 MAPK pathway.

Hispolon, a phenol compound isolated from Phellinus linteus (PL), possesses anti-inflammatory, antiproliferative, and antioxidant effects. However, the effects of hispolon on human nasopharyngeal carcinomas have yet to be evaluated..

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Image analysis technique as a tool to identify morphological changes in Trametes versicolor pellets according to exopolysaccharide or laccase production.

Image analysis technique was applied to identify morphological changes of pellets from white-rot fungus Trametes versicolor on agitated submerged cultures during the production of exopolysaccharide (EPS) or ligninolytic enzymes. Batch tests with four different experimental conditions were carried out..

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Immunomodulatory effect of polysaccharides extracted from the medicinal mushroom Antrodia camphorata (higher Basidiomycetes) in specific pathogen-free chickens.

The immunomodulatory effect of polysaccharides extracted from mycelia of the medicinal mushroom Antrodia camphorata in submerged culture was studied in 100 specific pathogen-free (SPF) chickens. The chickens were randomly divided into 2 groups (50 per group)..

OncologyImmune supportRespiratory

Chaga · 2014 · Research Support, Non U.S. Gov'T · International journal of oncology

Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9.

Polysaccharides isolated from the fruiting body of Inonotus obliquus (PFIO) are known to possess various pharmacological properties including antitumor activity. However, the anti-metastatic effect and its underlying mechanistic signaling pathway involved these polysaccharides in human non-small cell lung carcinoma….

OncologyImmune supportMetabolic health

Mesima · 2014 · Research Support, Non U.S. Gov'T · Journal of food science

Isolation, purification, and structural features of a polysaccharide from Phellinus linteus and its hypoglycemic effect in alloxan-induced diabetic mice.

Phellinus linteus is a medicinal mushroom that has been used in Oriental countries for centuries for its antitumor, antioxidant, immunomodulatory, and biological activity on hyperglycemia. A water-soluble crude polysaccharide was extracted using hot water from P.

Zhu Ling · 2014 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.

BACKGROUND: Khz-cp is a crude polysaccharide extract that is obtained after nuclear fusion in Ganoderma lucidum and Polyporus umbellatus mycelia (Khz). It inhibits the growth of cancer cells.

Turkey Tail · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

Metabolite secretion, Fe(3+)-reducing activity and wood degradation by the white-rot fungus Trametes versicolor ATCC 20869.

Trametes versicolor is a promising white-rot fungus for the biological pretreatment of lignocellulosic biomass. In the present work, T.

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Methanol extract of Antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-κB and MAPK pathways in mice.

Antrodia camphorata (AC) has been used as a herbal medicine for drug intoxication for the treatment of inflammation syndromes and liver-related diseases in Taiwan. This study demonstrates the protective effect of the methanol extract of AC (MAC) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice..

Immune supportEnergy & fatigue

Enoki · 2014 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Multiple-fingerprint analysis for investigating quality control of Flammulina velutipes fruiting body polysaccharides.

Quality control issues overshadow potential health benefits of the edible mushroom Flammulina velutipes, with the detection and isolation of polysaccharides posing particular problems..

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Optimization of enzyme-assisted extraction and characterization of polysaccharides from Hericium erinaceus.

The enzyme-assisted extraction (EAE) of polysaccharides from the fruits of Hericium erinaceus was studied. In this study, response surface methodology and the Box-Behnken design based on single-factor and orthogonal experiments were applied to optimize the EAE conditions..

Chaga · 2014 · Research Support, Non U.S. Gov'T · Oncology reports

Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-κB signaling pathway.

Polysaccharides derived from Inonotus obliquus (PIO) are known to possess multiple pharmacological activities including antitumor activity. However, the possible molecular mechanisms of these activities are unknown..

Chaga · 2014 · Research Support, Non U.S. Gov'T · International immunopharmacology

Polysaccharides from Inonotus obliquus sclerotia and cultured mycelia stimulate cytokine production of human peripheral blood mononuclear cells in vitro and their chemical characterization.

Inonotus obliquus is an edible and medicinal mushroom to treat many diseases. In the present study, polysaccharides and fractions were isolated and purified by DEAE-52 and Sephadex G-200 chromatography from I.

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Preparation, characterization, and anti-Helicobacter pylori activity of Bi3+-Hericium erinaceus polysaccharide complex.

Two new Bi3+-Hericium erinaceus polysaccharide (BiHEP) complexes were prepared using Bi3+ and two purified polysaccharides from H. erinaceus (HEPs), respectively.

Chaga · 2014 · Research Support, Non U.S. Gov'T · Bioprocess and biosystems engineering

Production of bioactive polysaccharides by Inonotus obliquus under submerged fermentation supplemented with lignocellulosic biomass and their antioxidant activity.

The effect of lignocellulose degradation in wheat straw, rice straw, and sugarcane bagasse on the accumulation and antioxidant activity of extra- (EPS) and intracellular polysaccharides (IPS) of Inonotus obliquus under submerged fermentation were first evaluated..

Enoki · 2014 · Research Support, Non U.S. Gov'T · Fungal biology

Stipe wall extension of Flammulina velutipes could be induced by an expansin-like protein from Helix aspersa.

Expansin proteins extend plant cell walls by a hydrolysis-free process that disrupts hydrogen bonding between cell wall polysaccharides. However, it is unknown if this mechanism is operative in mushrooms..

OncologyImmune supportGut & microbiomeSkin & hydration

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Carcinogenesis

A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.

Lung cancer is the leading cause of cancer deaths worldwide and current therapies fail to treat this disease in majority of cases. Antrodia camphorata is a medicinal mushroom being widely used as food dietary supplement for cancer prevention..

OncologyImmune supportMetabolic healthLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · Chemico-biological interactions

Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.

Our previous study showed that polysaccharide (P1) from Phellinus linteus exhibits a significant inhibitive activity on human colorectal carcinoma cells (HT-29). However its novel molecular mechanism remains unknown..

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.

Eburicoic acid (TR1) and dehydroeburicoic acid (TR2), an active ingredient from Antrodia camphorata (AC) solid-state culture, were evaluated for analgesic and anti-inflammatory effects..

Chaga · 2013 · Research Support, Non U.S. Gov'T · Food chemistry

Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus.

Mushroom Inonotus obliquus (I. obliquus) has been used as functional food and traditional Chinese herbs for long time.

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of natural products

Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.

Four new lanostanoids, ethyl lucidenate A (1), ethyl lucidenate F (2), 15-O-acetylganolucidate A (3), and 3,11,15,23-tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid (4), and two new lactone derivatives, 5-hydroxy-5-(methoxymethyl)-4-methylfuran-2(5H)-one (5) and 3-(4-methoxy-2-oxo-2H-pyran-6-yl)propanoic acid (6), together….

Immune supportEnergy & fatigueLiver supportSkin & hydration

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology

Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis.

Antrodia camphorata is a unique fungus in Taiwan; the submerged fermentation product is used as the functional food for liver protection. Deep ocean water (DOW) containing rich metals and trace elements is proven to stimulate the production of functional metabolites and health function of functional fungus product in….

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Chemical analysis and antioxidant activity of polysaccharides extracted from Inonotus obliquus sclerotia.

Three water-soluble polysaccharide fractions (IOP40, IOP60 and IOP80) were isolated by using different concentrations of alcohol precipitation from Inonotus obliquus sclerotia. Their physicochemical properties, including total sugar content, protein content, monosaccharide composition and percentage were analyzed..

Immune supportCognition & nervesMetabolic healthLiver support

Almond Mushroom · 2013 · Research Support, Non U.S. Gov'T · BioMed research international

Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.

The action of an Agaricus blazei aqueous extract pretreatment on paracetamol injury in rats was examined not only in terms of the classical indicators (e.g., levels of hepatic enzymes in the plasma) but also in terms of functional and metabolic parameters (e.g., gluconeogenesis)..

Enoki · 2013 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Effects of extraction methods on the antioxidant activities of polysaccharides obtained from Flammulina velutipes.

Four polysaccharides (CFP, UFP, MFP and EFP) were extracted from Flammulina velutipes using hot water, ultrasonic, microwave or enzymatic methods optimized by orthogonal test. Preliminary structural characterizations were conducted using physicochemical properties..

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Applied biochemistry and biotechnology

Endopolysaccharides from Ganoderma resinaceum, Phlebia rufa, and Trametes versicolor affect differently the proliferation rate of HepG2 cells.

Fungi have been used for medicinal purposes for long time by Asian countries, being a putative source of powerful new phytopharmaceuticals such as polysaccharides..

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of biotechnology

Functional expression of FIP-fve, a fungal immunomodulatory protein from the edible mushroom Flammulina velutipes in Pichia pastoris GS115.

FIP-fve is a bioactive protein isolated from the mushroom Flammulina velutipes, which belongs to the fungal immunomodulatory protein (FIP) family and demonstrates several kinds of biological activities including anti-allergy, anti-tumor and immunomodulation..

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Food chemistry

Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.

The hepatoprotective effects of eburicoic acid (TR1) and dehydroeburicoic acid (TR2) from Antrodia camphorata (AC) against carbon tetrachloride (CCl4)-induced liver damage were investigated in mice. TR1 and TR2 was administered intraperitoneally (i.p.) for 7 days prior to the administration of CCl4..

OncologyImmune supportMetabolic healthLiver support

Mesima · 2013 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells.

Hispolon (a phenolic compound isolated from Phellinus linteus) has been shown to possess strong antioxidant, anti-inflammatory, anticancer, and antidiabetic properties..

Maitake · 2013 · Research Support, Non U.S. Gov'T · The American journal of Chinese medicine

Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent.

Grifola frondosa (GF), a high value medicinal mushroom in China and Japan, is popularly consumed as traditional medicines and health foods, especially for enhancing immune functions..

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa, through dectin-1 in macrophages.

Polysaccharides, especially β-glucans isolated from various species of mushrooms, are considered as biological response modifiers (BRMs) to be widely used in the treatment of cancer, especially due to their immunostimulatory activity..

OncologyImmune supportEnergy & fatigueLiver support

Yellow Morel · 2013 · Research Support, Non U.S. Gov'T · Biotechnology letters

Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta.

A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway..

OncologyImmune supportSkin & hydrationRespiratory

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes.

FIP-fve is an immunomodulatory protein isolated from Flammulina velutipes that possesses anti-inflammatory and immunomodulatory activities. However, little is known about its anticancer effects.

Chaga · 2013 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Physical modifications of polysaccharide from Inonotus obliquus and the antioxidant properties.

Physical modification of polysaccharides exerted better biological properties because of the change of physicochemical properties. Polysaccharides from Inonotus obliquus (IOPS) were modified by acid, alkali hydrolysis, thermal and ultrasonic treatment in this study..

Immune supportEnergy & fatigue

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · PloS one

Sclerotial formation of Polyporus umbellatus by low temperature treatment under artificial conditions.

BACKGROUND: Polyporus umbellatus sclerotia have been used as a diuretic agent in China for over two thousand years. A shortage of the natural P.

OncologyImmune supportEnergy & fatigueGut & microbiome

Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Antrodia camphorata (AC) is well known in Taiwan as a traditional Chinese medicinal fungus. However, the anticancer activity of AC against human HER-2/neu-overexpressing ovarian cancers is poorly understood..

OncologyImmune supportGut & microbiome

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · PloS one

Trametes versicolor protein YZP activates regulatory B lymphocytes - gene identification through de novo assembly and function analysis in a murine acute colitis model.

BACKGROUND: Trametes versicolor (Yun-Zhi) is a medicinal fungus used as a chemotherapy co-treatment to enhance anti-tumor immunity. Although the efficacies of T.

Lion's Mane · 2012 · English Abstract · Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]

[Submerged cultivation and chemical composition of Hericium erinaceus mycelium].

Submerged cultivation of Hericium erinaceus in various media was studied. The yield of the biomass was shown to depend mainly on the carbon source, whereas the content of water soluble polysaccharides depended mainly on the nitrogen source..

Immune supportLiver support

Chaga · 2012 · English Abstract · Yao xue xue bao = Acta pharmaceutica Sinica

[Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4].

To investigate the effects of lanosterol (1), inotodiol (2) and trametenolic acid (3) from Inonotus obliquus against oxidative damage induced by CCl4 in mice, 1, 2 and 3 (20, 10 and 5 mg x kg(-1)) were respectively administered to mice, once a day for 3 days..

Snow Fungus · 2012 · Research Support, Non U.S. Gov'T · Bioresource technology

A three-stage culture process for improved exopolysaccharide production by Tremella fuciformis.

Tremella fuciformis produces several bioactive secondary metabolites including exopolysaccharides. Cultivation of the fungus was carried out in a three-stage process consisting of a 1.5-day cultivation with orbital shaking at 200 rpm, a 1.5-day cultivation with reciprocal shaking at 200 strokes, and a 1.5-day….

Mesima · 2012 · Research Support, Non U.S. Gov'T · PloS one

Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.

Inotilone was isolated from Phellinus linteus. The anti-inflammatory effects of inotilone were studied by using lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells and λ-carrageenan (Carr)-induced hind mouse paw edema model..