MycoData

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Targeted disruption of hir1 alters the transcriptional expression pattern of putative lignocellulolytic genes in the white-rot fungus Pleurotus ostreatus.

Pleurotus ostreatus is frequently used in molecular genetics and genomic studies on white-rot fungi because various molecular genetic tools and relatively well-annotated genome databases are available. To explore the molecular mechanisms underlying wood lignin degradation by P..

Zhu Ling · 2021 · Research Support, Non U.S. Gov'T · Scientific reports

Use of transcriptomic profiling to identify candidate genes involved in Polyporus umbellatus sclerotial formation affected by oxalic acid.

Polyporus umbellatus is a precious medicinal fungus. Oxalic acid was observed to affect sclerotial formation and sclerotia possessed more medicinal compounds than mycelia.

Immune supportCognition & nervesMetabolic healthGut & microbiome

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Journal of translational medicine

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis.

BACKGROUND: Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes (L.

Immune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2026 · Preprint · journal metadata

Ultrasound-Assisted Extraction of Polysaccharides from Pleurotus ostreatus By-Products: Box–Behnken Optimization and Low-Fat Cookies Formulation

Spent mushroom substrate (SMS), the main by-product of mushroom production, is rich in valuable compounds that could be recovered by ultrasound-assisted extraction (UAE) and exploited as fat-mimetic functional ingredients in food formulations..

OncologyImmune supportCognition & nerves

Almond Mushroom · 2025 · Preprint · journal metadata

Agaricus blazei extract FA-2b-β inhibits microglial pyroptosis by regulating the activation of the NF-κB signaling pathway mediated by Aβ 1-42 through the NLRP3 pathway

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Intracellular neurofibrillary tangles (NFTs) and neuroinflammatory plaques formed by amyloid-β (Aβ) are the main pathological features of AD..

Metabolic healthGut & microbiomeLiver support

Reishi · 2025 · Preprint · journal metadata

Integrated analysis of NAFLD mitigation mechanism by Ganoderma lucidum insoluble dietary fiber based on transcriptomics, metabolomics and gut microbiota

Abstract The study established a mouse model of NAFLD induced by a 12-week high-fat diet (HFD). Utilizing hepatic transcriptomics, 16S rDNA sequencing, and metabolomics, the study examined the mechanisms by which GIDF exerts hepatic protection and modulates lipid metabolism in NAFLD through the gut-liver axis.The….

Almond Mushroom · 2025 · Preprint · journal metadata

WITHDRAWN: Agaricus blazei extract FA2bβ enhances the sensitivity of K562/ADR cells through the PI3K/Akt/mTOR signalling pathway

Abstract The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference.

Turkey Tail · 2024 · Preprint · journal metadata

Immobilization of Trametes versicolor laccase on polystyrene microspheres containing diazonium groups

Abstract Laccases are versatile enzymes employed in the degradation of pollutants and in organic synthesis reactions. Their immobilization enables the reuse of these biocatalysts, thereby reducing the overall process costs..

Shiitake · 2024 · Preprint · journal metadata

Novel Biosynthesis and Evaluation Cytotoxic Effect of Tellurium Nano-Particle on Breast Cancer Using Co-Culture of Spirulina and Lentinula Edodes

Abstract Introduction Bio-based nanoparticle production has been an alternative method for preparing nanoparticles for pharmaceutical and biomedical applications..

Oncology

Shiitake · 2023 · Research Support, Non U.S. Gov'T · Proceedings of the National Academy of Sciences of the United States of America

A global phylogenomic analysis of the shiitake genus Lentinula.

Lentinula is a broadly distributed group of fungi that contains the cultivated shiitake mushroom, L. edodes.

Cognition & nerves

Shiitake · 2023 · Case Reports · Military medicine

Shiitake Dermatitis and Potential Implications for Military Readiness.

Shiitake flagellate dermatitis is an intensely pruritic erythematous or violaceous eruption marked by "whip-like" linear streaks consisting of papules or plaques following the ingestion of undercooked shiitake mushrooms (Lentinula edodes)..

Skin & hydration

Shiitake · 2023 · Research Support, Non U.S. Gov'T · Fungal biology

Water concentration and rate of decrease in shiitake cultivation log during fruiting body development, as measured by MRI.

Large shiitake mushrooms (Lentinula edodes, pileus > 8 cm in diameter) are difficult to cultivate and account for only 3-5% of the total harvest. This study focused on the water absorption process within a log during the growth of fruiting bodies in order to increase the yield of large shiitake mushrooms..

OncologyImmune supportMetabolic healthSkin & hydration

Chaga · 2022 · Case Reports · Medicine

Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report.

RATIONALE: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species.

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Cordyceps cicadae and Cordyceps gunnii have closer species correlation with Cordyceps sinensis: from the perspective of metabonomic and MaxEnt models.

Cordyceps sinensis is a second-class nationally-protected medicinal fungus and functional food. Cordyceps sinensis resources are endangered, and finding new medicinal materials is a fast and economical way to meet the current demonstrated demand, which can effectively solve the shortage of C.

Reishi · 2022 · Review · Foods (Basel, Switzerland)

Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.

Dietary interventions for people suffering from major depressive disorder (MDD) are an ongoing field of research. In this article, we present a comprehensive background for understanding the possibility of using edible medicinal mushrooms as an adjunctive treatment for MDD..

Cognition & nerves

Chaga · 2021 · Brief Report · Mycoscience

Accumulation and distribution of 40K in the chaga mushroom.

This work is the first report on activity concentrations of 40K in Inonotus obliquus sampled in a virgin forest of Siberia. The results have shown that the chaga conk is characterized by high activity concentrations of 40K, averaging 1,641 Bq/kg dry weight (DW) and peaking at 3,502 Bq/kg DW..

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Genetic Linkage and Physical Mapping for an Oyster Mushroom (Pleurotus cornucopiae) and Quantitative Trait Locus Analysis for Cap Color.

Oyster mushrooms are grown commercially worldwide, especially in many developing countries, for their easy cultivation and high biological efficiency. Pleurotus cornucopiae is one of the main oyster mushroom species because of its gastronomic value and nutraceutical properties..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2021 · Research Support, Non U.S. Gov'T · Experimental eye research

PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.

Oxidative stress-related ocular surface epithelial damage can be initiated by ambient oxygen, UV radiation, and chemical burns. The oxidative damage to cornea can lead to inflammation and even vision loss..

Energy & fatigueGut & microbiomeSkin & hydration

Reishi · 2021 · Comparative Study · Archiv der Pharmazie

The C-terminally shortened analogs of a hexapeptide derived from Lingzhi hydrolysate with enhanced tyrosinase-inhibitory activity.

Ganoderma lucidum or Lingzhi (Chinese) is a medicinal fungus widely used in traditional medicine as a health supplement. This study was conducted to identify an approach to enhance the anti-tyrosinase activity of a peptide from G.

Cordyceps · 2020 · Comparative Study · Genomics

Alternative metabolic routes in channeling xylose to cordycepin production of Cordyceps militaris identified by comparative transcriptome analysis.

The responsive mechanism of C. militaris TBRC7358 on xylose utilization was investigated by comparative analysis of transcriptomes, growth kinetics and cordycepin productions.

Cordyceps · 2020 · Published Erratum · Scientific reports

Author Correction: Characterization of novel endo-β-N-acetylglucosaminidases from Sphingobacterium species, Beauveria bassiana and Cordyceps militaris that specifically hydrolyze fucose-containing oligosaccharides and human IgG.

An amendment to this paper has been published and can be accessed via a link at the top of the paper..

Zhu Ling · 2020 · Preprint · journal metadata

Cell Wall Strengthening and Remodeling Provide New Insights on Sclerotia Development of Medicinal Fungus Polyporus Umbellatus

Sclerotium is a special form of many species of fungi and cell wall thickening is a common phenomenon in sclerotium. Rational manipulation of sclerotium would be an innovative approach for pathogenic control as well as for medicinal fungal resource revival..

Shiitake · 2020 · Preprint · journal metadata

Comparative phosphoproteome analysis to identify candidate phosphoproteins involved in blue light-induced brown film formation in Lentinula edodes

Background: Light plays an important role in the growth and differentiation of Lentinula edodes mycelia, and mycelial morphology is influenced by light wavelengths. The blue light-induced formation of brown film on the vegetative mycelial tissues of L.

Cordyceps · 2020 · Published Erratum · Oxidative medicine and cellular longevity

Corrigendum to "Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway".

[This corrects the article DOI: 10.1155/2019/7850863.]..

King Oyster · 2020 · Research Support, Non U.S. Gov'T · Toxins

Degradation of Aflatoxin B1 by a Sustainable Enzymatic Extract from Spent Mushroom Substrate of Pleurotus eryngii.

Ligninolytic enzymes from white-rot fungi, such as laccase (Lac) and Mn-peroxidase (MnP), are able to degrade aflatoxin B1 (AFB1), the most harmful among the known mycotoxins. The high cost of purification of these enzymes has limited their implementation into practical technologies..

Mesima · 2020 · Clinical Trial Protocol · Medicine

Efficacy of Phellinus linteus (sanghuang) extract for improving immune functions: Study protocol for a randomized, double-blinded, placebo-controlled pilot trial.

BACKGROUND: With the increase in the prevalence of chronic diseases, enhancing immunity has become an important challenge. Health functional foods, such as Phellitus linteus (PL), are known to improve immune function.

OncologyImmune support

Shiitake · 2020 · Preprint · journal metadata

Enzymatic activities and analysis of a mycelium-based composite formation using peach palm (Bactris gasipaes) residues on Lentinula edodes

Abstract By seeding fungus on top of industry residues, a mycelium can grow and form a compact network structure; however, it may not develop due to lack of optimal nutrients from the substrate..

Shiitake · 2020 · Preprint · journal metadata

Expression and in vitro anticancer activity of Lp16-PSP, a member of the YjgF/YER057c/UK114 protein family from the mushroom Lentinula edodes C 91-3

Latcripin-16 (Lp16-PSP) is a gene that was extracted as a result of de novo characterization of the Lentinula edodes strain C 91-3 transcriptome. The aim of the present study was to clone, express and investigate the selective in vitro anticancer potential of Lp16-PSP in human cell lines..

Oncology

Lion's Mane · 2020 · Preprint · journal metadata

Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory

The traditional medicinal mushroom Hericium erinaceus has long been known for enhancing the peripheral nerve regeneration through targeting nerve growth factor (NGF) neurotrophic activity..

Cognition & nerves

Snow Fungus · 2020 · Preprint · journal metadata

Intra-specific comparison of mitochondrial genomes reveals host gene fragment exchange via intron mobility in Tremella fuciformis

Abstract Background: Mitochondrial genomic sequences are known to be variable. Comparative analyses of mitochondrial genomes can reveal the nature and extent of their variation.

Immune supportMetabolic health

Lion's Mane · 2020 · Preprint · journal metadata

Key metabolism pathways and regulatory mechanisms of high polysaccharide yielding in Hericium erinaceus

Abstract Background Hericium erinaceus, a rare edible and medicine fungus, is widely used in the food and medical field. H.

Cordyceps · 2020 · Preprint · journal metadata

mRNA-seq and miRNA-seq Profiling Analyses Reveal Molecular Mechanisms Regulating Induction of Fruiting Bodies in Ophiocordyceps Sinensis

Ophiocordyceps sinensis has been a source of valuable materials in traditional Asian medicine for over two thousand years. With recent global warming and overharvest, however, the availability of these wild fungi has decreased dramatically.

OncologyImmune supportCognition & nerves

Chaga · 2020 · Preprint · journal metadata

Polysaccharides from the fungus Inonotus obliquus activate macrophages into a tumoricidal phenotype via interaction with TLR2, TLR4 and Dectin-1a

Background Tumor-associated macrophages (TAMs) may both promote and suppress tumor development. Therefore, molecules that are able to activate and repolarize these cells into a tumoricidal phenotype could be of great interest as a new strategy for cancer immunotherapy..

Cordyceps · 2020 · Research Support, Non U.S. Gov'T · Biochimica et biophysica acta. Molecular cell research

Suppression of urease, which affects nitrogen metabolism and biological efficacy, by Ca2+/calmodulin in Cordyceps militaris.

Metadata-grounded summary: This research support, non u.s. gov't indexes research on Cordyceps militaris in Biochimica et biophysica acta.

OncologyImmune supportGut & microbiome

Chaga · 2020 · Preprint · journal metadata

The apoptotic effect of polysaccharides with specific molecular weight extracted from Inonotus obliquus on HT-29 colon cancer cells

Background: Recently, natural products, particularly Inonotus obliquus ( I. obliquus ), have attracted lots of attention due to their effective anticancer effects with relatively low toxicity.

Zhu Ling · 2020 · Preprint · journal metadata

Transcriptomic Profiling Identifies Candidate Genes Involved in Polyporus Umbellatus Sclerotial Formation Affected by Oxalic Acid

Polyporus umbellatus is a precious medicinal fungus. The whole transcriptome of P.

Cordyceps · 2020 · Preprint · journal metadata

Uncovering fungal community composition in natural habitat of Ophiocordyceps sinensis using high-throughput sequencing and culture-dependent approaches

Background: The fungal communities inhabiting natural Ophiocordyceps sinensis play critical ecological roles in alpine meadow ecosystem, contribute to infect host insect, influence the occurrence of O. sinensis, and are repertoire of potential novel metabolites discovery..

Gut & microbiome

Immune supportCognition & nervesMetabolic healthGut & microbiome

Shiitake · 2020 · Preprint · journal metadata

β-glucan from Lentinula Edodes Prevents Cognitive Impairments in High-Fat Diet-Induced Obese Mice: Involvement of Colon-Brain Xxis

Abstract Background: Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ( L.

Enoki · 2019 · Preprint · journal metadata

Combining transcriptomics and metabolomics to characterize ergosterol biosynthesis in Flammulina velutipes during the fruiting process

Abstract Background: Flammulina velutipes (F. velutipes) is one of the most important mushrooms in Japan and China because of its potential medicinal and nutritional value.

OncologyMetabolic health

Cordyceps · 2019 · Comment · Annals of translational medicine

Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products.

Metadata-grounded summary: This comment indexes research on Cordyceps militaris in Annals of translational medicine in 2019. MycoData maps the paper to energy & fatigue based on its title, species context, article metadata, and study classification..

Cordyceps · 2019 · Comment · Annals of translational medicine

New insights into cordycepin production in Cordyceps militaris and applications.

Cordyceps · 2017 · Published Erratum · Journal of diabetes research

Corrigendum to "Hypoglycemic Activity through a Novel Combination of Fruiting Body and Mycelia of Cordyceps militaris in High-Fat Diet-Induced Type 2 Diabetes Mellitus Mice".

[This corrects the article DOI: 10.1155/2015/723190.]..

Enoki · 2016 · Preprint · journal metadata

Selenium uptake, toxicity and reduction in Flammulina velutipes supplied with selenite

Recently, selenium (Se) enriched mushrooms have been exploited as diary Se supplements, but our knowledge of the metabolism process during the Se enrichment process is far from complete..

Cordyceps · 2015 · Journal Article · JOURNAL OF THE BREWING SOCIETY OF JAPAN

Anti-inflammatory effect from an extract of cordyceps militaris soaked in sweetpotato shochu

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in JOURNAL OF THE BREWING SOCIETY OF JAPAN in 2015. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Cordyceps · 2015 · Journal Article · JOURNAL OF THE BREWING SOCIETY OF JAPAN

Anticancer activity of an extract of Cordyceps militaris soaked in sweetpotato shochu in human leukemia cells

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in JOURNAL OF THE BREWING SOCIETY OF JAPAN in 2015. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Oncology

Immune supportGut & microbiome

Shiitake · 2015 · Journal Article · Mushroom Science and Biotechnology

Autoradiography of the fruiting body and spore print of wood-cultivated shiitake mushroom (Lentinula edodes) from a restricted habitation area

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2015. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Energy & fatigueMetabolic health

Cordyceps · 2015 · Journal Article · The Journal of Poultry Science

Effect of Cordyceps Militaris Waster Medium on Production Performance, Egg Traits and Egg Yolk Cholesterol of Laying Hens

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in The Journal of Poultry Science in 2015. MycoData maps the paper to energy & fatigue, metabolic health based on its title, species context, article metadata, and study classification..

Cordyceps · 2015 · Journal Article · International Journal of Wild Silkmoth and Silk

Growth of Cordyceps militaris on Plant Substrates Supplemented with Pupal Powder of Thai Variety of the Silkworm, Bombyx mori

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in International Journal of Wild Silkmoth and Silk in 2015. MycoData maps the paper to energy & fatigue based on its title, species context, article metadata, and study classification..