MycoData

While bacterial dysbiosis has been extensively studied in schizophrenia with metabolic syndrome (SZ-MetS), the role of gut mycobiota in this comorbidity remains unclear..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Medium relevance

Reishi · 2025 · Journal Article · Poultry Science

Harnessing mushrooms for poultry nutrition: Boosting health, immunity, and productivity

Edible mushrooms, the fruiting bodies of fungi, are emerging as promising functional feed additives in poultry nutrition, offering a sustainable alternative to synthetic growth promoters..

Immune supportMetabolic healthGut & microbiome

Medium relevance

Oyster Mushroom · 2025 · Journal Article · Food chemistry

Identification of new selenium compounds produced by edible mushrooms.

The ability of two common edible mushroom species, Pleurotus ostreatus and Hericium coralloides, to metabolize selenium when grown in the presence of selenite (Se(IV)) and selenate (Se(VI)) was investigated. The efficiency of selenium absorption was 4-8 times higher when Se(IV) was used as selenium source..

Immune support

Medium relevance

Turkey Tail · 2025 · Journal Article · Journal of Ethnopharmacology

Inhibition of Pseudomonas aeruginosa Quorum Sensing-Regulated Behaviors by Mushroom Extracts

Microbial biofilm formation, a quorum sensing (QS) phenomenon based on cell-to-cell communication through ligand-receptor interactions, is one of the major causes of nosocomial and chronic infections, foodborne diseases and associated deaths..

Immune support

Medium relevance

Turkey Tail · 2025 · Journal Article · Journal of ethnopharmacology

Inhibition of Pseudomonas aeruginosa quorum sensing-regulated behaviors by mushroom extracts.

ETHNOPHARMACOLOGICAL RELEVANCE: Microbial biofilm formation, a quorum sensing (QS) phenomenon based on cell-to-cell communication through ligand-receptor interactions, is one of the major causes of nosocomial and chronic infections, foodborne diseases and associated deaths..

Immune support

Medium relevance

Zhu Ling · 2025 · Journal Article · Journal of ethnopharmacology

Injinoryeong-San attenuates metabolic dysfunction-associated steatohepatitis via regulation of YAP/TAZ-signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Injinoryeong-san (IJO), known as Yinchen-Wuling Powder in Chinese medicine, is a traditional herbal formula comprising six herbal medicinal plants, including Atractylodes macrocephala Koidz., Polyporus umbellatus (Pers.) Fries, Poria cocos (Schw.) Wolf, Cinnamomum cassia Presl, Alisma….

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Integrated Process for Mycoprotein and Enzyme Production during Solid-State Fermentation of Lignocellulosic Materials Using Medicinal Mushrooms.

This study evaluated the potential of Ganoderma lucidum BCC447 and Pleurotus ostreatus BCC2191 to enrich plant materials with mycoproteins and cellulases through solid-state fermentation (SSF) of wheat bran, shredded wheat, and soybean meal for the use of the fermented product as a natural food additive in poultry and….

Immune support

Medium relevance

Almond Mushroom · 2025 · Research Article · Digestive diseases and sciences

LeLISA: A New Lectin-Based Immunoassay for Evaluation of Mucinous and Serous Content in Pancreatic Cystic Neoplasms.

BACKGROUND: The discrimination of mucinous from serous pancreatic cysts and pseudocysts is an important clinical issue. We aimed to investigate the possibility of using our LeLISA test for distinguishing between different types of pancreatic cysts..

OncologyImmune supportGut & microbiome

Medium relevance

Shiitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Lentinan attenuates histone deacetylation of SOCS1 promoter to remodel autophagy via JAK2/STAT3 pathway for the prevention of intervertebral disc degeneration

Intervertebral disc degeneration (IVDD), driven by nucleus pulposus cell (NPCs) apoptosis, extracellular matrix (ECM) dyshomeostasis, and inflammation, lacks effective therapies. Lentinan (LNT), a polysaccharide from lentinula edodes, has anti-inflammatory and antioxidant properties..

OncologyImmune supportEnergy & fatigue

Medium relevance

Shiitake · 2025 · Journal Article · International journal of biological macromolecules

Lentinan attenuates histone deacetylation of SOCS1 promoter to remodel autophagy via JAK2/STAT3 pathway for the prevention of intervertebral disc degeneration.

OncologyImmune supportEnergy & fatigue

Medium relevance

Shiitake · 2025 · Research Article · Frontiers in immunology

Lentinan enhances CAR-T cell potency in solid tumors by optimizing T cell differentiation.

CAR-T cell therapy has demonstrated remarkable success in treating hematologic malignancies; however, its efficacy in solid tumors remains constrained. In this study, we demonstrate that Lentinan (LTN), an active polysaccharide derived from Lentinula edodes, potently enhances CAR-T cell function against solid tumors..

OncologyImmune supportCognition & nervesGut & microbiome

Medium relevance

Turkey Tail · 2025 · Research Article · Communications biology

Metabolic profiling of two white-rot fungi during 4-hydroxybenzoate conversion reveals biotechnologically relevant biosynthetic pathways.

White-rot fungi are efficient organisms for the mineralization of lignin and polysaccharides into CO2 and H2O. Despite their biotechnological potential, WRF metabolism remains underexplored..

Immune supportMetabolic health

Medium relevance

Agarikon · 2025 · Journal Article · ACS applied bio materials

Natural Flavonoid and Fungal Polysaccharide-Based Redox-Responsive Nanogels for Synergistic Tumor Chemo-Immunotherapy.

Cancer remains a leading cause of global mortality, underscoring the urgent need for safe, effective, and innovative therapeutic strategies. Nanotechnology, particularly nanogels, offers promising opportunities for cancer treatment..

OncologyImmune support

Medium relevance

Snow Fungus · 2025 · Journal Article · Food Research International

Natural polysaccharides mediated “low-molecular-bridging" network in fermented soybean protein gels: Interaction, microstructure, and rheological properties

This study investigated the interactions, microstructure, and rheological properties of Lactobacillus plantarum JYLP-326-fermented protein gels formed by soybean protein isolate (SPI) and three natural polysaccharides: fucoidan (FU), tremella fuciformis polysaccharide (TFP), and lycium barbarum polysaccharide (LBP)..

Immune supportEnergy & fatigueGut & microbiomeSkin & hydration

Medium relevance

Snow Fungus · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Natural polysaccharides mediated "low-molecular-bridging" network in fermented soybean protein gels: Interaction, microstructure, and rheological properties.

Immune supportEnergy & fatigueGut & microbiomeSkin & hydration

Medium relevance

Snow Fungus · 2025 · Research Article · Foods (Basel, Switzerland)

Natural Tremella Polysaccharide Mitigates DEHP-Induced Oxidative Stress and Apoptosis via Dual Regulation of Survival and Antioxidant Pathways.

Diethylhexyl phthalate (DEHP), a common environmental plasticizer, induces oxidative damage and cell apoptosis without efficient treatment. Tremella fuciformis polysaccharides (TFPs) are known natural antioxidants, yet their protection against DEHP toxicity remains unclear..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2025 · Research Article · International journal of molecular sciences

Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer.

Integrating network pharmacological analysis and bioinformatic techniques, this study systematically investigated the molecular mechanisms of six medicinal food homologous plants (Astragalus membranaceus, Ganoderma lucidum, Dioscorea opposite, Curcuma longa, Glycyrrhiza uralensis, and Pueraria lobata) against….

OncologyImmune supportCognition & nerves

Medium relevance

Turkey Tail · 2025 · Research Article · Nutrients

Neuroprotective Effects of Mushroom Biomass Digestive Fractions and Gut Microbiota Metabolites in Microglial and Caenorhabditis elegans Models of Neurodegeneration.

Background: The accumulation of β-amyloid plaques, neurofibrillary tangles, and neuroinflammation are key hallmarks of Alzheimer's disease (AD). Reactive oxygen species (ROS) act as major triggers and amplifiers of neuroinflammatory responses, contributing to immune dysregulation and neuronal damage..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Medium relevance

Oyster Mushroom · 2025 · Research Article · ACS omega

One-Health Approach to Managing Aflatoxin-Producing Aspergillus flavus Using Spent Mushroom Substrate of Pleurotus spp.

Food loss represents a critical global concern. Aspergillus flavus is central to this issue, contaminating maize crops with aflatoxins.

Immune support

Medium relevance

Zhu Ling · 2025 · Research Article · International journal of molecular sciences

Polyporusterone B Alleviates Inflammatory Injury via Suppression of Pro-Inflammatory Cytokine Production.

Polyporusterone B, a triterpene carboxylic acid isolated from Polyporus umbellatus Fries, exhibits anti-cancer and anti-hemolytic activities; however, its anti-inflammatory properties and underlying mechanisms remain unelucidated..

OncologyImmune supportLiver supportRespiratory

Medium relevance

Reishi · 2025 · Journal Article · Food Research International

Radioprotective effect of edible and medicinal mushrooms against ionizing radiation: Components, potential mechanisms, and applications

Ionizing radiation can cause severe damage to the body. The use of natural products as radioprotective agents has gained increasing popularity and attention in recent years..

OncologyImmune support

Medium relevance

Reishi · 2025 · Journal Article · Food Research International

Reducing cellular inflammation and oxidation by supercritical CO2 extracts from edible-medicinal mushrooms

Extracts from Hericium erinaceus, Ganoderma lucidum and Tremella fuciformis obtained with supercritical CO₂ showed high cellular antioxidant activity (CAA) when tested on Caco-2 cell cultures. Extract obtained in separator 2 (5 MPa) after 3 h extraction at 30 MPa and 40 °C from G..

Immune support

Medium relevance

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Reducing cellular inflammation and oxidation by supercritical CO2 extracts from edible-medicinal mushrooms.

Extracts from Hericium erinaceus, Ganoderma lucidum and Tremella fuciformis obtained with supercritical CO2 showed high cellular antioxidant activity (CAA) when tested on Caco-2 cell cultures. Extract obtained in separator 2 (5 MPa) after 3 h extraction at 30 MPa and 40 °C from G..

Immune support

Medium relevance

Reishi · 2025 · Journal Article · Carbohydrate polymers

Refined regulation of polysaccharide biosynthesis in edible and medicinal fungi: From pathways to production

Polysaccharides derived from edible and medicinal fungi (EMF) exhibit various biological activities, rendering them useful in the pharmaceutical, nutraceutical, and food industries..

Immune supportMetabolic health

Medium relevance

Snow Fungus · 2025 · Research Article · Food chemistry: X

Regulation of corn starch on the properties of tremella polysaccharide-egg white protein-orange juice composite gel and its application in 3D printing.

The purpose of this paper was to explore the regulation of corn starch (CS) on tremella fuciformis polysaccharide-egg white protein-orange juice (TFP-EWP-OJ) composite gel to develop a new 3D printing material..

Immune supportEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Sedative-hypnotic effects of an herbal formulation comprising Ganoderma, Gastrodiae Rhizoma, and Chrysanthemi Flos in mice.

BACKGROUND: The tri-herb formulation GGC, consisting of Ganoderma (GL, the dried fruiting body of Ganoderma lucidum), Gastrodiae Rhizoma (GR, the dried tuber of Gastrodia elata), and Chrysanthemi Flos (CF, the dried flower head of Chrysanthemum morifolium), has shown clinical potential for managing sleep disorders..

Immune supportCognition & nerves

Medium relevance

Oyster Mushroom · 2025 · Research Article · Molecules (Basel, Switzerland)

Solid-State Fermentation of Riceberry Rice with Mushroom Mycelium for Enhanced Beta-Glucan Production and Health Applications.

Beta-glucans (β-glucans), polysaccharides found in cereals and fungi, are recognized for their prebiotic and potential anti-cancer activities, particularly in the colorectal area..

OncologyImmune supportEnergy & fatigueGut & microbiome

Medium relevance

Reishi · 2025 · Research Article · Bioactive materials

Spore-inspired inhalation drug delivery system for asthma therapy.

The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading to insufficient delivery efficiency.

Immune supportLiver supportRespiratory

Medium relevance

Yellow Morel · 2025 · Journal Article · Journal of food composition and analysis

State-of-the-art review of morel: From chemistry to nutrition and health benefits

Morchella esculenta (L.) Pers. (M.

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Reishi · 2025 · Journal Article · Carbohydrate research

Structural basis of immunomodulation by edible fungal polysaccharides: From molecular characteristics to action mechanisms

Edible Fungal polysaccharides as Immunomodulators: A Systematic Review at the Crossroads of Immunology, Natural Products Chemistry, and Microbiology. The chemical structure—specifically molecular weight, branching degree, and functional group modifications—directly dictates immunological activity..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Enoki · 2025 · Journal Article · Food chemistry

Study on the nutritional relationships in mycelia and fruiting bodies of Hypsizygus marmoreus under defined nutrient conditions.

Edible fungal fruiting bodies develop from mycelia that experienced physiological knotting, establishing a tight nutrient connection between mycelia and fruiting bodies. Despite this connection, limited research has explored this field..

Immune support

Medium relevance

Reishi · 2025 · Journal Article · Chemico-biological interactions

The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway.

Alzheimer's disease (AD) is a degenerative disease of the central nervous system, characterized by a gradual decline in cognitive and memory abilities, social disorders, and behavioral abnormalities. Ferroptosis, an iron-dependent type of programmed cell death, is closely associated with the pathogenesis of AD..

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Research Article · Frontiers in pharmacology

Therapeutic potential of combination medicinal mushrooms (NevG) in ischemic stroke: correlating motor function, cognitive recovery, and hippocampal integrity in MCAO rats.

BACKGROUND: Ischemic stroke is a major neurological disorder that is characterized by cognitive decline and sensorimotor impairment. Despite the potential of therapeutic effects and anti-inflammatory properties of medicinal mushrooms, most current research focuses on single-species effects rather than combined….

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2025 · Research Article · Foods (Basel, Switzerland)

Using Commercial Bio-Functional Fungal Polysaccharides to Construct Emulsion Systems by Associating with SPI.

Fungi polysaccharides are nutraceutical-rich compounds with bioactive properties, offering promising applications in food formulation. This study examined the non-covalent complexation of commercial polysaccharides derived from the fruiting bodies of Auricularia auricula-judae (AA) and Ganoderma lucidum (GL) and soy….

Immune supportEnergy & fatigue

Medium relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Water-soluble β-glucan from G. lucidum as a potential functional food ingredient with gut microbiota-regulating and immune-enhancing activities.

Ganoderma lucidum is a nutraceutical and a traditional medicinal mushroom. β-glucans are the predominant bioactive components in G.

Immune supportGut & microbiome

Medium relevance

Turkey Tail · 2024 · Research Article · Polymers

A Novel Bio-Adhesive Based on Chitosan-Polydopamine-Xanthan Gum for Glass, Cardboard and Textile Commodities.

The escalating environmental concerns associated with petroleum-based adhesives have spurred an urgent need for sustainable alternatives. Chitosan, a natural polysaccharide, is a promising candidate; however, its limited water resistance hinders broader application..

Immune support

Medium relevance

Reishi · 2024 · Research Article · International journal of molecular sciences

A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.

The electrospinning process is an effective technique for creating micro- and nanofibers from synthetic and natural polymers, with significant potential for biomedical applications and drug delivery systems due to their high drug-loading capacity, large surface area, and tunable release times..

Immune supportLiver supportSkin & hydration

Medium relevance

Almond Mushroom · 2024 · Research Article · Arhiv za higijenu rada i toksikologiju

An in vitro evaluation of the cytotoxic potential of medicinal mushrooms against human breast cancer cell lines.

Medicinal mushroom extracts, i.e. their dried biomass, have long been known as sources of bioactive compounds with positive effects on the human health.

OncologyImmune supportRespiratory

Medium relevance

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Anti-inflammatory activity of β-glucans from different sources before and after fermentation by fecal bacteria in vitro.

BACKGROUND: β-Glucans are widely sourced and have various physiological effects, including anti-inflammatory effects. However, the strength of the anti-inflammatory activity of β-glucans from different sources remains unknown due to the lack of rapid and effective biomarkers..

Immune supportEnergy & fatigueGut & microbiome

Medium relevance

Mesima · 2024 · Research Article · Botanical studies

Antioxidant, anti-acetylcholinesterase, and anti-amyloid-β peptide aggregations of hispolon and its analogs in vitro and improved learning and memory functions in scopolamine-induced ICR mice.

BACKGROUND: Hispolon, one of bioactive phenolic compounds from a medicinal mushroom of sang-huang (Phellinus linteus) has been reported to exhibit anticancer and anti-inflammatory activities. The Alzheimer's disease (AD) is ranked one of the top ten leading causes of death worldwide..

OncologyImmune supportCognition & nerves

Medium relevance

Chaga · 2024 · Journal Article · Frontiers in nutrition

Beet supplementation mitigates post-exercise inflammation.

OBJECTIVES: This study investigated the efficacy of a mixed beet-based supplement (BEET) versus placebo (PL) in countering inflammation during recovery from 2.25 h of intensive cycling in 20 male and female cyclists. A multi-omics approach was used that included untargeted proteomics and a targeted oxylipin panel..

Immune supportEnergy & fatigue

Medium relevance

Oyster Mushroom · 2024 · Journal Article · Journal of agricultural and food chemistry

Buddlejasaponin IVb Alleviates DSS-Induced Ulcerative Colitis through the Nrf2/GPX4 Pathway and Gut Microbiota Modulation.

Buddlejasaponin IVb (BJP-IVb), a triterpenoid saponin derived from Pleurotus ostreatus, is abundant in bioactive constituents. However, its potential therapeutic benefits and underlying mechanism of action against ulcerative colitis (UC) remain elusive..

Immune supportGut & microbiome

Medium relevance

Niu-Chang-Chih · 2024 · Research Article · International journal of biological sciences

Coenzyme Q0 inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells.

Coenzyme Q0 (CoQ0), a quinone derivative from Antrodia camphorata, has antitumor capabilities. This study investigated the antitumor effect of noncytotoxic CoQ0, which included NLRP3 inflammasome inhibition, anti-EMT/metastasis, and metabolic reprogramming via HIF-1α inhibition, in HNSCC cells under normoxia and….

OncologyImmune supportMetabolic healthSkin & hydration

Medium relevance

Chaga · 2024 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Comparative genomic analysis of Sanghuangporus sanghuang with other Hymenochaetaceae species.

Sanghuangporus sanghuang is a medicinal macrofungus with antioxidant and antitumor activities, and it is enriched with secondary metabolites such as polysaccharides, terpenes, polyphenols, and styrylpyrone compounds..

OncologyImmune supportEnergy & fatigue

Medium relevance

Chaga · 2024 · Journal Article · International journal of medicinal mushrooms

Crude Polysaccharides from Mushrooms Elicit an Anti-Allergic Effect Against Type 1 Allergy In Vitro.

Type 1 allergic disease is a global challenge, hence the search for alternative therapies. Mushrooms have several medicinal and health benefits.

OncologyImmune supportGut & microbiome

Medium relevance

Shiitake · 2024 · Research Article · Cancer medicine

Edodes Cultured Extract Regulates Immune Stress During Puberty and Modulates MicroRNAs Involved in Mammary Gland Development and Breast Cancer Suppression.

BACKGROUND: Immune stressors, such as lipopolysaccharides (LPS), profoundly affect microbiota balance, leading to gut dysbiosis. This imbalance disrupts the metabolic phenotype and structural integrity of the gut, increasing intestinal permeability..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Turkey Tail · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of dual-strain fermentation on physicochemical properties of Rosa roxburghii Tratt and coix seed beverage

This study delved into the feasibility of fermenting Rosa roxburghii Tratt and coix seed beverage (RRTCSB) using dual-strain fermentation. The impact of Trametes versicolor and Lactiplantibacillus plantarum LB12 fermentation on RRTCSB's physicochemical properties was investigated..

Immune supportMetabolic health

Medium relevance

Reishi · 2024 · Journal Article · Animals: an open access journal from MDPI

Effects of Plant Polysaccharides Combined with Boric Acid on Digestive Function, Immune Function, Harmful Gas and Heavy Metal Contents in Faeces of Fatteners.

The experiment aimed to investigate the effects of plant polysaccharides combined with boric acid on digestive function, immune function and harmful gas and heavy metal contents in the faeces of fatteners..

Immune supportEnergy & fatigueGut & microbiome

Medium relevance

Reishi · 2024 · Journal Article · Journal of ethnopharmacology

Ganoderic acid A mitigates dopaminergic neuron ferroptosis via inhibiting NCOA4-mediated ferritinophagy in Parkinson's disease mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum, a renowned tonic traditional Chinese medicine, is widely recognized for the exceptional activity in soothing nerves and nourishing the brain. It has been extensively employed to alleviate various neurological disorders, notably Parkinson's disease (PD)..

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Reishi · 2024 · Journal Article · Journal of agricultural and food chemistry

Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism.

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged as a potential therapeutic target..

Immune supportGut & microbiome