MycoData

Reishi · 2026 · Research Article · Scientific reports

Multi-dimensional immunoprotection of Ganoderma lucidum spore oil in immunosuppressed mice via microbiome-proteome-metabolome network analysis.

Ganoderma lucidum has a long-standing history of use as a medicinal mushroom, with its spore oil (GLSO) extracted from broken cell walls using CO2 supercritical extraction..

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Nutritional Improvement of Sugar-Snap Cookies Supplemented with Ganoderma sessile and Pleurotus ostreatus Solid-State Fermentation Flours.

Wheat and rice are major sources of human nutrition worldwide. Solid-state fermentation (SSF) with lignocellulolytic mushrooms can enhance their nutritional value and increase their functional properties.

OncologyImmune supportCognition & nervesGut & microbiome

Shiitake · 2026 · Research Article · Scientific reports

Oral Lentinula edodes mycelia extract enhances the antitumor effect of radiotherapy via gut-associated activation of dendritic and cytotoxic T cells.

Oral administration of Lentinula edodes mycelia extract (L.E.M.) has been shown to stimulate systemic T cell-mediated antitumor immunity and inhibit tumor growth in mice, suggesting its potential to modulate host immune responses. However, the route of this systemic antitumor effect remains unclear..

Metabolic healthGut & microbiome

Oyster Mushroom · 2026 · Journal Article · Food chemistry

Physicochemical and digestive properties of low-sodium bread enriched with Agaricus bisporus and Pleurotus ostreatus co-products.

The work explored the use of Agaricus bisporus (ABSF) and Pleurotus ostreatus (POSF) co-products as functional ingredients to partially or fully replace NaCl in bread (eight formulations, 0.5-6%; 50-100% replacement). Chemical, physicochemical, sensory, and in vitro digestion analyses were performed..

OncologyImmune supportGut & microbiome

Oyster Mushroom · 2026 · Journal Article · Harmful algae

Pleurotus ostreatus polysaccharides improve microcystin-LR-induced intestinal damage in tadpoles by regulating the interaction between microbiota and intestine.

Exposure to microcystins (MCs) can cause severe intestinal damage. This study aimed to assess the efficacy of Pleurotus ostreatus polysaccharide in alleviating intestinal damage induced by microcystin-leucine-arginine (MC-LR) in tadpoles..

Oyster Mushroom · 2026 · Journal Article · Journal of microbiological methods

Preparation of multi-enzyme cocktail from antagonistic Pleurotus ostreatus mycelia grown in broth containing dead fungal tissue and its potential application for isolating protoplast of filamentous fungi.

Protoplast generation is a prerequisite for fungal genetic manipulation, yet dependence on costly and variable commercial lysing enzymes limits its accessibility..

Yellow Morel · 2026 · Research Article · BMC plant biology

Regulatory effects of winter Morchella esculenta cultivation on the summer maize phyllosphere microbiome and plant health-related traits.

In response to the intensifying demand for reduced fertilizer use and increased climate instability, the strategic incorporation of cover crops to improve the maize (Zea mays L.) phyllosphere microenvironment and leaf functional traits has emerged as an important approach for sustaining and enhancing crop….

Lion's Mane · 2026 · Journal Article · Poultry science

Selenium-modified Hericium erinaceus polysaccharides improves intestinal immunity and ND vaccine responses in chickens.

This study aimed to investigate the immunomodulatory effects of selenium-modified Hericium erinaceus polysaccharides on intestinal immunity and Newcastle disease (ND) vaccine responses in chickens..

Shiitake · 2026 · Research Article · NPJ science of food

Structural divergence of lentinula edodes polysaccharides is associated with distinct anti-hyperuricemia pathways.

Lentinula edodes (L. edodes) polysaccharides hold therapeutic potential for hyperuricemia (HUA), but their mechanisms remain unclear.

Gut & microbiomeSkin & hydration

Maitake · 2026 · Research Article · Gels (Basel, Switzerland)

Structural, Interfacial, Gelling, and Digestive Properties of Protein from Grifola frondosa Fruiting Body.

Culture medium formulation influences mushroom yield and composition, but its effect on the properties of edible fungal protein remains unclear. To explore the functional and nutritional properties of proteins from Grifola frondosa (GF) fruiting bodies, the study examined the structural, interfacial, gelling, and….

Reishi · 2026 · Journal Article · Phytopathologische Zeitschrift

Systemic Effect of Ganoderma lucidum Filtrate on Septoria Leaf Spot and Pycnidia Formation by Septoria lycopersici

This study aimed to evaluate the potential of the mycelial growth filtrate (MGF) from Ganoderma lucidum in providing systemic protection to tomato plants against Septoria lycopersici‐induced leaf spot and inhibiting the production of reproductive structures by the phytopathogen..

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2026 · Research Article · International journal of molecular sciences

The Brown Strain of Flammulina velutipes Singer Attenuates 5-Fluorouracil-Induced Intestinal Injury by Suppressing Inflammation, Oxidative Stress, and Barrier Disruption via Modulation of Epithelial-Mesenchymal Transition and Tight Junction Integrity.

5-Fluorouracil (5-FU) remains a cornerstone chemotherapeutic for colorectal cancer, exerting its antitumor effects primarily through disruption of DNA and RNA synthesis and subsequent induction of apoptosis. Nonetheless, its clinical efficacy is often compromised by prominent adverse effects, particularly mucositis..

Immune supportCognition & nervesGut & microbiome

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

The Ganoderma lucidum and Rosa roxburghii Tratt Formulation Prevents Depressive-like Behaviors in Mice by Modulating Tryptophan Metabolism via the Gut-Brain Axis and Upregulating the BDNF/TrkB/PI3K/AKT Pathway.

Depression is a common mental disorder that substantially impairs patients' daily life and work. To identify natural and safe preventive options, we investigated the preventive effect and underlying mechanism of the Ganoderma lucidum and Rosa roxburghii Tratt formula (GLRRTF) on depression..

OncologyImmune supportGut & microbiome

Reishi · 2026 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

The paradox of potency: Insights into emergent mechanisms of Ganoderma lucidum's antitumor effects.

BACKGROUND: An arms race between cancer cells and therapeutic pressure fuels drug resistance, immune evasion, and tumor heterogeneity, hindering therapy. Ganoderma lucidum (G.

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2026 · Journal Article · Molecular and cellular biochemistry

The role of mitochondrial regulation in macrophage polarization by Ganoderma lucidum polysaccharide for the treatment of colitis-associated colorectal cancer.

Colorectal cancer (CRC) is a common malignant tumor of the digestive tract. Ganoderma lucidum polysaccharide (GLP) has shown significant potential in regulating macrophage polarization and treating CRC..

Turkey Tail · 2026 · Journal Article · International journal of food microbiology

Trametes versicolor mycelium fermenting whole kidney beans into tempeh-like product.

This research explored the feasibility of using Trametes versicolor mycelium as a culture for fermenting kidney beans into tempeh-like products within 5 days, with citric acid (0, 3, and 6%, w/w; dry bean basis) applied as an abiotic stressor to enhance bioactive compound synthesis. The results showed that T..

Enoki · 2026 · Journal Article · Bioresource technology

Valorization of Flammulina velutipes residue into a feed additive via co-fermentation to control Escherichia coli.

Flammulina velutipes residue (FVR) was valorized into a functional feed additive targeting multi-drug resistant (MDR) Escherichia coli B2 (E. coli B2) via multi-strain co-fermentation..

Lion's Mane · 2026 · Research Article · Foods (Basel, Switzerland)

Valorization of Hericium erinaceus By-Products for β-Glucan Recovery via Pulsed Electric Field-Assisted Alkaline Extraction and Prebiotic Potential Analysis.

Hericium erinaceus is a well-known edible fungus rich in β-glucans, widely recognized for its immune-boosting and prebiotic properties. This study used a pulsed electric field (PEF) combined with alkaline extraction to improve β-glucan yield from H.

OncologyImmune supportEnergy & fatigueGut & microbiome

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

β-Glucan-rich Hericium erinaceus hot-water extract ameliorates acute colitis by suppressing inflammation, preserving the epithelial barrier, and modulating gut microbiota ecosystem.

Inflammatory bowel disease (IBD) is a chronic disorder marked by mucosal barrier disruption, immune imbalance, and gut dysbiosis. Polysaccharide-enriched extracts of Hericium erinaceus (HE) have shown anti-colitic effects, but the role of its β-glucan-rich water extract (HE-HW) remains unclear..

Immune supportCognition & nervesGut & microbiome

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A glucan from Ganoderma lucidum: Structural characterization and the anti-inflammatory effect on Parkinson's disease via regulating dysfunctions of intestinal microecology and inhibiting TLR4/MyD88/NF-κB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Curtis) P. Karst (G.

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H₂ receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway.

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H2 receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Shiitake · 2025 · Journal Article · Bioresource Technology Reports

Agro-industrial waste valorization through solid-state fermentation by Lentinula edodes for high-protein and β-glucans flour development for human diet: Chemical characterization, drying kinetics evaluation, and bioaccessibility

This study aimed to develop a high-protein and β-glucans flour for the human diet through the solid-state fermentation of peach palm shells by Lentinula edodes. Six biomasses were produced to analyze the effects of cultivation substrate on the physicochemical properties, using soya bran, cassava bagasse, and sorghum….

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Plant Foods Hum Nutr

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis.

In order to investigate the effects of Lentinula edodes (L. edodes) on hyperuricemia, a polysaccharide-protein complex (LEPP) was prepared and characterized, and the activity was also systematically studied..

Wood Ear · 2025 · Research Article · Ultrasonics sonochemistry

Anti-inflammatory and gut microbiota regulatory effects of ultrasonic degraded polysaccharides from Auricularia auricula-judae in DSS-induced colitis mice.

Auricularia auricula-judae is a widely cultivated mushroom species known for its edible and medicinal properties. Polysaccharides have been the focus of research because of their potential bioactivities; nonetheless, the structural complexity and molecular weight have hindered a complete understanding of their….

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · BMB reports

Anti-inflammatory effects of Hericium erinaceus hot water extract via the JAK1/STAT3 pathway in LPS-stimulated RAW 264.7 macrophages.

Several individual bioactive compounds isolated from Hericium erinaceus exhibit various physiological and biochemical activities, including neuroprotective, neurotrophic, gastrointestinal protective, immunoregulatory, and anti-inflammatory effects. However, the specific anti-inflammatory effects of H..

Yellow Morel · 2025 · Journal Article · Bioorganic chemistry

Antioxidant and immunomodulatory effects of acetylated Morchella esculenta polysaccharide in DSS-induced ulcerative colitis mice.

This study follows the current attempt to discover and develop natural therapeutic substances for counteracting ulcerative colitis. Commercial Morchella esculenta polysaccharide after deproteinization (yielding MP) was hydrolyzed with commercial snailase (yielding EMP) then acetylated (yielding AEMP)..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of medicinal food

Antioxidant Properties of Mexican Ganoderma lucidum Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.

Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom Ganoderma lucidum (Gl) contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties..

Immune supportEnergy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models.

ETHNOPHARMACOLOGICAL RELEVANCE: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G.

Metabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Betulinic acid from Inonotus obliquus ameliorates T2DM by modulating short-chain fatty acids producing bacteria and amino acids metabolism in db/db mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus has also been used as a traditional folk medicine in Europe and Northeastern China to treat metabolic diseases. Betulinic acid (BA) is a major ingredient with anti-diabetic property derived from I.

Immune supportEnergy & fatigueGut & microbiomeLiver support

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Biomacromolecular composite microspheres based on sodium alginate and tremella fuciformis polysaccharide for enhanced protection and delivery of camellia oil: A comprehensive study in simulated digestion.

This study presents the development of a novel polysaccharide biomolecule composite microsphere system based on sodium alginate (SA) and tremella fuciformis polysaccharide (TFP) for the encapsulation and controlled release of camellia oil (CO)..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Food Hydrocolloids

Co-microencapsulation of Lactobacillus paracasei and Inonotus obliquus polysaccharide in alginate system: Physicochemical and functional properties

In this study, sodium alginate (SA) was used as shell material, and Lactobacillus paracasei JY062/Inonotus obliquus polysaccharide (IOP) were used as core material (JY062-IOP/SA). The microcapsules were prepared by polymer gel technology and analyzed by SEM, FTIR, TGA and XRD..

Immune supportMetabolic healthGut & microbiomeSkin & hydration

Enoki · 2025 · Journal Article · Food chemistry

Effect of Flammulina velutipes polysaccharidees on the quality and digestibility of fresh wet rice noodles: A study perspective from physicochemical and postprandial glucose homeostasis in vivo.

This study investigated the effects of alkali-extracted Flammulina velutipes polysaccharides (AEFP) on the physicochemical properties, starch digestibility, and glycemic response of fresh wet rice noodles (WRN)..

Immune supportEnergy & fatigueGut & microbiome

Enoki · 2025 · Research Article · BMC veterinary research

Effects of flammulina velutipes stipe wastes on egg performance, cecum microbiota, intestinal barrier and serum immune response of laying hens.

BACKGROUND: Improving production performance and health is the key goal of laying hens farming. This experiment was conducted to examine the effects of Flammulina velutipes stipe wastes (FVW) on the performance of laying hens by regulating cecum microbiota, intestinal barrier and immune response..

Immune supportCognition & nervesGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Die Naturwissenschaften

Effects of Ganoderma lucidum polysaccharide on learning and memory impairment and intestinal flora in mice with D-galactose-induced aging.

Learning and memory impairment is one of the main manifestations of cognitive impairment. Gut flora can affect cognitive function and behavior through the gut-brain axis.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Research Article · Animals: an open access journal from MDPI

Effects of Ganoderma lucidum Polysaccharides on Dexameth-Asone-Induced Immune Injury in Goslings.

This study aimed to investigate the role of ganoderma lucidum polysaccharides (GLP) in mitigating dexamethasone (DEX)-induced immune injury in goslings. Dexamethasone (DEX) is commonly used to establish an animal model of immune suppression, which mimics the immune injury caused by stress or certain pathological….

Maitake · 2025 · Journal Article · Journal of food science

Effects of Simulated Digestion on the Structure and Macrophages and Dendritic Cells Activation of Grifola frondosa Polysaccharides.

The present work was analyzed the effects of simulated digestion on the structure of a multibranched polysaccharide (PM) from Grifola frondosa. Additionally, the activation effect of PM on macrophages and dendritic cells was compared before and after simulated digestion..

Metabolic healthGut & microbiome

Wood Ear · 2025 · Research Article · Clinical nutrition research

Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial.

This study aimed to evaluate the effects of functional foods containing Auricularia auricula-judae powder on gut health and clinical indicators in middle-aged and older adults..

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Efficient production, structural characterization and bioactivity of an extracellular polysaccharide from Grifola frondosa endophytic Burkholderia sp.

Endophytic bacteria Burkholderia sp. (GFB) was firstly identified and isolated from Grifola frondosa.

Enoki · 2025 · Journal Article · Chemistry & biodiversity

Elicitor-Induced Modulation of Secondary Metabolites in Laetiporus Sulphureus and Flammulina Velutipes With Extraction Efficiency Evaluation in Artificial Digestive Juices.

Mushrooms are increasingly being studied for the development of new dietary supplements and drugs, which necessitates the analysis of their chemical profiles to assess their nutritional and health benefits. This research focused on the mycelium of edible mushrooms, Laetiporus sulphureus and Flammulina velutipes..

Oyster Mushroom · 2025 · Research Article · Food science & nutrition

Enhancing Nutritional Quality and Functionality of Legumes: Application of Solid-State Fermentation With Pleurotus ostreatus.

Legumes are recognized for their nutritional and economic value as a high-quality protein source. However, antinutrients present in legumes can hinder digestibility and nutrient absorption, ultimately limiting the bioavailability of essential dietary components..

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function

Morchella esculenta, a nutritious and medicinal edible mushroom, has gained an increasing attention due to the bioactive properties of its polysaccharides. This study employed in vitro simulated human digestion and fecal fermentation models to evaluate the effects of M..

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring Morchella esculenta polysaccharide extracts: In vitro digestion, fermentation characteristics, and prebiotic potential for modulating gut microbiota and function.

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina Velutipes polysaccharides ameliorate cisplatin-induced acute kidney injury in mice via regulation of gut microbiota and Ferroptosis pathway.

Acute kidney injury (AKI) is a common and serious clinical complication with high incidence. Polysaccharides extracted from Flammulina velutipes (FVPs) have been proven to possess anti-inflammatory and antioxidant properties..

Enoki · 2025 · Journal Article · Journal of agricultural and food chemistry

Flammulina velutipes residue Polysaccharide Alleviates Immunosuppression and Intestinal Injury by Modulating Gut Microbiota and Associated Metabolites.

This study elucidated the mechanisms underlying the immunoregulatory and gut-microbiota-modulating effects of Flammulina velutipes residue polysaccharide (FVRP) using cyclophosphamide (CTX)-induced mouse models..

Oyster Mushroom · 2025 · Journal Article · Environmental science and pollution research international

Fungal-assisted harvesting of Chlorella sorokiniana cultivated in diluted anaerobic digestate using the edible mushroom Pleurotus ostreatus.

The use of fungi as a bio-flocculant for microalgae harvesting has gained great attention in recent years. However, most of the examined fungi were pathogenic, making the harvested biomass unsuitable for human or animal consumption..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum dietary fiber and lactobacillus fermentum CECT5716 alleviate constipation via regulation of gut barrier and microbiota.

The rising incidence of constipation, as well as the side effects of constipation medications, have prompted people to look for substances of natural origin to treat constipation..

Reishi · 2025 · Journal Article · Journal of the science of food and agriculture

Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice.

BACKGROUND: There are few studies about the differences in the composition of moisture, ash, crude protein, crude fat, crude polysaccharide and ergothioneine in Ganoderma lucidum spore powder (GLSP) from different origins. As for GLSP after oil extraction (OE-GLSP), there are still lots of bioactive substance in it..