MycoData
Medicinal fungi research database
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Immune support
Immune modulation, polysaccharides, beta-glucans, and host-response studies.
Species records
Species record
Oyster Mushroom
Pleurotus ostreatus
- Studies
- 1,947
- Avg relevance
- 53
- Latest
- 2026
Species record
Reishi · Lingzhi
Ganoderma lucidum
- Studies
- 1,830
- Avg relevance
- 60
- Latest
- 2026
Species record
Turkey Tail · Yun Zhi
Trametes versicolor
- Studies
- 1,828
- Avg relevance
- 41
- Latest
- 2026
Species record
Shiitake · Hua Gu
Lentinula edodes
- Studies
- 1,766
- Avg relevance
- 60
- Latest
- 2026
Species record
Cordyceps · Scarlet Club
Cordyceps militaris
- Studies
- 1,635
- Avg relevance
- 67
- Latest
- 2026
Species record
Cordyceps · Caterpillar Fungus
Ophiocordyceps sinensis
- Studies
- 1,576
- Avg relevance
- 59
- Latest
- 2026
Species record
Almond Mushroom · ABM
Agaricus blazei
- Studies
- 1,441
- Avg relevance
- 54
- Latest
- 2026
Species record
Enoki · Winter Mushroom
Flammulina velutipes
- Studies
- 1,403
- Avg relevance
- 47
- Latest
- 2026
Species record
King Oyster · Eryngii
Pleurotus eryngii
- Studies
- 1,278
- Avg relevance
- 60
- Latest
- 2026
Species record
Maitake · Hen of the Woods
Grifola frondosa
- Studies
- 1,276
- Avg relevance
- 48
- Latest
- 2026
Species record
Snow Fungus · Silver Ear
Tremella fuciformis
- Studies
- 1,052
- Avg relevance
- 29
- Latest
- 2026
Species record
Lion's Mane · Yamabushitake
Hericium erinaceus
- Studies
- 862
- Avg relevance
- 67
- Latest
- 2026
Species record
Chaga
Inonotus obliquus
- Studies
- 738
- Avg relevance
- 65
- Latest
- 2026
Species record
Mesima · Sanghwang
Phellinus linteus
- Studies
- 722
- Avg relevance
- 58
- Latest
- 2026
Species record
Niu-Chang-Chih
Antrodia camphorata
- Studies
- 496
- Avg relevance
- 63
- Latest
- 2026
Species record
Nameko · Nametake
Pholiota microspora
- Studies
- 421
- Avg relevance
- 29
- Latest
- 2026
Species record
Yellow Morel
Morchella esculenta
- Studies
- 392
- Avg relevance
- 42
- Latest
- 2026
Species record
Zhu Ling · Umbrella Polypore
Polyporus umbellatus
- Studies
- 263
- Avg relevance
- 55
- Latest
- 2026
Species record
Wood Ear · Kikurage
Auricularia auricula-judae
- Studies
- 254
- Avg relevance
- 51
- Latest
- 2026
Species record
Agarikon · Quinine Conk
Fomitopsis officinalis
- Studies
- 47
- Avg relevance
- 55
- Latest
- 2026
Articles
7,168 results
Showing 4,851–4,900 of 7,168
Lion's Mane · 2001 · Journal Article · The Kaohsiung journal of medical sciences
Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp.
The fruiting body and culture broth of many edible mushrooms contain water-soluble polysaccharides. Numerous researchers have reported that these polysaccharides have immunoenhancing effects.
Enoki · 2000 · Journal Article · Journal of Shandong University National Science Edition)
Improvement of purifying procedure of flammulin
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Journal of Shandong University National Science Edition) in 2000. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Yellow Morel · 2000 · Journal Article · Journal of Plant Resources and Environment
Isolation, purification and characterization of polysaccharides from morchella essulenta L.
Metadata-grounded summary: This journal article indexes research on Morchella esculenta in Journal of Plant Resources and Environment in 2000. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Enoki · 1999 · Journal Article · Journal of Hubei Institute for Nationalities( Natural Science)
Current progress in the study of Se - accumulating mushroom
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Journal of Hubei Institute for Nationalities( Natural Science) in 1999. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Enoki · 1999 · Journal Article · Anhui nongxueyuan xuebao = Journal of Anhui Agricultural College
Detection of taurine in Basidiomycetes
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Anhui nongxueyuan xuebao = Journal of Anhui Agricultural College in 1999. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Enoki · 1999 · Research Article · World journal of gastroenterology
Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma SMMC-7721 cell and mouse implanted S180 tumor.
AIM:To determine the activities of polysaccharide extracts from Flammulina velutipes (Curt. ex Fr.) Sing (FV), Lentinus edodes (LE)and Agaricus bispo-rus Sing (AB) on the proliferation of human hepatoma SMMC-7721 cells in vitro and on mouse implanted S-180 tumors in vivo.METHODS:The polysaccharide extracts were….
Enoki · 1998 · Journal Article · Hang tian yi xue yu yi xue gong cheng = Space medicine & medical engineering
[Biological effect of space flight on edible fungi onboard recoverable scientific satellite].
In order to breed good variety of edible fungi and provide data of cultivation of edible fungi in Controlled Ecological Life Support System (CELSS) in the future, 2 species of the edible fungi (Pleurotus ostreatus and Flammulina velutipes )were carried into space by a recoverable scientific satellite..
Wood Ear · 1998 · Journal Article · Journal of nutritional science and vitaminology
Ameliorating Effects of Water-Soluble Polysaccharides from Woody Ear (Auricularia auricula-judge Quel.) in Genetically Diabetic KK-Ay Mice
We investigated the ameliorating effects of the three groups of water-soluble polysaccharides, a mixture of crude polysaccharides (FA), acidic polysaccharide fractions (FA-A), and neutral polysaccharide fractions (FA-N), obtained from the hot water extracts of the fruit bodies of Auricularia auricula-judae Quel..
Enoki · 1998 · Journal Article · Wei sheng wu xue za zhi
Toxicity assay of fungicide Qiangli^an
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Wei sheng wu xue za zhi in 1998. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Snow Fungus · 1997 · Journal Article · Journal of the science of food and agriculture
Dietary fibre content and composition of some edible fungi determined by two methods of analysis
Six common edible fungi from four orders of Basidiomycetes, namely Agaricus bisporus (Agaricales), Auricularia auricula and Auricularia polytricha (Auriculariales), Tremella fuciformis (Tremellates), Ganoderma lucidum and Poria cocos (Aphyllophorales), were analysed for their total dietary fibre (TDF) content using….
Maitake · 1996 · Journal Article · FEMS immunology and medical microbiology
Blood clearance of (1-->3)-beta-D-glucan in MRL lpr/lpr mice.
(1-->3)-beta-D-Glucans have a variety of biological and immunopharmacological properties, and they are used clinically as biological response modifiers (BRMs). Clinically, these glucans have often been used for long periods by multiple dosing..
Maitake · 1996 · Journal Article · Biological & pharmaceutical bulletin
Effect of β-Glucans on the Nitric Oxide Synthesis by Peritoneal Macrophage in Mice
Nitric oxide (NO) is an important effector molecule on antimicrobial and antitumor effects of macrophages. (1 -> 3)-beta-D-Glucan (beta-glucan) is well known to show various immunopharmacological effects such as antimicrobial effect and antitumor effect by activating various points of host defense mechanisms..
Enoki · 1996 · Journal Article · Edible Fungi of China
Studies on the physiological reaction of trace element of edible fungi
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Edible Fungi of China in 1996. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Lion's Mane · 1995 · Journal Article · Zhongguo nong ye ke xue = Zhongguo nongye kexue
Determination of the components of polysaccharides in eight edible mushrooms and their effects on the transformation of lymphocytes
Metadata-grounded summary: This journal article indexes research on Hericium erinaceus in Zhongguo nong ye ke xue = Zhongguo nongye kexue in 1995. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Maitake · 1995 · Journal Article · Biological & pharmaceutical bulletin
Enhancement of LPS Triggered TNF-α (Tumor Necrosis Factor-α) Production by (1→3)-β-D-Glucans in Mice
Effects of (1-->3)-beta-D-glucans on tumor necrosis factor-alpha (TNF-alpha) production in mice in vivo were investigated with or without triggering stimulation of lipopolysaccharide (LPS)..
Enoki · 1995 · Journal Article · Wei sheng wu xue bao = Acta microbiologica Sinica
Inactivated protoplast electrofusion of edible mushrooms and characterization of intergeneric fusion products
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Wei sheng wu xue bao = Acta microbiologica Sinica in 1995. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Maitake · 1995 · Journal Article · Biological & pharmaceutical bulletin
Structure-Activity Relationship of (1→3)-β-D-Glucans in the Induction of Cytokine Production from Macrophages, in Vitro
In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro..
Maitake · 1995 · Journal Article · Carcinogenesis, Teratogenesis and Mutagenesis
Study on the antimutagenic effect of extract from Polyporus frondosus
Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Carcinogenesis, Teratogenesis and Mutagenesis in 1995. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Enoki · 1990 · Journal Article · Journal of food protection
Nutritional and medicinal value of specialty mushrooms
Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Journal of food protection in 1990. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..
Enoki · 1990 · Journal Article · Journal of food protection
Nutritional and Medicinal Value of Specialty Mushrooms.
Although the button mushroom ( Agaricus bisporus ) accounts for slightly over half of total world mushroom production, specialty mushrooms, e.g., shiitake ( Lentinula edodes ), straw ( Volvariella volvacea ), oyster ( Pleurotus spp.), and enokitake ( Flammulina velutipes ), are increasing in popularity..
Maitake · 1987 · Journal Article · Journal of pharmacobio-dynamics
Antitumor effect of polysaccharide grifolan NMF-5N on syngeneic tumor in mice.
Antitumor activity of grifolan NMF-5N, a beta-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N showed antitumor activities in allogeneic and syngeneic murine tumor systems..
Snow Fungus · 1983 · Journal Article · Journal of pharmacobio-dynamics
Polysaccharides in fungi. XIV. Anti-inflammatory effect of the polysaccharides from the fruit bodies of several fungi.
Anti-inflammatory assays on the carrageenin-induced edema and scald-induced hyperalgesia in the hindpaw of rats were studied on polysaccharides obtained from the fruit bodies of various fungi (polysaccharide AC, BC: Tremella fuciformis;MEA, MHA, MCW-A, MCW-N: Auricularia auricula-judae; T-2-HN: Dictophora….
Chaga · 2020 · Research Support, Non U.S. Gov'T · Cells
3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice.
Aging is a predominant risk factor for the development and progression of cardiovascular complications. Physiologically and anatomically, the heart undergoes numerous changes that result in poor cardiac function in the elderly population..
Shiitake · 2019 · Case Reports · The American Journal of dermatopathology
Histological Features of Flagellate Erythema.
Flagellate erythema is a distinctive eruption characterized by "whip-like" linear or curvilinear streaks and plaques, occurring mainly on the trunk. It has classically been described in 2 disparate clinical settings: chemotherapy with bleomycin and ingestion of mushrooms (most commonly Shiitake mushrooms)..
Lion's Mane · 2015 · Journal Article · Pharmacology, biochemistry, and behavior
Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration.
Accumulating evidence suggests that inflammation plays a role in the pathophysiology of depression and that anti-inflammatory substances have antidepressant effects. Amycenone is obtained from extracts of the Yamabushitake (Hericium erinaceum)..
Shiitake · 2014 · Journal Article · Journal of biological regulators and homeostatic agents
A natural formulation (imoviral) increases macrophage resistance to LPS-induced oxidative and inflammatory stress in vitro.
Imoviral is a natural product formulation containing a mixture of uncaria, shiitake and ribes extracts. All ingredients are recognized as antioxidant, anti-inflammatory agent and immunomodulant..
Maitake · 2013 · Journal Article · Integrative cancer therapies
Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C.
HYPOTHESIS: Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available, the unsatisfactory outcomes demand establishing more effective interventions..
Maitake · 2001 · Patent · journal metadata
HERBAL COMPOSITION FOR TREATING VIRAL INFECTION OF THE LIVER
An herbal treatment composition includes a combination of mushroom derived polysaccharides wherein the polysaccharides are derived from at least two mushrooms from the group consisting of Maitake, Shiitake, Reishi, Poria, Cordyceps and Hericium..
Lion's Mane · 2001 · Patent · journal metadata
Method for the preparation of a deodorized mushroom powder
The present invention relates to a method for preparing a powder without unpleasant odor at a higher beta-glucans content, a larger bulk density and a smaller bacterial number, from the fruit body of Maitake or Yamabushitake, comprising immersing the fruit body of Maitake or Yamabushitake in a heated aqueous acid….
Niu-Chang-Chih · 2015 · Comparative Study · Toxicology and applied pharmacology
4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype.
4-Acetylantroquinonol B (4-AAQB), closely related to the better known antroquinonol, is a bioactive isolate of the mycelia of Antrodia camphorata, a Taiwanese mushroom with documented anti-inflammatory, hypoglycemic, vasorelaxative, and recently demonstrated, antiproliferative activity..
Niu-Chang-Chih · 2015 · Research Support, Non U.S. Gov'T · Scientific reports
Antroquinonol Lowers Brain Amyloid-β Levels and Improves Spatial Learning and Memory in a Transgenic Mouse Model of Alzheimer's Disease.
Alzheimer's disease (AD) is the most common form of dementia. The deposition of brain amyloid-β peptides (Aβ), which are cleaved from amyloid precursor protein (APP), is one of the pathological hallmarks of AD.
Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers
Efficacy of Zhuling polyporus polysaccharide with BCG to inhibit bladder carcinoma.
There is growing interest in reducing Bacille Calmette-Guerin (BCG) side effects while keeping intact its therapeutic efficacy. In the present study, we evaluated the efficacy of Sclerotia of Polyporus umbellatus FRIES (Zhuling) and its main ingredient Polyporus Polysaccharide (PPS) to attenuate side effects of BCG….
Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine
Oryeongsan suppressed high glucose-induced mesangial fibrosis.
BACKGROUND: The pathological change of kidney in diabetic nephropathy is represented hypertrophy, inflammation, and renal fibrosis. Oryeongsan, traditional oriental herbal formula, is widely used for the treatment of nephrosis, dropsy, and uremia..
Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms
Anti-inflammatory activity of mycelial extracts from medicinal mushrooms.
Medicinal mushrooms have been essential components of traditional Chinese herbal medicines for thousands of years, and they protect against diverse health-related conditions. The components responsible for their anti-inflammatory activity have yet to be fully studied..
Mesima · 2014 · Research Support, Non U.S. Gov'T · International journal of molecular sciences
Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9.
Hispolon is one of the most important functional compounds that forms Phellinus linteus (Berkeley & Curtis) Teng. Hispolon has antioxidant, anti-inflammatory, antiproliferative and anticancer effects.
Mesima · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology
Hispolon inhibition of inflammatory apoptosis through reduction of iNOS/NO production via HO-1 induction in macrophages.
ETHNOPHARMACOLOGICAL RELEVANCE: Phellinus linteus (Berkeley & Curtis), a well-known medical fungus, has long been used as a traditional medicine in Oriental countries to treat various diseases, and hispolon (HIS) is one of its bioactive components..
Turkey Tail · 2014 · Dissertation · journal metadata
Investigating the role of laccase and laccase mediator systems to improve the saccharification of biomass for bioethanol production
Metadata-grounded summary: This dissertation indexes research on Trametes versicolor in 2014. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..
Maitake · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers
Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells.
Polysaccharides are believed to be strong immunostimulants that can promote the proliferation and activity of T cells, B cells, macrophages and natural killer (NK) cells. This study aimed to investigate the effects of five polysaccharides (Grifola frondosa polysaccharide (GFP), lentinan (LNT), G..
Snow Fungus · 2014 · Evaluation Study · International journal of medicinal mushrooms
The optimum submerged culture condition of the culinary-medicinal white jelly mushroom (Tremellomycetes) and its antioxidant properties.
Tremella fuciformis is a natural edible and medicinal mushroom commercially available in Taiwan. In this study, the effects of initial pH, incubation time, and various media to optimize exopolysaccharide (EPS) production by T.
Maitake · 2013 · Research Support, Non U.S. Gov'T · Carbohydrate polymers
A chemically sulfated polysaccharide from Grifola frondos induces HepG2 cell apoptosis by notch1-NF-κB pathway.
Sulfated polysaccharides have been known to inhibit proliferation in tumor cells. However, the molecular mechanisms involved in sulfated polysaccharides-induced apoptosis are still uncharacterized..
Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · Applied spectroscopy
A sensitive spectrofluorometric method for determination of ergosta-4,6,8(14),22-tetraen-3-one in rat plasma, feces, and urine for application to pharmacokinetic studies using cerium(III) as a probe.
Ergosta-4,6,8(14),22-tetraen-3-one (ergone) isolated from Polyporus umbellatus possesses a variety of pharmacological activities in vivo and in vitro, including cytotoxic, diuretic, and immunosuppressive effect..
Niu-Chang-Chih · 2013 · Research Support, Non U.S. Gov'T · Free radical biology & medicine
Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.
High levels of reactive oxygen species (ROS), systemic T cell activation, and macrophage infiltration in the kidney are implicated in the acceleration and progression of IgA nephropathy (IgAN), the most frequent type of primary glomerulonephritis..
Enoki · 2013 · Comparative Study · International immunopharmacology
Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs).
In this study, two novel FIPs have been identified and characterized. The first is FIP-nha, identified in the ascomycete Nectria haematococca, and as such, FIP-nha would be the first FIP to be identified outside the order of Basidiomycota.
Wood Ear · 2013 · Research Support, Non U.S. Gov'T · The journal of physical chemistry. B
Effect of heating on chain conformation of branched β-glucan in water.
The thermal stability of polysaccharides under heat treatment is an important factor to their functionality in food and pharmaceutical fields. The stiff branched β-glucan coded as AF1-1 isolated from Auricularia auricula-judae was investigated with viscometry, dynamic light scattering (DLS), and size-exclusion….
Enoki · 2013 · Research Support, Non U.S. Gov'T · Cytokine
Effect of the fungal immunomodulatory protein FIP-fve on airway inflammation and cytokine production in mouse asthma model.
The allergy is dependent on the balance between Th1 and Th2. The fungal immunodulatory protein (FIP-fve) was isolated from Flammulina velutipes.
Enoki · 2013 · Research Support, Non U.S. Gov'T · Applied microbiology and biotechnology
In vitro rapid evolution of fungal immunomodulatory proteins by DNA family shuffling.
Fungal immunomodulatory proteins (FIPs) found in a wide variety of mushrooms hold significant therapeutic potential. Despite much research, the structural determinants for their immunomodulatory functions remain unknown..
Maitake · 2013 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine
Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.
BACKGROUND: Mushrooms are not only regarded as gourmet cuisine but also as therapeutic agent to promote cognition health. However, little toxicological information is available regarding their safety..
Maitake · 2013 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine
Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.
BACKGROUND: Senescence of the neurons is believed to be a focal factor in the development of age-related neurodegenerative diseases such as Alzheimer's disease. Diminutions in the levels of nerve growth factor (NGF) lead to major declines in brain cell performance..
Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · International journal of molecular sciences
An efficient total synthesis of a potent anti-inflammatory agent, benzocamphorin F, and its anti-inflammatory activity.
A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies..
Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · Arthritis and rheumatism
Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis.
OBJECTIVE: Accelerated severe lupus nephritis (ASLN), with an acute onset of severe clinical manifestations and histopathologic renal lesions, may represent transformation of mild LN to a severe form of glomerulonephritis..