MycoData

OncologyImmune supportGut & microbiome

Shiitake · 2022 · Brief Report · Frontiers in immunology

AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer.

Treatment strategies combining immune checkpoint blockade (ICB) with other agents have emerged as a promising approach in the treatment of cancers. AHCC®, a standardized extract of cultured Lentinula edodes mycelia, has been reported to inhibit tumor growth and enhance immune cell function..

Immune supportSkin & hydration

Reishi · 2022 · Research Support, Non U.S. Gov'T · Aging

An active ingredient isolated from Ganoderma lucidum promotes burn wound healing via TRPV1/SMAD signaling.

The mushroom Ganoderma lucidum is a traditional Chinese medicine and G. lucidum spore oil (GLSO) is the lipid fraction isolated from Ganoderma spores.

OncologyImmune supportRespiratory

Reishi · 2022 · Video Audio Media · Journal of visualized experiments: JoVE

Co-Fermentation of Marsdenia tenacissima with Ganoderma lucidum and Anti-Lung Cancer Effect of the Fermentation Products.

Marsdenia tenacissima (Roxb.) Wight et Arn. (MT), as a traditional Chinese and Dai herbal medicine, has anti-inflammatory, antibacterial, and antitumor properties.

Chaga · 2022 · Research Support, Non U.S. Gov'T · Biomolecules

Comparative Analyses of Bioactive Compounds in Inonotus obliquus Conks Growing on Alnus and Betula.

Inonotus obliquus grows in the Northern Hemisphere on some living broadleaved tree species as a pathogen, causing stem rot. In Estonia, the fungus is well known in the Betula species but can also be found on Alnus.

Enoki · 2022 · Brief Report · Frontiers in nutrition

Comparative Aroma Profile Analysis and Development of a Sensory Aroma Lexicon of Seven Different Varieties of Flammulina velutipes.

Flammulina Velutipes (F. velutipes) is widely planted all over the world and is rich in nutrients, which is of great benefit to the human body.

OncologyGut & microbiomeRespiratory

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Journal of virological methods

Curing two predominant viruses occurring in Lentinula edodes by chemotherapy and mycelial fragmentation methods.

Previous research has established that Lentinula edodes mycovirus HKB (LeV-HKB) and L. edodes partitivirus 1(LePV1) are major mycoviruses identified in L.edodes germplasm..

Snow Fungus · 2022 · Brief Report · Microbiology resource announcements

Draft Genome Sequences of Two Basidiomycetous Yeasts, Tremella yokohamensis and Tremella fuciformis.

In this study, the genome sequences of two Basidiomycetous yeasts, Tremella yokohamensis and Tremella fuciformis, which have very similar morphological characteristics, were determined. The genomic sequence data obtained will be useful for understanding the taxonomy and metabolic-related genes of basidiomycete yeasts..

Immune supportEnergy & fatigue

Maitake · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Effect of low-intensity magnetic field on the growth and metabolite of Grifola frondosa in submerged fermentation and its possible mechanisms.

This study aimed to investigate the effects of low intensity alternating magnetic field on the submerged fermentation of Grifola frondosa, and its possible mechanism was also explored..

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · International journal of environmental research and public health

Fluoxetine Removal from Aqueous Solutions Using a Lignocellulosic Substrate Colonized by the White-Rot Fungus Pleurotus ostreatus.

One of the main challenges in both the design of new wastewater treatment plants and the expansion and improvement of existing ones is the removal of emerging pollutants. Therefore, the search for economic and sustainable treatments is needed to enhance the removal of pharmaceuticals..

Gut & microbiome

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · PeerJ

Genome-wide identification and expression analyses of C2H2 zinc finger transcription factors in Pleurotus ostreatus.

The C2H2-type zinc finger proteins (C2H2-ZFPs) regulate various developmental processes and abiotic stress responses in eukaryotes. Yet, a comprehensive analysis of these transcription factors which could be used to find candidate genes related to the control the development and abiotic stress tolerance has not been….

Energy & fatigueGut & microbiomeLiver support

Maitake · 2022 · Research Support, Non U.S. Gov'T · Frontiers in endocrinology

Grifola frondosa may play an anti-obesity role by affecting intestinal microbiota to increase the production of short-chain fatty acids.

BACKGROUND: Grifola frondosa (G. frondosa) is a fungus with good economic exploitation prospects of food and medicine homologation.

Lion's Mane · 2022 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Hericium erinaceus ethanol extract and ergosterol exert anti-inflammatory activities by neutralizing lipopolysaccharide-induced pro-inflammatory cytokine production in human monocytes.

Edible mushrooms are known to exert anti-inflammatory effects. In this study, the effects of ethanol extracts from edible mushrooms, such as Hericium erinaceus, and other edible mushrooms on inflammatory responses were investigated..

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · Immunotherapy

Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer.

Aim: To evaluate the effect of pleuran (β-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I-II) in clinical and imaging remission..

OncologyImmune support

Immune supportGut & microbiome

Snow Fungus · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

In vitro fecal fermentation properties of polysaccharides from Tremella fuciformis and related modulation effects on gut microbiota.

Tremella fuciformis is an edible and medicinal mushroom. Polysaccharides from T.

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Introducing multiple-gene mutations in Pleurotus ostreatus using a polycistronic tRNA and CRISPR guide RNA strategy.

The white-rot fungus Pleurotus ostreatus is an agaricomycete that is frequently used in molecular genetics studies as many useful tools are applicable to the fungus..

Immune supportEnergy & fatigueLiver support

Mesima · 2022 · Research Support, Non U.S. Gov'T · Aging

Phellinus linteus polysaccharides mediates acetaminophen-induced hepatotoxicity via activating AMPK/Nrf2 signaling pathways.

Overdose of acetaminophen (APAP) is currently one of the main causes of hepatoxicity and acute liver injury, which is often linked to oxidative stress. Phellinus linteus polysaccharides (Phps) have shown many hepatoprotective effects, however, the mechanism of Phps on APAP-induced acute liver injury has not been….

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Journal of advanced research

Population genomics provides insights into the genetic basis of adaptive evolution in the mushroom-forming fungus Lentinula edodes.

INTRODUCTION: Mushroom-forming fungi comprise diverse species that develop complex multicellular structures. In cultivated species, both ecological adaptation and artificial selection have driven genome evolution..

Reishi · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Production Ganoderma lucidum extract nanoparticles by expansion of supercritical fluid solution and evaluation of the antioxidant ability.

Due to the growing human tendency to treat with natural substances, fungi such as Ganoderma lucidum can be a good source to meet this need. Effectiveness, ease of use and a rich source of active ingredients such as ganoderic acids have caused G.

Enoki · 2022 · Brief Report · Biochemistry and biophysics reports

Relationship between fruiting body development and extracellular laccase production in the edible mushroom Flammulina velutipes.

The biochemical mechanism underlying the development of fruiting bodies in Flammulina velutipes, an edible mushroom, was investigated using the YBLB colorimetric assay to distinguish between the normal strain (FVN-1) and the degenerate strain (FVD-1)..

Energy & fatigueGut & microbiomeLiver support

Lion's Mane · 2022 · Research Support, Non U.S. Gov'T · Biomacromolecules

Smart pH-Sensitive Hydrogel Based on the Pineapple Peel-Oxidized Hydroxyethyl Cellulose and the Hericium erinaceus Residue Carboxymethyl Chitosan for Use in Drug Delivery.

Pineapple and hericium erinaceus (HE) produce a lot of residues in the process of food processing. These processed residues are good potential derivative precursors..

OncologyCognition & nerves

Niu-Chang-Chih · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells.

Antrodia camphorata (A. camphorata) is an edible fungus containing various bioactive compounds generally used for health benefits.

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Temporal characterization of biocycles of mycelium-bound composites made from bamboo and Pleurotus ostreatus for indoor usage.

Mycelium-bound composites (MBCs) are materials obtained by growing fungi on a ligno-cellulosic substrate which have various applications in packaging, furniture, and construction industries. MBCs are particularly interesting as they are sustainable materials that can integrate into a circular economy model..

Immune supportMetabolic healthLiver support

Maitake · 2022 · Research Support, Non U.S. Gov'T · Frontiers in immunology

The anti-obesity effects of a water-soluble glucan from Grifola frondosa via the modulation of chronic inflammation.

Polysaccharides from Grifola frondosa (G. frondosa) have anti-obesity and anti-inflammatory activities.

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Biomolecules

The Effect of Novel Selenopolysaccharide Isolated from Lentinula edodes Mycelium on Human T Lymphocytes Activation, Proliferation, and Cytokines Synthesis.

Polysaccharides isolated from Lentinula edodes are bioactive compounds with immunomodulatory properties. In our previous studies from L.

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Toxicity evaluation of decabromodiphenyl ethane (DBDPE) to Pleurotus ostreatus: Oxidative stress, morphology and transcriptomics.

Decabromodiphenyl ethane (DBDPE), one widely used new brominated flame retardant, was of great concern due to its biotoxicity. The toxic evaluation of DBDPE (1-50 mg/L) to white-rot fungus (Pleurotus ostreatus), including oxidative stress, morphology and transcriptomics was conducted aiming at improving its….

Chaga · 2022 · Research Support, Non U.S. Gov'T · Fungal biology

Ultraviolet radiation promotes the production of hispidin polyphenols by medicinal mushroom Inonotus obliquus.

Production of hispidin polyphenols in Inonotus obliquus is a stress-induced response triggered by environmental factors. As one of the important environmental factors, ultraviolet (UV) radiation plays regulatory roles in fungal growth and development..

Skin & hydration

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Understanding the promotion of heat treatment on the flavor of Lentinula edodes using metabolomics integrated with transcriptomics.

The transcriptome and metabolome analyses revealed the differentially expressed metabolites (DEMs) and genes (DEGs) in the dried Lentinula edodes' response to heat treatment..

Immune supportRespiratory

Turkey Tail · 2022 · Research Support, Non U.S. Gov'T · Viruses

β-Glucans from Trametes versicolor (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection.

Coriolus versicolor (C. versicolor) is a higher fungi or mushroom which is now known by its accepted scientific names as Trametes versicolor (L.) Lloyd.

Immune supportEnergy & fatigueMetabolic health

Lion's Mane · 2021 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

A novel polysaccharide from Hericium erinaceus: Preparation, structural characteristics, thermal stabilities, and antioxidant activities in vitro.

A novel polysaccharide fraction (HEP) from Hericium erinaceus was successively isolated and purified in the present study. We researched its structure and thermal stabilities, and further studied its antioxidant activities in vitro..

Niu-Chang-Chih · 2021 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters

Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities.

In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7..

Oncology

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Comparative transcriptome analysis of abnormal cap and healthy fruiting bodies of the edible mushroom Lentinula edodes.

Lentinula edodes, a commercially important mushroom, is cultivated worldwide. Artificially cultivated L.

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Comparative transcriptome analysis reveals the differential response to cadmium stress of two Pleurotus fungi: Pleurotus cornucopiae and Pleurotus ostreatus.

Pleurotus has great potential for heavy metal mycoremediation. Using comparative transcriptome analysis, the response of Pleurotus ostreatus and Pleurotus cornucopiae under Cd contamination was evaluated.

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · PloS one

Effect of common foods as supplements for the mycelium growth of Ganoderma lucidum and Pleurotus ostreatus on solid substrates.

The transition from a linear to a circular economy is urgently needed to mitigate environmental impacts and loss of biodiversity. Among the many potential solutions, the development of entirely natural-based materials derived from waste is promising..

Gut & microbiome

Energy & fatigueSkin & hydration

Shiitake · 2021 · Evaluation Study · Journal of the science of food and agriculture

Effects of pre-cutting treatments and combination drying with different orders on drying characteristics and physicochemical properties of Lentinula edodes.

BACKGROUND: Combination drying is recognized as an energy-efficient method utilized for dry product processing, and proper order of combination is a critical factor determining the effectiveness of the technique..

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Functional analyses of Pleurotus ostreatus pcc1 and clp1 using CRISPR/Cas9.

Understanding the molecular mechanisms controlling dikaryon formation in Agaricomycetes, which is basically controlled by A and B mating-type loci, contributes to improving mushroom cultivation and breeding..

Oyster Mushroom · 2021 · Evaluation Study · FEMS microbiology letters

Gene targeting using pre-assembled Cas9 ribonucleoprotein and split-marker recombination in Pleurotus ostreatus.

Until recently, classical breeding has been used to generate improved commercial mushroom strains; however, classical breeding remains to be laborious and time-consuming..

Lion's Mane · 2021 · Comparative Study · International journal of biological macromolecules

Immunomodulatory effects of polysaccharides enzymatic hydrolysis from Hericium erinaceus on the MODE-K/DCs co-culture model.

The aim of this study was to explore the indirect immunomodulatory activities and its mechanism of enzymatic hydrolysis of Hericium erinaceus polysaccharides (EHEP) in the MODE-K/DCs co-culture model..

Chaga · 2021 · Research Support, Non U.S. Gov'T · Analytical methods: advancing methods and applications

Isolation of potential α-glucosidase inhibitor from Inonotus obliquus by combining ultrafiltration-liquid chromatography and consecutive high-speed countercurrent chromatography.

Inonotus obliquus is a rare medicinal fungus that contains several potential therapeutic ingredients. In this study, the α-glucosidase inhibitory activity of I.

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Scientific reports

Macrosynteny analysis between Lentinula edodes and Lentinula novae-zelandiae reveals signals of domestication in Lentinula edodes.

The basidiomycete fungus Lentinula novae-zelandiae is endemic to New Zealand and is a sister taxon to Lentinula edodes, the second most cultivated mushroom in the world. To explore the biology of this organism, a high-quality chromosome level reference genome of L.

Immune supportMetabolic health

Snow Fungus · 2021 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Moisture and caking resistant Tremella fuciformis polysaccharides microcapsules with hypoglycemic activity.

Tremella fuciformis polysaccharides (TPs) have attracted extensive attention as functional food constituents due to their bioactivity. However, β-D-glucan obtained from TPs is readily degraded by oxidation and easy to absorb water and agglomerate..

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Scientific reports

mRNA-seq and miRNA-seq profiling analyses reveal molecular mechanisms regulating induction of fruiting body in Ophiocordyceps sinensis.

Ophiocordyceps sinensis has been a source of valuable materials in traditional Asian medicine for over two thousand years. With recent global warming and overharvest, however, the availability of these wild fungi has decreased dramatically.

Enoki · 2021 · Research Support, Non U.S. Gov'T · ACS biomaterials science & engineering

Natural Flammulina velutipes-Based Nerve Guidance Conduit as a Potential Biomaterial for Peripheral Nerve Regeneration: In Vitro and In Vivo Studies.

The treatment and repair of serious peripheral nerve injuries remain challenging in the clinical practice, while the application of multifunctional nerve guidance conduits (NGCs) based on naturally derived polymers has attracted much attention in recent years because of their excellent physicochemical properties and….

Cognition & nerves

Chaga · 2021 · Video Audio Media · Preparative biochemistry & biotechnology

Optimization for the extraction of polyphenols from Inonotus obliquus and its antioxidation activity.

In order to study the extraction process and antioxidative activity of Inonotus obliquus polyphenols (IOP), the optimal extraction process was determined by orthogonal experiment optimization. The clearance rate of DPPH and hydroxyl radicals were used as indicators to evaluate the antioxidant activity of IOP..

Oyster Mushroom · 2021 · Research Support, Non U.S. Gov'T · Environmental microbiology

Overexpressing Pleurotus ostreatus rho1b results in transcriptional upregulation of the putative cellulolytic enzyme-encoding genes observed in ccl1 disruptants.

The transcriptional expression pattern of lignocellulolytic enzyme-encoding genes in white-rot fungi differs depending on the culture conditions. Recently, it was shown that 13 putative cellulolytic enzyme-encoding genes were significantly upregulated in most Pleurotus ostreatus ligninolysis-deficient mutant strains….

Lion's Mane · 2021 · Journal Article · Journal of food biochemistry

Prospecting medicinal properties of Lion's mane mushroom.

Hericium erinaceus (Bull.) Persoon, a popular medicinal edible mushroom, owns a long history of usage in traditional Chinese medicine and also in other oriental countries. Along with this, its several bioactive compounds have been evolved into food supplements..

OncologyRespiratory

Turkey Tail · 2021 · Research Support, Non U.S. Gov'T · Toxins

Recombinant Expression of Trametes versicolor Aflatoxin B1-Degrading Enzyme (TV-AFB1D) in Engineering Pichia pastoris GS115 and Application in AFB1 Degradation in AFB1-Contaminated Peanuts.

Aflatoxins seriously threaten the health of humans and animals due to their potential carcinogenic properties. Enzymatic degradation approach is an effective and environmentally friendly alternative that involves changing the structure of aflatoxins..

Turkey Tail · 2021 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Remediation of bentazone contaminated water by Trametes versicolor: Characterization, identification of transformation products, and implementation in a trickle-bed reactor under non-sterile conditions.

Bentazone, an herbicide widely applied in rice and cereal crops, is widespread in the aquatic environment. This study evaluated the capacity of Trametes versicolor to remove bentazone from water.

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Biomolecules

Selective Biological Effects of Selenium-Enriched Polysaccharide (Se-Le-30) Isolated from Lentinula edodes Mycelium on Human Immune Cells.

A common edible mushroom Lentinula edodes, is an important source of numerous biologically active substances, including polysaccharides, with immunomodulatory and antitumor properties..

OncologyImmune support

Chaga · 2021 · Letter · Magnetic resonance in chemistry: MRC

Structure elucidation of a new triterpene from Inonotus obliquus.

Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)-induced murine BV2 microglial cells..