MycoData

The aim of this study was to investigate sulfuric acid degradation of the Pholiota nameko polysaccharide (AIPS-1). Three stepwise degraded polysaccharides (AIPS-2, AIPS-3, and AIPS-4) were obtained by sequentially increasing the strength of sulfuric acid treatment..

Immune support

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Journal of agricultural and food chemistry

Influence of a Biotechnologically Produced Oyster Mushroom (Pleurotus sajor-caju) on the Gut Microbiota and Microbial Metabolites in Obese Zucker Rats.

Mushrooms are a rich source of dietary fiber. This study aimed to characterize the modulation of colonic microbiota in Zucker rats after supplementing their diet with a biotechnologically produced oyster mushroom (Pleurotus sajor-caju)..

Immune supportGut & microbiomeLiver support

Medium relevance

Shiitake · 2021 · Journal Article · Bioscience, biotechnology, and biochemistry

Mixed polysaccharides derived from shiitake mushroom, Poriacocos, Ginger, and Tangerine peel prevent the H1N1 virus infections in mice.

The pandemic influenza A (H1N1) virus spread globally and posed one of the most serious global public health challenges. The traditional Chinese medicine is served as a complementary treatment strategy with vaccine immunization..

Immune supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · ACS omega

Novel Fatty Acid in Cordyceps Suppresses Influenza A (H1N1) Virus-Induced Proinflammatory Response Through Regulating Innate Signaling Pathways.

Influenza virus (IV) infections usually cause acute lung injury characterized by exaggerated proinflammatory responses. The paucity of therapeutic strategies that target host immune response to attenuate lung injury poses a substantial challenge in management of IV infections..

Immune supportRespiratory

Medium relevance

Cordyceps · 2021 · Journal Article · International journal of molecular sciences

Potential Protection Effect of ER Homeostasis of N6-(2-Hydroxyethyl)adenosine Isolated from Cordyceps cicadae in Nonsteroidal Anti-Inflammatory Drug-Stimulated Human Proximal Tubular Cells.

Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to a class of universally and commonly used anti-inflammatory analgesics worldwide. A diversity of drawbacks of NSAIDs have been reported including cellular oxidative stress, which in turn triggers the accumulation of unfolded proteins, enhancing endoplasmic….

Immune support

Medium relevance

Cordyceps · 2021 · Journal Article · Frontiers in pharmacology

Supercritical Carbon Dioxide Extracts of Cordyceps sinensis: Chromatography-based Metabolite Profiling and Protective Efficacy Against Hypobaric Hypoxia.

The toxicity and disposal concerns of organic solvents used in conventional extraction purposes has entailed the need for greener alternatives. Among such techniques, supercritical fluid extraction (SFE) has gained popularity by yielding extracts of high purity in a much faster manner..

Immune supportEnergy & fatigueMetabolic health

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Journal of proteomics

Tandem mass tag-based proteomics for studying the effects of a biotechnologically produced oyster mushroom against hepatic steatosis in obese Zucker rats.

Hepatic steatosis is a very common response to liver injury and often attributed to metabolic disorders. Prior studies have demonstrated the efficacy of a biotechnologically produced oyster mushroom (Pleurotus sajor-caju, PSC) in alleviating hepatic steatosis in obese Zucker rats..

Immune supportEnergy & fatigueMetabolic healthLiver support

Medium relevance

Maitake · 2019 · Research Support, Non U.S. Gov'T · PloS one

Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake.

A key characteristic of mushroom polysaccharides that elicit an immunomodulatory response is that they are rich in β-glucans and low in α-glucans. In this study we analysed nine commercially available preparations from three mushroom species, Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes) and Maitake (Grifola….

Immune support

Medium relevance

Shiitake · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production.

Lentinan extracted from shiitake (Lentinula edodes) is a β-glucan that has been reported as an intravenous anti-tumor polysaccharide via enhancement of the host immune system. In this study, we determined the effect of lentinan on inflammasome activation, a multi-protein platform, in myeloid cells..

OncologyImmune support

Medium relevance

Cordyceps · 2017 · Research Support, Non U.S. Gov'T · Trends in biotechnology

Myths and Realities Surrounding the Mysterious Caterpillar Fungus.

The caterpillar fungus Ophiocordyceps sinensis is a medicinal mushroom increasingly used as a dietary supplement for various health conditions, including fatigue, chronic inflammation, and male impotence..

Immune supportEnergy & fatigue

Medium relevance

Enoki · 2016 · Review · Frontiers in pharmacology

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties.

Flammulina velutipes (enoki, velvet shank, golden needle mushroom or winter mushroom), one of the main edible mushrooms on the market, has long been recognized for its nutritional value and delicious taste..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Maitake · 2009 · Journal Article · International immunopharmacology

Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice.

Cisplatin is broadly used clinically as an anticancer drug. Despite its significant anticancer activity, cisplatin-induced nephrotoxicity and myelosuppression limit its use..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Chaga · 2004 · Research Support, Non U.S. Gov'T · BioFactors (Oxford, England)

Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.

The Chaga mushroom (Inonotus obliquus) is claimed to have beneficial properties for human health, such as anti-bacterial, anti-allergic, anti-inflammatory and antioxidant activities. The antioxidant effects of the mushroom may be partly explained by protection of cell components against free radicals..

Immune support

Medium relevance

Chaga · 2004 · Patent · journal metadata

CHAGA MUSHROOM FISH STEW USING EXTRACT OF CHAGA MUSHROOM IN PLACE OF WATER

PURPOSE: Chaga mushroom fish stew made by adding an extract of Chaga mushroom(Inonotus obliquus) in place of broth or water to conventional fish stew is provided. The product has characteristic taste and flavor of fish stew together with the immunization effect of Chaga mushroom..

Immune support

Medium relevance

Chaga · 2004 · Patent · journal metadata

CHAGA MUSHROOM SEAFOOD STEW USING EXTRACT OF CHAGA MUSHROOM IN PLACE OF WATER

PURPOSE: Chaga mushroom seafood stew made by adding an extract of Chaga mushroom(Inonotus obliquus) in place of water to conventional seafood stew is provided. Everyone containing an infant, a child, an adult or the elderly can obtain components having immunization effect of Chaga mushroom through the product..

Immune support

Medium relevance

King Oyster · 2026 · Journal Article · International journal of biological macromolecules

Antidiabetic effects of Agaricus bisporus polysaccharide in HFD/STZ-induced mice.

Fungal polysaccharides have garnered attention for their antidiabetic potential. Here, we evaluated five edible fungal polysaccharides-Agaricus bisporus (ABP), Pleurotus eryngii (PEP), Boletus spp.

Immune supportEnergy & fatigueMetabolic healthLiver support

Medium relevance

Cordyceps · 2026 · Journal Article · International journal of molecular sciences

Antithrombotic Effects of Cordycepin-Enriched WIB-801CE via Inhibition of Thromboxane A2-Induced αIIbβ3 Activation and Thrombin-Mediated Fibrin Clot Retraction.

WIB-801CE, a standardized Cordyceps militaris extract containing 7.0% cordycepin, suppresses platelet activation induced by thrombin, collagen, and adenosine diphosphate (ADP)..

OncologyImmune supportSkin & hydration

Medium relevance

Cordyceps · 2026 · Journal Article · Journal of chromatography. A

Construction of porous adsorbent for selective enrichment of cis-diol-containing flavonoids and evaluation of green performance based on life cycle analysis.

Flavonoids exhibit anti-inflammatory, anti-cancer, antibacterial and anti-aging properties. However, their complex structures make the separation and purification of flavonoids pharmacologically significant..

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Cordyceps · 2026 · Research Article · Drug design, development and therapy

Cordycepin Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Inhibiting IL-6/IL-6R-Mediated p38 MAPK and NF-κB Activation Through Adenosine A2A Receptor Stimulation.

BACKGROUND: Current ulcerative colitis (UC) therapies often cause adverse effects, and novel treatments are urgently needed. Cordycepin (COR), a bioactive compound from Cordyceps militaris, shows anti-inflammatory and intestinal protective potential, its precise role and mechanisms in UC remain unclear..

Immune supportGut & microbiome

Medium relevance

Cordyceps · 2026 · Journal Article · Journal of clinical laboratory analysis

Edible Fungus Compound Cordycepin Protects Against Acetaminophen-Induced Liver Injury.

BACKGROUND: Medicinal-edible natural products like Cordyceps militaris (C.militaris), a functional food rich in cordycepin (COR), are promising for health maintenance..

OncologyImmune supportLiver support

Medium relevance

Cordyceps · 2026 · Journal Article · Bioresource technology

Efficient production of cordycepin in engineered Saccharomyces cerevisiae.

Cordycepin (COR) is an important bioactive nucleoside with antitumor and immunomodulatory activities, but its conventional production via Cordyceps militaris fermentation is limited by long cultivation periods and low titers. Therefore, microbial heterologous synthesis represents an attractive alternative..

OncologyImmune supportMetabolic health

Medium relevance

Cordyceps · 2026 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota.

INTRODUCTION: Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder characterized by excessive pulmonary vascular remodeling and aberrant proliferation of pulmonary artery smooth muscle cells (PASMCs). Emerging evidence suggests that gut microbiota dysbiosis contributes to PH development..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

King Oyster · 2026 · Journal Article · Food science and biotechnology

Enhancing technofunctional properties of an emulsion-type meat analog formulated with mealworm and TVP: mushroom incorporation at the optimal concentration.

UNLABELLED: Mushrooms are commonly used as functional additives in meat products and show promise in alternative protein development. This study evaluated the impact of five mushroom species-Ganoderma lucidum, Pleurotus eryngii, Pleurotus ostreatus, Agaricus bisporus, and Lentinula edodes-at 3% concentration on the….

Immune support

Medium relevance

Shiitake · 2026 · Research Article · Frontiers in immunology

Evaluation of Imoviral® effects on early immune response in Sparus aurata challenged with Vibrio anguillarum.

BACKGROUND: An acute phase response (APR) was experimentally induced in Sparus aurata (Linnaeus, 1758) by intraperitoneal (IP) injection of Vibrio anguillarum to evaluate the effects of dietary supplementation with the Imoviral® complex (CRISTALFARMA) on fish growth performance and health status, through the analysis….

Immune supportEnergy & fatigueRespiratory

Medium relevance

Reishi · 2026 · Research Article · Chinese medicine

Guominkang formula alleviates airway inflammation in HDM-induced asthma mice by regulating Wnt/β-Catenin pathway.

BACKGROUND: The Guominkang formula (GMK), formulated according to the principle of "treatment based on constitution differentiation," comprises Prunus mume (Siebold) Siebold & Zucc. (Wumei), Saposhnikovia divaricata (Turcz.

Immune supportGut & microbiomeRespiratory

Medium relevance

Cordyceps · 2026 · Research Article · Toxics

Integrating Speciation Analysis and Bioaccessibility to Reassess Cadmium Exposure Risk from Six Mushrooms.

Accurate assessment of dietary exposure to cadmium in mushrooms is crucial for food safety. The inherent limitation lies in relying solely on total cadmium content, failing to reflect its actual bioaccessibility.

Immune supportGut & microbiome

Medium relevance

Cordyceps · 2026 · Journal Article · Journal of ethnopharmacology

Paecilomyces hepiali Chen (Cs-4) polysaccharides ameliorate chronic liver fibrosis via inhibiting TGF-β1/Smad and NLRP3/Caspase-1-mediated hepatic stellate cells activation in vivo and in vitro.

ETHNOPHARMACOLOGICAL RELEVANCE: Paecilomyces hepiali Chen (Cs-4), recognized as the classic deficiency-tonifiying medicine of traditional Chinese medicine (TCM), is the principal and most valuable medicinal species of Ophiocordyceps sinensis (known as Cordyceps sinensis (Berk.) Sacc., or 'Dong-Chong-Xia-Cao' in….

Immune supportEnergy & fatigueLiver supportSkin & hydration

Medium relevance

Cordyceps · 2026 · Journal Article · International journal of biological macromolecules

Physicochemical, structural, digestive stability, and microbiota effects of five edible mushroom polysaccharides (EMPs).

EMPs are widely used for their food-medicine characteristics and bioactivities. However, the lack of unified standards has resulted in inconsistent product quality..

Immune supportGut & microbiome

Medium relevance

Cordyceps · 2026 · Journal Article · Current microbiology

Selective Carbohydrate Modulation Enhances BLIS-Mediated Bioprotection Against Multidrug-Resistant Foodborne Pathogens During Vegetable Fermentation.

Lactic acid bacteria (LAB) play a pivotal role in food fermentation by shaping microbial ecosystems and enhancing product safety through the production of antimicrobial metabolites..

Immune supportGut & microbiome

Medium relevance

Cordyceps · 2025 · Research Article · Foods (Basel, Switzerland)

Bioactive Polysaccharides Prevent Lipopolysaccharide-Induced Intestinal Inflammation via Immunomodulation, Antioxidant Activity, and Microbiota Regulation.

Intestinal inflammation involves barrier impairment, immune hyperactivation, and oxidative stress imbalance. Bioactive polysaccharides universally alleviate inflammation via anti-inflammatory, antioxidant, and microbiota-modulating effects, yet exhibit distinct core mechanisms..

Immune supportGut & microbiome

Medium relevance

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

Blending polysaccharides from three edible mushrooms represents a promising approach for augmenting their anti-oxidant and anti-fatigue activities.

It has been well documented that a number of polysaccharides with potent free-radical scavenging capability possess notable anti-fatigue activity. Interestingly, recent evidence also suggested mixed polysaccharides derived from multiple sources may yield augmented bioactivities compared to the polysaccharides from a….

Immune supportEnergy & fatigue

Medium relevance

King Oyster · 2025 · Journal Article · Carbohydrate polymers

Chemical structure characterization of polysaccharides using diffusion ordered NMR spectroscopy (DOSY)

The potential of DOSY NMR spectroscopy to distinguish the linkage pattern of chemically related polysaccharides was evaluated using β-glucans isolated from yeast (Saccharomyces cerevisiae) and mushroom (Pleurotus eryngii). Laminarin from Laminaria digitata was included for chemical shift comparison..

Immune support

Medium relevance

King Oyster · 2025 · Journal Article · Carbohydrate polymers

Chemical structure characterization of polysaccharides using diffusion ordered NMR spectroscopy (DOSY).

Immune support

Medium relevance

Cordyceps · 2025 · Research Article · Bioresources and bioprocessing

Comparative evaluation of free radical scavenging activity and total metabolite profiles among 30 macrofungi species.

The high antioxidant content of mushrooms such as polyphenols, polysaccharides, carotenoids, ergothioneine, glutathione, vitamins, and other compounds, has sparked interest in their potential use in preventive and therapeutic medicine..

Immune supportMetabolic health

Medium relevance

Cordyceps · 2025 · Journal Article · Molecular immunology

Cordycepin ameliorates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells through Smad7-dependent manner.

Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease. The extracellular matrix deposition is potent pathogenic factors of renal fibrosis and injury.

Immune supportMetabolic healthSkin & hydration

Medium relevance

Cordyceps · 2025 · Journal Article · Molecular biotechnology

Cordycepin Ameliorates Psoriasis-Like Skin Lesion by Regulating p53/MDM2 Feedback Loop.

Apoptosis is a natural physiological process of programmed cell death. It is essential for maintaining the homeostasis of the body and the immune system.

OncologyImmune supportSkin & hydration

Medium relevance

Cordyceps · 2025 · Research Article · Scientific reports

Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.

Excessive exercise can lead to physical fatigue and disruption of the antioxidant system, resulting in neurological damage and cognitive decline. Cordycepin, the main component of Cordyceps militaris, has anti-inflammatory, antioxidant and neuroprotective effects..

Immune supportCognition & nervesEnergy & fatigueLiver support

Medium relevance

Cordyceps · 2025 · Journal Article · Molecular neurobiology

Cordycepin Mitigates Sepsis-Associated Encephalopathy by Promoting Microglial M2 Polarization via the IL-17a/IL-17RA/NF-κB Axis.

Sepsis-associated encephalopathy (SAE) is a serious neurological complication of systemic infection, marked by cognitive deficits, neuroinflammation, and increased mortality. Microglial activation and proinflammatory signaling pathways, particularly involving IL-17a and NF-κB, are key contributors to SAE pathogenesis..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Medium relevance

King Oyster · 2025 · Journal Article · Food Chemistry

Effects of three edible mushroom polysaccharides on the freeze-thaw stability of silver carp (Hypophthalmichthys molitrix) surimi gels: Water retention, gel quality, and structural properties

In this study, the effects of three edible mushroom crude polysaccharides, including Tremella polysaccharide (TP), Flammulina velutipes polysaccharide (FVP), and Pleurotus eryngii polysaccharide (PEP) on the freeze-thaw stability of silver surimi were investigated..

Immune support

Medium relevance

Cordyceps · 2025 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Evaluation of antidepressant and sleep-promoting effects of cordycepin in a menopause-like stress model.

The menopausal transition is often accompanied by mood disturbances and sleep disorders, exacerbated by estrogen deficiency and chronic stress. Although hormone replacement therapy (HRT) is effective, its use is limited by safety concerns, underscoring the need for non-hormonal alternatives..

Immune supportCognition & nerves

Medium relevance

King Oyster · 2025 · Research Article · Journal of applied glycoscience

Evaluation of Antifreeze Activity of Enzyme-Treated Extract from Mushroom Cell Wall.

Ice formation and growth during freezing in processed foods containing water can deteriorate food quality. Naturally derived antifreeze proteins and antifreeze polysaccharides are an attractive solution to this problem..

Immune supportSkin & hydration

Medium relevance

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

Identification and Nutrient Composition of a Wild Pleurotus pulmonarius Strain from Tibet, and the Antioxidant and Cytotoxic Activities of Polysaccharides from This Fungus.

The selection and breeding of high-quality wild edible fungal strains can bring significant economic and social benefits. A wild fungal strain (X21185) from the Tibetan Plateau was isolated and identified as a novel Pleurotus pulmonarius (P.

OncologyImmune supportLiver support

Medium relevance

Reishi · 2025 · Journal Article · Food Research International

Study on the intervention mechanism of Ganodermalucidum polysaccharides in mice with atopic dermatitis

Taishan Red Reishi Mushroom, also known as Taishan Ganoderma lucidum, is a medicinal and edible mushroom. Polysaccharides from Taishan Ganodermalucidum (GLP) represent its most significant bioactive component..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Study on the intervention mechanism of Ganodermalucidum polysaccharides in mice with atopic dermatitis.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Cordyceps · 2024 · Research Article · Neural regeneration research

3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.

JOURNAL/nrgr/04.03/01300535-202410000-00028/figure1/v/2024-02-06T055622Z/r/image-tiff Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity..

Immune supportCognition & nerves

Medium relevance

Cordyceps · 2024 · Research Article · Bioactive materials

Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease.

Radiation-induced heart disease (RIHD), characterized by severe oxidative stress and immune dysregulation, is a serious condition affecting cancer patients undergoing thoracic radiation. Unfortunately, clinical interventions for RIHD are lacking..

OncologyImmune supportLiver support

Medium relevance

Cordyceps · 2024 · Journal Article · South African journal of botany

Biotic elicitors influence boeravinone B production from cell suspension cultures of Boerhavia diffusa Linn.

Boerhavia diffusa L., (punarnava) is known for its rich, secondary metabolite content and potential pharmacological properties. Boeravinone B, a flavonoid, is a significant plant secondary metabolite found in punarnava, exhibiting various pharmacological properties that translate into anticancer, antioxidant,….

OncologyImmune support

Medium relevance

Cordyceps · 2024 · Journal Article · International immunopharmacology

Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence.

Cordycepin (CRD) is an active component derived from Cordyceps militaris, which possesses multiple biological activities and uses in liver disease. However, whether CRD improves liver fibrosis by regulating hepatic stellate cell (HSC) activation has remained unknown..

Immune supportLiver support

Medium relevance

Cordyceps · 2024 · Research Article · iScience

Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection.

Cordycepin, a natural derivative of adenosine from Cordyceps militaris, can inhibit the replication of the dengue virus (DENV). Here, we investigated its antiviral and anti-inflammatory effects in DENV infected cells.

Immune supportRespiratory

Medium relevance

Cordyceps · 2024 · Research Article · Reproductive biology and endocrinology: RB&E

Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro.

BACKGROUND: Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte..

Immune supportEnergy & fatigue