MycoData

Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains a major public health concern globally. However, administration of inactivated rabies vaccination without adjuvants is always inefficient and necessitates four to five injections..

Immune supportCognition & nervesMetabolic healthRespiratory

High relevance

Cordyceps · 2024 · Review · Bioengineering (Basel, Switzerland)

Advancing Cordyceps militaris Industry: Gene Manipulation and Sustainable Biotechnological Strategies.

Cordyceps militaris is considered to be of great medicinal potential due to its remarkable pharmacological effects, safety, and edible characteristics. With the completion of the genome sequence and the advancement of efficient gene-editing technologies, coupled with the identification of gene functions in Cordyceps….

Immune support

High relevance

Cordyceps · 2024 · Research Article · Journal of food and drug analysis

Alanine supplementation enhancing cordycepin production in Cordyceps militaris via upregulation of Cns2 and Cns3 genes expression levels.

Cordycepin, a key bioactive compound produced by Cordyceps militaris, faces the challenge of low productivity for commercial use. In this study, alanine supplementation in Cordyceps militaris boosted cordycepin production, peaking at 3 mg/g with 12 g/L concentration..

High relevance

Cordyceps · 2024 · Journal Article · Journal of pharmaceutical and biomedical analysis

Amelioration of hyperuricemia by cordycepin and Cordyceps militaris aqueous extract in mice via modulating gut microbiota and restoring metabolic profile.

In this study, we first screened and evaluated the inhibitory effects of seven medicinal fungi on diseases such as hyperuricemia (HUA). Then, using metabolomics and gut microbiome methods, the focus was on analyzing and evaluating the effects of the aqueous extract of Cordyceps..

Metabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Polish journal of veterinary sciences

Ameliorative effects of Ganoderma lucidum (Reishi) on testicular tissue of rats exposed to bisphenol A.

Bisphenol A (BPA), an endocrine disrupting chemical, is an environmental toxicant widely used in the production of polycarbonate plastics, epoxy resins and paints. Ganoderma lucidum (GDL) is a plant with biological activities widely used in Chinese medicine..

Oncology

High relevance

Chaga · 2024 · Journal Article · Forest ecology and management

An investigation of Inonotus obliquus in Estonia: Its distribution, abundance of conks, rot extent in infected trees, and peculiarities of basidiospore dispersal

Inonotus obliquus, a well-known forest fungal pathogen, started gaining attention for its potential medicinal uses. Known as Chaga, the fungus has become prominent due to the bioactive compounds present in its conks.

High relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

An sn-2 regioselective lipase with cis-fatty acid preference from Cordyceps militaris: Biochemical characterization and insights into its regioselective mechanism.

Lipase with unique regioselectivity is an attractive biocatalyst for elaborate lipid modification. However, the excavation of novel sn-2 regioselective lipases is difficult due to their scarcity in nature, with Candida antarctica lipase A (CALA) being the pronouncedly reported one..

Energy & fatigue

High relevance

Cordyceps · 2024 · Journal Article · International journal of food science & technology

Analysis of bioactive compounds in Cordyceps militaris fruiting bodies and dietary supplements: in vitro bioaccessibility determination in artificial digestive juices

In recent years, Cordyceps militaris has garnered increased attention in both scientific research and popular culture, exemplified by references in the entertainment industry, such as ‘The Last Of Us’..

Gut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Biology

Analysis of Metabolic Profiles and Antioxidant Activity of Chinese Cordyceps, Ophiocordyceps sinensis, and Paecilomyces hepiali Based on Untargeted Metabolomics.

Chinese cordyceps (GL) is a traditional medicinal fungus, with Ophiocordyceps sinensis (O. sinensis, BL) and Paecilomyces hepiali (P.

Metabolic health

High relevance

Cordyceps · 2024 · Research Article · Scientific reports

Analysis of metabolic spectrum characteristics of naturally and cultivated Ophiocordyceps sinensis based on non-targeted metabolomics.

The analysis of the differences in metabolic profiles between naturally Ophiocordyceps sinensis (NO) and cultivated Ophiocordyceps sinensis (CO) is an essential process for the medicinal value mining of Ophiocordyceps sinensis..

Energy & fatigueMetabolic health

High relevance

Almond Mushroom · 2024 · Research Article · International journal of molecular sciences

Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells.

UVB radiation is known to induce photodamage to the skin, disrupt the skin barrier, elicit cutaneous inflammation, and accelerate the aging process. Agaricus blazei Murill (ABM) is an edible medicinal and nutritional fungus..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

King Oyster · 2024 · Journal Article · International journal of biological macromolecules

Antibacterial and hemostatic chitin sponge directly constructed from Pleurotus Eryngii via top-down approach.

Chitin, the second most abundant polysaccharide on earth, possesses unique characteristics, including biosafety, biodegradability, and procoagulant activity, making it an attractive material for hemostasis. However, the conventional bottom-up construction of chitin-based materials is intricate and time-consuming..

Immune supportCognition & nervesLiver supportSkin & hydration

High relevance

Chaga · 2024 · Journal Article · Journal of complementary & integrative medicine

Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice.

OBJECTIVES: The Inonotus obliquus is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural Inonotus obliquus….

Metabolic healthLiver support

High relevance

Cordyceps · 2024 · Preprint · journal metadata

Antifungal Efficacy of Cordyceps militaris-Mycometabolites against major fungal diseases of Withania somnifera

Withania somnifera (Ashwagandha), a vital medicinal plant, faces significant losses due to fungal diseases such as root rot, wilt, and leaf spot caused by Fusarium annulatum and Alternaria alstroemeriae. To manage these pathogens, metabolites of Cordyceps militaris were extracted following methods from Vinale et al..

High relevance

King Oyster · 2024 · Research Article · Foods (Basel, Switzerland)

Antimicrobial Activity of Grapefruit Seed Extract on Edible Mushrooms Contaminations: Efficacy in Preventing Pseudomonas spp. in Pleurotus eryngii.

Pleurotus eryngii is an edible mushroom that suffers significant losses due to fungal contamination and bacteriosis. The Pseudomonadaceae family represents one of the most frequent etiologic agents..

High relevance

Shiitake · 2024 · Journal Article · Journal of general plant pathology

Antimicrobial activity of octan-3-one released from spent mushroom substrate of shiitake (Lentinula edodes) and its inhibitory effects on plant diseases

Volatiles released from the spent mushroom substrate (SMS) of shiitake mushrooms (Lentinula edodes) are known to be effective for suppressing the Alternaria sooty spot disease of cabbage that is caused by Alternaria brassicicola..

High relevance

Oyster Mushroom · 2024 · Research Article · Frontiers in nutrition

Antioxidant capacities and non-volatile metabolites changes after solid-state fermentation of soybean using oyster mushroom (Pleurotus ostreatus) mycelium.

Given the abundance of beneficial properties and enzymes secreted by edible oyster mushrooms, their mycelium could serve as a starter for fermented foods to enhance their nutritional and bioactive quality..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2024 · Journal Article · South African journal of botany

Antioxidant potential and cytotoxicity of Cordyceps militaris in vitro culture extracts

Cordyceps militaris is an entomopathogenic fungus with therapeutic potential in humans. The focus is on its hydroalcoholic extracts, which were obtained from biomass cultured in vitro in molasses..

OncologyMetabolic health

High relevance

Reishi · 2024 · Research Article · Frontiers in nutrition

Application of Electronic tongue and HPLC in rapid determination of functional triterpenes and origins of Ganoderma lucidum.

INTRODUCTION: Ganoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Ganoderic acid D, as well as the sensory characteristics could reflect the quality of G.

Energy & fatigue

High relevance

Reishi · 2024 · Journal Article · Drug and chemical toxicology

Assessment of redox homeostasis via genotoxicity, cytotoxicity, apoptosis and NRF-2 in colorectal cancer cell lines after treatment with Ganoderma lucidum extract.

This study aimed to investigate the cytotoxic and apoptotic effects of Ganoderma lucidum, Pleurotus ostreatus, Pleurotus eryngii, and Inonotus hispidus fungal extracts on HT-29 and HCT-116 colorectal cancer cell lines and to search the DNA damage and oxidative stress caused by these extracts..

OncologyGut & microbiome

High relevance

King Oyster · 2024 · Research Article · Plants (Basel, Switzerland)

Biochemical Characterization and Disease Control Efficacy of Pleurotus eryngii-Derived Chitosan-An In Vivo Study against Monilinia laxa, the Causal Agent of Plum Brown Rot.

Chitin (Ct) is a crucial biopolymer present in fungi, algae, arthropods, and is usually obtained from crustacean shells. Chitosan (Cs) is a derivative from Ct deacetylation, and possesses numerous uses in various agro-industrial fields..

Oncology

High relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Biodegradable bio-film based on Cordyceps militaris and metal-organic frameworks for fruit preservation.

In this study, Cordyceps militaris matrix was employed for the first time to fabricate a biodegradable food packaging. Carmine and Ag@CuBTC were introduced to cross-link with mycelium and were uniformly dispersed within the matrix to enhance the water resistance, antimicrobial, and antioxidant properties of the….

High relevance

King Oyster · 2024 · Journal Article · Environmental science and pollution research international

Biodegradation of malachite green by Pleurotus eryngii: a study on decolorization, mechanism, toxicity, and enzyme.

The purpose of this study was to investigate the biodegradation of malachite green (MG) by Pleurotus eryngii via decolorization. This study also explored the possible mechanisms and toxicity.

High relevance

Cordyceps · 2024 · Journal Article · Journal of natural products

Bioinformatic Approaches Identify Hybrid Antibiotics against Tuberculosis via d-Amino Acid-Activating Adenylation Domains from Cordyceps militaris.

The development of tuberculosis (TB) therapy has been marked by the discovery of natural-product-derived streptomycin, followed by the introduction of NP-derived rifampicin, representing a significant milestone in the history of TB management..

Oncology

High relevance

Cordyceps · 2024 · Preprint · journal metadata

Biological characteristics of Cordyceps militaris single mating-type strains

Abstract Cordyceps militaris has been extensively cultivated as a model cordyceps species for commercial purposes. Nevertheless, the problems related to strain degeneration and breeding technologies remain unresolved.

High relevance

Cordyceps · 2024 · Journal Article · Archives of microbiology

Biological characteristics of Cordyceps militaris single mating-type strains.

Cordyceps militaris has been extensively cultivated as a model cordyceps species for commercial purposes. Nevertheless, the problems related to strain degeneration and breeding technologies remain unresolved.

High relevance

Chaga · 2024 · Research Article · Biomolecules

Chaga Mushroom Triterpenoids Inhibit Dihydrofolate Reductase and Act Synergistically with Conventional Therapies in Breast Cancer.

Inonotus obliquus (Chaga) is a medicinal mushroom with several pharmacological properties that is used as a tea in traditional Chinese medicine. In this study, Chaga water extract was digested in vitro to mimic the natural processing and absorption of its biocomponents when it is consumed as functional beverage, and….

OncologyImmune supportGut & microbiome

High relevance

Cordyceps · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Changes in aggregation properties and the metabolite production of probiotics following treatment with polysaccharides derived from the edible mushroom Cordyceps militaris

Low-molecular-weight exopolysaccharides of Cordyceps militaris (LCMP), obtained by enzymatically digesting the exopolysaccharide produced by C. militaris, were purified and found to be comprised of 77.9% mannose and 22.1% glucose..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2024 · Journal Article · Journal of food composition and analysis

Characterization of two Tunisian strains of culinary oyster mushroom Pleurotus eryngii: Differences in the biopolymer composition

Two Tunissian strains of oyster mushrooms, identified as Pleurotus eryngii var. elaeoselini and var.

Immune support

High relevance

Cordyceps · 2024 · Research Article · Journal of microbiology and biotechnology

Characterization, Antioxidant Capacity and Protective Effect of Peptides from Cordyceps militaris Cultivated with Tussah Pupa on Oxidative Injured HepG2 Cells.

The antioxidant capacity and protective effect of peptides from protein hydrolysate of Cordyceps militaris cultivated with tussah pupa (ECPs) on H2O2-injured HepG2 cells were studied. Results indicated ECP1 (<3 kDa) presented the strongest antioxidant activity compared with other molecular weight peptides..

OncologySkin & hydration

High relevance

Chaga · 2024 · Preprint · journal metadata

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens

Chaga (Inonotus obliquus) is a pathogenic fungus that grows mostly on birch species (Betula pendula and B. pubescens) and has traditionally been used as an anti-cancer medicine.

Oncology

High relevance

Chaga · 2024 · Research Article · Pharmaceuticals (Basel, Switzerland)

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens.

Chaga mushroom (Inonotus obliquus) is a pathogenic fungus that grows mostly on birch species (Betula pendula Roth and B. pubescens Ehrh.) and has traditionally been used as an anticancer medicine.

Oncology

High relevance

Reishi · 2024 · Review · Chinese medicine

Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum.

Ganoderma lucidum is a precious fungus, particularly valued for its dual use as both medicine and food. Ganoderic acids (GAs), the distinctive triterpenoids found in the Ganoderma genus, exhibit a wide range of pharmacological activities..

High relevance

Maitake · 2024 · Research Article · Toxicology research

Chitosan and Grifola Frondosa nanoparticles insulate liver dysfunction in EAC-bearing mice.

BACKGROUND: Ehrlich ascites carcinoma (EAC) is a rapidly growing and undifferentiated tumor that can prompt oxidative stress and liver toxicity, whereas chitosan and Grifola Frondosa have widely recognized biological qualities..

OncologyMetabolic healthLiver support

High relevance

Cordyceps · 2024 · Research Article · Pharmaceuticals (Basel, Switzerland)

Coffee with Cordyceps militaris and Hericium erinaceus Fruiting Bodies as a Source of Essential Bioactive Substances.

Drinking coffee is a daily routine for many people. Supplement manufacturers have proposed adding powdered Cordyceps militaris, known for its ergogenic and immunostimulating properties, and Hericium erinaceus, known for its nerve growth factor (NGF)-stimulating properties, to coffee..

Immune supportCognition & nerves

High relevance

Cordyceps · 2024 · Research Article · BMC genomics

Combined metabolome and transcriptome analysis reveal the mechanism of water stress in Ophiocordyceps sinensis.

BACKGROUND: Ophiocordyceps sinensis (O. sinensis) is the dominant bacterium in the asexual stage of Chinese cordyceps, and its growth usually suffers from water stress.

Energy & fatigueMetabolic healthSkin & hydration

High relevance

Lion's Mane · 2024 · Research Article · ACS omega

Combining Deep Learning and Structural Modeling to Identify Potential Acetylcholinesterase Inhibitors from Hericium erinaceus.

Alzheimer's disease (AD) is the most common type of dementia, affecting over 50 million people worldwide. Currently, most approved medications for AD inhibit the activity of acetylcholinesterase (AChE), but these treatments often come with harmful side effects..

Cognition & nervesEnergy & fatigue

High relevance

Oyster Mushroom · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Comparative Analysis of Freeze-Dried Pleurotus ostreatus Mushroom Powders on Probiotic and Harmful Bacteria and Its Bioactive Compounds.

Pleurotus ostreatus (oyster mushroom) holds excellent promise worldwide, bringing several opportunities and augmenting the tool sets used in the biotechnology field, the food industry, and medicine. Our study explores the antimicrobial and probiotic growth stimulation benefits of freeze-dried P..

Immune supportGut & microbiomeSkin & hydration

High relevance

Oyster Mushroom · 2024 · Research Article · Scientific reports

Comparative antioxidant activity and phytochemical content of five extracts of Pleurotus ostreatus (oyster mushroom).

Reactive oxygen species reacts with numerous molecules in the body system causing oxidative damage, which requires antioxidants to ameliorate. Pleurotus ostreatus, a highly nutritious edible mushroom, has been reported to be rich in bioactive compounds..

Energy & fatigue

High relevance

Enoki · 2024 · Journal Article · Journal of food composition and analysis

Comparative Assessment of β-glucan Composition and Structural Characterization in Wild and Commercial Enoki Mushrooms, Flammulina velutipes

This study investigated the β-glucan content and structure in an indigenous Enoki mushroom compared with a European commercial strain. Both Enoki types belonged to the same species, Flammulina velutipes, and grew on the same substrate..

Immune supportEnergy & fatigue

High relevance

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Comparing application methods of reishi mushroom (Ganoderma lucidum) extract in deep‐fried meatballs: impact on heterocyclic aromatic amine formation

BACKGROUND: The present research was conducted to investigate the impact of reishi mushroom extract (RME) on the formation of heterocyclic aromatic amines (HAAs) in meatballs..

High relevance

King Oyster · 2024 · Research Article · Frontiers in chemistry

Composition and antimicrobial activity of hydroalcoholic extracts of Pleurotus eryngii var. ferulae and P. eryngii var. elaeoselini.

BACKGROUND: The basidiomycetes Pleurotus eryngii var. ferulae Lanzi and P.

High relevance

Enoki · 2024 · Journal Article · International journal of biological macromolecules

Comprehensive evaluation of Flammulina velutipes residues polysaccharide based on in vitro digestion and human fecal fermentation.

Flammulina velutipes residues (FVR) are the waste culture medium derived from the collection of Flammulina velutipes fruiting bodies, with an annual output that remains largely unexplored..

Immune supportGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Journal of microbiology and biotechnology

Construction of a New Agrobacterium tumefaciens-Mediated Transformation System based on a Dual Auxotrophic Approach in Cordyceps militaris.

Cordyceps militaris is a significant edible fungus that produces a variety of bioactive compounds. We have previously established a uridine/uracil auxotrophic mutant and a corresponding Agrobacterium tumefaciens-mediated transformation (ATMT) system for genetic characterization in C..

High relevance

Oyster Mushroom · 2024 · Research Article · Frontiers in microbiology

Contrasting effects of NADPH oxidases on the fungal hyphae growth and immune responses in Pleurotus ostreatus.

Pleurotus ostreatus is one of the most consumed mushroom species, as it serves as a high-quality food, favors a rich secondary metabolism, and has remarkable adaptability to the environment and predators..

Immune supportEnergy & fatigue

High relevance

King Oyster · 2024 · Research Article · Brazilian journal of microbiology: [publication of the Brazilian Society for Microbiology]

Copper increases laccase gene transcription and extracellular laccase activity in Pleurotus eryngii KS004.

The white-rot fungus Pleurotus eryngii secretes various laccases involved in the degradation of a wide range of chemical compounds. Since the laccase production is relatively low in fungi, many efforts have been focused on finding ways to increase it, so in this study, we investigated the effect of copper on the….

High relevance

Cordyceps · 2024 · Research Article · Antioxidants (Basel, Switzerland)

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets.

Cordycepin is considered a major bioactive component in Cordyceps militaris extract. This study was performed to evaluate the ameliorative effect of Cordyceps militaris extract (CME) and cordycepin (CPN) supplementation on intestinal damage in LPS-challenged piglets..

Immune supportGut & microbiome