MycoData

Gut & microbiomeRespiratory

King Oyster · 2007 · Journal Article · Biotechnology letters

Isolation and characterization of a novel mycovirus, PeSV, in Pleurotus eryngii and the development of a diagnostic system for it

A novel mycovirus was isolated from a cultivated edible mushroom, Pleurotus eryngii, with severe epidemic symptoms. Purification of the virus was carried out by a sequential procedure of polyethylene glycol precipitation, differential centrifugation, and equilibrium centrifugation in a CsCl gradient..

Snow Fungus · 2007 · Research Article · International journal of molecular sciences

Modification of Low Molecular Weight Polysaccharides from Tremella Fuciformis and Their Antioxidant Activity in Vitro

Metadata-grounded summary: This research article indexes research on Tremella fuciformis in International journal of molecular sciences in 2007. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Niu-Chang-Chih · 2007 · Journal Article · Journal of ethnopharmacology

Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats.

The hepatoprotective effects of the mycelia of Antrodia camphorata and Armillariella tabescens were evaluated in vivo using acute ethanol-intoxicated rats as an experimental model..

Liver support

King Oyster · 2007 · Journal Article · Pakistan journal of biological sciences: PJBS

The Pleurotus eryngii species-complex in Kurdistan region of Iran.

Pleurotus eryngii species-complex are known to be well distributed in Kurdistan region of Iran. During a survey in 2003-2005 fourteen wild populations of the Pleurotus eryngii species-complex were collected from Sanandaj, Hane Gelan and Saral areas..

King Oyster · 2007 · Journal Article · Bioresource technology

Yield, size and bacterial blotch resistance of Pleurotus eryngii grown on cottonseed hulls/oak sawdust supplemented with manganese, copper and whole ground soybean.

Experiments were performed to determine effects of supplementation of cottonseed hull/sawdust substrate with Mn, Cu, and ground soybean on yield, mushroom size, and bacterial blotch resistance of two commercial strains of Pleurotus eryngii..

King Oyster · 2006 · Journal Article · Applied microbiology and biotechnology

A hemolysin from the mushroom Pleurotus eryngii.

A monomeric 17-kDa hemolysin designated as eryngeolysin was isolated from fresh fruiting bodies of the mushroom Pleurotus eryngii, using a protocol that involved gel filtration on Superdex 75, ion exchange chromatography on Mono Q and gel filtration on Superdex 75..

Oncology

King Oyster · 2006 · Journal Article · Carbohydrate polymers

A β-glucan from the fruit bodies of edible mushrooms Pleurotus eryngii and Pleurotus ostreatoroseus

The glucans of basidiomycetes are an important class of polysaccharides with potential biological activities. In this work, the β-glucans were isolated from the fruiting bodies of edible mushrooms, Pleurotus eryngii and Pleurotus ostreatoroseus, via extraction with hot water, and then fractionation by freeze-thawing..

King Oyster · 2006 · Journal Article · Clinical nutrition (Edinburgh, Scotland)

Effects of mushroom, Pleurotus eryngii, extracts on bone metabolism.

We performed the present study to investigate whether Pleurotus eryngii extracts (PEX) play a role in bone metabolism. PEX treatment showed increase in the alkaline phosphatase activity of the osteoblasts and in the osteocalcin mRNA expression from primary osteoblasts..

King Oyster · 2006 · Journal Article · Phytotherapy research: PTR

Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii.

In the course of a search for natural estrogen-like materials from mushrooms, the proliferating effects of the methanol extracts of 14 edible mushrooms on the estrogen-dependent growth of MCF-7 cells were examined..

King Oyster · 2006 · Journal Article · Applied microbiology and biotechnology

Purification of a laccase from fruiting bodies of the mushroom Pleurotus eryngii.

A purification scheme involving ion exchange chromatography on diethylaminoethyl (DEAE) cellulose, carboxymethyl (CM) cellulose, and Q-Sepharose, followed by fast protein liquid chromatography-gel filtration on Superdex 75, was utilized to isolate a laccase from the fruiting bodies of the mushroom Pleurotus eryngii..

OncologyImmune supportEnergy & fatigueGut & microbiome

Cordyceps · 2024 · Meta-Analysis · Journal of ethnopharmacology

Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sinensis (CS) is a fungus parasitic on lepidopteran larvae which is often used to treat lung diseases and regulate immune function. AIM OF THE STUDY: This review aimed to evaluate the efficacy of CS in the adjuvant treatment of lung cancer..

Cordyceps · 2024 · Systematic Review · Frontiers in medicine

Efficacy of traditional Chinese medicine Cordyceps sinensis as an adjunctive treatment in patients with renal dysfunction: a systematic-review and meta-analysis.

OBJECTIVE: The effectiveness of using Cordyceps sinensis as an adjuvant therapy for patients with renal dysfunction (RD), especially acute kidney injury (AKI), is still a topic of debate. In response to the current conflicting data, the present meta-analysis was conducted to assess the clinical effectiveness of C..

Immune supportEnergy & fatigue

Reishi · 2023 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Lean strategy for data mining and continuous improvement of Chinese pharmaceutical process: a case study of sporoderm-removal Ganoderma lucidum spore powder].

In the digital transformation of Chinese pharmaceutical industry, how to efficiently govern and analyze industrial data and excavate the valuable information contained therein to guide the production of drug products has always been a research hotspot and application difficulty..

Immune supportGut & microbiome

Lion's Mane · 2023 · Comparative Study · International journal of biological macromolecules

A comparison of study on intestinal barrier protection of polysaccharides from Hericium erinaceus before and after fermentation.

The intestinal barrier protects the host from harmful substances. This paper investigated two polysaccharides extracted from the Hericium erinaceus before and after fermentation (HEP and FHEP).

Liver supportSkin & hydration

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Journal of biomedical materials research. Part B, Applied biomaterials

Agaricus blazei Murill extract-loaded in alginate/poly(vinyl alcohol) films prepared by Ca2+ cross-linking for wound healing applications.

This work aimed the development and evaluation of the wound healing activity of films based on sodium alginate, polyvinyl alcohol (PVA) and Ca2+ loaded with Agaricus blazei Murill hydroalcoholic extract (AbE). Firstly, AbE was prepared using a previously standardized methodology..

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Agaricus blazei Murrill Polysaccharide Attenuates Periodontitis via H2 S/NRF2 Axis-Boosted Appropriate Level of Autophagy in PDLCs.

SCOPE: Periodontitis is one of the most prevalent chronic inflammatory diseases with impaired autophagy. Agaricus blazei Murrill polysaccharide (ABMP) shows beneficial effects in various inflammatory diseases..

Immune supportMetabolic healthLiver supportSkin & hydration

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats.

Liver disease is a serious health problem affecting people worldwide at an alarming rate. The present study aimed to investigate the protective effects of Ganoderma lucidum against CCl4-induced liver toxicity in rats..

Turkey Tail · 2023 · Research Support, Non U.S. Gov'T · PloS one

Arsenic(III)-induced oxidative defense and speciation changes in a wild Trametes versicolor strain.

Oxidative defense or arsenic(As) changes exhibited by Trametes versicolor in response to toxicity under As stress remain unclear. In this study, after internal transcribed spacer identification, a wild T.

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2023 · Research Support, Non U.S. Gov'T · The Journal of nutritional biochemistry

Auricularia polytricha and Flammulina velutipes reduce liver injury in DSS-induced Inflammatory Bowel Disease by improving inflammation, oxidative stress, and apoptosis through the regulation of TLR4/NF-κB signaling pathways.

Auricularia polytricha and Flammulina velutipes are two dietary mushrooms mostly consumed in China and known for their traditional use on gastric ulceration and to boost bowel movement..

Turkey Tail · 2023 · Brief Report · Frontiers in bioengineering and biotechnology

Distinct laccase expression and activity profiles of Trametes versicolor facilitate degradation of benzo[a]pyrene.

A Trametes versicolor isolate from the Changbai Mountain showed promising activity in degrading benzo[a]pyrene (BaP), which is a high molecular weight (HMW) polycyclic aromatic hydrocarbon (PAH) compound. It was hypothesized that the T..

Immune supportEnergy & fatigueGut & microbiome

Reishi · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Effects of drying methods on bioactive components of Ganoderma lucidum fermented whole wheat in products & in vitro digestive model.

The content of bioactive components is the key to determining the quality of Ganoderma lucidum fermented whole wheat (GW) products, and drying is a necessary link in the initial processing of GW, which will affect the bioactivity and quality of GW..

Lion's Mane · 2023 · Research Support, Non U.S. Gov'T · Journal of food and drug analysis

Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation.

Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion..

Cognition & nerves

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Environmental microbiology

Experimental evidence that lignin-modifying enzymes are essential for degrading plant cell wall lignin by Pleurotus ostreatus using CRISPR/Cas9.

Lignin-modifying enzymes (LMEs), which include laccases (Lacs), manganese peroxidases (MnPs), versatile peroxidases (VPs), and lignin peroxidases (LiPs), have been considered key factors in lignin degradation by white-rot fungi because they oxidize lignin model compounds and depolymerize synthetic lignin in vitro..

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Features of disruption mutants of genes encoding for hydrophobin Vmh2 and Vmh3 in mycelial formation and resistance to environmental stress in Pleurotus ostreatus.

Hydrophobins, which are small-secreted proteins with both hydrophobic and hydrophilic parts, can self-assemble into an amphiphilic film at the air-water interface, helping the fungus to form aerial hyphae. In the agaricomycete Pleurotus ostreatus, more than 20 putative hydrophobin genes have been predicted..

OncologyImmune supportMetabolic health

Reishi · 2023 · Research Support, Non U.S. Gov'T · Experimental gerontology

Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins.

Longer-term deterioration in saliva secretion has been observed to occur in response to aging. The functional deterioration of the salivary gland damages swallowing and chewing abilities and consequently reduces life quality of the elderly..

Energy & fatigueMetabolic health

Reishi · 2023 · Research Support, Non U.S. Gov'T · mBio

GlMPC activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum.

Mitochondrial pyruvate carrier (MPC) is a pyruvate transporter that plays a crucial role in regulating the carbon metabolic flow and is considered an essential mechanism for microorganisms to adapt to environmental changes. However, it remains unclear how MPC responds to environmental stress in organisms..

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Heat stress and excessive maturity of fruiting bodies suppress GABA accumulation by modulating GABA metabolism in Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm.

GABA is a health-promoting bioactive substance. Here, the GABA biosynthetic pathways were investigated, and then the dynamic quantitative changes in GABA and the expression levels of genes related to GABA metabolism under heat stress or at different developmental stages of fruiting bodies in Pleurotus ostreatus (Jacq..

Immune supportGut & microbiome

Lion's Mane · 2023 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Hericium erinaceus mycelium-Derived Polysaccharide Alleviates Ulcerative Colitis and Modulates Gut Microbiota in Cynomolgus Monkeys.

SCOPE: Ulcerative colitis (UC) is rapidly increasing worldwide but prolong use of available corticosteroids treatment is associated with numerous adverse effects. There is the urgent need to develop novel therapeutic options..

OncologyImmune supportLiver support

Reishi · 2023 · Research Support, Non U.S. Gov'T · Journal of materials chemistry. B

Improving nanochemoimmunotherapy efficacy by boosting "eat-me" signaling and downregulating "don't-eat-me" signaling with Ganoderma lucidum polysaccharide-based drug delivery.

To address the challenges posed by low immunogenicity and immune checkpoints during cancer treatment, we propose an alternative strategy that combines immunogenic cell death (ICD) effects with CD47/SIRPα blockade to reactivate phagocytosis of tumor cells by macrophages with polysaccharide-based drug delivery..

Chaga · 2023 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Inonotsutriol E from Inonotus obliquus exhibits promising anti breast cancer activity via regulating the JAK2/STAT3 signaling pathway.

The aim of the present study was to investigate the small molecule anticancer agents in the medicinal fungus Inonotus obliquus and further characterize their possible molecular mechanisms..

Oncology

Immune supportSkin & hydration

Chaga · 2023 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Inonotus obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity, and associated fungi.

Inonotus obliquus is a medicinal fungus with potential for use in various health applications. To better utilize this fungus, this study focused on epidermis and internal tissues of five sclerotia from different regions in Jilin, Inner Mongolia, and Heilongjiang, examining their polyphenols, polysaccharides,….

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Integrated metabolomics and transcriptomics reveal metabolites difference between wild and cultivated Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a traditional medicinal fungus endemic to the alpine and high-altitude areas of the Qinghai-Tibet plateau. The scarcity of the wild resource has led to increased attention to artificially cultivated O.

Metabolic health

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · PloS one

Isolation and identification of bioactive compounds from Antrodia camphorata against ESKAPE pathogens.

Antimicrobial resistance is a major threat to human health globally. Antrodia camphorata was grown in a malt/yeast extract broth liquid medium for 15 days.

Respiratory

OncologyImmune supportGut & microbiome

Reishi · 2023 · Research Support, Non U.S. Gov'T · Aging

Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.

CPT-11 (Irinotecan) remains an important chemotherapeutic agent against various solid tumors nowadays. Potential adverse effects, especially gastrointestinal toxicities, are the main limiting factor for its clinical utility..

Immune supportGut & microbiome

Enoki · 2023 · Research Support, Non U.S. Gov'T · mSystems

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens.

Because antibiotics have been phased out of use in poultry feed, measures to improve intestinal health have been sought. Dietary fiber may be beneficial to intestinal health by modulating gut microbial composition, but the exact changes it induces remain unclear..

Reishi · 2023 · Research Support, Non U.S. Gov'T · Biomaterials

Modifications of Ganoderma lucidum spores into digestive-tissue highly adherent porous carriers with selective affinity to hydrophilic or hydrophobic drugs.

Ganoderma lucidum spores (GLSs) have been suggested to provide optimal structures for transporting orally bioavailable drugs. However, the double-layer wall and cavities of GLSs are naturally closed..

Gut & microbiome

Reishi · 2023 · Research Support, Non U.S. Gov'T · Organic letters

One-Pot Assembly of the Highly Branched Tetradecasaccharide from Ganoderma lucidum Glycan GLSWA-1 with Immune-Enhancing Activities.

The highly branched tetradecasaccharide repeating unit and shorter sequences of GLSWA-1 with immune-enhancing activities from Ganoderma lucidum have been prepared via a one-pot glycan assembly strategy..

Reishi · 2023 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Pivotal biological processes and proteins for selenite reduction and methylation in Ganoderma lucidum.

Microbial transformations, especially the reduction and methylation of Se oxyanion, have gained significance in recent years as effective detoxification methods. Ganoderma lucidum is a typical Se enrichment resource that can reduce selenite to elemental Se and volatile Se metabolites under high selenite conditions..

Shiitake · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Potential Role of Lysine Acetylation and Autophagy in Brown Film Formation and Postripening of Lentinula edodes Mycelium.

Lentinula edodes is one of the most widely cultivated edible mushrooms in the world. When cultivated in sawdust, the surface mycelium of L.

OncologyImmune supportCognition & nervesMetabolic health

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus ostreatus.

Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.

Reishi · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum

PRMT5 regulates the polysaccharide content by controlling the splicing of thaumatin-like protein in Ganoderma lucidum.

PRMT5 contributes to secondary metabolite biosynthesis in Ganoderma lucidum. However, the mechanism through which PRMT5 regulates the biosynthesis of secondary metabolites remains unclear.

Immune supportRespiratory

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · Organic & biomolecular chemistry

Regio-specific enzymatic glucosylation of triterpenoids from Antrodia camphorata and their biological activities.

The bacterial glycosyltransferase YjiC1 was used to glycosylate triterpenoids from the medicinal fungus Antrodia camphorata. Eleven new compounds were obtained from enzymatic reactions..

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Salicylic Acid Treatment Alleviates the Heat Stress Response by Reducing the Intracellular ROS Level and Increasing the Cytosolic Trehalose Content in Pleurotus ostreatus.

Pleurotus ostreatus is usually cultivated in horticultural facilities that lack environmental control systems and often suffer heat stress (HS). Salicylic acid (SA) is recognized as a plant defense-related hormone.

Turkey Tail · 2023 · Research Support, Non U.S. Gov'T · Journal of hazardous materials

Synergistic degradation of Azure B and sulfanilamide antibiotics by the white-rot fungus Trametes versicolor with an activated ligninolytic enzyme system.

The treatment of complex polluted wastewater has become an increasingly critical concern for the various types of hazardous organic compounds, including synthetic dyes and pharmaceuticals..

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

The Cas9-gRNA ribonucleoprotein complex-mediated editing of pyrG in Ganoderma lucidum and unexpected insertion of contaminated DNA fragments.

Gene editing is a promising alternative to traditional breeding for the generation of new mushroom strains. However, the current approach frequently uses Cas9-plasmid DNA to facilitate mushroom gene editing, which can leave residual foreign DNA in the chromosomal DNA raising concerns regarding genetically modified….

Immune supportEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2023 · Research Support, Non U.S. Gov'T · PloS one

The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics.

Ophiocordyceps sinensis is a fungus with medicinal value in treating lung diseases, but no study has reported how to prevent acute lung injury using this fungus. The mice were divided into normal, model, positive control, and O..

Immune supportLiver support

Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T · Aging

Triterpene acid from Antrodia camphorata alleviates inflammation in acute liver injury.

This study aimed to investigate the role and mechanism of Anctin A, the Antrodia camphorata terpene component, in resisting liver injury. Network pharmacology analysis revealed that MAPK3 was the major action target of Antcin A..

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Fungal biology

Visualizing organelles with recombinant fluorescent proteins in the white-rot fungus Pleurotus ostreatus.

White-rot fungi secrete numerous enzymes involved in lignocellulose degradation. However, the secretory mechanisms or pathways, including protein synthesis, folding, modification, and traffic, have not been well studied..

Lion's Mane · 2022 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[A new sesquiterpene lactone from biological transformation of Hericium erinaceus and Artemisiae Annuae Herba].

This study aimed to investigate the chemical constituents from the biological transformation of Hericium erinaceus and Artemisiae Annuae Herba(HQ biological transformation)..