MycoData

Cordyceps · 2026 · Journal Article · Frontiers in bioscience (Landmark edition)

Context-Dependent Modulation of Macrophage Plasticity by Cordycepin Drives Tumor Regression in Melanoma.

BACKGROUND AND AIM: Cordycepin (CDC), an adenosine (ADO) analog from Cordyceps mushrooms, exhibits potent anti-tumor and immunomodulatory activities. However, the precise mechanisms governing its effects on macrophage plasticity remain poorly understood..

Immune supportGut & microbiomeRespiratory

Almond Mushroom · 2026 · Research Article · Materials today. Bio

Inhalable engineered probiotic outer membrane vesicles co-expressing multiple mpox antigens induce potent specific systemic and mucosal immune responses.

Monkeypox virus (MPXV) is transmitted through respiratory mucosa and close contact, including sexual transmission, especially among men who have sex with men (MSM). Using bioengineering, we constructed an inhaled bacterial outer membrane vesicles (OMVs) vaccine, ABM@OMV, to block MPXV transmission..

Almond Mushroom · 2026 · Journal Article · Biophysical journal

Investigating TGF-β1-induced renal fibrosis in a parallel computational-experimental spheroid system.

Epithelial-mesenchymal transition (EMT) drives tubular atrophy and extracellular matrix (ECM) remodeling during renal fibrosis. The cytokine transforming growth factor-beta 1 (TGF-β1) is a major regulator of EMT and other profibrotic cell processes that drive renal fibrosis..

Almond Mushroom · 2026 · Journal Article · Computational biology and chemistry

Numerical approximation of fractional order HIV/AIDS model with treatment using Levenberg-Marquardt backpropagation approach.

HIV specifically targets the immune system's T cells, mainly the CD4+ T cells, leading to a chronic and severe illness characterized by a long incubation period. In this study, we propose a novel nonlinear fractional-order model for analyzing and controlling HIV proliferation dynamics..

OncologyImmune supportMetabolic health

Cordyceps · 2026 · Journal Article · Carbohydrate polymers

Structural characteristics and bioactivities of an exopolysaccharide from mycelial fermentation of a medicinal fungus Cs-HK1.

Cs-HK1 fungus is originated from the Chinese caterpillar fungus, Cordyceps (=Ophiocordyceps) sinensis, a valuable in Chinese Tibetan medicine. The exopolysaccharides (EPS) produced by Cs-HK1 mycelial fermentation have shown multiple bioactivities that are dependent on their structural characteristics..

Immune supportEnergy & fatigueMetabolic health

Almond Mushroom · 2026 · Research Article · Frontiers in sports and active living

The exploration of immune system function changes in marathon athletes after high-intensity training by Agent-Based Model.

BACKGROUND: Marathon running imposes substantial metabolic demand. While the acute effects of exercise are well-documented, the chronic immunometabolic alterations associated with intensified training blocks in elite populations remain characterized by complex, non-linear dynamics..

OncologyImmune supportCognition & nerves

Almond Mushroom · 2025 · Research Article · PloS one

Agent-based modeling for personalized prediction of an experimental immune response to immunotherapeutic antibodies.

Targeting immune checkpoint pathways to evoke an immune response against tumors has revolutionized clinical oncology over the last decade. Antibodies that block the PD-1/PD-L1 pathway have demonstrated effective antitumor activity in cancer patients and are approved for treatment of several different types of cancer..

OncologyImmune supportMetabolic health

Almond Mushroom · 2025 · Journal Article · Oral diseases

Ameloblastoma Diagnosis From Serum Metabolic Profiling.

INTRODUCTION: Ameloblastoma (ABM) is an aggressive, localized, infiltrating epithelial odontogenic neoplasm. The molecular pathogenesis of ABM is unknown, and studying its metabolic profile may allow the identification of biomarkers relevant to the diagnosis and prediction of pathology..

Immune supportCognition & nerves

Almond Mushroom · 2025 · Journal Article · BMC infectious diseases

Analytical and data-driven fractional-order malaria transmission model with vector and non-vector pathways.

BACKGROUND: Classical malaria models often focus solely on vector-borne transmission and employ integer-order dynamics that neglect memory effects. Yet malaria spread can also occur through non-vector exposure routes, and its progression is influenced by historical infection and immunity patterns..

Immune supportMetabolic healthGut & microbiomeLiver support

Wood Ear · 2025 · Research Article · Journal of agricultural and food chemistry

Auricularia auriculaPolysaccharides Exert Anti-inflammatory Effects in Hepatic Fibrosis by the Gut-Liver Axis and Enhancing SCFA Metabolism.

Auricularia auricula, esteemed in Chinese culture for their culinary and medicinal properties, exhibits notable metabolic and immunomodulatory effects. The principal active constituents are indigestible fermentable polysaccharides, which not only exhibit anti-inflammatory activities but also facilitate the….

OncologyImmune supportCognition & nervesRespiratory

Almond Mushroom · 2025 · Journal Article · Cancer treatment and research communications

Efficacy and safety of upfront radiotherapy with immune checkpoint inhibitors for brain metastasis in non-small cell lung cancer.

INTRODUCTION: The optimal timing of radiotherapy (RT) for asymptomatic brain metastasis (aBM) in patients with non-small cell lung cancer (NSCLC) without targetable oncogenic drivers treated with immune checkpoint inhibitors (ICIs) remains unclear..

Almond Mushroom · 2025 · Journal Article · Biomaterials

Engineered endothelium model enables recapitulation of vascular function and early atherosclerosis development.

Human health relies heavily on the vascular endothelium. Here, we propose a novel engineered endothelium model (EEM), which recapitulated both normal vascular function and pathology..

Immune supportRespiratory

Almond Mushroom · 2025 · Research Article · The Journal of infectious diseases

Estimates of SARS-CoV-2 Infections and Population Immunity After the COVID-19 Pandemic in Austria: Analysis of National Wastewater Data.

BACKGROUND: Postpandemic surveillance data on coronavirus disease 2019 (COVID-19) infections may help inform future public health policies regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, vaccinations, or other COVID-19 measures..

Immune supportEnergy & fatigueSkin & hydration

Almond Mushroom · 2025 · Journal Article · Clinical spine surgery

Preclinical Evaluation of Synthetic Bone Graft Materials in an Instrumented Sheep Posterolateral Lumbar Spinal Fusion Model.

STUDY DESIGN: This study conducted a multi-endpoint analysis of synthetic bone grafts used as standalone in a clinically relevant instrumented sheep PLF model. OBJECTIVE: The objective was to evaluate the efficacy of commercially available synthetic bone grafts when used as standalone in a state-of-the-art….

Shiitake · 2025 · Journal Article · Preparative biochemistry & biotechnology

Statistical optimization of fermentation conditions for metabolites production by Lentinus edodes and investigation of anticancer activity.

A statistical method was utilized in this study to enhance Lentinus edodes (shiitake) secondary metabolites, thereby improving its anticancer properties. The importance of employing the statistical method in this study stemmed from the initial statistical optimization of the substrate in submerged conditions, and the….

Immune supportGut & microbiome

Almond Mushroom · 2025 · Journal Article · Environmental science and pollution research international

Sublethal pesticide exposure alters stress response, detoxification, and immunity gene expression in larvae of the stingless bee Frieseomelitta varia (Apidae: Meliponini).

During foraging, stingless bees are at risk of pesticide contamination from treated field crops. Frieseomellita varia workers, for example, frequently visit pepper plants that are often treated with the herbicide clomazone (CLZ), the fungicide difenoconazole (DFZ), and the insecticide abamectin (ABM)..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Two Mycopolysaccharides from Hirsutella sinensis mycelia: Structural characterization and dual antioxidant-cardioprotective functions.

Cordyceps sinensis, a precious traditional Chinese herb, exhibits diverse polysaccharide structures and functions across strains. This study screened Hirsutella sinensis 02-3 and successfully extracted two mycopolysaccharides (fungal polysaccharides): ISP-AII (MW = 4.70 kDa) and ISP-BII (MW = 75.42 kDa)..

Immune supportEnergy & fatigue

Almond Mushroom · 2024 · Journal Article · Journal of biomechanics

A quantitative study of the effects of a dual layer coating drug-eluting stent on safety and efficacy.

A key strategy for increasing drug mass (DM) while maintaining good safety is to improve the drug release profile (RP). We designed a dual layer coating drug-eluting stent (DES) that exhibited smaller concentration gradients between the coating and the artery wall and significantly impacted the drug RP..

Immune supportCognition & nervesEnergy & fatigue

Almond Mushroom · 2024 · Journal Article · International immunopharmacology

Acupressure bladder meridian alleviates anxiety disorder via HMGB1.

UNLABELLED: The aim of this study was to investigate the effects of acupressure bladder meridian (ABM) on anxiety in rats with chronic stress. METHODS: The sugar water preference (SPF), tail suspension time (TST) and forced swimming time (FST) of rats were measured..

Almond Mushroom · 2024 · Research Article · Cancers

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy.

Since the introduction of the first immune checkpoint inhibitor (ICI), immunotherapy has changed the landscape of molecular therapeutics for cancers. However, ICIs do not work equally well on all cancers and for all patients..

Almond Mushroom · 2024 · Research Article · PloS one

Agent-based vs. equation-based multi-scale modeling for macrophage polarization.

Macrophages show high plasticity and result in heterogenic subpopulations or polarized states identified by specific cellular markers. These immune cells are typically characterized as pro-inflammatory, or classically activated M1, and anti-inflammatory, or alternatively activated M2..

OncologyImmune supportLiver support

Almond Mushroom · 2024 · Journal Article · Tissue & cell

Citrus reticulata peel extract mitigates oxidative stress and liver injury induced by abamectin in rats.

The prevalent use of abamectin (ABM) has latterly raised safety attention as it has different toxicities to non-target living organisms. Citrus fruits are widely renowned for their nutritional and health-promoting qualities, and their peels are full of phenolic constituents..

Immune supportMetabolic health

Reishi · 2024 · Journal Article · International journal of medicinal mushrooms

Comparative Analysis of Agronomic Traits, Yield, and Effective Components of Main Cultivated Ganoderma Mushrooms (Agaricomycetes) in China.

To assess the strain resources and address production challenges in Ganoderma cultivation. 150 Ganoderma strains were collected from 13 provinces in China.

Almond Mushroom · 2024 · Research Article · Frontiers in immunology

Dysregulated FGFR3 signaling alters the immune landscape in bladder cancer and presents therapeutic possibilities in an agent-based model.

Bladder cancer is an increasingly prevalent global disease that continues to cause morbidity and mortality despite recent advances in treatment. Immune checkpoint inhibitors (ICI) and fibroblast growth factor receptor (FGFR)-targeted therapeutics have had modest success in bladder cancer when used as monotherapy..

Almond Mushroom · 2024 · Research Article · PloS one

In silico agent-based modeling approach to characterize multiple in vitro tuberculosis infection models.

In vitro models of Mycobacterium tuberculosis (Mtb) infection are a valuable tool for examining host-pathogen interactions and screening drugs. With the development of more complex in vitro models, there is a need for tools to help analyze and integrate data from these models..

OncologyImmune supportCognition & nerves

Almond Mushroom · 2024 · Research Article · Scientific reports

In silico study of heterogeneous tumour-derived organoid response to CAR T-cell therapy.

Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy for treating cancers. This method consists in modifying the patients' T-cells to directly target antigen-presenting cancer cells.

Almond Mushroom · 2024 · Research Article · APL bioengineering

Integrating mechanism-based T cell phenotypes into a model of tumor-immune cell interactions.

Interactions between cancer cells and immune cells in the tumor microenvironment influence tumor growth and can contribute to the response to cancer immunotherapies. It is difficult to gain mechanistic insights into the effects of cell-cell interactions in tumors using a purely experimental approach..

Cordyceps · 2024 · Research Article · Biology

MAT1-1 and MAT1-2 Ophiocordyceps xuefengensis and Comparison of Their Chemical Composition.

Many Cordyceps sensu lato species are used as traditional Chinese medicines. However, Cordyceps are entomopathogenic fungi in the family Clavicipitaceae of Ascomycota, and excessive harvesting severely disrupts natural habitat ecosystems..

OncologyImmune supportMetabolic health

Oyster Mushroom · 2024 · Research Article · Molecules (Basel, Switzerland)

Pleurotus sajor-caju (Fr.) Singer β-1,3-Glucanoligosaccharide (Ps-GOS) Suppresses RANKL-Induced Osteoclast Differentiation and Function in Pre-Osteoclastic RAW 264.7 Cells by Inhibiting the RANK/NFκB/cFOS/NFATc1 Signalling Pathway.

Edible grey oyster mushroom, Pleurotus sajor-caju, β (1,3), (1,6) glucan possesses a wide range of biological activities, including anti-inflammation, anti-microorganism and antioxidant. However, its biological activity is limited by low water solubility resulting from its high molecular weight..

Immune supportLiver support

Almond Mushroom · 2024 · Journal Article · Journal of pharmaceutical and biomedical analysis

Potential degradation products of abemaciclib: Identification and structural characterization employing LC-Q/TOF-MS and NMR including mechanistic explanation.

Degradation products are the potential drug impurities that can be generated during transport and storage of pharmaceuticals. Before this study, degradation chemistry and potential degradation products of abemaciclib (ABM) were unknown..

OncologyImmune supportMetabolic healthGut & microbiome

Agarikon · 2024 · Research Article · Frontiers in pharmacology

Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.

INTRODUCTION: Colorectal cancer ranks as the third most common cancer in both men and women, with approximately 35% of cases being stage IV metastatic at diagnosis. Even with treatment advancements, the survival rates for these patients remain suboptimal..

Almond Mushroom · 2024 · Research Article · Radiation oncology (London, England)

Spatially fractionated GRID radiation potentiates immune-mediated tumor control.

BACKGROUND: Tumor-immune interactions shape a developing tumor and its tumor immune microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed tumor beds, or immune deserts with low levels of infiltration..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2024 · Journal Article · Frontiers in nutrition

UPLC-ESI-MS/MS-based widely targeted metabolomics reveals differences in metabolite composition among four Ganoderma species.

The Chinese name "Lingzhi" refers to Ganoderma genus, which are increasingly used in the food and medical industries. Ganoderma species are often used interchangeably since the differences in their composition are not known..

Immune supportMetabolic healthRespiratory

Cordyceps · 2023 · Review · Nutrients

Edible and Medicinal Progress of Cryptotympana atrata (Fabricius) in China.

As an important resource insect, the Cryptotympana atrata is widely distributed in the eastern and central parts of China. The cicada slough is one of the traditional crude drugs in East Asia, and the main component is polysaccharide, which has the functions of anti-convulsion, relieving asthma and improving lipid….

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2022 · Review · International journal of medicinal mushrooms

Cordycepin as a Metabolite with Pharmacological Potential: A Review.

The pharmacological values of Cordyceps spp. are substantially associated with the existence of an extremely potent biometabolite: cordycepin.

OncologyImmune supportSkin & hydration

Shiitake · 2021 · Review · Histology and histopathology

Immunology of tissue homeostasis, ovarian cancer growth and regression, and long lasting cancer immune prophylaxis - review of literature.

Data on the substantial physiological role of the immune system in the organism's ability to manage proper differentiation and function of normal tissues (tissue homeostasis), and detailed causes of the immune system's essential role for the in-vivo stimulation of cancer growth, are severely lacking..

Immune supportCognition & nervesRespiratory

Almond Mushroom · 2021 · Review · AIDS research and therapy

New-onset focal seizure as a presenting feature of HIV infection: a case report and mini review to the challenge in resource-limited settings.

BACKGROUND: The frequency of new-onset HIV-associated seizure in the HIV-infected patient is estimated to be between 2 and 11%. Identifying the underlying etiology of new-onset seizure will have a vital impact on the mortality and morbidity of patients living with HIV infection..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2019 · Research Article · International journal of molecular sciences

Adenosine Induces EBV Lytic Reactivation through ADORA1 in EBV-Associated Gastric Carcinoma.

Cordyceps species are known to contain numerous bioactive compounds, including cordycepin. Extracts of Cordyceps militaris (CME) are used in diverse medicinal purposes because of their bioactive components..

Almond Mushroom · 2019 · Journal Article · Biological trace element research

Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens.

Cadmium (Cd) can cause animal organism damage, but there have been few studies on the damage of cadmium to the immune organs of birds. Most fungal polysaccharide has antioxidant and immunomodulatory effects..

Immune supportEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2017 · Journal Article · Animal feed science and technology

The use of Basidiomycota mushrooms in poultry nutrition—A review

Recently, there has been a noticeable growth in interest in the potential of edible mushrooms and their application in prevention and therapy. The numerous health-promoting properties of edible mushrooms include: antioxidant, immunostimulatory, anti-inflammatory, antibacterial, antiviral and hypocholesterolemic….

King Oyster · 2017 · Journal Article · Food chemistry

Wild mushrooms and their mycelia as sources of bioactive compounds: Antioxidant, anti-inflammatory and cytotoxic properties.

Mushrooms are important sources of natural bioactive compounds. Pleurotus eryngii (DC.) Quél is recognized for its organoleptic quality and health effects, being extensively commercialized.

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2010 · Research Support, Non U.S. Gov'T · Cancer immunology, immunotherapy: CII

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity.

Bone marrow myelotoxicity is a major limitation of chemotherapy. While granulocyte colony stimulating factor (G-CSF) treatment is effective, alternative approaches to support hematopoietic recovery are sought..

OncologyImmune supportLiver support

Enoki · 2010 · Research Support, Non U.S. Gov'T · International immunopharmacology

Oral administration of an Enoki mushroom protein FVE activates innate and adaptive immunity and induces anti-tumor activity against murine hepatocellular carcinoma.

FVE is a documented immunomodulatory protein purified from Enoki mushroom (Flammulina velutipes) and known as an activator for human T lymphocytes. This present study was aimed to investigate the anti-tumor effect and the related mechanisms of oral administration of FVE using a murine hepatoma model..

OncologyImmune supportMetabolic healthLiver support

Maitake · 2009 · Review Article · International journal of general medicine

Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy.

Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as beta-glucan..

OncologyImmune supportGut & microbiome

Maitake · 2007 · Research Support, Non U.S. Gov'T · Clinical and vaccine immunology: CVI

Enhancement of umbilical cord blood cell hematopoiesis by maitake beta-glucan is mediated by granulocyte colony-stimulating factor production.

Maitake beta-glucan (MBG) is an extract from the fruit body of the Grifola frondosa mushroom that is being widely used to treat cancer in Asia. We have previously reported that MBG enhances mouse bone marrow cell (BMC) hematopoiesis in vitro and protects BMC from doxorubicin (DOX) toxicity..

OncologyImmune supportMetabolic healthSkin & hydration

Turkey Tail · 2007 · Patent · journal metadata

STRAIN OF TURKEY TAIL MUSHROOM, EXTRACT FROM THE SAME, AND USE OF THE SAME

Disclosed is a strain of turkey tail mushroom (Trametes versicolor) having excellent biological activities (Accession number: FERM BP-10633). The strain is excellent in platelet aggregation inhibitory effect, chemokine gene expression inhibitory effect, anti-mutagenic effect, anti-tumor effect, anti-hypertensive….

Immune supportCognition & nervesGut & microbiome

Cordyceps · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.

This systematic review examines the antidepressant potential of edible medicinal fungi (EMFs), focusing on their bioactive compounds and mechanisms of action. EMFs modulate neurotransmitter systems, including serotonin (5-HT) and dopamine (DA), alleviating depressive symptoms..

King Oyster · 2025 · Evaluation Study · Food chemistry

Effects of three edible mushroom polysaccharides on the freeze-thaw stability of silver carp (Hypophthalmichthys molitrix) surimi gels: Water retention, gel quality, and structural properties.

In this study, the effects of three edible mushroom crude polysaccharides, including Tremella polysaccharide (TP), Flammulina velutipes polysaccharide (FVP), and Pleurotus eryngii polysaccharide (PEP) on the freeze-thaw stability of silver surimi were investigated..