MycoData

The Pleurotus eryngii polysaccharides (PEP1) were isolated and purified. The structure of PEP1 was characterized, and its anti-fatigue activity was studied.

Immune supportEnergy & fatigueGut & microbiomeLiver support

High relevance

Reishi · 2026 · Research Article · Biomedicines

Protective Antioxidant Effects of Ganoderma lucidum Against Prenatal Chlorpyrifos-Induced Developmental Nephrotoxicity in Rats.

Background/Objectives: Chlorpyrifos (CPF), a widely used organophosphate pesticide, has been associated with oxidative stress-mediated renal injury. Prenatal exposure may pose a risk for developmental nephrotoxicity; however, data regarding protective natural agents remain limited..

Immune support

High relevance

Cordyceps · 2026 · Journal Article · Neurotoxicity research

Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model.

BACKGROUND AND OBJECTIVES: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neurons in specific areas of the brain, often worsened by cigarette smoke through oxidative stress and inflammation. Cordyceps militaris (C..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2026 · Journal Article · Experimental eye research

Protective effects of topical and oral Ganoderma lucidum extracts against ultraviolet B-induced cataract development and chemical ocular surface injury in a rat model.

PURPOSE: To evaluate protective and therapeutic effects of oral and topical Ganoderma lucidum in a rat model of ultraviolet B (UVB)- and sodium hydroxide (NaOH)-induced ocular injury. METHODS: Twenty-eight male Sprague-Dawley rats were allocated to sham, injury, oral G.

Skin & hydration

High relevance

Lion's Mane · 2026 · Journal Article · Journal of agricultural and food chemistry

Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery of Membrane-Associated Proteins in Hericium erinaceus.

Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations..

Energy & fatigue

High relevance

Chaga · 2026 · Journal Article · Planta medica

Quantitative Analysis and Simultaneous Characterization of Triterpenoids and Phenolics in Inonotus obliquus (Chaga) Using LC-PDA-ELSD and LC-DAD-QToF.

Inonotus obliquus is widely recognized as the Chaga mushroom. Chaga contains various bioactive compounds, including polysaccharides, triterpenoids, polyphenols, and melanin..

Immune supportSkin & hydration

High relevance

Oyster Mushroom · 2026 · Research Article · Sensors (Basel, Switzerland)

Research on Precise Detection Methods for the Maturity of Pleurotus ostreatus in Complex Mushroom Cultivation Environments.

Addressing the challenges of complex background interference, low lighting conditions, small target recognition, and difficulty in maturity grading in the automated detection of Pleurotus ostreatus, this study proposes a lightweight improved scheme based on color feature enhancement..

Cognition & nerves

High relevance

Snow Fungus · 2026 · Review · International journal of biological macromolecules

Research progress in polysaccharides from the Tremella fuciformis (silver ear): extraction, purification, structural features, health-promoting activities, and potential applications.

Tremella fuciformis polysaccharides (TFPs), as one of the pivotal functional constituents of T. fuciformis, have attracted increasing attention because of their diverse health-promoting activities..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2026 · Journal Article · Bioresource technology

Role of the global regulatory factor VeA in Cordyceps militaris and its overexpression combined with tea polyphenols to enhance cordycepin production.

Cordyceps militaris has recently been regarded as a promising chassis for high-value compound production owing to its advantage in liquid fermentation, while further exploration of genetic targets and exogenous effectors is needed to enhance its productivity..

Metabolic health

High relevance

Enoki · 2026 · Research Article · Gels (Basel, Switzerland)

Root-Derived Flammulina velutipes Polysaccharides Improve Myofibrillar Protein Stability and Maintain Catfish Surimi Quality During Freeze-Thaw Cycling.

Frozen surimi, a commonly used raw material in processed aquatic products, is vulnerable to repeated freeze-thaw fluctuations that accelerate protein denaturation and quality loss..

Immune support

High relevance

Oyster Mushroom · 2026 · Research Article · ACS omega

Screening of Natural Inhibitors from Pleurotus ostreatus against PHGDH for Enhancing Antiviral Innate Immunity through Mendelian Randomization, Machine Learning, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation.

The human innate immune response plays a critical role in limiting and controlling viral infections. Consequently, therapeutic strategies that promote or modulate innate antiviral immunity are regarded as promising approaches to combating viral pathogens..

Immune supportCognition & nervesEnergy & fatigueRespiratory

High relevance

Lion's Mane · 2026 · Research Article · Molecules (Basel, Switzerland)

Simultaneous UHPLC-UV Determination of Hericenones, Hericenes, Erinacines and Ergosterol in Hericium erinaceus Raw Materials or Products.

This study describes a single-laboratory validation of an ultra-high-performance liquid chromatographic (UHPLC) method for the determination of key compounds like hericenones, hericenes, erinacines, and ergosterol in Hericium erinaceus (H. erinaceus, Lion's Mane) raw materials and finished products..

Cognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2026 · Journal Article · Current drug metabolism

Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.

BACKGROUND: Cordyceps militaris is a medicinal fungus known for producing bioactive compounds, including cordycepin, adenosine, and polysaccharides, that exhibit antioxidant, immunomodulatory, and anticancer properties..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Cordyceps · 2026 · Journal Article · The Journal of pharmacy and pharmacology

Study on the potential mechanism of Cordyceps militaris in chronic obstructive pulmonary disease via integrating metabolomics and network pharmacology.

OBJECTIVE: This research aimed to evaluate the beneficial impact of Cordyceps militaris (CM) on chronic obstructive pulmonary disease (COPD) and methodically clarify its underlying processes. METHODS: The fingerprint analysis and content determination of CM were carried out by HPLC..

Metabolic healthRespiratory

High relevance

Reishi · 2026 · Review · Journal of chromatography. A

Sustainable downstream processing of ganoderma lucidum triterpenoids: Integrated chromatographic strategies and techno-economic evaluation.

Ganoderma lucidum triterpenoids (GLTs) are high-value bioactive metabolites with increasing demand in pharmaceutical and nutraceutical sectors. However, their structural diversity, characterized by numerous analogs and structural isomers, coupled with the complexity of sources such as spores, fruiting bodies, and….

High relevance

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

Synergistic Mechanistic Insights into Anti-T2DM Benefits of Lentinula edodes: A Peptide- and Polysaccharide-Based Network Pharmacology and Molecular Docking Study.

In recent years, dietary intervention has garnered significant attention for T2DM prevention and adjunctive treatment. Lentinula edodes (commonly known as shiitake mushroom), a common edible fungus, has been demonstrated to improve T2DM, primarily attributed to its main bioactive components like peptides and….

Immune supportMetabolic health

High relevance

King Oyster · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Synergistic regulation of P. eryngii quality and protein properties by dielectric-guided gradient conversion drying and ultrasound-assisted functional rehydration of by-products.

Quality deterioration and underutilization of by-products (Pleurotus eryngii root wastes) limit the industrial drying and protein valorization of Pleurotus eryngii (P. eryngii)..

Skin & hydration

High relevance

Chaga · 2026 · Research Article · Antioxidants (Basel, Switzerland)

Three Polyphenolic Compounds from Inonotus obliquus: Antioxidant Activity, Xanthine Oxidase Inhibition, and Regulatory Effects on MyD88/TLR4/NF-κB Pathway in MSU-Induced RAW 264.7 Macrophages.

BACKGROUND: Inonotus obliquus (Chaga), a medicinal and edible macrofungus abundant in bioactive polyphenols, is a potential source of natural antioxidants and anti-inflammatory agents for functional foods..

Immune supportEnergy & fatigue

High relevance

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

Transcriptome Analysis of Postharvest Lentinula edodes Cell Wall Metabolism During Storage Indicating a Laccase-Mediated Regulatory Network.

Postharvest Lentinula edodes (shiitake mushroom) undergoes rapid textural deterioration, which is primarily driven by complex cell wall remodeling. This study investigates the physiological and transcriptomic changes in L.

Immune supportEnergy & fatigue

High relevance

Shiitake · 2026 · Research Article · Applied microbiology and biotechnology

Transcriptomic insights into fruiting body malformations in Lentinula edodes.

Lentinula edodes (shiitake mushroom), the world's most cultivated edible fungus, frequently develops malformed fruiting bodies during commercial cultivation, leading to significant economic losses..

Cognition & nerves

High relevance

Cordyceps · 2026 · Research Article · AMB Express

Transcriptomic insights into the role of CmLec4 in infection and development of Cordyceps militaris.

Entomopathogenic fungi are a diverse group of ascomycetes that infect insects and form fruiting bodies, with over 1,000 species reported globally. Among them, Cordyceps militaris has long been valued in East Asia as a traditional medicinal resource, reflecting its recognized pharmacological potential..

Cognition & nervesMetabolic health

High relevance

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Understanding the integral stereoselectivity of Cordyceps militaris lipase for medium-chain triglycerides: Tricaprylin-based kinetic and molecular docking analysis.

Medium-chain triglycerides (MCTs) have garnered considerable attention in the food and health industries due to their rapid absorption, efficient metabolism, and nutritional benefits compared to long-chain triglycerides..

Metabolic health

High relevance

Cordyceps · 2026 · Preprint · journal metadata

Untargeted metabolomics reveals species-specific metabolic signatures in Pholiota nameko, Cordyceps militaris and Lentinula edodes

Abstract Edible fungi are increasingly valued for their nutritional and medicinal properties, yet systematic comparisons of metabolic profiles among commercially important species remain limited..

Metabolic health

High relevance

Reishi · 2026 · Research Article · RSC advances

Use of Ganoderma lucidum grown on agricultural waste to remove antibiotics from water.

Antibiotic-rich effluents from farming and medical establishments into waterways pose a serious risk for antibiotics resistance, promoting a need for effective strategies of removal from the food chain and the environment..

High relevance

Shiitake · 2026 · Journal Article · Food Research International

Why does co-stewing shiitake mushrooms (Lentinula edodes) and beef synergistically enhance umami? An exploration from the perspective of umami peptides

This study investigated the synergistic umami effect of co-stewed shiitake mushroom (Lentinula edodes) and beef (SSB), focusing on umami peptides. Results showed that SSB exhibited significantly higher umami intensity than did the separately stewed and mixed preparation (SS-SB), despite no difference in equivalent….

High relevance

Shiitake · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Why does co-stewing shiitake mushrooms (Lentinula edodes) and beef synergistically enhance umami? An exploration from the perspective of umami peptides.

High relevance

Reishi · 2025 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on chemical constituents and pharmacological effects of Ganoderma lucidum spore oil].

Originating from sporoderm-broken Ganoderma lucidum spores, Ganoderma lucidum spore oil(GLSO) is prepared by supercritical fluid extraction. Chemical composition studies show that GLSO mainly contains nonpolar substances, such as fatty acids, triglycerides, and steroids..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2025 · Journal Article · Food Hydrocolloids

A comparison study on compounding oat β-glucan onto Pleurotus eryngii protein by using different methods: In vitro digestion and fermentation characteristics

This study aimed to investigate the effects under four different composite methods (electrostatic self-assembly, ultrasonic cavitation, high-pressure homogenization, and wet glycosylation), oat β-glucan (OG) on the in vitro digestion properties and in vitro fermentation properties of Pleurotus eryngii protein (PEP)..

Gut & microbiome

High relevance

Shiitake · 2025 · Research Article · PeerJ

A first trial to supplement local hardwood sawdust at the first soaking for the cultivation of Shiitake (Lentinula edodes).

Supplementation of the growing substrate has been reported to enhance the production of cultivated mushrooms; however, supplementation using nano-sized additives is not yet investigated on Shiitake (Lentinula edodes)..

High relevance

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways.

BACKGROUND AND AIM: Poria cocos (PC) is traditional Chinese medicine with sedative, diuretic, and tonic properties. Cordyceps militaris rice (CMR) is a matrix used for the solid-state culture of C.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of Ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway

According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against H2O2-induced oxidative damage.

Morchella esculenta (L.) Pers. is considered a precious edible and medicinal fungus due to its strict growth environment requirements, difficult to cultivate, resulted in expensive in the market.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

A review of the extraction technologies, structural characterization, chemical modification, and pharmacological effects of Ganoderma lucidum polysaccharides.

Ganoderma lucidum (GL) is a medicinal and edible fungal material with a long history. Ganoderma lucidum polysaccharides (GLPs), as one of the primary bioactive components in GL, exhibit multiple pharmacological effects including anti-tumor, anti-inflammatory, immunomodulatory, antioxidant, and metabolic regulatory….

OncologyImmune supportMetabolic health

High relevance

Turkey Tail · 2025 · Research Article · Frontiers in toxicology

A toxicological assessment of Hericium erinaceus (Lion's mane) and Trametes versicolor (Turkey tail) mushroom powders.

Hericium erinaceus (Lion's mane) and Trametes versicolor (Turkey Tail) mushrooms have an extensive history of use in traditional medicine and as food. Oftentimes, they are available as extract preparations produced from selected life stages such as fruiting body or mycelium..

Metabolic health

High relevance

Lion's Mane · 2025 · Journal Article · Food & function

Absorption and immune-modulating effects of active peptides from Hericium erinaceus proteins in an in vitro gastrointestinal model.

The mechanism by which fungal proteins retain immunomodulatory activity after gastrointestinal digestion remains unknown. To shed light on the mechanism, the proteins and peptides from Hericium erinaceus were explored through in vitro digestion using a Caco-2/RAW264.7 co-culture model..

Immune supportGut & microbiome

High relevance

Yellow Morel · 2025 · Journal Article · Food Chemistry

ACE-inhibitory peptides from Morchella esculenta: screening, kinetics, and molecular dynamics simulation

The global prevalence of hypertension has doubled over the past three decades and it is projected to escalate further. Hypertension is a global health concern that is closely linked to angiotensin-converting enzyme (ACE) regulation..

Metabolic health

High relevance

Yellow Morel · 2025 · Journal Article · Food chemistry

ACE-inhibitory peptides from Morchella esculenta: screening, kinetics, and molecular dynamics simulation.

Metabolic health

High relevance

Lion's Mane · 2025 · Research Article · Frontiers in nutrition

Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.

INTRODUCTION: Animal studies have suggested that Lion's Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones..

Cognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2025 · Research Article · Scientific reports

Agri-food wastes as substrates for oyster mushroom (Pleurotus ostreatus) cultivation and their agricultural potential.

Fungi of the Pleurotus genus, are known for their health-promoting properties. They are grown on a wide range of lignocellulosic substrates, including i.e.

Gut & microbiome

High relevance

Lion's Mane · 2025 · Research Article · Nutrients

Alteration of Gastrointestinal Function and the Ameliorative Effects of Hericium erinaceus Polysaccharides in Tail Suspension Rats.

Background/Objectives: Long-term spaceflight in a microgravity environment frequently results in gastrointestinal dysfunction, presenting substantial challenges to astronauts' health..

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Preprint · journal metadata

Altered stereostructures of the DNA-binding domains in the mutant mating proteins of Ophiocordyceps sinensis and the Cordyceps sinensis insect‒fungal complex

The MATα_HMGbox and HMG-box_ROX1-like domains of the MAT1-1-1 and MAT1-2-1 proteins, respectively, play essential roles in DNA binding and the downstream regulation of gene transcription that controls sexual reproduction in Ophiocordyceps sinensis..

High relevance

Wood Ear · 2025 · Research Article · Frontiers in nutrition

Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation.

As a major nutraceutical component of a traditional edible fungus Auricularia auricula-judae, Auricularia auricula-judae polysaccharide (AAP) has been well-documented due to its outstanding hypolipidemic and hypoglycemic bioactivities..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Preprint · journal metadata

Analysis of codon usage bias between Ophiocordyceps sinensis and Thitarodes xiaojinensis

Abstract Background Ophiocordyceps sinensis is a well - known entomogenous fungus, which has attracted much attention due to its unique medicinal value and complex ecological relationships..

Energy & fatigue

High relevance

Reishi · 2025 · Research Article · PeerJ

Analysis of the chitin synthase gene family in Ganoderma lucidum: its structure, phylogeny, and expression patterns.

BACKGROUND: Chitin synthases are essential enzymes in fungi, contributing to various biological processes such as hyphal growth, sporulation, and cell wall stability. Despite their well-documented functions in other fungal species, the specific roles of chitin synthases in Ganoderma lucidum remain unexplored..

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Anti-Allergic Effects of Dietary Caterpillar Mushroom Cordyceps militaris (Ascomycota) Derived from Eri Silkworm.

Allergic disorders affect a substantial proportion of the global population, and current treatments often focus on symptom management rather than addressing the underlying immunological imbalances. Cordyceps militaris (L.) Fr.

Immune supportGut & microbiome

High relevance

Snow Fungus · 2025 · Research Article · Nutrients

Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study.

Background/Objectives: Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2025 · Journal Article · Journal of basic microbiology

Antifungal Efficacy of Cordyceps militaris-Mycometabolites Against Major Fungal Diseases of Withania somnifera.

Withania somnifera (Ashwagandha), a vital medicinal plant, faces significant losses due to fungal diseases such as root rot, wilt, and leaf spot caused by Fusarium annulatum and Alternaria alstroemeriae..

High relevance

Cordyceps · 2025 · Journal Article · Journal of Basic Microbiology

Antifungal Efficacy of Cordyceps militaris‐Mycometabolites Against Major Fungal Diseases of Withania somnifera

High relevance

Enoki · 2025 · Journal Article · Food Research International

Antimicrobial effect of lauroyl arginate ethyl on Listeria monocytogenes and its application in controlling microbial contamination of enoki mushrooms (Flammulina velutipes)

The aim of this study was to investigate the antimicrobial activity and antimicrobial mechanisms of lauroyl arginate ethyl (LAE) against Listeria monocytogenes and its practical application in controlling microbial growth on enoki mushrooms. LAE showed strong antimicrobial activity against L.

Energy & fatigue