MycoData

The MATα_HMGbox domain in the MAT1-1-1 protein and the HMG-box_ROX1-like domain in the MAT1-2-1 protein play essential roles in DNA binding and regulating the transcription of genes that control sexual reproduction in Ophiocordyceps sinensis..

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Cordyceps · 2026 · Journal Article · International journal of biological macromolecules

Identification of differential proteins in Cordyceps militaris cultured with different nitrogen sources via proteomic analysis.

Cordyceps militaris is a rare edible and medicinal fungus rich in functional components. To clarify the regulatory mechanisms of different nitrogen sources on protein synthesis and functional properties, the study established a differential culture system using three supplementary nitrogen sources with wheat as the….

Energy & fatigue

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Yellow Morel · 2026 · Research Article · Foods (Basel, Switzerland)

In Silico Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from Morchella esculenta.

Natural food-derived proteins are increasingly explored as alternatives to synthetic inhibitors for managing Type 2 diabetes mellitus. Despite the recognized health-promoting properties of Morchella esculenta, the potential of its bioactive proteins to modulate glucose metabolism remains largely unexplored..

Cognition & nervesMetabolic healthGut & microbiome

High relevance

King Oyster · 2026 · Journal Article · International journal of medicinal mushrooms

In Vitro Antioxidant and Anti-Inflammatory Activity and Phenolic Compound Determination of King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) from Algeria.

The current study investigates the biological efficacy and polyphenol and flavonoid content of aqueous and ethanolic 80% extracts of Pleurotus eryngii from the western region of Algeria. Total phenolic content (TPC) and total flavonoid content (TFC) were determined using colorimetric methods..

Immune support

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King Oyster · 2026 · Journal Article · Innovative Food Science and Emerging Technologies

Incorporation of yeast protein improves the textural properties of a fungal meat analogue from Pleurotus eryngii mycelium

The increasing demand for high-quality mycoprotein meat analogues necessitates the development of innovative ingredients and formulations. This study aimed to develop a novel mycoprotein meat analogue from Pleurotus eryngii mycelium (PM) produced via submerged fermentation and to systematically investigate the….

Metabolic health

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Cordyceps · 2026 · Journal Article · Bioscience, biotechnology, and biochemistry

Inhibition of hepatic lipogenesis and adipogenesis by cordyanhydride A isolated from Cordyceps Militaris cultivated on germinated soybeans.

Regulation of lipid homeostasis requires coordinated control of fatty acid (FA) oxidation, lipogenesis, and adipocyte differentiation. Cordyanhydride A (CA) was isolated from Cordyceps militaris (CM) extract cultivated on germinated soybean through bioactivity-guided fractionation and structurally characterized using….

Immune supportMetabolic healthLiver support

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Oyster Mushroom · 2026 · Research Article · Food chemistry: X

Innovative research of xian-Ling-Gu-bao herbal residue in regulating soluble carbon-to-nitrogen ratio to promote the growth and nutritional quality of Pleurotus ostreatus: A metabolomics and gut microbiota perspective.

This study evaluated the cultivation of Pleurotus ostreatus on a composite substrate consisting of Xin-Ling-Gu-Bao herbal residue (XLGB) and sauce-flavor Baijiu lees (SFL), both agro-industrial by-products rich in lignocellulose and bioactive compounds..

Gut & microbiome

High relevance

Chaga · 2026 · Journal Article · Journal of ethnopharmacology

Inonotus obliquus (Ach. ex Pers.) Pilát aqueous extract alleviates acute cold exposure/rewarming-induced myocardial injury by regulating mitochondrial dynamics via liver kinase B1/adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway activation.

ETHNOPHARMACOLOGICAL RELEVANCE: Acute cold exposure affects the cardiovascular system substantially. Inonotus obliquus (Ach.

Energy & fatigueMetabolic healthLiver support

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Chaga · 2026 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Inonotus obliquus polysaccharides alleviate UVB-irradiated skin photodamage by regulating calcium homeostasis through endoplasmic reticulum-mitochondria crosstalk.

Skin photodamage is closely related to mitochondrial dysfunction, and endoplasmic reticulum (ER) stress can induce excessive mitochondrial reactive oxygen species (ROS) accumulation, triggering inflammation, and inducing cell apoptosis..

OncologyImmune supportEnergy & fatigueSkin & hydration

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Chaga · 2026 · Review · Nutrients

Inonotus obliquus Polysaccharides: Preparation, Structural Characteristics, Structure-Activity Relationships, Biological Activities and Applications.

Inonotus obliquus, a rare medicinal and edible fungus, is rich in bioactive polysaccharides. These polysaccharides exhibit diverse biological activities, including gut microbiota-modulating, hypoglycemic, immunomodulatory, antitumor, antioxidant, hypolipidemic, and antiviral activities..

OncologyImmune supportMetabolic healthGut & microbiome

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Oyster Mushroom · 2026 · Research Article · Veterinary sciences

Investigation of Pleurotus Ostreatus Mushroom-Based Feed Supplementations on Growth Performance and Immune Function in Male Japanese Quails (Coturnix Japonica).

Growing concern over antibiotic resistance in poultry production has increased interest in natural feed additives such as Pleurotus ostreatus (oyster mushroom)-derived products..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

King Oyster · 2026 · Research Article · Nutrients

King Oyster Mushroom, Pleurotus eryngii, Inhibits Microglia Activation via the Interplay of NLRP3 to Alleviate Neuroinflammation.

Background: Mushrooms have gained attention for their potential to improve brain health. We evaluated extracts of king oyster mushroom, as well as two of its bioactive compounds-ergothioneine (ERG) and N-acetyltryptamine (NAT)-for their ability to prevent microglia activation by reducing neuroinflammation and….

Immune supportCognition & nerves

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Cordyceps · 2026 · Journal Article · International journal of medicinal mushrooms

LED Light Spectra Modulate Growth, Morphogenesis, and Bioactive Compound Production in Cordyceps militaris (Ascomycota).

Light is a crucial environmental factor influencing fungal development and secondary metabolite biosynthesis. In this study, we investigated the effects of nine different LED light spectra on the growth, morphogenesis, and production of bioactive compounds in Cordyceps militaris strain DT22..

Gut & microbiome

High relevance

Lion's Mane · 2026 · Journal Article · International journal of medicinal mushrooms

Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Polysaccharides for Improved In Vitro Probiotic Growth, Adhesion, Antioxidant Activity, and Cryoprotective Properties.

Hericium erinaceus, commonly known as lion's mane mushroom, is a rare edible and medicinal fungus that is highly valued in both the culinary and medical fields. Its primary bioactive component, polysaccharides, holds significant therapeutic potential, particularly in healthcare..

Immune supportGut & microbiome

High relevance

Maitake · 2026 · Randomized Controlled Trial · Journal of nutritional science and vitaminology

Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

Extended longevity has resulted in an increased number of patients with dementia. Therefore, new methods for treating and preventing dementia are highly desirable.

Immune supportCognition & nerves

High relevance

Reishi · 2026 · Systematic Review · Frontiers in pharmacology

Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complications.

Characterized by a total or partial shortage of insulin, diabetes is a chronic metabolic condition. Its widespread occurrence and related complications present a significant global public health issue.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Metabolomic and proteomic analysis reveals the metabolic changes of alkaloids in Ganoderma lucidum fermented tea.

Fermentation is the key to the quality formation of Ganoderma lucidum fermented tea (GLFT). This study reveals the metabolic changes of alkaloids and related metabolites during the fermentation process of Ganoderma lucidum tea..

Metabolic health

High relevance

Lion's Mane · 2026 · Preprint · journal metadata

Methyl viologen boosts Erinacine A biosynthesis in Hericium erinaceus fermentation: Multi-omics insights

Abstract Erinacine A, a critical secondary metabolite of Hericium erinaceus, has garnered significant interest due to its bioactive properties. This study aimed to investigate the effects of methyl viologen (MV) on the synthesis of Erinacine A during liquid fermentation of Hericium erinaceus, employing a multi-omics….

Cognition & nervesEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Microbial Community Dynamics Driven by Different Nitrogen Sources During Forestry Waste Composting for Pleurotus ostreatus Cultivation.

Bioconversion of lignocellulosic biomass into edible, nutrient-rich products using low-cost forestry waste offers substantial ecological and economic benefits. Composting forestry waste as a substrate for oyster mushroom (Pleurotus ostreatus) cultivation is an effective recovery strategy..

Energy & fatigueGut & microbiome

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Reishi · 2026 · Journal Article · International journal of medicinal mushrooms

Microwave-Assisted Extraction Optimization, Solubility, and Bioactivity Evaluation of Polysaccharides from Broken Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder.

One of the main active components of broken Ganoderma lucidum spore powder was polysaccharide (BGSPP), but the extraction time was long, and the yield was low at present. Therefore, the extraction and activity of BGSPP were studied in this paper..

Immune supportEnergy & fatigue

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Cordyceps · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Molecular Mechanisms of Temperature-Regulated Cordycepin Biosynthesis in Cordyceps militaris.

Cordycepin is a key active component of Cordyceps militaris, but the molecular mechanism underlying temperature-regulated biosynthesis remains unclear. In this study, Cordyceps militaris strain KN-1 was used as experimental material, with low-temperature (15 °C), control (20 °C), and high-temperature (25 °C)….

High relevance

Reishi · 2026 · Journal Article · Journal of food science

Morphology Engineering: Uniform Ganoderma lucidum Pellet Formation in Coconut Juice by Bidirectional Submerged Fermentation.

Two different mycelia morphologies (clumps and pellets) of Ganoderma lucidum can be produced by bidirectional submerged fermentation (BSF) with coconut water. No mycelia growth was observed when coconut milk was used as the substrate..

Immune support

High relevance

Cordyceps · 2026 · Research Article · Journal of ginseng research

Multi-omics and compositional analysis of bidirectional solid fermentation products from Cordyceps militaris and Panax quinquefolius L.

BACKGROUND: Ginsenosides, the main active compounds in American ginseng, have notable pharmacological effects, with rare ginsenosides offering higher bioavailability and bioactivity despite low abundance..

Energy & fatigue

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Reishi · 2026 · Research Article · Journal of nanobiotechnology

Multicomponent Ganoderma lucidum spore-based solid self-nanoemulsifying system of paclitaxel for improved lymphatic absorption and immune synergistic antitumor strategy.

In colorectal cancer, the cancer-immunity cycle is often disrupted by the lack of effective tumor-associated antigens, impaired activation of antigen-presenting cells, and insufficient T cell infiltration, leading to tumor immune escape and disease progression..

OncologyImmune supportGut & microbiomeLiver support

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Shiitake · 2026 · Journal Article · Computational biology and chemistry

Multilocus genetic and functional profiling of Indian-origin Lentinula edodes strains: Implications for cultivation and nutraceutical breeding.

Lentinula edodes (shiitake mushroom) is a widely cultivated edible and medicinal fungus, valued for its bioactive compounds. While East Asian strains have been well studied, Indian populations remain under-characterized.

High relevance

Oyster Mushroom · 2026 · Journal Article · Bioorganic chemistry

Mushroom-mediated silver nanoparticles from Pleurotus ostreatus as antimicrobial candidates against multidrug-resistant bacteria: Physicochemical, in-silico, cytotoxicity, and immunobiological evaluation.

The rise of antimicrobial resistance has heightened the demand for alternatives to traditional antibiotics, especially against multidrug-resistant (MDR) strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniaei, and Pseudomonas aeruginosa..

OncologyImmune supportEnergy & fatigueRespiratory

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Cordyceps · 2026 · Preprint · journal metadata

Nano-Encapsulated Cordyceps militaris Grown on Germinated Black Bean Attenuates PM- and LPS-Induced Airway Inflammation

Exposure to particulate matter (PM) containing bacterial endotoxins triggers oxidative stress and inflammation in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-encapsulated Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food–derived….

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Cordyceps · 2026 · Review · Journal of food science and technology

Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.

UNLABELLED: This review article delves into the multiphase composition of Cordyceps militaris mushroom and explores its implications as a dietary supplement. C.

Immune supportEnergy & fatigueRespiratory

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Cordyceps · 2026 · Journal Article · Food Research International

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide

Diet-based modulation of the gut microbiota has emerged as a promising strategy to alleviate obesity and its related complications. Our previous study demonstrated that polysaccharide derived from Cordyceps militaris (CMP) exerts anti-obesity effects, yet the specific mechanism linking gut microbiota to its metabolic….

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide.

Immune supportMetabolic healthGut & microbiomeLiver support

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Lion's Mane · 2026 · Research Article · International journal of molecular sciences

Neuroprotective Potential of Hericium erinaceus Through Modulation of Inflammatory Signaling in THP-1 Macrophages Under Low-Level Lead Exposure.

Exposure to lead is associated with microglial dysfunction and the development of neuroinflammation. This contributes to accelerated neurodegeneration.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

OmniEdit: A unified CRISPR/Cas9 platform for precise genome engineering and strain optimization of the Cordyceps militaris cell factory.

Cordyceps militaris serves as a critical microbial cell factory for high-value bioactive compounds; however, the scarcity of versatile and sophisticated genome-editing toolsets significantly restricts its systematic metabolic engineering..

Energy & fatigueMetabolic healthLiver support

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Cordyceps · 2026 · Journal Article · Current topics in medicinal chemistry

Ophiocordyceps sinensis in Cancer Therapy: Bridging Traditional Medicine and Modern Oncology.

INTRODUCTION: Ophiocordyceps sinensis, a parasitic fungus traditionally used in Asian medicine, has drawn attention for its potential anticancer properties. Its bioactive components- such as cordycepin, polysaccharides, and nucleosides-exhibit anti-inflammatory, antioxidant, immunomodulatory, and anticancer….

OncologyImmune supportGut & microbiomeLiver support

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Cordyceps · 2026 · Journal Article · Scientific reports

Optimization of cordycepin fermentation by Cordyceps militaris via response surface methodology.

Cordycepin is a bioactive compound with demonstrated immunoregulatory, antioxidant, and organ-protective properties. This study aimed to significantly enhance the production of cordycepin in Cordyceps militaris fermentation through systematic process optimization..

Immune supportMetabolic health

High relevance

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Optimization of the Probiotic Fermentation Process of Ganoderma lucidum Juice and Its In Vitro Immune-Enhancing Potential.

Fermented products have recently garnered substantial interest in both research and commercial contexts. Although probiotic fermentation is predominantly practiced with dairy, fruits, vegetables, and grains, its application to dual-purpose food-medicine materials like Ganoderma lucidum has been comparatively….

Immune supportMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2026 · Journal Article · Protein expression and purification

Optimized Laccase production from the white rot fungi Pleurotus ostreatus and Trametes versicolor.

Laccases are predominantly found in bacteria, fungi, plants, and insects, and they have numerous industrial and biotechnological applications. Laccases are utilized in the pharmaceutical, food, pulp, and paper industries, and their cost-effective production in submerged culture conditions is of significant commercial….

High relevance

Oyster Mushroom · 2026 · Journal Article · Burns: journal of the International Society for Burn Injuries

Oral Pleurotus ostreatus supplementation modulates systemic inflammation and enhances collagen density in a full-thickness burn rat model.

Severe burn injuries cause hypermetabolic and inflammatory responses characterized by hypoalbuminemia and elevated cytokines that delay wound healing. Pleurotus ostreatus, known for its bioactive compounds and high-quality protein, may support recovery by improving systemic nutritional and inflammatory balance..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Cordyceps · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Pelletized Growth in Cordyceps militaris Is Associated with Coordinated Cell Wall Remodeling and Stress Defense.

Morphological control in submerged fermentation is a well-established method for enhancing bioactive metabolite production in filamentous fungi. However, the molecular mechanisms linking morphology to fermentation efficiency remain insufficiently understood..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2026 · Research Article · Frontiers in pharmacology

Peptidomics-based identification of endogenous free peptides from Ophiocordyceps sinensis and functional validation of immunomodulatory peptide WALGT.

Ophiocordyceps sinensis (formerly known as Cordyceps sinensis), commonly referred to as "dongchongxiacao" in Chinese, is a valuable traditional Chinese medicine whose bioactive small molecules form the essential material basis for its therapeutic effects..

Immune supportGut & microbiome

High relevance

Mesima · 2026 · Preprint · journal metadata

Phellinus linteus polysaccharides alleviate DSS-induced colitis in mice by restoring gut microbiota homeostasis, preserving intestinal barrier integrity, and attenuating JAK2/STAT3-associated inflammatory signaling

Abstract Background & aims Phellinus linteus polysaccharides (PLP), bioactive polysaccharides derived from the traditional medicinal fungus Phellinus linteus, have shown potential anti-inflammatory activity..

Immune supportGut & microbiome

High relevance

Cordyceps · 2026 · Journal Article · Bioresource technology

Pheromone-mediated quorum sensing enables dynamic regulation of cordycepin biosynthesis in Cordyceps militaris.

Cordycepin is a nucleoside compound with broad pharmacological activities, whose biosynthesis is tightly regulated by multilayered metabolic mechanisms. Dynamic regulation strategies allow for precise modulation of target product synthesis while maintaining cell growth, thus overcoming the limitations of static….

Metabolic health

High relevance

Shiitake · 2026 · Journal Article · International journal of biological macromolecules

Physicochemical and functional properties of isolated proteins from shiitake mushroom, Lentinula edodes.

Edible mushrooms, characterized by high protein and low fat contents, represent a valuable protein resource for humans. Lentinula edodes has long been consumed, and is the most widely cultivated mushroom species globally..

High relevance

Reishi · 2026 · Research Article · Metabolites

Phytochemical Profiling and Bioactivity Evaluation of Ganoderma lucidum (Reishi Mushroom) Fractions: In Vitro Antioxidant, Antimicrobial, and Antidiabetic Activities.

Background/Objectives:Ganoderma lucidum (Curtis) P. Karst.

Immune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2026 · Preprint · journal metadata

Pleiotropic Bioactivity of Caterpillar Fungus and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework

The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus) is one of the most popular medicines in Asian traditional medical systems for its pleiotropic indications, including an ability to enhance “vitality”. However, the polyvalent adaptogenic potential of O..

OncologyImmune supportEnergy & fatigueMetabolic health

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Cordyceps · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.

Background/Objectives: The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus), known for its ability to enhance "vitality," is one of the most popular medicines in Asian traditional medical systems. According to the Chinese Pharmacopeia, O..

OncologyImmune supportEnergy & fatigueMetabolic health

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Snow Fungus · 2026 · Research Article · Nature communications

Polymorphism and evolutionary origins of accessory chromosomes in the basidiomycete Tremella fuciformis.

Accessory chromosomes are non-essential for growth but poorly characterized in basidiomycetes, unlike in Ascomycota. Here, we report whole-genome sequencing of 16 strains of the basidiomycete Tremella fuciformis (silver ear fungus), generating 27 complete haplotypes (5 monokaryons and 11 dikaryons, each contributing….

High relevance

Reishi · 2026 · Research Article · Biomolecules

Polysaccharide Peptide from Ganoderma lucidum Reduces Acute Kidney Injury Through Regulating the Integrin β3/Fn1 Axis.

Acute kidney injury (AKI) continues to pose a significant clinical challenge due to its high morbidity rates and limited therapeutic options. Recent evidence suggests that natural compounds may provide renoprotective benefits by modulating oxidative stress and inflammation..

Immune support

High relevance

King Oyster · 2026 · Research Article · Food chemistry: X

Polysaccharides from Pleurotus eryngii: sequential extraction and structural characterization.

Polysaccharides, a primary component from Pleurotus eryngii (P. eryngii), have diverse biological activities.

Immune support

High relevance

Cordyceps · 2026 · Journal Article · Journal of basic microbiology

Predictive Modeling of Cordycepin Content in Cordyceps militaris Using Machine Learning Based on Cultivation Conditions.

Cordycepin, a nucleoside analog derived from Cordyceps militaris, is a bioactive compound with potent pharmacological properties and growing relevance in functional food and pharmaceutical industries..

Cognition & nervesEnergy & fatigue

High relevance

King Oyster · 2026 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Preparation and characterization of Pleurotus eryngii polysaccharides/hyperbranched poly-L-lysine composite film and its application in cherry preservation

In this study, Pleurotus eryngii polysaccharides (PEP)-hyperbranched poly-L-lysine (HBPL) composite film was prepared, and its physicochemical and functional properties were characterized. Subsequently, cherries were selected as the model system to evaluate the preservation efficacy of the composite film..

Immune support