MycoData

Introduction: type 2 diabetes (T2DM) is a complex disease affected by lifestyle and genetic factors. Although the drugs currently used to treat T2DM have certain curative effects, they still have some adverse side effects.

Metabolic healthLiver support

High relevance

Niu-Chang-Chih · 2022 · Research Article · Frontiers in molecular biosciences

Antrodia camphorata-Derived Antrodin C Inhibits Liver Fibrosis by Blocking TGF-Beta and PDGF Signaling Pathways.

Hepatic stellate cells (HSCs) play an essential role in the development of liver fibrosis. Antrodia camphorata (A.

Energy & fatigueLiver supportSkin & hydration

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Enoki · 2022 · Research Article · Frontiers in bioengineering and biotechnology

Biocompatible and antibacterial Flammulina velutipes-based natural hybrid cryogel to treat noncompressible hemorrhages and skin defects.

Hemorrhage, infection, and frequent replacement of dressings bring great clinical challenges to wound healing. In this work, Flammulina velutipes extract (FV) and hydroxyethyl cellulose (HEC) were chemically cross-linked and freeze-dried to obtain novel HFV cryogels (named HFVn, with n = 10, 40, or 70 corresponding to….

Immune supportCognition & nervesLiver supportSkin & hydration

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Shiitake · 2022 · Research Article · Molecules (Basel, Switzerland)

Effect of Supplementation with the Combination of Se-Enriched Lentinula edodes Mycelium, Exogenous Enzymes, Acidifiers, Sodium Butyrate and Silicon Dioxide Nanoparticle Feed Additives on Selected Parameters in Calves.

During the initial months of calves’ lives, the young animals are exposed to bacterial and viral infections, and during this period, crucial physiological changes take place in their organisms..

Immune supportLiver supportRespiratory

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Enoki · 2022 · Research Article · Nutrients

Flammulina velutipes Mycorrhizae Attenuate High Fat Diet-Induced Lipid Disorder, Oxidative Stress and Inflammation in the Liver and Perirenal Adipose Tissue of Mice.

Flammulina velutipes (FV) is edible mushroom that has nutritional and medicinal values. FV mycorrhizae, the by-products of FV, are an abundant source and receive less attention..

Immune supportMetabolic healthLiver support

High relevance

Reishi · 2022 · Journal Article · Food & function

Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition.

Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It is well known that Ganoderma lucidum has excellent beneficial effects on liver function and lipid metabolism..

Immune supportMetabolic healthGut & microbiomeLiver support

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Reishi · 2022 · Journal Article · Current research in food science

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake.

Alcoholic liver injury is mainly caused by excessive alcohol consumption and has become a global public health problem threatening human health. It is well known that Ganoderma lucidum possesses various excellent beneficial effects on liver function and lipid metabolism..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2022 · Journal Article · Nutrients

Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain.

Although early life stress (ELS) can increase susceptibility to adulthood psychiatric disorders and produce a greater inflammatory response in a stressful event, targeted preventive and therapeutic drugs still remain scarce..

Immune supportCognition & nervesLiver support

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Reishi · 2022 · Research Article · Metabolites

Hypouricemic Effect of Submerged Culture of Ganoderma lucidum in Potassium Oxonate-Induced Hyperuricemic Rats.

Hyperuricemia is a disease caused by a high level of uric acid in the blood. It is an important factor for gout and may be linked to renal and hepatic failure.

Immune supportMetabolic healthLiver support

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Lion's Mane · 2022 · Research Article · Bioresources and bioprocessing

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents.

Infectious disease is one of the major threats to humans and it is the second leading cause of death worldwide. Edible mushrooms have many nutritional and medicinal values to human health..

Immune supportLiver supportRespiratory

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Chaga · 2022 · Journal Article · European journal of pharmacology

Inonotus obliquus and its bioactive compounds alleviate non-alcoholic fatty liver disease via regulating FXR/SHP/SREBP-1c axis.

Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide. However, there is still lack of specific drugs for treating NAFLD in clinic..

Metabolic healthLiver support

High relevance

Reishi · 2022 · Journal Article · Phytochemistry

Lanostane-type triterpenoids from the mycelial mat of Ganoderma lucidum and their hepatoprotective activities.

Ganoderma lucidum (G. lucidum), a well-known Polyporaceae family fungus, is valued for its edibility and medicinal properties.

Immune supportLiver support

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Yellow Morel · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) – A review

Mushrooms have been well known for centuries in traditional Chinese medicine for their medicinal properties. Morchella esculenta (L.) Pers.

OncologyImmune supportMetabolic healthLiver support

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Reishi · 2022 · Journal Article · International journal of biological macromolecules

Organic chromium derived from the chelation of Ganoderma lucidum polysaccharide and chromium (III) alleviates metabolic syndromes and intestinal microbiota dysbiosis induced by high-fat and high-fructose diet.

Organic chromium is of great interest and has become an important chromium supplement resource in recent years because of its low toxicity and easy absorption. In our previous study, we synthesized a novel organic chromium [GLP-Cr] through the chelation of Ganoderma lucidum polysaccharide and chromium (III)..

Immune supportMetabolic healthGut & microbiomeLiver support

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Oyster Mushroom · 2022 · Research Article · Nutrients

Pleurotus Ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet.

Pleurotus ostreatus (PO), a common edible mushroom, contains rich nutritional components with medicinal properties. To explore the effect of PO on ameliorating obesity and modulating the gut microbiota, we administered the mice with a low-fat diet or high-fat diet containing different dosages of PO (mass fraction: 0%,….

Immune supportMetabolic healthGut & microbiomeLiver support

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Maitake · 2022 · Journal Article · The Journal of pharmacy and pharmacology

Polysaccharides of Grifola frondosa ameliorate oxidative stress and hypercholesterolaemia in hamsters fed a high-fat, high-cholesterol diet.

OBJECTIVES: This study was to evaluate the antioxidant and anti-hypercholesterolaemia activities of Grifola frondosa in hamsters fed a high-fat, high-cholesterol (HFHC) diet. METHODS: G..

Immune supportMetabolic healthLiver support

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Reishi · 2022 · Journal Article · Molecular biology reports

Regulation of Nrf2 and Nrf2-related proteins by ganoderma lucidum ın hepatocellular carcinoma.

BACKGROUND: HCC is among the most common cancer. Ganoderma lucidum (G.lucidum) has been essential in preventing and treating cancer.

OncologyEnergy & fatigueLiver support

High relevance

Reishi · 2022 · Research Article · Frontiers in nutrition

Removing the sporoderm from the sporoderm-broken spores of Ganoderma lucidum improves the anticancer and immune-regulatory activity of the water-soluble polysaccharide.

Plant-derived polysaccharides have demonstrated promising anti-cancer effects via immune-regulatory activity. The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm-removed spores of the medicinal mushroom Ganoderma lucidum (RSGLP),….

OncologyImmune supportGut & microbiomeLiver support

High relevance

Reishi · 2022 · Journal Article · Ecotoxicology and environmental safety

Sporoderm-broken spores of Ganoderma lucidum alleviates liver injury induced by DBP and BaP co-exposure in rat.

Dibutyl phthalate (DBP) and Benzo(a)pyrene (BaP) are ubiquitous contaminants in environment and foodstuffs, which increase the chance of their combined exposure to humans in daily life. However, the combined effects of DBP and BaP on liver and the underlying mechanisms are still unclear..

Immune supportLiver support

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Reishi · 2022 · Research Article · Food chemistry: X

Structural characterization and hepatoprotective activity of an acidic polysaccharide from Ganoderma lucidum.

In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have protective effect on liver damage in mice caused by restraint stress through improving oxidative status..

Immune supportLiver support

High relevance

Mesima · 2022 · Research Article · Antioxidants (Basel, Switzerland)

Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice.

Phellinus linteus (PL), an edible and medicinal mushroom containing a diversity of styrylpyrone-type polyphenols, has been shown to have a broad spectrum of bioactivities. In this study, the submerged liquid culture in a 1600-L working volume of fermentor was used for the large-scale production of PL mycelia..

Energy & fatigueMetabolic healthLiver support

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Enoki · 2022 · Research Article · Frontiers in nutrition

The Effect of Flammulina velutipes Polysaccharide on Immunization Analyzed by Intestinal Flora and Proteomics.

Proteomics and intestinal flora were used to determine the mechanism of immune modulatory effects of Flammulina velutipes polysaccharide on immunosuppressed mice. The results showed that compared with the model group, F..

Immune supportGut & microbiomeLiver supportRespiratory

High relevance

Reishi · 2022 · Research Article · Foods (Basel, Switzerland)

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake.

This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake..

Metabolic healthGut & microbiomeLiver support

High relevance

Maitake · 2021 · Journal Article · Food & function

Anti-obesity effects of Grifola frondosa through the modulation of lipid metabolism via ceramide in mice fed a high-fat diet.

Obesity is characterized by massive fat deposition and is related to a series of metabolic complications, such as insulin resistance (IR) and steatohepatitis. Grifola frondosa (GF) is a basidiomycete fungus and a source of various nutritional ingredients related to human health..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Niu-Chang-Chih · 2021 · Journal Article · Food & function

Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake.

This study aimed to investigate the protective effect of Antrodin A (AdA) from Antrodia camphorata (A. camphorata) mycelium on alcohol-induced gut microbiota and liver metabolomic disorders..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Wood Ear · 2021 · Journal Article · Journal of food science

Auricularia auricula-judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ-induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota.

Auricularia auricula-judae is an edible fungus with high nutritional value due to abundant polysaccharides, and is acknowledged as traditional food and medicine in Asia. Polysaccharides from A.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Niu-Chang-Chih · 2021 · Research Article · Preventive nutrition and food science

Ergostatrien-3β-ol (EK100) from Antrodia camphorata Attenuates Oxidative Stress, Inflammation, and Liver Injury In Vitro and In Vivo.

Hepatic ischemia/reperfusion (IR) injury is a complication that occurs during liver surgery, whereby hepatic tissue is injured by oxygen deficiency during ischemia, then further damaged by a cascade of inflammatory and oxidative insults when blood is resupplied during reperfusion..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Reishi · 2021 · Journal Article · Internal medicine (Tokyo, Japan)

Hypereosinophilia with Hepatic Nodule Formation Caused by Ganoderma lucidum

A 61-year-old man who underwent surgery for rectal adenocarcinoma developed multiple hepatic nodules. The nodules were 1-3 cm without a capsular structure or contrast enhancement on computed tomography/magnetic resonance imaging, findings that were atypical for adenocarcinoma metastases..

OncologyLiver support

High relevance

Chaga · 2021 · Research Article · Foods (Basel, Switzerland)

Lipid-Lowering Effects of Inonotus obliquus Polysaccharide In Vivo and In Vitro.

Excessive lipid intake will cause hyperlipidemia, fatty liver metabolism disease, and endanger people's health. Edible fungus polysaccharide is a natural active substance for lipid lowering.

Immune supportMetabolic healthLiver support

High relevance

Lion's Mane · 2021 · Journal Article · International journal of biological macromolecules

Multi-walled carbon nanotube polysaccharide modified Hericium erinaceus polysaccharide as an adjuvant to extend immune responses.

In recent years, the utilization of CS-MWCNT as targeted drug carriers has attracted considerable attention. Hericium erinaceus polysaccharide (HEP) has been reported as an immunostimulant to improve immune responses.

Immune supportLiver support

High relevance

Oyster Mushroom · 2021 · Journal Article · International journal of food science & technology

Partial replacement of fat and salt in liver pâté by addition of Agaricus bisporus and Pleurotus ostreatus flour

The effect of incorporation of 7.5% (hydrated 50/50 w/w) and 10% (hydrated 70/30 w/w) of Agaricus bisporus (Ab) and Pleurotus ostreatus (Po) flours as partial replacers of fat and salts (sodium chloride and phosphates) on physicochemical properties, microbiological and sensory properties of pâté was studied during….

Liver support

High relevance

Enoki · 2021 · Journal Article · Food & function

Polysaccharide from Flammulina velutipes attenuates markers of metabolic syndrome by modulating the gut microbiota and lipid metabolism in high fat diet-fed mice.

Natural biological macromolecules with putative functions of gut microbiota regulation possess the advantage of improving metabolic syndrome (MS). In this research, we aimed to determine the effects of Flammulina velutipes polysaccharide (FVP) (Expt.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Mesima · 2021 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Potential Protective Activities of Extracts of Phellinus linteus and the Altered Expressions of GSTM3 on Age-Related Cataract.

Age-related cataract (ARC) is one of the leading causes of visual impairment and blindness worldwide among the elderly. Here, we used sodium selenite-induced cataract mouse model, which shares with similarities with human senile cataract to investigate whether the extracts of Phellinus linteus (PLE) could have the….

Liver support

High relevance

Shiitake · 2021 · Journal Article · Food & function

Protective effects of sulfated polysaccharides from Lentinula edodes on the lung and liver of MODS mice.

In this work, the effects of sulfated polysaccharides from Lentinula edodes (SPLE) on zymosan (ZYM)-induced multiple organ dysfunction syndrome (MODS) mice were investigated..

Immune supportLiver supportRespiratory

High relevance

Maitake · 2021 · Journal Article · International journal of biological macromolecules

The effects of quorum sensing molecule farnesol on the yield and activity of extracellular polysaccharide from Grifola frondosa in liquid fermentation.

A strategy by exogenous addition of quorum sensing molecule farnesol to improve the production, antioxidant activity and antitumor activity of extracellular polysaccharide (EPS) of Grifola frondosa by liquid fermentation was proposed in the study..

OncologyImmune supportLiver support

High relevance

Cordyceps · 2023 · Research Article · Molecules (Basel, Switzerland)

Characterization of Metabolite Landscape Distinguishes Medicinal Fungus Cordyceps sinensis and other Cordyceps by UHPLC-Q Exactive HF-X Untargeted Metabolomics.

Cordyceps represent a valuable class of medicinal fungi with potential utilization. The overexploitation and resource scarcity of Cordyceps sinensis (CS) have led to the emergence of Cordyceps such as Cordyceps militaris (CM) and Cordyceps cicadae (CC) as substitutes..

Metabolic healthLiver support

High relevance

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Toxicological safety evaluation of the cultivated Chinese cordyceps.

ETHNOPHARMACOLOGICAL RELEVANCE: The Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus complex in the Qinghai-Tibet Plateau, is one of the most valuable traditional Chinese medicines and health food for ameliorating conditions associated with aging and for treating fatigue, night sweats,….

Energy & fatigueMetabolic healthLiver supportRespiratory

High relevance

Almond Mushroom · 2017 · Review · Current pharmaceutical design

Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies.

BACKGROUND: The mushroom Agaricus blazei has evoked considerable scientific and practical interest in several fields, especially those linked to its medicinal properties. This review aims to summarize and evaluate the past decade findings related to nutritional and therapeutic uses of A..

OncologyImmune supportMetabolic healthLiver support

High relevance

Maitake · 2017 · Review · International journal of biological macromolecules

Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review.

Grifola frondosa (Dicks.) Gray is a widely consumed edible and medicinal fungus, Ancient books record that it can boost qi and fortify the spleen, moisten the lung and protect the liver. Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers.

OncologyImmune supportMetabolic healthLiver support

High relevance

Cordyceps · 2025 · Review · Current pharmaceutical design

Immunopharmacological Insights into Cordyceps spp.: Harnessing Therapeutic Potential for Sepsis.

Cordyceps spp. (CS), a well-known medicinal mushroom that belongs to Tibetan medicine and is predominantly found in the high altitudes in the Himalayas.

Immune supportCognition & nervesLiver supportRespiratory

High relevance

Cordyceps · 2024 · Review · Journal of industrial microbiology & biotechnology

Enhancement of bioactive metabolites from solid-state fermentation of Cordyceps fungus using various substrates on ameliorating oxidative stress to liver health.

Cordyceps, a genus of Ascomycetes, represents a group of fungi that has attracted considerable attention from both the scientific community and practitioners of traditional medicine..

Liver support

High relevance

Almond Mushroom · 2020 · Research Article · Food science & nutrition

Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ-induced diabetic rats.

Agaricus blazei Murrill (ABM) is an edible fungus. This study investigated the protective role of ABM fruiting body against streptozotocin (STZ)-induced diabetic rats.

Metabolic healthLiver support

High relevance

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses.

This study investigated the adjuvant effects for anticancer and antifatigue of the combination of Cordyceps militaris extract with sorafenib. The 5 extracts of C militaris were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity..

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Almond Mushroom · 2020 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats.

Agaricus blazei Murrill (ABM), is a medicinal mushroom, has beneficial effects on diabetes mellitus. In this study, ABM extracts (ethanol extract, EE and ethyl acetate extract, EA) were evaluated to explore the beneficial effect on hepatic antioxidant activity and recovery of the pancreatic tissue in….

Metabolic healthLiver support

High relevance

Maitake · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

A polysaccharide-peptide with mercury clearance activity from dried fruiting bodies of maitake mushroom Grifola frondosa.

Mercury is considered to be "a global pollutant" and raises concern worldwide. Once mercury enters the body, it will be distributed all over the body but will accumulate in the brain, kidney and liver.

Immune supportCognition & nervesLiver support

High relevance

King Oyster · 2018 · Research Support, Non U.S. Gov'T · Scientific reports

The characteristic, antioxidative and multiple organ protective of acidic-extractable mycelium polysaccharides by Pleurotus eryngii var. tuoliensis on high-fat emulsion induced-hypertriglyceridemic mice.

The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2017 · Research Support, Non U.S. Gov'T · Scientific reports

Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis.

Adjuvants are common component for many vaccines but there are still few licensed for human use due to low efficiency or side effects. The present work adopted Systems Pharmacology analysis as a new strategy to screen adjuvants from traditional Chinese medicine..

Immune supportLiver support

High relevance

King Oyster · 2016 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells.

This study was designed to investigate the chemical characterization and antitumor effects of Pleurotus eryngii polysaccharides (PEP). The crude PEP was fractionated into two fractions, namely PEP-1 and PEP-2..

OncologyImmune supportMetabolic healthLiver support

High relevance

Shiitake · 2016 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Extracts from Lentinula edodes (Shiitake) Edible Mushrooms Enriched with Vitamin D Exert an Anti-Inflammatory Hepatoprotective Effect.

Vitamin D has been known for its anti-inflammatory properties. Extracts derived from Lentinula edodes (Shiitake) edible mushroom exert an anti-inflammatory effect..

Immune supportLiver supportSkin & hydration

High relevance

King Oyster · 2016 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification.

Pleurotus eryngii is a medicinal/edible mushroom with great nutritional value and bioactivity. Its polysaccharide has recently been developed into an effective gene vector via cationic modification.

Immune supportLiver support