MycoData

BACKGROUND: Ganoderma lucidum extracts are widely used as adjuvants in the treatment of triple-negative breast cancers (TNBC) in China. However, its clinical value in TNBC remains unclear..

Oncology

High relevance

King Oyster · 2025 · Journal Article · Food Microbiology

Survival of Listeria monocytogenes on growing and harvested Trumpet Royale (Pleurotus eryngii), Alba Clamshell (Hypsizygus tessellatus), and Brown Clamshell (Hypsizygus tessellatus) mushrooms

Outbreaks and recalls of Listeria monocytogenes associated with commercial mushrooms have been reported in recent years. Unfortunately, knowledge about the survival of L.

High relevance

King Oyster · 2025 · Journal Article · Food microbiology

Survival of Listeria monocytogenes on growing and harvested Trumpet Royale (Pleurotus eryngii), Alba Clamshell (Hypsizygus tessellatus), and Brown Clamshell (Hypsizygus tessellatus) mushrooms.

Outbreaks and recalls of Listeria monocytogenes associated with commercial mushrooms have been reported in recent years. Unfortunately, knowledge about the survival of L.

High relevance

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Sustainable valorization of Inonotus obliquus via temperature-gated natural deep eutectic solvents extraction: Polysaccharide-antioxidant partitioning.

Inonotus obliquus is a medicinal mushroom rich in bioactive metabolites, including polysaccharides and antioxidants, that provide notable nutritional and therapeutic benefits..

Immune support

High relevance

Zhu Ling · 2025 · Research Article · Frontiers in microbiology

Symbiotic relationship between Polyporus umbellatus and Armillaria gallica shapes rhizosphere bacterial community structure and promotes fungal growth.

AIMS: Polyporus umbellatus sclerotium, known for its diuretic properties, relies on a symbiotic association with Armillaria for its growth and quality development. However, the impact of soil microorganisms on this symbiosis remains uncertain and warrants investigation..

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Synergistic anti-inflammatory effects of Ganoderma lucidum polysaccharide and ganoderic acid A on LPS-induced RAW264.7 cells by inhibition of TLR4/NF-κB activation.

Ganoderma lucidum, a food-grade medicinal mushroom, is rich in biologically active components that offer significant health benefits. This study investigated the synergistic anti-inflammatory effects of Ganoderma lucidum polysaccharide (GLP-1) and ganoderic acid A (GAA) in RAW264.7 cells..

Immune supportEnergy & fatigue

High relevance

King Oyster · 2025 · Journal Article · Journal of the science of food and agriculture

Systematic comparison of the effects of exogenous inorganic selenium and organic selenium on the quality and antioxidant capacity of Pleurotus eryngii

BACKGROUND: Pleurotus eryngii is an ideal food to improve the nutritional status of selenium (Se) in the human body. Besides Se accumulation and speciation, quality parameters and antioxidant capacity are key factors in determining the nutritional value of P.

Immune support

High relevance

Reishi · 2025 · Research Article · Discover oncology

Systematic network pharmacology and experimental validation reveal anti-glioma mechanisms of ganoderma lucidum via multi-target regulation.

BACKGROUND: Glioma is the most common and lethal primary brain tumor with limited therapeutic options and poor prognosis. Traditional Chinese medicine (TCM) offers a promising avenue for discovering multi-target agents against complex diseases..

OncologyCognition & nervesGut & microbiomeSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Current pharmaceutical design

Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking.

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced insulin sensitivity in the body's cells, leading to persistently high blood glucose levels..

Immune supportMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress.

Cordyceps militaris, a model species in the genus Cordyceps, is widely distributed globally and is known for its significant medicinal value. It has been traditionally used in Chinese medicine to enhance immunity, alleviate fatigue, and treat tumors, among other therapeutic purposes..

OncologyImmune supportEnergy & fatigue

High relevance

King Oyster · 2025 · Research Article · Polymers

Tenebrio molitor Could Be an Efficient Pre-Treatment Bioagent for Polystyrene Initial Deterioration and Further Application of Pleurotus eryngii and Trametes versicolor in Microplastic Biodegradation.

Plastic is a major organic pollutant globally but has only recently been recognized for its recalcitrant nature and resistance to degradation. Although vast amounts of plastic debris are overwhelming the planet, the search for solutions to its degradation has only recently begun..

High relevance

Chaga · 2025 · Journal Article · Bioscience, biotechnology, and biochemistry

The aqueous extracts of Inonotus obliquus (Chaga) augment host defense against Listeria monocytogenes infection.

Listeria monocytogenes, which grows in host cells intracellularly, is important as an opportunistic pathogen. Extracts of Chaga mushroom, Inonotus obliquus, have been shown to possess various biological activities.

OncologyImmune supportLiver support

High relevance

Oyster Mushroom · 2025 · Journal Article · Bulletin of experimental biology and medicine

The Effect of β-D-Glucans of Pleurotus ostreatus (Oyster Mushroom) on the Development of Myelosuppression and Colitis Induced by 5-Fluorouracil in Mice.

We studied the effect of the water-soluble fraction of the extract containing β-glucans from Pleurotus ostreatus (oyster mushroom) on myelosuppression and colitis induced by 5-fluorouracil (5-FU) in male BALB/c mice..

OncologyMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · Animal feed science and technology

The effects of dietary Cordyceps militaris substrate on growth, immunity, gonadal quality, and gut microbiota of the sea urchin Strongylocentrotus intermedius

Sea urchin Strongylocentrotus intermedius is a commercially valuable marine species in China. Cordyceps militaris culture (CMC), containing cordycepin, polysaccharides, cordycepic acid, amino acids, trace elements, and vitamins, was tested in varying concentrations (0.5 %, 1.0 %, and 1.5 %) in sea urchin feed to….

Immune supportGut & microbiome

High relevance

Cordyceps · 2025 · Journal Article · Journal of food science

The fermentation of Cordyceps militaris polysaccharide influenced gut bacterial LPS structure formation and changed its antigenicity.

Gut bacterial lipopolysaccharide (LPS) could be released into the circulatory system via the gut-liver axis and cause inflammatory immune response, while Cordyceps militaris polysaccharide (CMP40) has been reported to be effective in alleviating this inflammatory response..

Immune supportGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2025 · Research Article · Foods (Basel, Switzerland)

The Impact of Oyster Mushrooms (Pleurotus ostreatus) on the Baking Quality of Rye Flour and Nutrition Composition and Antioxidant Potential of Rye Bread.

This study aimed to evaluate the use of oyster mushroom (Pleurotus ostreatus) powder (OMP) for producing rye bread. The raw materials were low-extract rye flour and OMP, which were analyzed in terms of their nutritional and health-promoting qualities..

Gut & microbiome

High relevance

King Oyster · 2025 · Research Article · Food chemistry: X

The impact of Pleurotus eryngii on myofibrillar protein: Physicochemical properties and structural alterations in quick-frozen pork patties during freeze-thaw cycles.

This study investigated the impact of Pleurotus eryngii (PE) on the oxidative stability and gel characteristics of myofibrillar protein (MP) from pork patties undergoing multiple freeze-thaw (F-T) cycles. Pork patties with PE served as the experimental group, and those without PE as the control group..

High relevance

Oyster Mushroom · 2025 · Preprint · journal metadata

The Influence of Nematocidal Plants on the Effectiveness of Pleurotus ostreatus Mycelium Against Nematodes, a Model Organism - Caenorhabditis elegans and Phytopathogenic – Heterodera schachtii

The vegetative mycelium of Pleurotus ostreatus (oyster mushroom) exhibits the ability to reduce nematode populations. This property may be utilized in integrated management programs targeting harmful nematodes such as Heterodera schachtii, a major pest of sugar beet crops..

Gut & microbiome

High relevance

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo.

Lung injury is a critical health concern associated with severe inflammatory responses and tissue damage that can weaken respiratory function and potentially become life-threatening in severe cases..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Oyster Mushroom · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

The Mechanism of Ammonia-Assimilating Bacteria Promoting the Growth of Oyster Mushrooms (Pleurotus ostreatus).

Oyster mushrooms (Pleurotus ostreatus) are one of the most commonly grown edible mushrooms using compost, which contains high concentrations of ammonia. In this study, inoculation of the oyster mushroom culture substrate with ammonia-assimilating bacterium Enterobacter sp..

Energy & fatigue

High relevance

Reishi · 2025 · Review · Food science & nutrition

The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.

This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2025 · Research Article · Foods (Basel, Switzerland)

The Performance of Pleurotus eryngii β-Glucans on Protein Digestion and the Release of Free Amino Acids in the Bloodstream of Obese Adults.

Pleurotus eryngii is an edible mushroom with previously characterized β-glucans. Its potential to ameliorate postprandial glycemia and regulate appetite at the postprandial state has been previously shown.

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Research Article · Scientific reports

The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.

This study investigates the protective mechanisms of Ganoderma lucidum polysaccharides (GLP) on retinal neurovascular units (NVUs) in a rat model of retinal ischemia-reperfusion injury (RIR), focusing on oxidative stress, glial activation, vascular dysfunction, and functional recovery..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · Microbial cell factories

The Velvet protein vea: a key positive regulator of growth and cordycepin biosynthesis in Cordyceps militaris.

Cordyceps militaris (C. militaris) is a prized medicinal fungus and a rich source of bioactive compounds, notably cordycepin.

High relevance

King Oyster · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii.

Background/Objectives: Over the past twenty years, there has been a rapid increase in studies aimed at comprehending how cells communicate with each other via Extracellular Vesicles (EVs), accompanied by a heightened interest in plant-derived extracellular vesicles due to their potential relevance in dietary….

OncologyImmune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2025 · Research Article · Frontiers in pharmacology

Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy.

BACKGROUND: Diabetic nephropathy (DN), a leading cause of chronic kidney disease and end-stage renal disease, is a serious complication of type 2 diabetes mellitus (T2DM). Current therapies primarily slow disease progression but are unable to reverse kidney damage, highlighting the need for novel therapy to treat DN..

Metabolic healthLiver support

High relevance

Turkey Tail · 2025 · Research Article · Fungal biology and biotechnology

Transcriptome response of the white-rot fungus Trametes versicolor to hybrid poplar exhibiting unique lignin chemistry.

BACKGROUND: Production of biofuels and bioproducts from lignocellulosic material is limited due to the complexity of the cell wall structure. This necessitates the use of physical, chemical, and/or physico-chemical pretreatment technologies, which adds significant capital, operational, and environmental costs..

High relevance

Shiitake · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Transcriptomic analysis reveals cell wall polysaccharide metabolism associated with post-harvest softening in shiitake mushrooms (Lentinula edodes)

Shiitake mushrooms (Lentinula edodes) undergo rapid softening during postharvest storage, which reduces their texture, quality, and shelf life. To elucidate the underlying mechanisms, we examined cell wall polysaccharide metabolism during storage at 10 ± 0.5 °C..

Immune support

High relevance

Oyster Mushroom · 2025 · Preprint · journal metadata

Treatment of Pharmaceutical Wastewater Using Oyster Mushroom (Pleurotus Ostreatus)

Abstract Pharmaceutical wastewater contains hazardous contaminants, including analgesics and anti-inflammatory drugs, which pose significant environmental and health risks. Conventional treatment methods are often costly and inefficient, necessitating sustainable alternatives..

Immune support

High relevance

Maitake · 2025 · Research Article · Mycoscience

Two-stage wood decay by Grifola frondosa.

In nature, only white-rot fungi can completely decompose wood biomass in the environmental carbon cycle. However, their degradation strategy is still unclear.

Immune support

High relevance

Chaga · 2025 · Journal Article · Food Biophysics

Ultrasound-Assisted Treatment from Inonotus obliquus Polysaccharides: Extraction Optimization, Structures and Antioxidant Activity

This study examined the effect of sonication conditions on the extraction rate of Inonotus obliquus polysaccharides (IOPs) through a single-factor experiment. Meanwhile, the Box-Behnken design was utilized to optimize the sonication-assisted extraction technology..

Immune supportSkin & hydration

High relevance

Reishi · 2025 · Research Article · AMB Express

Unlocking Reishi's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.

Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assessed the in-vitro antimicrobial, antitumor, antiviral as well as antioxidant capacity of Ganoderma lucidum water extract (GLWE)..

OncologyEnergy & fatigueLiver supportRespiratory

High relevance

King Oyster · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Unlocking sustainable protein from Pleurotus eryngii: Enzymatic degradation of cell wall enhances digestibility in mycelia and fruiting bodies

The bioavailability of fungal protein is constrained by the resilient chitin-based cell wall. This study aimed to enhance the digestibility of Pleurotus eryngii protein—from both fruiting bodies and mycelia—through enzymatic cell wall disruption using lywallzyme I, lywallzyme II, and snailase..

Gut & microbiome

High relevance

Reishi · 2025 · Review · Pharmaceutics

Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances.

Background:Ganoderma lucidum (GL), commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine..

OncologyImmune support

High relevance

Reishi · 2025 · Review · 3 Biotech

Unlocking the therapeutic potential of bioactive compounds in Ganoderma lucidum: a new frontier in natural medicine.

Ganoderma lucidum (Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. This study presents a detailed and up-to-date examination of G..

OncologyImmune supportCognition & nervesSkin & hydration

High relevance

Lion's Mane · 2025 · Review · Frontiers in pharmacology

Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models.

The medicinal mushroom lion's mane (Hericium erinaceus) is suggested to have therapeutic potential for neurological disorders due to its neuroprotective and neurotrophic properties. Mycelia of H..

Immune supportCognition & nerves

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Upcycling Chitin Waste and Aged Rice into Fungi Protein Through Fermentation with Cordyceps militaris.

Microbial protein represents a sustainable alternative to conventional animal protein, yet optimizing substrates for fungal cultivation remains critical. This study demonstrates the successful upcycling of chitin waste and aged rice into fungal protein through fermentation with Cordyceps militaris..

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Journal of the Air & Waste Management Association (1995)

Valorization of date palm waste as a substrate for Reishi medicinal mushroom (Ganoderma lucidum) cultivation.

Ganoderma lucidum, commonly known as Reishi mushroom, is highly valued for its medicinal properties and economic importance. Date palm residues (DPR) offer a sustainable and cost-effective substrate for mushroom cultivation by promoting the efficient utilization of agricultural waste efficiently..

Energy & fatigue

High relevance

Reishi · 2025 · Research Article · PloS one

Valorization of various lignocellulosic wastes to Ganoderma lucidum (Curtis) P. Karst (Reishi Mushroom) cultivation and their FT-IR assessments.

Ganoderma lucidum (Curtis) P. Karst (Reishi) has significant pharmacological benefits, and optimizing its cultivation on diverse substrates enhances its commercial viability.

High relevance

Cordyceps · 2025 · Research Article · BMC genomics

Whole genome sequencing and resequencing provide insight into the genetic structure of wild Ophiocordyceps sinensis.

BACKGROUND: Ophiocordyceps sinensis in the Qinghai-Tibet Plateau parasitizes soil-borne larvae of Thitarodes/Hepialus ghost moths, forming valued Chinese cordyceps..

Metabolic health

High relevance

Lion's Mane · 2025 · Research Article · International journal of molecular sciences

Yamabushitake Mushroom (Hericium erinaceus (Bull.) Pers. 1797) Mycelium Improves Reproductive System Dysfunction in Male Rats Induced by Polystyrene Microplastics.

The use of plastic products has increased, leading to higher levels of plastic pollution, and it is becoming a major public health concern. Health risks-especially those related to reproductive system dysfunction caused by polystyrene microplastics (PS-MPs)-are emerging issues that require urgent attention..

Immune supportCognition & nerves

High relevance

Chaga · 2024 · Review · Heliyon

A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms.

This literature review offers an extensive exploration of Chaga mushrooms (Inonotus obliquus), focusing on their phytochemical composition, health-promoting attributes, and mechanisms of action..

OncologyImmune supportMetabolic health

High relevance

Maitake · 2024 · Journal Article · International journal of biological macromolecules

A novel angiotensin I-converting enzyme inhibitory peptide APPLRP from Grifola frondosa ameliorated the Ang II-induced vascular modeling in zebrafish model by mediating smooth muscle cells.

Grifola frondosa has garnered significant popularity as an edible mushroom attributable to its exceptional taste and nutritional benefits. This study isolated APPLRP, a potent ACE-inhibitory peptide, from the alcohol-soluble fraction of Grifola frondosa..

Energy & fatigueMetabolic healthGut & microbiomeSkin & hydration

High relevance

Cordyceps · 2024 · Journal Article · Environmental science and pollution research international

A novel approach in valorization of spent mushroom substrate of Cordyceps militaris as in-feed antibiotics in Labeo rohita against Aeromonas hydrophila infection.

The study was carried out to investigate Cordyceps militaris spent mushroom substrate (CMSMS), a renewable biomass, for its effect on fish as an alternative source of in-feed antibiotics..

Immune supportMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · Archives of virology

A novel betapartitivirus isolated from Cordyceps militaris, an edible-medicinal mushroom.

In this study, we identified a novel partitivirus, named "Cordyceps militaris partitivirus 1" (CmPV1), in Cordyceps militaris strain RCEF7506. The complete genome of CmPV1 comprises two segments, dsRNA1 and dsRNA2, each encoding a single protein..

Respiratory

High relevance

Cordyceps · 2024 · Research Article · International microbiology: the official journal of the Spanish Society for Microbiology

A novel complementary pathway of cordycepin biosynthesis in Cordyceps militaris.

We determined whether there exists a complementary pathway of cordycepin biosynthesis in wild-type Cordyceps militaris, high-cordycepin-producing strain C. militaris GYS60, and low-cordycepin-producing strain C.

High relevance

Cordyceps · 2024 · Journal Article · Life sciences

A novel exosome-like nanovesicles from Cordyceps militaris potentiate immunomodulatory and anti-tumor effect by reprogramming macrophages.

AIMS: Fungi-derived exosome-like nanovesicles (ENs) are emerging as a highly promising class of nanoparticles, particularly noted for their cost-effective production. However, their impact on immune regulation and their potential as anti-tumor agents need further exploration..

OncologyImmune support

High relevance

King Oyster · 2024 · Preprint · journal metadata

A Pleurotus eryngii based biomass porous carbon encapsulated phase change material for efficient thermal energy storage

With the sharp increase in modern energy consumption, phase change composites with the characteristics of rapid preparation are employed for thermal energy storage to meet the challenge of energy crisis..

Energy & fatigue

High relevance

Cordyceps · 2024 · Randomized Controlled Trial · Scientific reports

A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults.

Cordyceps militaris (L.) Link (C. militaris) contains various beneficial substances, including polysaccharides (galactomannan), nucleotides (adenosine and cordycepin), cordycepic acid, amino acids, and sterols (ergosterol and beta-sitosterol)..

Immune supportMetabolic healthLiver support

High relevance

Reishi · 2024 · Review · Foods (Basel, Switzerland)

A Review of Ganoderma lucidum Polysaccharide: Preparations, Structures, Physicochemical Properties and Application.

Ganoderma lucidum (GL) is a kind of edible fungus with various functions and a precious medicinal material with a long history. Ganoderma lucidum polysaccharide (GLP) is one of the main bioactive substances in GL, with anti-tumor, anti-oxidation, anti-cancer, and other biological activities..

OncologyImmune support