MycoData

Lentinula edodes (shiitake mushroom) is renowned for its distinctive aroma, chiefly attributed to lenthionine (1,2,3,5,6-pentathiepane), a cyclic organosulfur compound. Exogenous calcium ion (Ca2+) application is known to stimulate secondary metabolite biosynthesis in plants and fungi..

High relevance

Reishi · 2026 · Preprint · journal metadata

A historical specimen of False Lingzhi ( Ganoderma lucidum ) resolves a 245-year-old confusion within an important medicinal mushroom group

Summary Plants and fungi are major sources of natural products beneficial to society, making the study of distinct species essential for discovering new drugs and bioactive compounds..

OncologyImmune support

High relevance

Reishi · 2026 · Journal Article · Analytica chimica acta

A label-free magnetic bead affinity approach for direct target identification of herbal extract: Ganoderma lucidum as a case.

Ganoderma lucidum (Chinese name: Lingzhi) has been used for the treatment of diverse liver disorders for centuries in traditional Chinese medicinal practices. Ganoderic acids (GAs) have been well-established as the key bioactive constituents responsible for the hepatoprotective potential and the ability to alleviate….

OncologyLiver support

High relevance

Cordyceps · 2026 · Journal Article · Journal of agricultural and food chemistry

A Potent Fibrinolytic Enzyme Alp1 from Cordyceps militaris: From Sequence-Function Characterization to in Vivo Antithrombotic Application.

Alp1, a potent fibrinolytic enzyme from Cordyceps militaris CM03, was characterized and identified as an S8 family alkaline serine protease. Molecular simulations revealed that the pro-peptide enhances mature peptide flexibility, which is crucial for functional folding and catalytic accessibility..

High relevance

Snow Fungus · 2026 · Review · Carbohydrate research

Advances in extraction, structural characteristics, bioactivities, structure-activity relationship, quality control and applications of polysaccharides from Tremella fuciformis: A review.

ETHNOPHARMACOLOGICAL RELEVANCE: Tremella fuciformis is an edible fungus with a cultivation and consumption history of over a thousand years in China. In traditional Chinese medicine, it has the effects of moistening the lungs, soothing the intestines, nourishing the skin, and prolonging life, and is often used as a….

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Lion's Mane · 2026 · Journal Article · Food chemistry

AI-assisted discovery of dual antioxidant and ACE-inhibitory peptides from Hericium erinaceus.

Hericium erinaceus harbored rich peptides, however their biofunctional properties remained unclear. In this study, Hericium erinaceus protein hydrolysates (HEph) were analyzed using a large language model (LLM)-assisted annotation workflow on the DeepSeek platform, combined with liquid chromatography-tandem mass….

High relevance

Cordyceps · 2026 · Research Article · Biology

Altered Stereostructures of the DNA-Binding Domains of Variant Mating Proteins of Ophiocordyceps sinensis and the Wild Insect-Fungal Complex.

The MATα_HMGbox and HMG-box_ROX1-like domains of the MAT1-1-1 and MAT1-2-1 proteins, respectively, play essential roles in DNA binding and the subsequent regulation of gene transcription, controlling Ophiocordyceps sinensis sexual reproduction..

High relevance

Cordyceps · 2026 · Research Article · Current issues in molecular biology

An Acetyl-CoA-Gated Metabolic Checkpoint Links Precursor Supply to Cordycepin Biosynthesis in Cordyceps militaris.

The growth-specialized metabolism trade-off limits fungal natural product production. Here, we investigated cordycepin overproduction in Cordyceps militaris high-yield GYS60 and low-yield GYS80 via comparative proteomics, Post-Translational Modification (PTM) mapping, and metabolomics..

Metabolic health

High relevance

Cordyceps · 2026 · Journal Article · Journal of food composition and analysis

An eco-friendly and rapid HPLC method for simultaneous determination of adenosine and ergothioneine in ten kinds of Cordyceps spp. samples with blue applicability grade index assessment

This study developed a rapid and eco-friendly HPLC method for simultaneous determination of adenosine and ergothioneine in Cordyceps spp. samples.

High relevance

Cordyceps · 2026 · Review · Phytotherapy research: PTR

An Immunomodulatory Mushroom, Cordyceps militaris, and Its Constituents: A Review of In Vitro/In Vivo Studies and Clinical Trials.

Cordyceps, known as "winter-worm summer-grass", has been used as a medicinal mushroom to boost energy levels and immune activity. Among cordyceps types, Cordyceps militaris (CM) is the most commercially useful owing to its ease of artificial cultivation for mass production..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Shiitake · 2026 · Journal Article · Journal of ethnopharmacology

Anti-inflammatory potential of Lentinula edodes DMRO-356: Ethnopharmacological validation and multi-target molecular docking.

ETHNOPHARMACOLOGICAL RELEVANCE: Lentinula edodes (shiitake) has long been used in East Asian medicine to reduce inflammation, boost vitality, and support immune function..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2026 · Research Article · Nutrients

Bifidobacterium animalis ssp. lactis 420 and Cordyceps militaris Synergistically Modulate the Gut Microbiota by Increasing Mucin 2 Production.

BACKGROUND: Probiotics and medicine food homology are known to offer gentle approaches to prevent obesity, although it is difficult with such approaches to satisfy consumers' requirements to lose weight quickly. The probiotic strain Bifidobacterium animalis ssp..

Immune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2026 · Journal Article · International journal of medicinal mushrooms

Bioactives of Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Targeting PPAR Signaling Pathway: An Experimental and In Silico Investigation.

Hericium erinaceus is a widely consumed edible mushroom with significant ethnopharmacological value. Nevertheless, the pharmacological understanding of H.

Immune supportEnergy & fatigue

High relevance

King Oyster · 2026 · Journal Article · Scientific reports

Biological activity of Pleurotus eryngii based on antioxidant, anticholinesterase and antiproliferative effects using optimized extraction methods.

This study aims to evaluate the antioxidant potential, anticholinesterase activity, antiproliferative effects, and phenolic contents of optimized extracts derived from Pleurotus eryngii. Single-objective and multi-objective optimized extracts of P..

OncologyRespiratory

High relevance

Chaga · 2026 · Research Article · Journal of microbiology and biotechnology

Chaga Mushroom (Inonotus obliquus) Attenuates DNCB-Induced Atopic Dermatitis by Modulating Oxidative Stress and Cytokine Expression.

Recent studies highlight the immunomodulatory properties of Chaga mushrooms. Atopic dermatitis (AD) is a multifactorial skin disorder involving interactions between innate and adaptive immune responses..

Immune supportSkin & hydration

High relevance

King Oyster · 2026 · Research Article · NPJ science of food

Characterization of saltiness-enhancing peptides from Pleurotus eryngii: identification, sensory evaluations, and mechanism of saltiness-enhancing.

This study aimed to identify novel saltiness-enhancing peptides derived from Pleurotus eryngii and evaluate their influence on saltiness perception. Utilizing an integrated virtual screening strategy, 6 candidate peptides exhibiting potential saltiness-enhancing properties were identified..

High relevance

Oyster Mushroom · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Co-Infection of Three Novel Deltaflexiviruses in an Isolate of the Edible Fungus Pleurotus ostreatus Reduces Fruiting Body Yield by Inhibiting Cellulase Activity.

Pleurotus ostreatus, a globally cultivated oyster mushroom, is susceptible to viral infections that threaten yield and quality. This study reports the identification and characterization of three novel viruses from a symptomatic P..

Respiratory

High relevance

Cordyceps · 2026 · Journal Article · Fitoterapia

Comparative computational analysis of the hypolipidaemic potential of Cordyceps militaris and Ophiocordyceps sinensis, with in vivo validation of cordycepin.

Hyperlipidaemia (HLP) arises from impaired lipid homeostasis in the setting of chronic low-grade inflammation, yet mechanistic comparisons between the edible medicinal fungi Cordyceps militaris and Ophiocordyceps sinensis remain scarce..

Immune supportMetabolic healthLiver support

High relevance

Reishi · 2026 · Journal Article · Food Research International

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms

Ganoderma lucidum (Reishi mushroom) exhibits medicinal–edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Immune supportGut & microbiomeLiver support

High relevance

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms.

Ganoderma lucidum (Reishi mushroom) exhibits medicinal-edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Immune supportGut & microbiomeLiver support

High relevance

Cordyceps · 2026 · Research Article · Life (Basel, Switzerland)

Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin.

Chronic diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, oxidative stress, and defective tissue remodeling, leading to delayed healing..

Immune supportMetabolic healthSkin & hydration

High relevance

Shiitake · 2026 · Research Article · Journal of cosmetic dermatology

Cosmeceutical and Dermatological Potential of Shiitake Mushroom (Lentinula edodes) Extract.

BACKGROUND: Shiitake mushroom (Lentinula edodes) contains polysaccharides, phenolics, and β-glucans known for their antioxidant and nutraceutical properties; however, its dermatological applications remain limited..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2026 · Journal Article · International journal of cosmetic science

Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.

OBJECTIVE: The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline peptide and….

OncologyEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2026 · Review · Nutrients

Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative Review.

Cordyceps militaris is an entomopathogenic fungus traditionally used in Asian ethnomedicine and increasingly investigated for its potential health-promoting properties, including immunomodulatory and anti-inflammatory activities..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2026 · Journal Article · Molecular and cellular biochemistry

Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton's Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation.

Cordyceps militaris, a medicinal mushroom in traditional Chinese medicine, emerged as a promising source of bioactive compounds, exhibiting potent antioxidant, anti-inflammatory, anticancer, antiviral and immunomodulatory properties..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Reishi · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Development of a CRISPR/Cas9 Genome Editing System in Dikaryotic Ganoderma lucidum for Targeting Key CYP450 Gene Involved in Triterpenoid Synthesis.

Currently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains. However, the biological mechanisms in a monokaryotic state often do not accurately reflect the actual physiological and metabolic conditions of dikaryotic….

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

Discovery of functional compounds from dimorphic edible Ophiocordyceps sinensis fungus in host haemolymph.

Chinese cordyceps, with a fruiting body of Ophiocordyceps sinensis from insect cadaver, is well-known health food. During formation, O.

OncologyMetabolic health

High relevance

Chaga · 2026 · Journal Article · International journal of medicinal mushrooms

Diversity and Micromorphological Invariables of Chaga Medicinal Mushroom (Inonotus obliquus f. sterilis, Agaricomycetes) Raw Materials.

Inonotus obliquus f. sterilis, chaga mushroom, is a complex formation with significant participation of woody material, which combines the characteristics of a granular core and pseudosclerotium plate..

High relevance

King Oyster · 2026 · Journal Article · Journal of food engineering

Dual role of reusable Zingiber officinale in microwave synergistic drying of Pleurotus eryngii: Dielectric regulation and composite flavor formation

Microwave drying dehydrates rapidly but is limited by uneven heating and quality loss. To tackle this challenge, a mixed material system was designed by combining Pleurotus eryngii with reusable Zingiber officinale, where Z..

Skin & hydration

High relevance

Cordyceps · 2026 · Research Article · International journal of endocrinology

Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents.

The increasing global prevalence of obesity, exacerbated by factors such as high-fat diets and reduced physical activity, poses a substantial risk for lifestyle-related diseases, particularly in postmenopausal women..

Metabolic health

High relevance

Lion's Mane · 2026 · Research Article · Food chemistry: X

Effect of lion's mane mushroom (Hericium erinaceus) on dough rheology, protein structure, and quality of steamed bread.

This study investigates how Hericium erinaceus powder (HE powder) modulates the gluten network and influences steamed bread quality. HE powder altered water distribution and mobility, consistent with changes in dough thermo-mechanical behavior, pasting properties, and crumb microstructure..

Energy & fatigueGut & microbiome

High relevance

Reishi · 2026 · Research Article · Poultry science

Effect of selenium-enriched Ganoderma lucidum powder in testicular tissues, oxidative stress biomarkers and antiapoptotic capacities in roosters.

Selenium (Se) is an essential trace element for animals, playing irreplaceable roles in growth, development, reproduction, and health by enhancing antioxidant and anti-apoptotic functions..

High relevance

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Effects of Amaranth Seed- and Bambara Groundnut-Based Media on the Aroma-Active Volatile and Amino Acid Profiles of Oyster Mushroom (Pleurotus ostreatus) Mycelia.

The growing demand for sustainable alternative proteins has intensified interest in fungal mycelia as a nutrient-dense biomass for food applications. This study compared Pleurotus ostreatus fruiting bodies with mycelia grown in liquid state on amaranth seed- and Bambara groundnut-based media, evaluating aroma-active….

High relevance

Oyster Mushroom · 2026 · Journal Article · Journal of microbiological methods

Establishment of a CRISPR/Cas9 protocol by biolistic transformation of the filamentous basidiomycete Pleurotus ostreatus.

Genome editing was successfully performed by introducing a CRISPR/Cas9 expression vector through biolistic transformation of Pleurotus ostreatus, an oyster mushroom. This method can be applied for genome editing in filamentous basidiomycetes without protoplasting..

High relevance

Enoki · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Evaluation of F₀-based sterilization for microbial safety and mycelial growth of enoki mushroom (Flammulina velutipes) substrate.

Sterilization of enoki mushroom (Flammulina velutipes) substrate is a critical step to ensure both microbial safety and optimal mycelial growth for mushroom production..

High relevance

King Oyster · 2026 · Journal Article · Journal of toxicology and environmental health. Part A

Evidence of the toxic and genotoxic effect of the Pleurotus eryngii mushroom in Drosophila melanogaster.

The mushroom Pleurotus eryngii, commonly known as the king oyster or king trumpet mushroom, is valued for its high nutritional content and therapeutic properties. Although widely consumed, little is known regarding its potential genotoxic and mutagenic effects..

High relevance

Shiitake · 2026 · Journal Article · Bioscience, biotechnology, and biochemistry

Excavation of Lentinula edodes-stem-derived peptides doubly inhibiting DPP-IV and ACE activity.

Type Ⅱ diabetes and hypertension often coexist, affecting each other. Suppressing dipeptidyl peptidase-4 (DPP-Ⅳ) and angiotensin-I-converting enzyme (ACE) activity is crucial for managing these conditions..

Metabolic health

High relevance

Reishi · 2026 · Preprint · journal metadata

Exploring the effect and mechanism of Ganoderma lucidum Polysaccharides on improving Paediatric MASLD based on network pharmacology and animal experiment

Abstract Background Paediatric Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder resulting from chronic hepatic steatosis. Ganoderma lucidum polysaccharide (GLP) have several pharmacological effects..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Lion's Mane · 2026 · Research Article · PloS one

Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cells.

The regenerative capacity of mammalian RGC neurites after damage, such as glaucoma, is limited. Numerous studies have utilized herbal extracts to promote neural regeneration and exert neuroprotective effects in the hope of mitigating glaucoma..

OncologyCognition & nerves

High relevance

Turkey Tail · 2026 · Research Article · Applied and environmental microbiology

Functional characterization of a novel p-coumarate 3-hydroxylase from Trametes versicolor.

UNLABELLED: Lignin degradation by white-rot fungi proceeds through oxidative depolymerization of lignin polymers, followed by metabolism of the resulting low-molecular-weight aromatic fragments. Among these, the catabolism of the hydroxyphenyl (H) unit of p-coumaric acid (p-CA) remains poorly understood in fungi..

Energy & fatigue

High relevance

Reishi · 2026 · Journal Article · Biological & pharmaceutical bulletin

Ganoderic Acid A Derived from Reishi Mushroom Ganoderma lucidum Protects against Intestinal Immunity Reduction Due to Oxidative Stress in Rat

Reishi (Ganoderma lucidum) is known to enhance intestinal immunity, with ganoderic acid A (GA-A) identified as one of its active constituents. However, the specific role of GA-A in regulating immune components such as immunoglobulin A (IgA) from Peyer's patches (PPs) and α-defensin 5 from Paneth cells remains unclear..

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Research Article · Journal of Cancer

Ganoderma lucidum alcohol extract targets mutant p53 signaling to inhibit proliferation in triple-negative breast brain metastasis cancer.

Triple-negative breast cancer (TNBC) is among the most aggressive subtypes of breast cancer, frequently characterized by invasive growth, metastasis, and poor clinical outcomes. Brain metastasis, commonly observed in TNBC patients, significantly worsens prognosis and survival rates..

OncologyCognition & nerves

High relevance

Reishi · 2026 · Review · Metabolites

Ganoderma lucidum as a Functional Bioactive Candidate for Glycemic Regulation: Mechanisms, Preclinical Evidence, and Clinical Translation.

Type 2 diabetes mellitus (T2DM) is a major global health challenge that has intensified interest in multi-target nutraceuticals with potential adjunctive benefits..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2026 · Research Article · Chinese medicine

Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway.

Multiple Sclerosis (MS) is a neuroinflammatory disease affecting the central nervous system (CNS), for which effective therapeutic strategies remain limited. Ganoderma Lucidum (GL) is a nature healthy food supplement whose effects on MS remain unknown..

Immune supportCognition & nerves

High relevance

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum polysaccharides alleviate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through modulation of the Nrf2/SLC7A11/GPX4 signaling pathway.

Doxorubicin (Dox) is a chemotherapeutic agent widely used in clinical oncology; however, its application is limited by dose-dependent cardiotoxicity, in which ferroptosis has been identified as a key mechanism of myocardial injury..

OncologyImmune support

High relevance

Reishi · 2026 · Research Article · Scientific reports

Ganoderma lucidum spore oil with Ganoderma lucidum and Ganoderma sinense extracts (G2SO) shows antitumor and Immunomodulatory effects in mice.

Ganoderma is a highly valued medicinal fungus, especially in Traditional Chinese Medicine (TCM). A formulation of Ganoderma lucidum spore oil and aqueous extracts from the fruiting bodies of Ganoderma lucidum and Ganoderma sinense (G2SO) has been developed as a functional formulation proposed to support immune….

OncologyImmune support

High relevance

Shiitake · 2026 · Journal Article · Environmental microbiology

Genome-Wide Association Study Identified an α/β Hydrolase Gene LeABH Enhancing Lentinula edodes Resistance to Trichoderma.

Green mould disease caused by Trichoderma spp. severely threatens Lentinula edodes cultivation, resulting in heavy yield losses.

High relevance

Chaga · 2026 · Research Article · Molecules (Basel, Switzerland)

Green Extraction and Liposomal Encapsulation of Inonotus obliquus (Chaga) Extracts: Comparative Phytochemical and Antioxidant Analysis.

Inonotus obliquus (Chaga) is a medicinal basidiomycete fungus with diverse bioactive compounds and pharmacological properties. This study systematically compared green extraction techniques: maceration, ultrasound-assisted extraction (UAE), and combined supercritical CO2-pressurized liquid extraction (ScCO2-PLE),….

Liver support

High relevance

Maitake · 2026 · Research Article · Scientific reports

Grifola frondosa as a natural additive enhancing antioxidant activity and nutritional value in gluten-free bread.

Gluten-free breads enriched with maitake (Grifola frondosa) were developed to enhance functional value and evaluated for technological quality, antioxidant capacity, colour, texture, mineral composition, molecular features (FTIR), and consumer acceptance..

High relevance

Cordyceps · 2026 · Journal Article · Preparative biochemistry & biotechnology

Harnessing iron nanoparticles for scalable cordycepin and adenosine production in Cordyceps militaris.

Cordyceps militaris (CM) is one of the most valuable edible mushrooms, treasured for its health promoting properties, largely due to cordycepin and adenosine. In the present experiments CM was cultivated on four different substrates (brown rice, finger millet, barnyard millet and barley) to evaluate growth dynamics,….