MycoData

Precisely quantifying cancer cell morphology and physical properties is crucial for advancing cancer therapeutics, drug screening, and pharmacological assessment..

OncologyLiver support

High relevance

Reishi · 2025 · Journal Article · Organic letters

Chizhiaroterpenoids A-C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum.

Chizhiaroterpenoids A-C (1-3), three unprecedented skeletal benzofused lanostane-type triterpenoids with unprecedented 6/6/6/6/6 (1), 6/6/6/6/7 (2), and 6/6/6/5/6 (3) ring systems, were isolated from Ganoderma lucidum. Their biosynthetic pathways were proposed..

OncologyImmune supportCognition & nerves

High relevance

Niu-Chang-Chih · 2025 · Journal Article · Journal of functional foods

Coenzyme Q0, a quinone derivative from Antrodia camphorata, triggered ROS-mediated cytoprotective autophagy in human promyelocytic leukemia cells

Our previous investigation revealed that Coenzyme Q₀ (CoQ₀), a quinone derivative from Antrodia camphorata, triggered ROS-dependent voltage-dependent anion channel 1 (VDAC-1)-mediated apoptosis in human promyelocytic leukemia (HL-60) cells..

Oncology

High relevance

Shiitake · 2025 · Research Article · BMC complementary medicine and therapies

Comparative study on the therapeutic potential of aqueous extracts from commercially cultivated Agaricus bisporus and Lentinula edodes in Sri Lanka: antioxidant, anticancer, antidiabetic, and antibacterial properties.

BACKGROUND: Mushrooms have long been recognized as rich sources of bioactive compounds. Among edible mushrooms, Agaricus bisporus and Lentinula edodes are highly valued for their nutritional and medicinal profiles..

OncologyMetabolic health

High relevance

Shiitake · 2025 · Journal Article · Biological & pharmaceutical bulletin

Continuous Ingestion of a Standardized Extract of Cultured Lentinula edodes Mycelia Suppresses Spontaneous Carcinogenesis in a Murine Model

AHCC®, a standardized extract of cultured Lentinula edodes mycelia, suppresses the proliferation of both cancer cell line-derived and patient-derived xenografts transplanted into mice. However, the mechanism of action underlying the suppressive effect of AHCC on spontaneous carcinogenesis remains unclear..

OncologyLiver support

High relevance

Chaga · 2025 · Research Article · Polymers

Design and Evaluation of a Inonotus obliquus-AgNP-Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential.

Inonotus obliquus, a medicinal mushroom valued for its bioactive compounds, has not been previously characterized from Romanian sources. This study presents the first comprehensive chemical and biological screening of I..

OncologyLiver support

High relevance

Oyster Mushroom · 2025 · Research Article · Discover nano

Eco-friendly synthesis of ZnO, CuO, and ZnO/CuO nanoparticles using extract of spent Pleurotus ostreatus substrate, and their antioxidant and anticancer activities.

Biosynthesis techniques for nanomaterials have advanced significantly, promoting eco-friendly synthesis chemistry as a sustainable alternative to conventional methods..

Oncology

High relevance

Reishi · 2025 · Research Article · Food science & nutrition

Effect of Ganoderma lucidum to Produce Functional Chocolate: Physicochemical, Textural and Sensory Properties.

Functional chocolate was developed by incorporating various concentrations (0%, 5%, 10%, 15%, and 20%) of Ganoderma lucidum (GL). Proximate chemical analysis, total phenolic content (TPC) and total flavonoid content (TFC), as well as antioxidant and antitumor activity of chocolate samples, were measured at day 1 and….

Oncology

High relevance

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

Phellinus linteus (PL) is a medicinal fungus known for producing hispolon, a bioactive compound with antioxidant, anti-inflammatory, and anticancer properties. However, the natural scarcity of PL and the unsuccessful cultivation of its fruiting bodies have led to the exploration of alternative methods for enhancing….

OncologyImmune supportEnergy & fatigue

High relevance

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells

OncologyImmune supportEnergy & fatigue

High relevance

Mesima · 2025 · Journal Article · Biotechnology letters

Enhancement hispolon production from Phellinus linteus via epigenetic-modified culture to inhibit human breast cancer cells.

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism.

Ganoderma lucidum has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of G..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Research Article · Current issues in molecular biology

Evaluation of Bioactive Compounds, Antioxidant Activity, and Anticancer Potential of Wild Ganoderma lucidum Extracts from High-Altitude Regions of Nepal.

Wild Ganoderma lucidum from Nepal's high-altitude regions was studied to identify key bioactive compounds and assess the influence of solvent type-water, ethanol, methanol, and acetone-on extraction efficiency and biological activity..

Oncology

High relevance

Agarikon · 2025 · Research Article · Frontiers in pharmacology

Exploration of the role of Fomitopsis officinalis Ames in the treatment of gastric cancer using network pharmacology, molecular docking, and in vitro experiments.

BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors worldwide, with approximately one million people diagnosed with gastric cancer each year..

OncologyImmune supportCognition & nervesRespiratory

High relevance

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications.

Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms..

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Experimental cell research

Ganoderma lucidum extract reverses multidrug resistance in breast cancer cells through inhibiting ATPase activity of the P-glycoprotein via MAPK/ERK signaling pathway.

Breast cancer represents a persistent global health challenge, with multidrug resistance (MDR) posing a significant obstacle to effective treatment. In this study, we investigate the potential of Ganoderma lucidum extract (GLE) in reversing MDR in breast cancer and delve into the underlying mechanisms..

Oncology

High relevance

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

Ganoderma lucidum Glycoprotein Microemulsion: Improved Transdermal Delivery and Protective Efficacy in UV-Induced Cell and Animal Models.

BACKGROUND: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation..

OncologyImmune supportEnergy & fatigueLiver support

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant

Oxidative stress after spinal cord injury (SCI) significantly promotes neuronal apoptosis. The imbalance of flora leads to the destruction of the intestinal barrier, so that pro-inflammatory cytokines enter the blood and further aggravate neuroinflammation..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Reproductive biology

Ganoderma lucidum mitigates oxidative stress and apoptosis in chlorpyrifos‑induced testicular toxicity in male rats.

Chlorpyrifos (CPS) is an organophosphate pesticide known to induce oxidative stress, apoptosis, and histopathological damage in male reproductive tissues. Ganoderma lucidum (GDL), a medicinal fungus rich in bioactive polysaccharides and triterpenoids, has demonstrated potent antioxidant and antiapoptotic properties in….

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-κB pathways.

Sepsis, characterized by a severe immune response to infection, remains a leading cause of mortality, with few effective strategies to prevent organ damage. Targeting inflammation, oxidative stress, and apoptosis is crucial for improving outcomes and advancing sepsis management..

OncologyImmune support

High relevance

Reishi · 2025 · Research Article · Chinese medicine

Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosis.

BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially recognized in both Eastern and Western pharmacopeias.

OncologyImmune support

High relevance

Reishi · 2025 · Journal Article · Current pharmaceutical biotechnology

Ganoderma lucidum: A Medicinal Mushroom with Prebiotic and Anticancer Potential in Gastrointestinal Cancers.

INTRODUCTION: Ganoderma lucidum is considered a medicinal mushroom, as it primarily improves gut health by modulating the gut microbiota. As an abundant source of bioactive metabolites, antioxidants, and industrial enzymes, mushrooms make significant contributions to functional foods, nutrition, and pharmaceuticals..

OncologyImmune supportGut & microbiome

High relevance

Almond Mushroom · 2025 · Journal Article · International Journal of Biological Macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice

This study aims to isolate and characterize the physicochemical properties and evaluate the cytoprotective and gastroprotective potential of polysaccharides from the Agaricus blazei Murill mushroom (PAbM). The PAbM were isolated and characterized chemically..

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice.

OncologyImmune supportMetabolic health

High relevance

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharides Alleviated Cyclophosphamide-Induced Intestinal Injury Based on Microbiota, Metabolite and Immune Axis Modulation.

Grifola frondosa polysaccharides (GFP), which possess antitumor properties, can counteract intestinal injury induced by cyclophosphamide (CTX). The objective of this research was to evaluate the efficacy of GFP in protecting the intestinal barrier of mice and investigate the mechanisms behind this effect..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2025 · Journal Article · Animal Nutrition

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens

Hericium erinaceus polysaccharide (HEP) is widely regarded as a potential food additive because of its rich nutritional value. This study aimed to explore the effect of HEP on the eggshell quality of aged laying hens and to reveal the mechanisms with particular emphasis on the alterations of uterine microbiota and….

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Animal nutrition (Zhongguo xu mu shou yi xue hui)

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens.

OncologyImmune supportGut & microbiome

High relevance

Reishi · 2025 · Research Article · Pharmacological reports: PR

Impact of Hericium erinaceus and Ganoderma lucidum metabolites on AhR activation in neuronal HT-22 cells.

BACKGROUND: The proper functioning of the nervous system determines the homeostasis of the entire body. There are many known approaches designed to positively stimulate the functions of the central nervous system by applying various plants and fungal extracts, but their course of action is poorly understood..

OncologyCognition & nervesMetabolic health

High relevance

Reishi · 2025 · Research Article · Frontiers in pharmacology

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.

Granulomatous pulmonary nodules represent a substantial health threat, with no available targeted therapies. Interventions based on medicinal plants approaches are pivotal for prevention and treatment.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum.

Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects..

OncologyImmune supportLiver support

High relevance

Chaga · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Inonotus obliquus Polysaccharide in the Treatment of Rheumatoid Arthritis.

Background/Objectives: Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune-inflammatory disease primarily affecting small joints. Inonotus obliquus polysaccharide (IOP) is the main component of the parasitic fungus obliquus, which has anti-tumor, anti-inflammatory, and antioxidant effects..

OncologyImmune supportGut & microbiomeSkin & hydration

High relevance

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Investigation of the fingerprint-activity relationship of Tremella fuciformis polysaccharides and its mitigating effect on radiation-induced intestinal injury.

The aim of this study was to conduct a comprehensive analysis of the relationship between the fingerprint of Tremella fuciformis polysaccharides (TFPs) sourced from China and their bioactivities, with an emphasis on identifying the most bioactive TFP variety that significantly mitigated radiation-induced intestinal….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Frontiers in fungal biology

LED light spectra influence the stimulation of mycelial growth and anticancer activity in Hericium erinaceus mycelium.

INTRODUCTION: Hericium erinaceus is a medicinal mushroom known for producing diverse bioactive metabolites with therapeutic potential. However, cultivation strategies aimed at enhancing both fungal yield and metabolite bioactivity, particularly through light-mediated physiological modulation, remain insufficiently….

OncologyEnergy & fatigueGut & microbiomeLiver support

High relevance

Maitake · 2025 · Research Article · Food science & nutrition

Mesenchymal Stem Cell-Conditioned Media-Derived Exosomes Loaded With Grifola frondosa Extract Inhibit Lung Cancer via NF-κB and MAPK Pathway Modulation.

The increasing prevalence of drug resistance diminishes the efficacy of chemotherapy and other therapeutic modalities for individuals diagnosed with lung cancer. Therefore, it is imperative to develop novel treatment approaches..

OncologyEnergy & fatigueGut & microbiomeRespiratory

High relevance

Oyster Mushroom · 2025 · Research Article · Bioinformatics and biology insights

Molecular Docking Appraisal of Pleurotus ostreatus Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment.

INTRODUCTION: Breast cancer (BC) is a heterogeneous disease involving a network of numerous extracellular signal transduction pathways. The phosphoinositide 3-kinase (PI3K)/serine/threonine kinase (Akt)/mechanistic target of rapamycin (mTOR) pathway is crucial for understanding the BC development..

Oncology

High relevance

Yellow Morel · 2025 · Journal Article · Chinese journal of integrative medicine

Morchella conica, Morchella esculenta and Morchella delicosa Induce Apoptosis in Breast and Colon Cancer Cell Lines via Pro-apoptotic and Anti-apoptotic Regulation.

OBJECTIVE: To explore the potential apoptotic mechanisms of 3 Morchella extracts (Morchella conica, Morchella esculenta and Morchella delicosa) on breast and colon cancer cell lines using apoptotic biomarkers..

OncologyGut & microbiome

High relevance

Reishi · 2025 · Research Article · Scientific reports

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.

Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Multiomics Provides a New Understanding of the Effect of Temperature Change on the Fermentation Quality of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a medicinal fungus with significant nutritional and utilization value. Temperature is a crucial factor influencing its growth, as temperature changes can impact enzyme activity, metabolite content, and gene expression during fungal cultivation..

OncologyEnergy & fatigueMetabolic health

High relevance

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Myco-macromolecular symbiosis: Chitosan-folate ZnO nanoplatforms from Trametes versicolor for dual-functional oncological and antibacterial therapy.

The increasing prevalence of antibiotic-resistant bacteria and cancer necessitates the development of novel, targeted therapeutic strategies. This study aimed to develop a multifunctional nanoplatform combining antibacterial and anticancer properties through green synthesis and strategic surface functionalization..

OncologyLiver support

High relevance

Niu-Chang-Chih · 2025 · Research Article · International journal of molecular sciences

Natural Polysaccharide-Based Nanoparticles Enhance Intracellular Delivery and Cytotoxicity of Antrodia camphorata in Breast Cancer Cells.

Antrodia camphorata (AC), a medicinal fungus native to Taiwan, contains bioactive compounds such as triterpenoids with anticancer properties. However, their high lipophilicity results in poor aqueous solubility and limited bioavailability, restricting their therapeutic application..

OncologyImmune supportLiver supportSkin & hydration

High relevance

Almond Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Network Pharmacology and In Vitro Experiments Reveal the Mechanism of Agaricus blazei Murill Extract in Treating Chronic Myeloid Leukemia.

Chronic myeloid leukemia (CML) is a malignant hematological neoplasm. FA-2-b-β, extracted from Agaricus blazei Murrill, has demonstrated antitumor activity against multiple cancer types.

Oncology

High relevance

Lion's Mane · 2025 · Research Article · ACS omega

Phytoconstituents of Hericium erinaceus Exert Benefits for ADHD Conditions by Targeting SLC6A4: Extraction, Spectroscopic Characterization, Phytochemical Screening, In Vitro, and Computational Perspectives.

Attention-deficit/hyperactivity disorder (ADHD) is a persistent neurodevelopmental disorder. Despite pharmacological interventions, there is a need for effective lead molecules and therapeutic targets.

OncologyCognition & nerves

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy

Cancer remains a significant global health challenge. Given the limitations of conventional single-treatment modalities and the potential benefits of combination therapies, this study aimed to develop a multifunctional nanoplatform integrating immunotherapy, chemotherapy, and photothermal therapy for cancer treatment..

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Preparation and characterization of Ganoderma lucidum polysaccharide-based multifunctional tellurium nanorods to realize combination cancer therapy.

OncologyImmune supportEnergy & fatigue

High relevance

Mesima · 2025 · Research Article · BMC research notes

Protective mechanism of polysaccharides from Phellinus linteus on H9c2 cardiomyocyte injury induced by hypoxia/reoxygenation.

OBJECTIVE: This study aimed to explore the protective mechanism of Phellinus linteus polysaccharides (Phps) against hypoxia/reoxygenation (H/R)-induced injury in H9c2 cardiomyocytes, focusing on oxidative stress, apoptosis, and PI3K-AKT pathway regulation..

OncologyImmune supportEnergy & fatigue

High relevance

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Screening of Lentinula edodes Strains for High Polysaccharide Production and In Vitro Antioxidant Activities.

Lentinan is one of the main metabolites of Lentinula edodes and exhibits numerous biological properties, such as antitumor and antioxidant activity. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

OncologyImmune supportMetabolic health

High relevance

Maitake · 2025 · Journal Article · International Journal of Biological Macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates

In the study, Grifola frondosa polysaccharides (GFPs) and gallic acid (GA) were utilized to synthesize selenium nanoparticles (GFPs-GA-SeNPs) through a redox reaction involving sodium selenite and ascorbic acid..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Selenium release during the simulated gastrointestinal digestion and antioxidant activity of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Snow Fungus · 2025 · Journal Article · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory‐enhancing, anti‐inflammatory,….

OncologyImmune supportCognition & nervesMetabolic health