MycoData

Polysaccharides are biopolymers known to possess various bioactivities. Because of their molecular complexity, the structural characterization of polysaccharides remains challenging, and difficult to be completed with a single analytical method..

Immune supportGut & microbiome

Medium relevance

Reishi · 2022 · Journal Article · Phytotherapy research: PTR

Time-dependent dual beneficial modulation of interferon-γ, interleukin 5, and Treg cytokines in asthma patient peripheral blood mononuclear cells by ganoderic acid B.

Th2 cytokines play a dominant role in the pathogenesis of allergic asthma. Interferon gamma (IFN-γ), a Th1 cytokine, links to therapeutic mechanisms of allergic asthma.

Immune supportRespiratory

Medium relevance

Chaga · 2022 · Research Article · Journal of immunology research

Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways.

Diabetic nephropathy (DN) is a fatal complication of diabetes and the main cause of end-stage renal disease. Due to the suboptimal effects of current treatments, there is an urgent need to develop new therapeutic strategies for DN..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Turkey Tail · 2022 · Research Article · Frontiers in plant science

Wood degradation by Fomitiporia mediterranea M. Fischer: Physiologic, metabolomic and proteomic approaches.

Fomitiporia mediterranea (Fmed) is one of the main fungal species found in grapevine wood rot, also called "amadou," one of the most typical symptoms of grapevine trunk disease Esca..

Immune support

Medium relevance

Maitake · 2021 · Journal Article · Beneficial microbes

A blend of 3 mushrooms dose-dependently increases butyrate production by the gut microbiota.

The gut microbiota has been indicated to play a crucial role in health and disease. Apart from changes in composition between healthy individuals and those with a disease or disorder, it has become clear that also microbial activity is important for health..

Immune supportGut & microbiome

Medium relevance

Maitake · 2021 · Research Article · BMC complementary medicine and therapies

A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial-mesenchymal transition via the canonical Wnt/β-catenin signaling pathway.

BACKGROUND: Natural products, especially those with high contents of phytochemicals, are promising alternative medicines owing to their antitumor properties and few side effects..

OncologyImmune support

Medium relevance

Shiitake · 2021 · Journal Article · Applied microbiology and biotechnology

Antidepressant-like effect of Ganoderma lucidum spore polysaccharide-peptide mediated by upregulation of prefrontal cortex brain-derived neurotrophic factor.

A 28-kDa polysaccharide-peptide (PGL) with antidepressant-like activities was isolated from spores of the mushroom Ganoderma lucidum. It was unadsorbed on DEAE-cellulose.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Medium relevance

Lion's Mane · 2021 · Journal Article · Chemosphere

Antifungal agents, yeast abundance and diversity in surface water: Potential risks to water users.

South African surface waters are subject to various forms of pollution. Recent findings in aquatic systems suggest an association exists between yeast diversity, chemical pollutants and land coverage, which are important water quality determinants..

Immune support

Medium relevance

Lion's Mane · 2021 · Journal Article · Food & function

Apoptotic mechanisms of gastric cancer cells induced by isolated erinacine S through epigenetic histone H3 methylation of FasL and TRAIL.

Erinacine S, the new bioactive diterpenoid compound isolated from the ethanol extract of the mycelia of Hericium erinaceus, displays great health-promoting properties. However, the effects of erinacine S on inductive apoptosis in cancer cells such as gastric cancer and its molecular mechanisms remain unclear..

OncologyImmune supportCognition & nerves

Medium relevance

Shiitake · 2021 · Journal Article · Food & function

Effects of fungal beta-glucans on health - a systematic review of randomized controlled trials.

INTRODUCTION: Beta-glucans are polysaccharides that exhibit a wide range of biological properties as a result of their varying chemical composition. Like all dietary fibers, they avoid catabolism in the upper gastrointestinal tract, and they reach the large intestine undigested..

OncologyImmune supportGut & microbiomeRespiratory

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Carbohydrate polymers

Enhanced konjac glucomannan hydrolysis by lytic polysaccharide monooxygenases and generating prebiotic oligosaccharides.

Konjac glucomannan (KGM) hydrolysate is a potentially valuable prebiotic that could improve gastrointestinal health by modulating the growth of probiotic bacteria and by promoting the production of short-chain fatty acids (SCFAs)..

Immune supportEnergy & fatigueGut & microbiome

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Fungal biology

Enhancement of exopolysaccharide production from Ganoderma lucidum using a novel submerged volatile co-culture system.

Based on the impact of volatile organic compounds (VOCs) on secondary metabolite pathways, a novel submerged volatile co-culture system was constructed, and the effects of thirteen fungal and bacterial VOCs were investigated on Ganoderma lucidum exopolysaccharides production..

Immune support

Medium relevance

Niu-Chang-Chih · 2021 · Research Article · Molecules (Basel, Switzerland)

Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress.

Ergosta-7,9(11),22-trien-3β-ol (EK100) was isolated from the Taiwan-specific medicinal fungus Antrodia camphorata, which is known for its health-promotion and anti-aging effects in folk medicine. Alzheimer's disease (AD) is a major aging-associated disease..

Immune supportCognition & nervesSkin & hydration

Medium relevance

Shiitake · 2021 · Journal Article · Clinical nutrition (Edinburgh, Scotland)

Fungal beta-glucans as adjuvants for treating cancer patients - A systematic review of clinical trials.

BACKGROUND & AIMS: Fungal β-glucans have been considered as biological response modifiers (BRMs) promoting stimulation of immune system according to numerous scientific publications performed in vitro and in vivo. Some clinical trials involving such compounds started to be published since 1980's..

OncologyImmune supportCognition & nerves

Medium relevance

Mesima · 2021 · Research Article · Experimental and therapeutic medicine

Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling.

Neuroinflammation is associated with many neurodegenerative diseases. Abnormal activation of microglial cells in the central nervous system (CNS) is a major characteristic of neuroinflammation..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Zhu Ling · 2021 · Research Article · BMC complementary medicine and therapies

Homogeneous polyporus polysaccharide inhibits bladder cancer by polarizing macrophages to M1 subtype in tumor microenvironment.

BACKGROUND: Polyporus polysaccharide (PPS), an active ingredient of traditional Chinese medicinal Polyporus umbellatus, has multiple biological functions, such as anti-cancer, immune-regulating and hepatoprotective activities..

OncologyImmune supportLiver support

Medium relevance

Shiitake · 2021 · Research Article · Molecules (Basel, Switzerland)

Identification of the Primary Structure of Selenium-Containing Polysaccharides Selectively Inhibiting T-Cell Proliferation.

We previously described the biosynthesis, isolation, and immunosuppressive activity of the selenium-containing polysaccharide fraction isolated from the mycelial culture of Lentinula edodes..

Immune support

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Frontiers in molecular biosciences

Immobilization of Antibodies by Genetic Fusion to a Fungal Self-Assembling Adhesive Protein.

Although antibody immobilization on solid surfaces is extensively used in several applications, including immunoassays, biosensors, and affinity chromatography, some issues are still challenging. Self-assembling protein layers can be used to coat easily different surfaces by direct deposition..

Immune supportCognition & nervesEnergy & fatigue

Medium relevance

Chaga · 2021 · Journal Article · International immunopharmacology

Inonotsuoxide B regulates M1 to M2 macrophage polarization through sirtuin-1/endoplasmic reticulum stress axis.

We explored the effect of tetracyclic triterpenoid inonotsuoxide B (IB) extracts of Inonotus obliquus on M1 to M2 macrophage polarization and its possible underlying mechanism..

OncologyImmune support

Medium relevance

Cordyceps · 2021 · Research Article · International journal of molecular sciences

Isolation and Assessment of a Highly-Active Anti-Inflammatory Exopolysaccharide from Mycelial Fermentation of a Medicinal Fungus Cs-HK1.

The purpose of this work was to fractionate the complex exopolysaccharide (EPS) from a medicinal fungus Ophiocordyceps sinensis Cs-HK1 based on the molecular weight (MW) range and to assess the in vitro anti-inflammatory activity of different EPS fractions in THP-1 cell culture..

Immune supportMetabolic health

Medium relevance

Turkey Tail · 2021 · Journal Article · Food chemistry

Laccase-catalyzed conjugation of potato protein (PPT) with selected pectic polysaccharides (PPS): Conjugation efficiency and emulsification properties.

The current study focused on the investigation of laccase-catalyzed conjugation of potato protein (PPT) with selected pectic polysaccharides (PPS) and modulation of the conjugation in order to obtain desired functional ingredients..

Immune supportEnergy & fatigue

Medium relevance

Snow Fungus · 2021 · Journal Article · Journal of ethnopharmacology

Laxative effect and mechanism of Tiantian Capsule on loperamide-induced constipation in rats.

ETHNOPHARMACOLOGICAL RELEVANCE: Tiantian capsule (TTC), as a functional food, which consists of four herb medicines, including Aloe vera Burm.f. (25%), leaf juices, dried; Cucurbita moschata Duch.

Immune supportCognition & nervesGut & microbiome

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Environmental microbiology

Lytic polysaccharide monooxygenases promote oxidative cleavage of lignin and lignin-carbohydrate complexes during fungal degradation of lignocellulose.

Overcoming lignocellulosic biomass recalcitrance, especially the cleavage of cross-linkages in lignin-carbohydrate complexes (LCCs) and lignin, is essential for both the carbon cycle and industrial biorefinery..

Immune supportEnergy & fatigue

Medium relevance

Turkey Tail · 2021 · Research Article · Biomolecules

Oligosaccharides Derived from Tramesan: Their Structure and Activity on Mycotoxin Inhibition in Aspergillus flavus and Aspergillus carbonarius.

Food and feed safety are of paramount relevance in everyday life. The awareness that different chemicals, e.g., those largely used in agriculture, could present both environmental problems and health hazards, has led to a large limitation of their use..

Immune support

Medium relevance

Shiitake · 2021 · Research Article · Pharmaceuticals (Basel, Switzerland)

The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine.

The AHCC standardized extract of cultured Lentinula edodes mycelia, and the standardized extract of Asparagus officinalis stem, trademarked as ETAS, are well known supplements with immunomodulatory and anticancer potential..

OncologyImmune supportGut & microbiome

Medium relevance

Snow Fungus · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Whole Genome Sequencing and Annotation of Naematelia aurantialba (Basidiomycota, Edible-Medicinal Fungi).

Naematelia aurantialba is a rare edible fungus with both nutritional and medicinal values and especially rich in bioactive polysaccharides. However, due to the lack of genomic information, researches on the mining of active compounds, artificial breeding and cultivation, genetics, and molecular biology are limited..

Immune supportCognition & nerves

Medium relevance

Oyster Mushroom · 2020 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Spent mushroom substrate for a second cultivation cycle of Pleurotus mushrooms and dephenolization of agro-industrial wastewaters.

Spent mushroom substrate (SMS) of Pleurotus ostreatus was supplemented with wheat bran and soybean flour and used as substrate for a new cultivation cycle of the oyster mushrooms Pleurotus ostreatus and Pleurotus pulmonarius..

Immune supportGut & microbiome

Medium relevance

Niu-Chang-Chih · 2019 · Research Support, Non U.S. Gov'T · Mathematical biosciences and engineering: MBE

Attention based residual network for medicinal fungi near infrared spectroscopy analysis.

As an effective technology, near infrared spectroscopy (NIRS) can be widely applied to analysis of active ingredients in medicinal fungi. Multiple regression methods are used to compute the relationship between spectral vectors and ingredient contents..

Immune supportEnergy & fatigue

Medium relevance

Maitake · 2013 · Research Article · Indian journal of microbiology

Chemical composition and sensory evaluation of fermented tea with medicinal mushrooms.

In commercial tea production, plenty of tea leaf waste is generated, which may not only exert pollution risk to environment, but also a huge waste of bioactive ingredients in tea..

Immune support

Medium relevance

Enoki · 2007 · Research Article · Nutrition research and practice

Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2).

Cytoprotective ability of polysaccharides isolated from different edible mushrooms was investigated on the 7-ketocholesterol-induced damaged cell line. Polysaccharide extracts from six different edible mushrooms-Flammulina velutipes, Peurotus ostreatus, Lentinus edodes, Agrocybe aegerita, Agaricus blazei, and….

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Analytical chemistry

A Proof-of-Concept Sandwich Enzyme-Linked Immunoassay Development for Small Molecules.

A sandwich immunoassay theoretically exhibits higher sensitivity and specificity compared to a competitive counterpart; however, it is extremely difficult to obtain a pair of antibodies that can bind to a small molecule simultaneously, which is always thought to be a single epitope..

Immune supportCognition & nerves

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Journal of translational medicine

Atf4 regulates angiogenic differences between alveolar bone and long bone macrophages by regulating M1 polarization, based on single-cell RNA sequencing, RNA-seq and ATAC-seq analysis.

In the repair of maxillofacial bone defects, autogenous craniofacial bone can often provide superior clinical results over long bone grafts. Most current studies have focused on the osteogenic differences between alveolar bone marrow (ABM) and long bone marrow (LBM), however, studies about the angiogenic differences….

Immune support

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Bulletin of mathematical biology

Circulation of Respiratory Viruses in the City: Towards an Agent-Based Ecosystem model.

Mathematical models play an important role in management of outbreaks of acute respiratory infections (ARI). While such models are generally used to study the spread of a solitary virus, in reality multiple viruses co-circulate in the population..

Immune supportRespiratory

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Stem cells and development

Effect of Insulin on Bone Formation Ability of Rat Alveolar Bone Marrow Mesenchymal Stem Cells.

The alveolar bone marrow mesenchymal stem cells (ABM-MSCs) play an important role in oral bone healing and regeneration. Insulin is considered to improve impaired oral bones due to local factors, systemic factors and pathological conditions..

Immune supportMetabolic healthSkin & hydration

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Cancer communications (London, England)

Glutamine metabolic microenvironment drives M2 macrophage polarization to mediate trastuzumab resistance in HER2-positive gastric cancer.

BACKGROUND: Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2 (HER2)-positive gastric cancer. However, the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit, and there is currently no effective reversal measure..

OncologyImmune supportMetabolic healthSkin & hydration

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · Toxicology

Molecular mechanism of kidney damage caused by abamectin in carp: Oxidative stress, inflammation, mitochondrial damage, and apoptosis.

Indiscriminate use of pesticides not only leads to environmental pollution problems, but also causes poisoning of non-target organisms. Abamectin (ABM), a widely used insecticide worldwide, is of wide concern due to its persistence in the environment and its high toxicity to fish..

OncologyImmune supportEnergy & fatigue

Medium relevance

Almond Mushroom · 2023 · Research Support, Non U.S. Gov'T · PLoS computational biology

Quantification of spatial and phenotypic heterogeneity in an agent-based model of tumour-macrophage interactions.

We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial relationships between points marked with combinations of discrete and continuous labels..

OncologyImmune support

Medium relevance

Almond Mushroom · 2022 · Research Support, Non U.S. Gov'T · Journal of the Royal Society, Interface

A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics.

In-stent restenosis (ISR) is a maladaptive inflammatory-driven response of femoral arteries to percutaneous transluminal angioplasty and stent deployment, leading to lumen re-narrowing as consequence of excessive cellular proliferative and synthetic activities..

Immune support

Medium relevance

Almond Mushroom · 2022 · Research Support, Non U.S. Gov'T · Journal of immunology (Baltimore, Md.: 1950)

Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs.

Immunodeficient mice reconstituted with immune systems from patients, or personalized immune (PI) mice, are powerful tools for understanding human disease. Compared with immunodeficient mice transplanted with human fetal thymus tissue and fetal liver-derived CD34+ cells administered i.v..

Immune supportLiver support

Medium relevance

Almond Mushroom · 2022 · Research Support, Non U.S. Gov'T · PLoS computational biology

Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model.

Quantitative systems pharmacology (QSP) models and spatial agent-based models (ABM) are powerful and efficient approaches for the analysis of biological systems and for clinical applications..

OncologyImmune support

Medium relevance

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · BMC immunology

Clinical observations of bone marrow transfusion for promoting bone marrow reconstruction after chemotherapy for AIDS-related lymphoma.

BACKGROUND: This study investigates the effect of autologous bone marrow transfusion (BMT) on the reconstruction of both bone marrow and the immune system in patients with AIDS-related lymphoma (ARL). METHODS: A total of 32 patients with ARL participated in this study..

OncologyImmune support

Medium relevance

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · Stem cells and development

Effects of rhBMP-2 on Bone Formation Capacity of Rat Dental Stem/Progenitor Cells from Dental Follicle and Alveolar Bone Marrow.

Dental stem/progenitor cells are a promising cell sources for alveolar bone (AB) regeneration because of their same embryonic origin and superior osteogenic potential. However, their molecular processes during osteogenic differentiation remain unclear..

Immune supportGut & microbiomeSkin & hydration

Medium relevance

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · Analytical biochemistry

Procalcitonin measurement using antibody-conjugated fluorescent microspheres distinguishes atypical bacterial meningitis from viral encephalitis in children.

Examination of cerebrospinal fluid in atypical bacterial meningitis (ABM) is similar to that of viral encephalitis (VE), so ABM can easily be misdiagnosed as VE, which can delay diagnosis and treatment..

Immune supportRespiratory

Medium relevance

Shiitake · 2020 · Journal Article · Journal for the Integrated Study of Dietary Habits

Contents of 5’-GMP, free amino acids and lentinic acid among the different cultivars of shiitake mushroom

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Journal for the Integrated Study of Dietary Habits in 2020. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

Medium relevance

Oyster Mushroom · 2020 · Journal Article · Mushroom Science and Biotechnology

Effects of dietary ethanol extract from fruiting bodies of golden oyster mushroom (Pleurotus citrinopileatus) on chronic colon inflammation in mice treated with dextran sulfate sodium salt

Metadata-grounded summary: This journal article indexes research on Pleurotus ostreatus in Mushroom Science and Biotechnology in 2020. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

Medium relevance

Shiitake · 2020 · Journal Article · Mushroom Science and Biotechnology

Effects of lightning strike on the occurrence of shiitake mushrooms

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Mushroom Science and Biotechnology in 2020. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

Medium relevance

Shiitake · 2020 · Journal Article · Mushroom Science and Biotechnology

Efficacy of entomopathogenic fungus Beauveria bassiana against adults of Shiitake-pest mushroom fly, Neoempheria carinata

Immune supportGut & microbiome

Medium relevance

Oyster Mushroom · 2020 · Journal Article · International journal of medicinal mushrooms

In Vitro and In Vivo Medicinal Value of Culinary-Medicinal Lung Oyster Mushroom Pleurotus pulmonarius var. stechangii (Agaricomycetes).

Pleurotus pulmonarius var. stechangii is a culinary-medicinal mushroom commonly cultivated in subtropical countries in Asia.

Immune supportMetabolic healthRespiratory

Medium relevance

Shiitake · 2020 · Journal Article · Journal of the Japanese Society of Agricultural Machinery and Food Engineers

Optimization of the Lighting Environment in Sawdust-Based Shiitake Cultivation

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Journal of the Japanese Society of Agricultural Machinery and Food Engineers in 2020. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

Medium relevance

Shiitake · 2020 · Journal Article · Food Science and Technology Research

Quality Evaluation of Shiitake Mushrooms Dried by Vacuum Microwave Treatment

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Food Science and Technology Research in 2020. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome