MycoData

Chaga · 2023 · Preprint · journal metadata

The Elusive Trypanosoma cruzi Disperse Gene Protein Family (DGF-1)

Abstract Chaga´s disease caused by Trypanosoma cruzi infections is included in the group of neglected diseases, and efforts to develop new therapeutic or immunoprevention approaches have not been successful. After the publication of the T..

Agarikon · 2020 · Research Article · Molecules (Basel, Switzerland)

Antitumor, Immunomodulatory and Antiangiogenic Efficacy of Medicinal Mushroom Extract Mixtures in Advanced Colorectal Cancer Animal Model.

Due to frequent drug resistance and/or unwanted side-effects during conventional and targeted cancer treatments, development of multi-target therapies is an important research field..

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2020 · Journal Article · Frontiers in oncology

Comparison of Hematologic Toxicity and Bone Marrow Compensatory Response in Head and Neck vs. Cervical Cancer Patients Undergoing Chemoradiotherapy.

Background: Hematologic toxicity is a critical problem limiting treatment delivery in cancer patients undergoing concurrent chemoradiotherapy. However, the extent to which anatomic variations in radiation dose limit chemotherapy delivery is poorly understood..

Almond Mushroom · 2020 · Journal Article · The Journal of infection

Etiology, clinical presentation, outcome and the effect of initial management in immunocompromised patients with community acquired bacterial meningitis.

OBJECTIVES: The aim was to analyze differences in clinical presentation, etiology, management, and outcome between immunocompromised and immunocompetent patients with acute bacterial meningitis (ABM)..

Almond Mushroom · 2020 · Journal Article · mSphere

Multicenter Hospital-Based Prospective Surveillance Study of Bacterial Agents Causing Meningitis and Seroprevalence of Different Serogroups of Neisseria meningitidis, Haemophilus influenzae Type b, and Streptococcus pneumoniae during 2015 to 2018 in Turkey.

The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP)..

Shiitake · 2020 · Journal Article · International journal of medicinal mushrooms

Quantification of Mushroom-Derived Soluble β-1,6-Glucan Using the Function-Modified Recombinant β-1,6-Glucanase.

Mushroom is one of the major sources of β-glucan used in medical applications and traditional therapies. Thus, structure analysis and quantification of β-glucan content is crucial to evaluate medicinal mushrooms.

Immune supportGut & microbiome

Shiitake · 2020 · Journal Article · Food & function

Wheat-derived arabinoxylans reduced M2-macrophage functional activity, but enhanced monocyte-recruitment capacity.

The immunomodulatory properties of non-digestible polysaccharides (NDPs) have been recognized in in vitro and in vivo studies. The latter mostly demonstrated altered frequencies and inflammatory status of immune cells as clinical parameters..

Immune supportSkin & hydration

Almond Mushroom · 2019 · Journal Article · Frontiers in physiology

Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling.

Wound healing and fibrosis following myocardial infarction (MI) is a dynamic process involving many cell types, extracellular matrix (ECM), and inflammatory cues. As both incidence and survival rates for MI increase, management of post-MI recovery and associated complications are an increasingly important focus..

King Oyster · 2019 · Research Article · Nutrients

The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species.

Cardiovascular diseases remain the leading global cause of mortality indicating the need to identify all possible factors reducing primary and secondary risk. This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus,….

Immune supportEnergy & fatigueSkin & hydration

Almond Mushroom · 2019 · Research Article · Applied sciences (Basel, Switzerland)

Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification.

Agent based models (ABM) were developed to numerically simulate the biological response to surgical vocal fold injury and repair at the physiological level. This study aimed to improve the representation of existing ABM through a combination of empirical and computational experiments..

OncologyImmune supportEnergy & fatigueMetabolic health

Shiitake · 2015 · Clinical Trial · Nutrition and cancer

Antioxidant and Anticoagulant Status Were Improved by Personalized Dietary Intervention Based on Biochemical and Clinical Parameters in Cancer Patients.

We investigated whether personalized dietary intervention could improve clinical measurements such as immune cell-mediated cytotoxicity, serum albumin, derivatives of reactive oxygen metabolites (D-ROMS), D-dimer, and fibrinogen..

Nameko · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Effects of Pholiota nameko polysaccharide on NF-κB pathway of murine bone marrow-derived dendritic cells.

This study investigated the effect of a polysaccharide purified from Pholiota nameko (PNPS-1) on the NF-κB signaling pathway of murine bone marrow-derived dendritic cells (BMDCs) and relevant mechanisms. The results showed that PNPS-1 could decrease the expression of maturation markers CD40 and CD80 on BMDCs..

Nameko · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Recognization of receptors on bone marrow-derived dendritic cells bound with Pholiota nameko polysaccharides.

Three major active polysaccharides isolated from Pholiota nameko (PNPS), including PNPS-1, PNPS-2 and PNPS-3, had been proved to inhibit the maturation of the murine bone marrow-derived dendritic cells (BMDCs)..

OncologyImmune supportMetabolic health

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Structure characterization and antitumor activity of a polysaccharide from the alkaline extract of king oyster mushroom.

A water-soluble polysaccharide, designated as KOMAP, was isolated and purified from the alkaline extract of king oyster mushroom, which was composed of glucose (Glc), mannose (Man) and arabinose (Ara) in a molar ratio of 6.2:2.1:2.0. It had an average molecular weight of 2.1×10(4)Da..

Immune supportMetabolic healthLiver support

Nameko · 2014 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Antihyperlipidemic and hepatoprotective activities of mycelia zinc polysaccharide from Pholiota nameko SW-02.

The objective of this study was to set up the mice hyperlipidemic model to observe the pharmacological effects of mycelia zinc polysaccharide (MZPS) of Pholiota nameko SW-02 on lipid metabolism and oxidative stress. IR spectrum of MZPS showed typical structure of fungi polysaccharides..

Nameko · 2014 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Effects of polysaccharides from Pholiota nameko on maturation of murine bone marrow-derived dendritic cells.

This paper studied some structure characters of the Pholiota nameko polysaccharides (PNPS-1), including morphology under SEM and AFM, also the effects of PNPS-1 on the maturation of bone marrow dendritic cells (BMDCs) via concrete changes both inside and outside BMDCs..

Immune supportMetabolic healthGut & microbiome

Wood Ear · 2014 · Comparative Study · International journal of food sciences and nutrition

In vitro hypoglycemic effects of hot water extract from Auricularia polytricha (wood ear mushroom).

Viscous dietary fibers were shown to alleviate postprandial blood glucose. Auricularia polytricha (wood ear mushroom, WEM) contains rich amount fibers and water extract WEM was highly viscous.

Niu-Chang-Chih · 2013 · Review · Recent patents on food, nutrition & agriculture

Analysis of Taiwan patents for the medicinal mushroom "Niu-Chang- Chih".

"Niu-Chang-Chih" (Antrodia cinnanomea) is a medicinal mushroom that has only been collected from the aromatic tree, Cinnamomum kanehirai, which is native to Taiwan. A total of 105 Taiwan patent applications and patents for "Niu-Chang-Chih" were collected and analyzed..

Immune supportCognition & nerves

Wood Ear · 2013 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Heat-stable components of wood ear mushroom, Auricularia polytricha (higher Basidiomycetes), inhibit in vitro activity of beta secretase (BACE1).

The consumption of mushrooms has been linked with protection against dementia, including Alzheimer's disease (AD), by several biological pathways including inhibiting beta-site APP-cleaving enzyme (BACE1), which is responsible for releasing toxic β-amyloid peptide in the brain..

Nameko · 2012 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Effects of the polysaccharide from Pholiota nameko on human cytokine network in serum.

Some physico-chemical characterizations of Pholiota nameko polysaccharides (PNPS-1) were studied, including sulfate content, UV/visible and infrared spectra, also the variation of cytokine communication network in serum to clarify the pharmacological effects of PNPS-1 by determination of 39 cytokines in serum of….

Nameko · 2008 · Research Support, Non U.S. Gov'T · Biochemistry. Biokhimiia

Anti-inflammatory activity of polysaccharide from Pholiota nameko.

Pholiota nameko polysaccharide (PNPS-1) has been isolated and purified by enzymatic hydrolysis, hot water extraction, ethanol precipitation, and ion-exchange and gel-filtration chromatography..

Immune supportSkin & hydration

Enoki · 2008 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

High processing tolerances of immunomodulatory proteins in Enoki and Reishi mushrooms.

This study investigated the processing tolerances of two mushroom proteins with immunomodulatory activities, including FVE from Enoki ( Flammulia velutipes ) and LZ8 from Reishi ( Ganoderma lucidum ) mushrooms, under food processing treatments such as heating, sterilization, frozen storage, extraction in acid/alkaline….

Almond Mushroom · 2006 · Review · journal metadata

Gentian Violet

Metadata-grounded summary: This review indexes research on Agaricus blazei in 2006. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Enoki · 1999 · Journal Article · Food Science

Study on bioenrichment action of iron zine and selenium ions by edible fungi

Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Food Science in 1999. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Risk analysis: an official publication of the Society for Risk Analysis

Evolutionary analysis of a coupled epidemic-voluntary vaccination behavior model with immunity waning on complex networks.

Vaccination is the most effective method of preventing and controlling the transmission of infectious diseases within populations. However, the phenomenon of waning immunity can induce periodic fluctuations in epidemic spreading..

Immune supportSkin & hydration

Shiitake · 2024 · Brief Report · The journal of allergy and clinical immunology. Global

Agaricus bisporus mushroom anaphylaxis: A case report and review of the literature.

BACKGROUND: Anaphylaxis in response to edible mushrooms is uncommon, and sensitization may be independent of occupational exposure. Globally, A garicus bisporus is one the most cultivated mushroom species, comprising the button, portobello, and Swiss brown varietals..

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Chaos (Woodbury, N.Y.)

Chaotic dynamics and optimal therapeutic strategies for Caputo fractional tumor immune model in combination therapy.

In this paper, a Caputo fractional tumor immune model of combination therapy is established. First, the stability and biological significance of each equilibrium point are analyzed, and it is demonstrated that chaos may arise under specific conditions..

OncologyImmune supportMetabolic healthLiver support

Cordyceps · 2023 · Journal Article · Advances in biochemical engineering/biotechnology

Bioactive Compounds from Medicinal Mushrooms.

Research progress of active compounds and biological activities of medicinal mushroom-Ganoderma spp., Hericium spp., Phellinus spp., and Cordyceps spp. were summarized systematically..

Cordyceps · 2023 · Journal Article · Biological & pharmaceutical bulletin

Cordycepin Enhances the Cytotoxicity of Human Natural Killer Cells against Cancerous Cells.

Cancer treatment with natural killer (NK) cell immunotherapy is promising. NK cells can recognize and kill cancer cells without sensitization, making them a potential cancer treatment alternative.

Immune supportGut & microbiome

Almond Mushroom · 2023 · Journal Article · International breastfeeding journal

Does the Academy of Breastfeeding Medicine's Clinical Protocol #36 'The Mastitis Spectrum' promote overtreatment and risk worsened outcomes for breastfeeding families? Commentary.

BACKGROUND: In 2022 the Academy of Breastfeeding Medicine (ABM) published Clinical Protocol #36: The Mastitis Spectrum, which aims to update clinical approaches to management of benign lactation-related breast inflammation..

Immune supportGut & microbiome

Cordyceps · 2023 · Journal Article · Life (Basel, Switzerland)

Effect of Different Feeds on the Fungi Microbiome of Suffolk Crossed with Tibetan Sheep.

The gut microbiome plays an important role in the metabolism, nutrient absorption and immunocompetency of animals. The dynamics of the microbiota can be influenced by modulatory factors that involve nutrition, environment, health, diseases, etc..

Immune supportCognition & nerves

Cordyceps · 2023 · Journal Article · Neural regeneration research

Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury.

Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms..

Cordyceps · 2023 · Journal Article · Insects

Increased Phenoloxidase Activity Constitutes the Main Defense Strategy of Trichoplusia ni Larvae against Fungal Entomopathogenic Infections.

The cabbage looper Trichoplusia ni is an important agricultural pest worldwide and is frequently used as a model organism for assessing entomopathogenic fungi virulence, though few studies have measured the host response repertoire to fungal biocontrol agents. Here, we quantified the immune response of T..

Immune supportMetabolic healthRespiratory

Almond Mushroom · 2023 · Journal Article · Frontiers in systems biology

Investigating the comorbidity of COPD and tuberculosis, a computational study.

Recent research has shown that people who suffer from chronic obstructive pulmonary disease (COPD) have a greater propensity to contract and develop tuberculosis (TB) than the general population..

Almond Mushroom · 2023 · Journal Article · Cancers

Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model.

Spatial heterogeneity is a hallmark of cancer. Tumor heterogeneity can vary with time and location.

OncologyImmune supportLiver support

Shiitake · 2023 · Journal Article · Euroasian journal of hepato-gastroenterology

Role of Biobran (Arabinoxylan Rice Bran) on Patients with Advanced Stage Hepatocellular Carcinoma.

BACKGROUND AND OBJECTIVES: Carcinoma of liver - renowned, has taken third position in world ranking, comparing to other causes for cancer-related death, however, curative treatment of hepatocellular carcinoma (HCC) is largely absent and even proper management of HCC patients is extremely difficult..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2023 · Journal Article · Journal of separation science

Simultaneous determination of cordycepin and its metabolite 3'-deoxyinosine in rat whole blood by ultra-high-performance liquid chromatography coupled with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry and its application to accurate pharmacokinetic studies.

Cordycepin from Cordyceps possesses excellent pharmacological properties, including anti-inflammation and anti-tumor effects, therefore representing a potential alternative medicine. However, doubts about the pharmacokinetic results of cordycepin had been raised in the previous study due to its rapid deamination..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Almond Mushroom · 2023 · Journal Article · Cytokine

The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis.

BACKGROUND: Acute bacterial meningitis (ABM) causes excessive activation of N-methyl-D-aspartate receptors (NMDAr), leading to cortical and hippocampal neuron death. As opposite, enteroviral meningitis is more frequently benign..

Immune supportLiver support

Shiitake · 2023 · Journal Article · The Journal of nutritional biochemistry

Transcriptomics of natural and synthetic vitamin D in human hepatocyte lipotoxicity.

Vitamin D (VD) has been used to prevent nonalcoholic fatty liver disease (NAFLD), a condition of lipotoxicity associated with a defective metabolism and function of this vitamin. Different forms of VD are available and can be used for this scope, but their effects on liver cell lipotoxicity remain unexplored..

Almond Mushroom · 2023 · Journal Article · Vaccine

Using neural networks to calibrate agent based models enables improved regional evidence for vaccine strategy and policy.

Distribution and administration strategy are critical to successful population immunization efforts. Agent-based modeling (ABM) can reflect the complexity of real-world populations and can experimentally evaluate vaccine strategy and policy..

Shiitake · 2022 · Journal Article · International journal of biological macromolecules

A quantitative method for polysaccharides based on endo-enzymatic released specific oligosaccharides: A case of Lentinus edodes.

Polysaccharides exhibit multiple pharmacological activities, which are closely related to their structural characteristics. Therefore, quantitative quality control of polysaccharides based on chemical properties is of importance for their applications..

Immune supportEnergy & fatigue

Cordyceps · 2022 · Journal Article · Antioxidants (Basel, Switzerland)

Acremonium terricola Culture's Dose-Response Effects on Lactational Performance, Antioxidant Capacity, and Ruminal Characteristics in Holstein Dairy Cows.

Acremonium terricola culture (ATC) has similar bioactive constituents to Cordyceps and is known for its nutrient and pharmacological value, indicating the potential of ATC as a new feed additive in dairy cow feeding..

Shiitake · 2022 · Journal Article · Food chemistry

All-natural protein-polysaccharide conjugates with bead-on-a-string nanostructures as stabilizers of high internal phase emulsions for 3D printing.

The combination of proteins and polysaccharides creates an exceptional platform for stabilizing biphasic systems such as oil in water emulsions. In this paper, we propose the use of natural protein-polysaccharide conjugates (PPCs) extracted from shiitake mushroom roots to stabilize high internal phase emulsions….

Immune supportLiver supportSkin & hydration

Almond Mushroom · 2022 · Journal Article · Scientific reports

Computational simulation of liver fibrosis dynamics.

Liver fibrosis is a result of homeostasis breakdown caused by repetitive injury. The accumulation of collagens disrupts liver structure and function, which causes serious consequences such as cirrhosis.

Almond Mushroom · 2022 · Journal Article · Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Control of COVID-19 Outbreaks under Stochastic Community Dynamics, Bimodality, or Limited Vaccination.

Reaching population immunity against COVID-19 is proving difficult even in countries with high vaccination levels. Thus, it is critical to identify limits of control and effective measures against future outbreaks..

Cordyceps · 2022 · Journal Article · Evidence-based complementary and alternative medicine: eCAM

Cordycepin Induces Apoptosis through JNK-Mediated Caspase Activation in Human OEC-M1 Oral Cancer Cells.

Cordycepin, a bioactive compound extracted from Cordyceps sinensis, can induce apoptosis in human OEC-M1 oral cancer cells. However, the exact mechanism is still unclear.

Immune supportCognition & nerves

Cordyceps · 2022 · Journal Article · Biochemical pharmacology

Cordycepin prevents and ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte infiltration and reducing neuroinflammation.

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease characterized by multifocal perivascular infiltration of immune cells in the central nervous system (CNS)..

Almond Mushroom · 2022 · Journal Article · Microbiology spectrum

Cysteine-Dependent Conformational Heterogeneity of Shigella flexneri Autotransporter IcsA and Implications of Its Function.

Shigella IcsA is a versatile surface virulence factor required for early and late pathogenesis stages extracellularly and intracellularly. Despite IcsA serving as a model Type V secretion system (T5SS) autotransporter to study host-pathogen interactions, its detailed molecular architecture is poorly understood..