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Immune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · Mycopathologia

Exopolysaccharides of Ganoderma lucidum Activate the NLRP3 Inflammasome, Modulating Phagocytes and the Response of Mice to Infection with Cryptococcus neoformans.

Interleucin-1β (IL-1β) is a pivotal cytokine in pro-inflammatory response induction, and it is regarded as protective in various diseases. IL-1β secretion is mainly associated with activation of the inflammasome complex, which normally is tightly regulated, depending on two signals for significant activity..

Immune supportEnergy & fatigue

Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina velutipes polysaccharide exerts immunomodulatory function involving RSAD2 to regulate the NF-κB/MAPK signaling pathway in RAW264.7 macrophage cells and in mouse spleen cells.

There are ongoing efforts to explore the potential of natural bioactive substances including polysaccharides in immunological regulation and understand the mechanisms under their immune-regulating function..

Energy & fatigueMetabolic health

Turkey Tail · 2025 · Journal Article · Enzyme and microbial technology

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids

Cytochrome P450 monooxygenases (P450) play crucial roles in the diversification of secondary metabolic systems in living organisms. Basidiomycetes produce a wide variety of natural products as secondary metabolites, with their relevance to pharmaceutical and agricultural applications garnering significant interest..

Energy & fatigueMetabolic health

Turkey Tail · 2025 · Journal Article · Enzyme and microbial technology

Functional analysis of cytochrome P450 monooxygenases from the white-rot basidiomycete Trametes versicolor: CYP502B15 decorates cadinane-type sesquiterpenoids.

Immune supportEnergy & fatigueMetabolic healthRespiratory

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Functional characterization of Ganoderma lucidum polysaccharide and the mechanism of inducing tomato resistance to Tomato yellow leaf curl virus.

Using functional polysaccharides as elicitors to induce plant disease resistance has emerged as an effective plant protection strategy. In this study, we found that crude polysaccharides derived from by-products of Ganoderma lucidum can effectively prevent and control the Tomato Yellow Leaf Curl Virus (TYLCV)..

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

Ganoderma lucidum Glycoprotein Microemulsion: Improved Transdermal Delivery and Protective Efficacy in UV-Induced Cell and Animal Models.

BACKGROUND: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant

Oxidative stress after spinal cord injury (SCI) significantly promotes neuronal apoptosis. The imbalance of flora leads to the destruction of the intestinal barrier, so that pro-inflammatory cytokines enter the blood and further aggravate neuroinflammation..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant.

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2025 · Journal Article · Biomacromolecules

Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing.

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound healing process..

Immune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Frontiers in immunology

Ganoderma lucidum spore powder alleviates rheumatoid arthritis-associated pain hypersensitivity through inhibiting accumulation, N1 polarization, and ROS production of neutrophils in mice.

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic condition characterized by joint pain that significantly impairs patients' work and daily lives. The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management..

Reishi · 2025 · Journal Article · Archives of microbiology

Genome-wide identification of CYP450 in Ganoderma lucidum and expression analysis of genes related to ganoderic acid synthesis.

The biosynthesis mechanism of ganoderic acid, a class of secondary metabolites of Ganoderma lucidum, is currently unknown. Members of G.

Reishi · 2025 · Journal Article · Applied biochemistry and biotechnology

Identification of Novel Laccase from Ganoderma lucidum and Application in Biotransformation to Bio-based Fragrances Using Alkaline Lignin as Raw Material.

A novel laccase, Lac3, was purified from Ganoderma lucidum fermentation broth by salting out, gel filtration chromatography, and Native-PAGE protein recovery. The molecular mass of Lac3 was 58.4 kDa as estimated by SDS-PAGE and exhibited catalytic properties with 2,2'-Biazobis-3-ethylbenzothiazoline-6-sulfonic acid….

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Immobilization of Trametes versicolor laccase on LDH/alginate composite beads for improved textile dyes decolorization.

Laccase is an oxido-reductase known for its applications in biomass valorization (lignin depolymerization), in fine chemicals (building-blocks synthesis) or in environment (wastewater treatment). It works with molecular oxygen and produces water as its only by-product..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide.

Oxidative stress, driven by impaired antioxidant defence systems, is a major contributor to cognitive decline and neurodegenerative processes in brain ageing. This study investigates the neuroprotective effects of a natural compound mixture-composed of Hericium erinaceus, Palmitoylethanolamide, Bilberry extract, and….

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Proteomics and Metabolomics Reveal Regulatory Pathways Underlying Quality Differences Between Wild and Cultivated Ophiocordyceps sinensis.

Ophiocordyceps sinensis, is an entomopathogenic fungus renowned for its medicinal properties, thriving in the frigid and high-altitude regions of the Qinghai-Tibet plateau. Given the limited availability of wild resources and the increasing recognition of their medicinal value, the cultivation of O..

OncologyEnergy & fatigueGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Frontiers in fungal biology

LED light spectra influence the stimulation of mycelial growth and anticancer activity in Hericium erinaceus mycelium.

INTRODUCTION: Hericium erinaceus is a medicinal mushroom known for producing diverse bioactive metabolites with therapeutic potential. However, cultivation strategies aimed at enhancing both fungal yield and metabolite bioactivity, particularly through light-mediated physiological modulation, remain insufficiently….

OncologyEnergy & fatigueGut & microbiomeRespiratory

Maitake · 2025 · Research Article · Food science & nutrition

Mesenchymal Stem Cell-Conditioned Media-Derived Exosomes Loaded With Grifola frondosa Extract Inhibit Lung Cancer via NF-κB and MAPK Pathway Modulation.

The increasing prevalence of drug resistance diminishes the efficacy of chemotherapy and other therapeutic modalities for individuals diagnosed with lung cancer. Therefore, it is imperative to develop novel treatment approaches..

Immune supportEnergy & fatigueMetabolic health

Chaga · 2025 · Journal Article · Chemistry & biodiversity

Microwave Extraction of New Polysaccharides From Inonotus obliquus, Structural Characterization, and Antioxidant Activity.

To address the low extraction yield and structural degradation issues of conventional methods, this study optimized microwave-assisted extraction (61°C, 64 min, 30:1 mL/g ratio) to obtain Inonotus obliquus polysaccharides (IOP), followed by DEAE-52 and Sephadex G-100 purification to isolate two fractions: neutral….

Energy & fatigueMetabolic healthRespiratory

Lion's Mane · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Mitochondrial energy homeostasis-mediated respiration suppression: A novel mechanism for combating wilting of Hericium erinaceus via electron beam generated X-ray irradiation

This study explored the mechanism of Hericium erinaceus wilting delayed by 1.0 kGy electron-beam generated X-ray (EBGX) irradiation from modulating respiratory pathways and energy homeostasis perspectives..

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Research Article · Frontiers in microbiology

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers.

Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier function and intestinal microbial community in broilers under….

Oyster Mushroom · 2025 · Journal Article · Physiological and Molecular Plant Pathology

Molecular characterization of thermostable chitinases from Indian Pleurotus ostreatus and their effectiveness against the plant pathogenic Alternaria solani and Fusarium oxysporum

Chitinase has diverse applications across agriculture, energy production, food processing, pharmaceuticals, and human healthcare. Characterizing chitinase is essential for understanding its potential uses in these fields..

Reishi · 2025 · Journal Article · Food chemistry

Molecular networking and Paterno-Büchi reaction guided glycerides characterization and antioxidant activity assessment of Ganoderma lucidum spore oil.

Ganoderma lucidum spore oil (GLSO) is a dietary supplement, with glycerides (GLs) recognized as its important active component. However, comprehensive profiling and accurate structural characterization of GLs in GLSO remain underexplored..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Research Article · Scientific reports

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.

Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyEnergy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Multiomics Provides a New Understanding of the Effect of Temperature Change on the Fermentation Quality of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a medicinal fungus with significant nutritional and utilization value. Temperature is a crucial factor influencing its growth, as temperature changes can impact enzyme activity, metabolite content, and gene expression during fungal cultivation..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2025 · Research Article · International journal of molecular sciences

Neuroprotective Terpenoids Derived from Hericium erinaceus Fruiting Bodies: Isolation, Structural Elucidation, and Mechanistic Insights.

Hericium erinaceus, a medicinal macrofungus, is renowned for its potential neuroprotective benefits. Here, we isolated and characterized secondary metabolites from H.

Turkey Tail · 2025 · Research Article · Molecules (Basel, Switzerland)

Nicotine Degradation by Trametes versicolor: Insights from Diverse Environmental Stressors and Wastewater Medium.

Nicotine, a major alkaloid in tobacco, poses significant environmental risks due to its persistence in wastewater. This study explores the degradation of naturally extracted nicotine from tobacco leaves by the white-rot fungus Trametes versicolor, aiming to assess its biodegradation capacity under diverse….

Chaga · 2025 · Research Article · International journal of molecular sciences

NO Activates the Triterpenoid Biosynthetic Pathway in Inonotus obliquus Through Multilevel Signaling Regulation to Enhance Its Production.

Triterpenoids are the bioactive components in Inonotus obliquus with extensive medicinal prospects, but their low content in fermentation production is the main limiting factor for their application..

Maitake · 2025 · Journal Article · Fungal biology

Olive oil additive enhances hyphal growth and triterpenes accumulation in submerged fermentation of Grifola frondosa.

Grifola frondosa, a famous mushroom worldwide, is highly valued for its multiple health benefits. However, the limited mycelial biomass and low triterpenes (GFTs) yield remain critical constraints for large-scale utilization of this fungus..

Enoki · 2025 · Research Article · Ultrasonics sonochemistry

Optimization of bioactive polyphenols recovery from Flammulina velutipes stem waste using nonionic surfactant-integrated ultrasound-assisted extraction.

The process of cultivating edible and medicinal mushrooms results in considerable biomass waste, which can be a rich source of bioactive compounds. This research aimed at optimizing the yield of polyphenols and improving the antioxidant potential of extracts derived from the stem waste of Flammulina velutipes (FVS)..

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Journal Article · International journal of medicinal mushrooms

Phellinus linteus (Agaricomycetes) Polysaccharides Ameliorate Inflammatory Injury in H2O2-Induced Caco-2 Cells and DSS-Induced Ulcerative Colitis Mice.

Phellinus linteus (Agaricomycetes) is a valuable medicinal mushroom traditionally used as a food supplement and medicinal ingredient. Polysaccharides of Ph.

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Enoki · 2025 · Journal Article · ACS applied materials & interfaces

Photo-Cross-Linked and Photothermal Flammulina velutipes Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing.

Diabetic ulcers remain a persistent global health challenge. Developing therapeutic systems with antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic properties presents a promising strategy for effectively and rapidly treating diabetic wounds and preventing the development of diabetic ulcers..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Reishi · 2025 · Journal Article · Metabolic brain disease

Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation.

Oxidative stress and mitochondrial dynamics imbalance are key contributors to AD pathogenesis. GLPS, an extract from Ganoderma lucidum spores, exhibits anti-inflammatory, antioxidant, and immunomodulatory properties..

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy

Cancer remains a significant global health challenge. Given the limitations of conventional single-treatment modalities and the potential benefits of combination therapies, this study aimed to develop a multifunctional nanoplatform integrating immunotherapy, chemotherapy, and photothermal therapy for cancer treatment..

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy.

Reishi · 2025 · Research Article · Microbial cell factories

PRMT5 promotes cellulase production by regulating the expression of cellulase gene eg2 through histone methylation in Ganoderma lucidum.

BACKGROUND: Cellulase can degrade cellulose into reducing sugar, participating in the natural carbon cycle. Simultaneously, cellulase enhances the efficiency and quality of industrial production while also demonstrating significant potential in environmental protection and bioenergy development..

OncologyImmune supportEnergy & fatigue

Mesima · 2025 · Research Article · BMC research notes

Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation.

OBJECTIVE: This study aimed to explore the protective mechanism of Phellinus linteus polysaccharides (Phps) against hypoxia/reoxygenation (H/R)-induced injury in H9c2 cardiomyocytes, focusing on oxidative stress, apoptosis, and PI3K-AKT pathway regulation..

Energy & fatigueMetabolic health

Reishi · 2025 · Research Article · BMC genomics

Proteome study of dikaryotic and monokaryotic mycelia reveals the transfer between biological processes contributing to dikaryon growth advantage of the medicinal fungus Ganoderma lucidum.

BACKGROUND: Ganoderma lucidum, a well-known medicinal fungus in traditional Chinese medicine, exhibits a superior growth rate in its dikaryotic mycelia compared to monokaryons, and this is essential for its fruiting body formation and medicinal utilization..

Reishi · 2025 · Journal Article · Heliyon

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs..

Reishi · 2025 · Research Article · Heliyon

Removal of cyanobacterial harmful algal blooms (HABs) from contaminated local park lake using Ganoderma lucidum mycelial pellets.

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Restoring Mitochondrial Function and Remodeling Gut Microbiota by Low-Molecular-Weight β-Glucan of Hericium erinaceus in Alcohol-Induced Gastrointestinal Injury.

Excessive alcohol consumption poses significant risks for gastrointestinal injury; β-glucans from Hericium erinaceus are known for gastroprotective properties; however, the efficacy of its high-molecular-weight β-glucan is often limited by poor solubility and bioavailability, leaving its protective mechanisms against….

Enoki · 2025 · Journal Article · Food Bioscience

Screening of mixed lactic acid bacteria starter and exploring the sources of flavor substances in co-fermentation of Flammulina velutipes with different vegetables

To augment the flavor components of Flammulina velutipes pickles (FVP) and enhance its acceptability, F. velutipes were co-fermented with various raw materials (cabbages, cowpeas, radishes, millet peppers, gingers, Sichuan peppercorns) using lactic acid bacteria (LAB)..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates

In the study, Grifola frondosa polysaccharides (GFPs) and gallic acid (GA) were utilized to synthesize selenium nanoparticles (GFPs-GA-SeNPs) through a redox reaction involving sodium selenite and ascorbic acid..

OncologyImmune supportEnergy & fatigueGut & microbiome

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

Energy & fatigueMetabolic healthGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Structural characterisation and cholesterol and bile salts adsorption properties of Ganoderma lucidum dietary fiber

This study prepared Ganoderma lucidum insoluble dietary fiber (GIDF) and soluble dietary fiber (GSDF) via enzymatic methods. The structural and physicochemical properties of GIDF and GSDF were systematically characterized using scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray….

Energy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Surface-modifying Ganoderma lucidum spores as improved microcarriers in protein delivery

Bioactive proteins and peptides hold significant potential in the food industry, particularly for the development of functional foods and nutraceuticals. However, their effectiveness is often limited by poor oral bioavailability..

Cognition & nervesEnergy & fatigueSkin & hydration

Shiitake · 2025 · Preprint · journal metadata

Sustainable Memristors from Shiitake Mycelium for High-Frequency Bioelectronics

Neuromorphic computing, inspired by the structure of the brain, offers advantages in parallel processing, memory storage, and energy efficiency. However, current semiconductor-based neuromorphic chips require rare-earth materials and costly fabrication processes, whereas neural organoids need complex bioreactor….

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

The Effects of Iterative Freeze-Thaw Cycles on the Structure, Functionality, and Digestibility of Grifola frondosa Protein.

To improve the processing performance and application potential of Grifola frondosa protein (GFP), this study employed multiple freeze-thaw (F-T) cycles to modify GFP and systematically evaluated the changes in its structure, functional properties, and digestive behavior..

Immune supportEnergy & fatigueLiver support

Wood Ear · 2025 · Journal Article · International journal of medicinal mushrooms

The In Vitro and In Vivo Antioxidant Capacities of Auricularia auricula-judae (Agaricomycetes) Polysaccharides Prepared via Free Radical-Mediated Methods.

As a basidiomycete fungus, the cell wall of the Auricularia auricula-judae fruiting body is extremely tough and complex, making it difficult to extract the polysaccharides. In this study, A..