MycoData

INTRODUCTION: Recurrent respiratory tract infections (RRTIs) are common in childhood and impose substantial socioeconomic burden. β-Glucans, particularly pleuran from Pleurotus ostreatus, demonstrate immunomodulatory properties through the pathogen-associated molecular pattern receptor interactions..

Immune supportRespiratory

Medium relevance

Cordyceps · 2023 · Journal Article · Journal of natural medicines

Cordythiazole A, the first member of thiazole alkaloids from Chinese cordyceps, with α-glucosidase inhibitory activity.

Chinese cordyceps, also known as Dong-Chong-Xia-Cao, is widely recognized as a famous precious tonic herb, and used as traditional Chinese medicine for centuries..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Cordyceps · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

A Novel Gammapartitivirus That Causes Changes in Fungal Development and Multi-Stress Tolerance to Important Medicinal Fungus Cordyceps chanhua.

Cicada flower, scientifically named Cordyceps chanhua, is an important and well-known Chinese cordycipitoid medicinal mushroom. Although most mycoviruses seem to induce latent infections, some mycoviruses cause host effects.

Respiratory

Medium relevance

Cordyceps · 2022 · Journal Article · Archives of virology

Complete genome sequence of a novel victorivirus infecting cicada flower (Cordyceps chanhua).

Cicada flower, Cordyceps chanhua, is a precious edible and medicinal mushroom with uses in both medicine and food in China. In this study, Cordyceps chanhua strain RCEF5995 was found to be coinfected by a previously characterized alternavirus, Cordyceps chanhua alternavirus 1 (CcAV1), and a novel victorivirus,….

Respiratory

Medium relevance

Chaga · 2022 · Research Article · Computers in biology and medicine

Interference of Chaga mushroom terpenoids with the attachment of SARS-CoV-2; in silico perspective.

Finding a potent inhibitor to the pandemic SARS-CoV-2 is indispensable nowadays. Currently, in-silico methods work as expeditious investigators to screen drugs for possible repurposing or design new ones..

OncologyCognition & nervesMetabolic healthRespiratory

Medium relevance

Cordyceps · 2022 · Journal Article · Archives of virology

Molecular characterization of a novel alternavirus infecting the entomopathogenic fungus Cordyceps chanhua.

In this study, a novel double-stranded (ds) RNA mycovirus, named Cordyceps chanhua alternavirus 1 (CcAV1), was detected in the entomogenous fungus Cordyceps chanhua in China and characterized..

Respiratory

Medium relevance

Almond Mushroom · 2022 · Research Article · Pattern recognition

The CP-ABM approach for modelling COVID-19 infection dynamics and quantifying the effects of non-pharmaceutical interventions.

The motivation for this research is to develop an approach that reliably captures the disease dynamics of COVID-19 for an entire population in order to identify the key events driving change in the epidemic through accurate estimation of daily COVID-19 cases..

Cognition & nervesRespiratory

Medium relevance

Almond Mushroom · 2021 · Research Article · Royal Society open science

A hybrid PDE-ABM model for viral dynamics with application to SARS-CoV-2 and influenza.

We propose a hybrid partial differential equation-agent-based (PDE-ABM) model to describe the spatio-temporal viral dynamics in a cell population. The virus concentration is considered as a continuous variable and virus movement is modelled by diffusion, while changes in the states of cells (i.e..

Respiratory

Medium relevance

Chaga · 2021 · Research Article · Food science & nutrition

Targeting SARS-CoV-2 with Chaga mushroom: An in silico study toward developing a natural antiviral compound.

The novel coronavirus (SARS-CoV-2) has caused large-scale global outbreaks and mainly mediates host cell entry through the interaction of its spike (S) protein with the human angiotensin-converting enzyme-2 (ACE-2) receptor..

Immune supportEnergy & fatigueRespiratory

Medium relevance

Enoki · 2007 · Journal Article · American journal of industrial medicine

Hypersensitivity pneumonitis caused by Penicillium citrinum, not Enoki spores.

BACKGROUND: Flammulina velutipes is called the Enoki mushroom in Japanese and is cultivated indoors. Mushroom workers face occupational exposure to a tremendous number of fungi and organic antigens capable of causing hypersensitivity pneumonitis (HP)..

Immune supportRespiratory

Medium relevance

Reishi · 2025 · Research Article · Food science & nutrition

Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via TNF/NF-κB/MAPKs Signaling Pathway.

Ganoderma lucidum (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for its medicinal properties, particularly in alleviating respiratory issues like cough and asthma..

Immune supportEnergy & fatigueRespiratory

Medium relevance

Cordyceps · 2023 · Review · International journal of molecular sciences

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer.

Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Almond Mushroom · 2021 · Review · Scandinavian journal of immunology

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation?

Medicinal mushrooms have documented effects against different diseases, including infections and inflammatory disorders. The related Basidiomycota Agaricus blazei Murill (AbM), Hericium erinaceus (HE), and Grifola frondosa (GF) have been shown to exert antimicrobial activity against viral agents, Gram-positive and….

Immune supportRespiratory

Medium relevance

Reishi · 2021 · Review · International journal of medicinal mushrooms

Rationalization of Mushroom-Based Preventive and Therapeutic Approaches to COVID-19: Review.

Since December 2019, a de novo pattern of pneumonia, later named coronavirus disease 2019 (COVID-19), has caused grave upset throughout the global population. COVID-19 is associated with several comorbidities; thus, preventive and therapeutic strategies targeting those comorbidities along with the causative agent,….

Respiratory

Medium relevance

Almond Mushroom · 2024 · Systematic Review · Neurocritical care

Detection and Management of Elevated Intracranial Pressure in the Treatment of Acute Community-Acquired Bacterial Meningitis: A Systematic Review.

Acute bacterial meningitis (ABM) is associated with severe morbidity and mortality. The most prevalent pathogens in community-acquired ABM are Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae..

Immune supportCognition & nervesRespiratory

Medium relevance

Niu-Chang-Chih · 2005 · Journal Article · Journal of agricultural and food chemistry

Mycelia from Antrodia camphorata in Submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway.

The objective of this study was to investigate the antiproliferative effect and the mechanism of the methanol extracts of mycelia (MEM) form Antrodia camphorata in submerged culture toward HepG2 cells..

OncologyLiver supportRespiratory

Medium relevance

Snow Fungus · 2003 · Research Article · Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University

Effects of Culture Condition on the Mating Pheromone Production of Tremella fuciformis Berk. Spore

Investigated was the serum amylase activity in calves at different age, in lambs, goats, rabbits, and birds. Some species variations were established in the amylase activity, it being highest in rabbits, followed by birds, cattle, goats, and sheep..

Respiratory

Medium relevance

Enoki · 2003 · Research Article · Journal of Fujian Agriculture and Forestry University(Natural Science Edition)

The purification of antiviral protein in Flammulina velutipes and its characteristic against tobacco mosaic virus

The clinical picture of a tumour involving the amygdaloid nucleus was characterized over a period of 6 years by generalised epileptic fits, then a state of agitated delirium with oneirism evolving during 2 months and leading finally to pulmonary embolism..

OncologyCognition & nervesRespiratory

Medium relevance

Enoki · 1999 · Journal Article · FEMS microbiology letters

Double-stranded RNA and virus-like particles in the edible basidiomycete Flammulina velutipes (Enokitake).

One of the commercial strains of Flammulina velutipes was analyzed for the presence of double-stranded RNA (dsRNA) elements to examine the underlying mechanism of strain degeneration. As a result, two dsRNA elements sized 1.9 and 1.8 kb were detected in mycelium derived from spontaneously brown-colored fruit body..

Energy & fatigueRespiratory

Medium relevance

Mesima · 1999 · Journal Article · Immunopharmacology

The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis.

It was previously reported that polysaccharides (PL) isolated from Phellinus linteus strongly stimulated cell-mediated and humoral immunity. This study was undertaken to investigate the immunochemotherapeutic activity of PL against tumor growth and metastasis..

OncologyImmune supportRespiratory

Medium relevance

Enoki · 1998 · Journal Article · Zhongguo sheng hua yao wu za zhi

Antitumor activity and effect on immunocompetence of Flammulina velutipes mycelia glycoprotein

Three cases of total unilateral pulmonary venous connection of the left lung with intact atrial septum are described. All patients were acyanotic and had findings of volume overload of the right side of the heart..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2026 · Journal Article · Phytotherapy research: PTR

Bioactive Sphingolipids of Cordyceps sinensis Modulate Tumor Immunity Through the SphK1-Mediated Cer/S1P Axis.

Cordyceps sinensis is a traditional medicinal fungus known for its immunomodulatory properties. Its bioactive sphingolipids (SPLs) exhibit antitumor potential, though their mechanisms remain poorly understood.

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2026 · Research Article · Scientific reports

Cordyceps sinensis enhances the efficacy of anti-PD-1 immunotherapy in Lewis lung adenocarcinoma.

Lung cancer, primarily non-small cell lung cancer (NSCLC), causes the highest cancer-related mortality. Although PD-1/PD-L1 inhibitors have improved survival in advanced NSCLC, they can cause immune-related adverse events.

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Cordyceps · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Integrating proteomics, metabolomics, and network pharmacology to investigate the mechanism of Cordyceps sinensis in the treatment of COPD rats.

Chronic obstructive pulmonary disease (COPD) causes significant morbidity and mortality, ranking as the third leading cause of death globally. Cordyceps sinensis (C..

Immune supportMetabolic healthRespiratory

Medium relevance

Cordyceps · 2025 · Research Article · ACS omega

The Effect of Cordyceps sinensis Polysaccharide Combined with Cisplatin on LLC1 Lung Cancer.

Although cisplatin (DDP) is commonly used in the clinical treatment of lung cancer, the associated side effects remained serious. Chinese medicine can be used to increase the sensitivity of the body to antitumor drugs while reducing their adverse effects..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2025 · Journal Article · Journal of Asian natural products research

Therapeutic potential of Cordyceps sinensis targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis.

This study aimed to investigate the effects of wild Cordyceps sinensis on chronic obstructive pulmonary disease (COPD) rats through metabolomics approach, combined with biochemical parameters evaluations. Consequently, C.

Immune supportMetabolic healthRespiratory

Medium relevance

Agarikon · 2024 · Research Article · Journal of traditional and complementary medicine

Chemical profiling and mechanisms of Agarikon pill in a rat model of cigarette smoke-induced chronic obstructive pulmonary disease.

BACKGROUND AND AIM: Agarikon pill (AGKP), a traditional Chinese herbal formula, and has been used for chronic obstructive pulmonary disease (COPD) treatment clinically. However, the active components and exact pharmacological mechanisms are still unclear..

Immune supportEnergy & fatigueRespiratory

Medium relevance

Cordyceps · 2024 · Research Article · Chinese medicine

Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway.

OBJECTIVE: To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). METHODS: We created a murine model of NSCLC and studied the potential molecular mechanism by which C..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2024 · Research Article · Frontiers in pharmacology

Efficacy and safety of Cordyceps sinensis (Hirsutella sinensis, Cs-C-Q80) in chronic bronchitis.

Background: Cordyceps sinensis is a traditional Chinese medicine that has shown promise for the management of chronic bronchitis (CB). We aim to assess the efficacy and safety of a preparation of C sinensis named Bailing capsule (Hirsutella sinensis, Cs-C-Q80) compared with a placebo in patients with CB..

Gut & microbiomeRespiratory

Medium relevance

Cordyceps · 2024 · Research Article · Frontiers in microbiology

Roles of CcDFR and CcOMT9 in the cyanidin biosynthesis and development of Cordyceps cicadae.

INTRODUCTION: Cordyceps cicadae is a traditional Chinese medicinal fungus known for its rich production of bioactive substances, particularly cyanidin, an anthocyanin commonly found in plants with notable anti-inflammatory, anti-tumor, antiviral, and antibacterial properties..

OncologyImmune supportRespiratory

Medium relevance

Maitake · 2018 · Research Article · Oncotarget

Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells.

Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy.

OncologyImmune supportRespiratory

Medium relevance

Shiitake · 2017 · Other · Food & nutrition research

Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit.

β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained from Shiitake mushrooms were chemically characterized..

Immune supportCognition & nervesRespiratory

Medium relevance

King Oyster · 2026 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms.

Infections affecting the nervous system require a rapid expansion of effective therapeutic strategies. The emergence of new viral pathogens continues to pose a substantial threat to brain health worldwide, as evidenced by the recent pandemic..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Medium relevance

Chaga · 2025 · Review · Bulletin of experimental biology and medicine

Antiviral Activity of Plant-Based Preparations against SARS-CoV-2 and Herpes Simplex Virus Type 2 In Vitro: A Review of Experimental Findings.

We reviewed published data on the efficacy of plant-derived preparations, including the authors' original in vitro findings on the antiviral activity of aqueous and dry ethanol extracts against the RNA virus SARS-CoV-2 and the DNA virus herpes simplex virus type 2 (HSV-2)..

Respiratory

Medium relevance

Oyster Mushroom · 2024 · Preprint · journal metadata

In vitro anti-influenza virus (H1N1) activity of eleven species of Korean medicinal mushrooms

Abstract Background: Oseltamivir is the most commonly used antiviral drug for the treatment and prevention of influenza. However, there are growing concerns about its use due to the risk of psychiatric side effects..

OncologyRespiratory

Medium relevance

Oyster Mushroom · 2022 · Brief Report · Frontiers in pediatrics

Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections: An international, multicentre, open-label, prospective study.

Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors..

Immune supportRespiratory

Medium relevance

Reishi · 2022 · Abstract · Free radical biology & medicine

Ganoderma lucidum extract, Lycopene, Sulforaphane, Royal Jelly and Resveratrol as a combination demonstrate antioxidant and anti-inflammatory effects in COVID-19

Metadata-grounded summary: This abstract indexes research on Ganoderma lucidum in Free radical biology & medicine in 2022. MycoData maps the paper to immune support, respiratory based on its title, species context, article metadata, and study classification..

Immune supportRespiratory

Medium relevance

Chaga · 2015 · English Abstract · Voprosy virusologii

[Antiviral activity of aqueous extracts of the birch fungus Inonotus obliquus on the human immunodeficiency virus].

Fractions of aqueous and water-alcohol extracts of the birch fungus Inonotus obliquus have antiviral effect against the human immunodeficiency virus type 1 (HIV-1)..

Immune supportRespiratory

Medium relevance

Enoki · 2015 · Research Support, Non U.S. Gov'T · Bioscience, biotechnology, and biochemistry

Alleviation of Dermatophagoides microceras-induced allergy by an immunomodulatory protein, FIP-fve, from Flammulina velutipes in mice.

Asthma is a major public health concern. Its greatest risk factor is house dust mite (HDM).

Immune supportGut & microbiomeRespiratory

Medium relevance

Enoki · 2014 · Research Support, Non U.S. Gov'T · Antiviral research

Alleviation of respiratory syncytial virus replication and inflammation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes.

Respiratory syncytial virus (RSV) causes bronchiolitis in children followed by inflammation and asthma-like symptoms. The development of preventive therapy for this virus continues to pose a challenge.

Immune supportRespiratory

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · Journal of natural products

Antcamphins A-L, ergostanoids from Antrodia camphorata.

Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A..

OncologyRespiratory

Medium relevance

Wood Ear · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Dichlormethane extract of the jelly ear mushroom Auricularia auricula-judae (higher Basidiomycetes) inhibits tumor cell growth in vitro.

In this study, a dichloromethane fraction (DCMF) from 70% Auricularia auricula-judae ethanol extract showed the highest level of antitumor activity compared to other solvent fractions (ethyl acetate, butanol, and water)..

OncologyRespiratory

Medium relevance

Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Oxidative medicine and cellular longevity

Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria.

Dysfunction of the mitochondrial respiratory chain and increased oxidative stress is a striking phenomenon in the brain of aged individuals. For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems..

Cognition & nervesEnergy & fatigueRespiratory

Medium relevance

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal

Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence.

In this study, the neuroprotective effect of an extract of Antrodia camphorata (A. camphorata), a fungus commonly used in Chinese folk medicine for treatment of viral hepatitis and cancer, alone or in combination with aspirin was investigated in a rat embolic stroke model..

OncologyCognition & nervesLiver supportRespiratory

Medium relevance

Chaga · 2014 · Research Support, Non U.S. Gov'T · International journal of oncology

Inonotus obliquus-derived polysaccharide inhibits the migration and invasion of human non-small cell lung carcinoma cells via suppression of MMP-2 and MMP-9.

Polysaccharides isolated from the fruiting body of Inonotus obliquus (PFIO) are known to possess various pharmacological properties including antitumor activity. However, the anti-metastatic effect and its underlying mechanistic signaling pathway involved these polysaccharides in human non-small cell lung carcinoma….

OncologyImmune supportRespiratory

Medium relevance

Mesima · 2014 · Brief Report · Mycobiology

Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus.

During a search for neuraminidase inhibitors derived from medicinal fungi, we found that the fermentation broth of Phellinus linteus exhibited potent neuraminidase inhibitory activity..

Respiratory

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation.

This study innovatively investigated the anticancer effect of Flammulina velutipes sterols (FVSs), the in vivo pharmacokinetics, and the tissue distribution of FVS-loaded liposomes..

OncologyLiver supportRespiratory

Medium relevance

Enoki · 2013 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes.

FIP-fve is an immunomodulatory protein isolated from Flammulina velutipes that possesses anti-inflammatory and immunomodulatory activities. However, little is known about its anticancer effects.

OncologyImmune supportSkin & hydrationRespiratory

Medium relevance

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Nutrition (Burbank, Los Angeles County, Calif.)

Polysaccharides from extracts of Antrodia camphorata mycelia and fruiting bodies modulate inflammatory mediator expression in mice with polymicrobial sepsis.

OBJECTIVES: Antrodia camphorata (AC) is a traditional Chinese medicine, and the polysaccharides contained within AC (AC-PSs) are reported to possess various biological functions..

OncologyImmune supportRespiratory

Medium relevance

Chaga · 2011 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Protective effects and mechanism of Inonotus obliquus on asthmatic mice].

OBJECTIVE: To explore the protective effects and mechanism of ethanol extract of Inonotus obliquus (EEIO) injection on asthmatic mice. METHOD: OVA was injected intraperitoneally and inhaled to produce the asthmatic model.

Immune supportRespiratory