MycoData

Pathological cardiac hypertrophy is an important risk factor for cardiovascular disease. Ganoderic acid A (GAA), the primary bioactive constituent of Ganoderma lucidum (G.

OncologyImmune support

Medium relevance

Reishi · 2026 · Journal Article · Journal of agricultural and food chemistry

Ganoderic Acid A Modulates Enteric Neurons and Intestinal Homeostasis in Irritable Bowel Syndrome by Microbiota Sensing.

Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is characterized by visceral hypersensitivity and intestinal dysmotility. Ganoderic acid A (GAA), a bioactive triterpenoid from the edible mushroom Ganoderma lucidum, has been reported to exert multiple health-promoting effects; yet, its….

Immune supportCognition & nervesGut & microbiome

Medium relevance

Reishi · 2026 · Research Article · Exploration (Beijing, China)

Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy.

Neuroinflammation plays a critical role in cerebral ischemic injury, making it an important therapeutic target for stroke treatment. Ganoderic acids (GAs), the primary bioactive compounds isolated from Ganoderma lucidum, exhibit well-demonstrated anti-inflammatory properties..

Immune supportCognition & nerves

Medium relevance

Reishi · 2026 · Journal Article · Carbohydrate polymers

Identification of multiple galectins as receptors for β-1,3-glucans.

β-1,3-glucans are natural polysaccharides widely distributed in bacterial capsules and fungal cell walls. β-1,3-glucans are potent immunomodulators traditionally recognized by receptors like Dectin-1 and CD204, yet the complete receptor repertoire has remained ill-defined..

OncologyImmune support

Medium relevance

Cordyceps · 2026 · Journal Article · International journal of medicinal mushrooms

Immunomodulatory Effects of Medicinal Mushroom Extracts in the Sensitized Human Keratinocyte Cell Line NCTC2544.

Contact dermatitis (CD) is a common skin condition characterized by inflammation caused by exposure to allergens. In Malaysia, it accounts for a significant portion of skin diseases, with irritant contact dermatitis being the most prevalent type..

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Turkey Tail · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Impact of DNA Extraction Strategies on Genomic and Bioinformatic Outcomes in Eight Selected Fungal Strains.

High-quality genomic DNA extraction remains a major bottleneck for fungal genomics, particularly for worldwide aerobic and non-photosynthetic mushroom species that rely on their rigid cell walls, interference between metabolites, polysaccharides, etc., and complex genomes..

Immune support

Medium relevance

Reishi · 2026 · Research Article · International journal of molecular sciences

In Vitro Anti-Glioblastoma Activity of a Novel Pt(IV)-Ganoderic Acid A Conjugate.

Glioblastoma is the most aggressive primary malignant tumor of the central nervous system in adults, with a poor prognosis and high resistance to conventional therapies. Platinum drugs like cisplatin are effective but limited by systemic toxicity, poor blood-brain barrier penetration, and resistance..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Oyster Mushroom · 2026 · Journal Article · Food chemistry

In-vitro digestion assessment of DIAAR, protein digestibility, and ACE/COX inhibitory activity of solid-state fermented beans.

Adequate protein intake is critical during childhood to support growth, development, and immune function. This in vitro study evaluated the effect of solid-state fermentation with Pleurotus ostreatus on protein digestibility, amino acid profile, and bioactivity (ACE and COX inhibition) in two local bean varieties..

Immune supportGut & microbiome

Medium relevance

Turkey Tail · 2026 · Journal Article · Fitoterapia

MALDI-MSI spatial mapping of phenanthrenes in Bletilla striata leaves uncovers BsLAC1 as the first laccase catalysing phenanthrene dimerisation.

Bletilla striata, a traditional Chinese medicinal herb, is particularly rich in phenanthrenes and their dimers, which exhibit anti-inflammatory, antibacterial, and antitumor properties..

OncologyImmune support

Medium relevance

Shiitake · 2026 · Journal Article · Food Research International

Molecular weight-engineered lentinan fractions as prebiotic modulators: Steering gut microbiota for precision obesity intervention

Lentinus edodes polysaccharides are widely recognized for their potential contributions to human health, in part due to their interactions with the gut microbiota..

Immune supportGut & microbiome

Medium relevance

Shiitake · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Molecular weight-engineered lentinan fractions as prebiotic modulators: Steering gut microbiota for precision obesity intervention.

Lentinus edodes polysaccharides are widely recognized for their potential contributions to human health, in part due to their interactions with the gut microbiota..

Immune supportGut & microbiome

Medium relevance

Reishi · 2026 · Research Article · Frontiers in pharmacology

Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury.

Ganoderic acid A (GAA), a major bioactive triterpenoid from Ganoderma lucidum, is known for its anti-inflammatory effects; however, its precise molecular targets in sepsis-related liver injury (SRLI) remain unclear..

OncologyImmune supportLiver support

Medium relevance

Lion's Mane · 2026 · Journal Article · International journal of biological macromolecules

Multiscale interaction of Hericium coralloides polysaccharide with maize starch: Impact on structural properties and digestibility.

Regulating starch digestion to alleviate postprandial hyperglycemia is one of the core challenges in the field of nutrition. Edible mushroom polysaccharides have become highly promising natural starch modifiers due to their dual functions of modulating food structure and potentially inhibiting digestive enzyme….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Medium relevance

Snow Fungus · 2026 · Journal Article · Carbohydrate polymers

Naturally derived polysaccharides and ganoderic acid A hydrogel with whitening potential to combat oxidative stress and melanin production caused by ultraviolet B

The intersection of natural products and precision skin care has become a new trend in cosmetic development. This study developed a hydrogel composed of oxidized Tremella fuciformis polysaccharide, carboxymethyl chitosan, and Ganoderic acid A..

Immune supportSkin & hydration

Medium relevance

Snow Fungus · 2026 · Journal Article · Carbohydrate polymers

Naturally derived polysaccharides and ganoderic acid A hydrogel with whitening potential to combat oxidative stress and melanin production caused by ultraviolet B.

Immune supportSkin & hydration

Medium relevance

Cordyceps · 2026 · Journal Article · Applied biochemistry and biotechnology

Ophiocordyceps indica from the Indian Himalayas Ameliorates the IgA Nephropathy in Mice.

Immunoglobulin A nephropathy (IgAN) is the most common form of chronic glomerulonephritis and a major cause of end-stage renal disease worldwide, currently lacks safe, effective therapies. Ophiocordyceps sinensis, a well-known traditional medicinal fungus and used for treating kidney-related disorders..

OncologyImmune support

Medium relevance

Turkey Tail · 2026 · Journal Article · BMC immunology

Polypore mushroom mycelia as an adjunct to COVID-19 vaccination: a randomized clinical trial.

BACKGROUND: Use of fungal mycelium as a vaccination adjunct may constitute a novel antiviral strategy to address newly emerging viruses. We evaluated safety and feasibility of a fungal mycelium-based natural product (Fomitopsis officinalis and Trametes versicolor, FoTv) as an adjunct to human COVID-19 vaccination, as….

Immune supportLiver supportRespiratory

Medium relevance

Oyster Mushroom · 2026 · Research Article · Aquaculture nutrition

Species- and Level-Dependent Modulation of Growth and Skin and Intestinal Mucosal Microbiota in Rainbow Trout Fed Mushroom Stem Meals.

Mucosal microbiomes play key roles in fish physiology by supporting digestion, nutrient absorption, metabolism, immune modulation, and pathogen defense. This study evaluated the effects of mushroom stem meals from Agaricus bisporus (AB) and Pleurotus ostreatus (PO) as nutritional alternatives to soybean meal (SBM) on….

Immune supportEnergy & fatigueGut & microbiomeSkin & hydration

Medium relevance

Snow Fungus · 2026 · Research Article · Molecules (Basel, Switzerland)

Structural Elucidation and Moisturizing Potential of a Polysaccharide Derived from Tremella mesenterica.

Tremella mesenterica, commonly known as the yellow brain or golden jelly fungus, has been traditionally used for its medicinal properties. In this study, we elucidated the structural characteristics of T..

Immune supportCognition & nervesMetabolic healthSkin & hydration

Medium relevance

Reishi · 2026 · Journal Article · Industrial crops and products

Synergistic interplay of deep eutectic solvents and multi-modal extraction techniques: A paradigm shift in natural polysaccharide yield, structural modulation, and biofunctional enhancement

Natural polysaccharides are essential macromolecules found in both plant and animal kingdoms, playing significant roles in food, medicine, biomaterials, and packaging. Deep eutectic solvents (DES), formed through hydrogen-bond interactions, offer simple synthesis, eco-friendliness, and lower melting points..

Immune supportMetabolic health

Medium relevance

Oyster Mushroom · 2026 · Journal Article · Pharmaceuticals (Basel, Switzerland)

The Use of Biomass from In Vitro Fungal Cultures as a Bioactive Ingredient with Antimicrobial Activity in Hydrogel Dressings.

Background/Objectives: Chronic wounds represent a significant clinical burden and require multimodal treatment strategies targeting inflammation, infection, moisture balance, and tissue remodeling, as defined by the TIME framework..

Immune supportEnergy & fatigueSkin & hydration

Medium relevance

Snow Fungus · 2026 · Research Article · Regenerative biomaterials

Three-dimensional-printed ROS-scavenging and immunomodulatory hydrogel accelerates diabetic wound healing through synergistic microenvironment regulation.

The management of diabetic wounds remains clinically challenging, primarily owing to three interrelated pathological mechanisms: excessive accumulation of reactive oxygen species (ROS), dysregulated angiogenesis and sustained, non-resolving inflammation..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Medium relevance

Agarikon · 2025 · Journal Article · International journal of biological macromolecules

A TME-responsive polysaccharide nanoplatform integrating synergetic therapy for cancer.

A self-assembling nanoplatform based on FOB (a heteropolysaccharide from Fomitopsis officinalis) named QU@FOB-FcDBA was developed in this study. A dynamic boronate ester bond, a pH-sensitive covalent linkage formed through reversible dehydration reactions, linked FOB and 1,1'-ferrocenediboronic acid (FcDBA) while….

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Turkey Tail · 2025 · Journal Article · International journal of medicinal mushrooms

Analysis of Antioxidant and Anticancer Activities of Selected Trametes Species (Agaricomycetes) from Iran.

The remarkable spectrum of bioactive compounds in medicinal mushrooms makes them an excellent source for treating a variety of diseases. Among these, Trametes Fr.

OncologyImmune supportMetabolic health

Medium relevance

Maitake · 2025 · Journal Article · Journal of agricultural and food chemistry

Antihypertension and Improvement Effects of Hexapeptide APPLRP on Exosomes-Mediated Vascular Endothelial Inflammation in Spontaneously Hypertensive Rats.

The hexapeptide APPLRP from the edible Grifola frondosa mushroom has been verified to possess significant ACE inhibitory activity and ameliorates vascular remodeling. However, in vivo effects have not been systematically investigated..

Immune supportMetabolic healthSkin & hydration

Medium relevance

Reishi · 2025 · Journal Article · International journal of molecular sciences

Antrodia cinnamomea Formula Suppresses Prostate Cancer Progression via Immune Modulation and PD-1/PD-L1 Pathway Inhibition.

Prostate cancer remains a significant global health challenge, necessitating the development of novel therapeutic approaches. This study investigated the therapeutic potential of the Antrodia cinnamomea formula (XIANZHIFANG formula, XZF), comprising Antrodia cinnamomea, Sanghuangporus sanghuang, Ganoderma lucidum,….

OncologyImmune support

Medium relevance

Niu-Chang-Chih · 2025 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Antroquinonol mitigates Tau hyperphosphorylation, neuronal damage and cognitive impairments in a chronic cerebral ischemia rat model.

Chronic cerebral ischemia (CCI) induced hyperphosphorylated Tau has been associated with an increased risk of neurodegenerative disorders such as Alzheimer's and vascular dementia..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Niu-Chang-Chih · 2025 · Research Article · Frontiers in nutrition

Antroquinonol reduces IL-1β production in macrophages through enhancing the DNA methylation of Tlr4.

INTRODUCTION: Macrophages represent one of the most pivotal immune cells in the innate immune responses of weaned piglets. Emerging studies have revealed that numerous plant- or fungal-derived extracts significantly modulate macrophage functions..

Immune support

Medium relevance

Reishi · 2025 · Journal Article · Natural product research

Bioactive secondary metabolites from an endophytic fungus Chloridium virescens GLQ05 and structural revision of alteamide.

Two previously undescribed metabolites, chlovirescenols A (1) and B (5), along with six known compounds including amides (2-4), macrolides (6 and 8), meroterpenoid (7), were obtained from the Ganoderma lucidum-derived endophyte Chloridium virescens GLQ05..

Immune support

Medium relevance

Reishi · 2025 · Journal Article · Zeitschrift fur Naturforschung. C, Journal of biosciences

Comparison of lignocellulosic enzymes and CAZymes between ascomycetes (Trichoderma) and basidiomycetes (Ganoderma) species: a proteomic approach.

Wood decomposing ascomycetes and basidiomycetes group of fungi are the most valuable microbes on the earth's ecosystem that recycles the source of carbon; therefore, they are essential for the biorefinery industries..

Immune supportMetabolic health

Medium relevance

Oyster Mushroom · 2025 · Research Article · BMC complementary medicine and therapies

Computational development of mushroom-6-glucan/paclitaxel as a synergistic complementary medicine for breast cancer therapy.

BACKGROUND: Breast cancer is chemo-resistant and highly metastatic, often resulting in patient mortality. One of the primary factors contributing to the metastasis and chemotherapy resistance is the presence of cancer stem-like cells..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · Natural product research

Decalin derivatives from an endophytic fungus Trichoderma harzianum GLQ03 and their anti-inflammatory activities.

Eight metabolites (1-8) including a new compound tandyukisin J (1) were isolated from Trichoderma harzianum GLQ03 isolated from Ganoderma lucidum. Their absolute configurations were determined based on spectroscopic analysis and CD comparison..

Immune support

Medium relevance

Reishi · 2025 · Research Article · Frontiers in nutrition

Development and preliminary mechanistic analysis of compound effervescent hepatoprotective granules.

BACKGROUND: The causes of acute liver injury (ALI) are complex and diverse, including alcohol, drugs, infections, and toxic substances, and it has become a major global health issue..

Immune supportMetabolic healthLiver support

Medium relevance

Niu-Chang-Chih · 2025 · Research Article · Molecular medicine reports

Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.

Atherosclerosis (AS)‑related coronary artery disease is the main cause of morbidity and mortality around the globe. Eburicoic acid, a triterpenoid compound from Antrodia camphorata, exerts anti‑inflammatory and anti‑hyperlipidemic effects, although its role in atherogenesis remains unknown..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Zhu Ling · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation.

Background: The dysregulation of both glucose and lipid metabolism is the main clinical features of type 2 diabetes. Qihua Tongtiao Formula (QHTTF) is our team's current clinical empirical formula, and the related patent has been granted..

Immune supportMetabolic healthLiver support

Medium relevance

Lion's Mane · 2025 · Journal Article · The Journal of pharmacy and pharmacology

Effects of dietary supplementation with arboreal medicinal mushrooms on stress coping strategies, depressive and anxiety-like behavior of rats.

BACKGROUND: Preclinical studies have demonstrated that the edible arboreal medicinal mushroom Hericium erinaceus (HE) mitigates high corticosterone levels and enhances stress-coping strategies in rodents, with emerging evidence suggesting similar neuroprotective potential for Fomitopsis officinalis (FO) and Pleurotus….

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Effects of Ganoderma spent substrate containing with polysaccharides and triterpenoids on the growth performance, antioxidant capacity and immunity level of chickens.

Ganoderma spent substrate (GSS) is the residual material of Ganoderma lucidum (GL) cultivation, which has abundant polysaccharides and triterpenoids. GL is widely recognized for its antioxidant and immune-boosting properties, however, the effects of GSS remain largely unexplored..

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Reishi · 2025 · Research Article · Frontiers in pharmacology

Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease.

INTRODUCTION: Ethnic groups worldwide use mushrooms, particularly polypores (a group of fungi with woody fruiting bodies), to manage inflammatory conditions. In this study, the in vitro anti-inflammatory potential and mycochemical composition of six polypore extracts derived from the fruit bodies of Fomes fomentarius….

OncologyImmune supportEnergy & fatigueSkin & hydration

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Innovative Food Science and Emerging Technologies

Exploring an eco-friendlier strategy for chitosan production and valuable compounds recovery from mushroom by-products with modified subcritical water

Chitosan is the deacetylated derivative of chitin, the second most abundant polysaccharide in nature. It is a promising eco-friendly polymer with immense potential owing to its unique properties and high versatility, offering notable contributions to various industries..

Immune support

Medium relevance

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Exploring the Nutraceutical Potential of a Food-Medicine Compound for Metabolic-Associated Fatty Liver Disease via Lipidomics and Network Pharmacology.

Metabolic-associated fatty liver disease (MAFLD) is a prevalent global health issue closely tied to dietary habits, impacting a significant portion of the adult population..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Enoki · 2025 · Research Article · Scientific reports

Fungal immunomodulatory protein FIP-fve mitigates airway inflammation and metabolic dysfunction in an obese allergic asthma model.

Obesity is a growing global health concern that exacerbates the risk and severity of allergic asthma, yet effective therapies and mechanistic understanding remain limited..

Immune supportMetabolic healthLiver supportRespiratory

Medium relevance

Shiitake · 2025 · Research Article · Microorganisms

Fungal β-Glucans Enhance Lactic Acid Bacteria Growth by Shortening Their Lag Phase and Increasing Growth Rate.

The gut microbiome has a significant role in general health and well-being. Novel types of prebiotics, such as fungal polysaccharides, show potential for the formulation of new synbiotic formulations.

Immune supportGut & microbiome

Medium relevance

Lion's Mane · 2025 · Journal Article · Histology and histopathology

Galangin alleviates gastric mucosal injury in rats with chronic atrophic gastritis by reducing ferroptosis.

OBJECTIVE: Chronic atrophic gastritis (CAG) is a precancerous lesion and is the first stage in a multistep precancerous cascade that can lead to gastric adenocarcinoma. This study aimed to reveal the role and mechanism of galangin in CAG..

OncologyImmune supportEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · J Nat Med

Ganoderic acid A ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation

Research context reveals that major depressive disorder (MDD), as a prevalent chronic relapsing psychiatric condition affecting up to one-third of patients with treatment resistance, necessitates urgent development of novel therapeutic agents..

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · Journal of natural medicines

Ganoderic acid A ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation.

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · World journal of surgical oncology

Ganoderic acid a potentiates cisplatin's cytotoxicity on gallbladder cancer cells by promoting DNA damage and inhibiting cell stemness.

BACKGROUND: Ganoderma acid A (GAA), a triterpenoid compound from Ganoderma lucidum, has gained attention for its anti-tumor properties. Herein, we hypothesized that GAA may enhance cisplatin's (DDP) anticancer effect in gallbladder cancer (GBC) cells by promoting DNA damage response, particularly through upregulation….

OncologyImmune supportGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · International immunopharmacology

Ganoderic acid A regulates CSF1R to reprogram tumor-associated macrophages for immune therapy of hepatocellular carcinoma.

BACKGROUND: The tumor microenvironment (TME) plays a crucial role in cancer progression, with tumor-associated macrophages (TAMs) constituting the core cell population of the tumor immune microenvironment. TAMs can differentiate into M1 or M2 types based on the TME, either inhibiting or promoting tumor development..

OncologyImmune supportLiver support

Medium relevance

Reishi · 2025 · Research Article · International journal of molecular sciences

Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.

Ulcerative colitis (UC) is a chronic and recurrent gastrointestinal disease that affects millions of humans worldwide and imposes a huge social and economic burden. It is necessary to find safe and efficient drugs for preventing and treating UC..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Snow Fungus · 2025 · Research Article · Journal of advanced research

Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice.

INTRODUCTION: Over decades, the source-function relationships of bioactive polysaccharides have been progressively investigated, however, it is still unclear how a defined structure may conduce to the bioactivities of polysaccharides..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2025 · Research Article · Biotechnology and bioengineering

Gold Nanoparticles Coated With Hydrophobin-ProteinA Fusion Protein: Development of a Versatile Immunosensing Platform.

Advancing immunosensing technologies hinges on the development of next-generation surface functionalization methods, as the precise anchoring of antibodies on transducer interface is essential for achieving high sensitivity and selectivity..

OncologyImmune supportEnergy & fatigueRespiratory