MycoData

In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder. Two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) Ganoderma lucidum spore powder.

Immune supportMetabolic health

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Maitake · 2023 · Research Article · Frontiers in nutrition

Structural properties and anti-inflammatory activity of purified polysaccharides from Hen-of-the-woods mushrooms (Grifola frondosa).

Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients of this mushroom are polysaccharides.

OncologyImmune supportMetabolic healthGut & microbiome

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Yellow Morel · 2023 · Journal Article · Carbohydrate polymers

Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide

The water-soluble Morchella esculenta polysaccharide 2 (MEP2) was purified and isolated from an aqueous extract of the Morchella esculenta fruiting bodies. MEP2, having a molecular weight of 959 kDa, has a →4)-α-D-Glcp-(1→ glucan backbone, and this branch was substituted at the H-6 position by an α-D-Glcp-(1 →….

Immune supportGut & microbiomeLiver support

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Yellow Morel · 2023 · Journal Article · Carbohydrate polymers

Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide.

Immune supportGut & microbiomeLiver support

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Reishi · 2023 · Journal Article · Food & function

The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway.

The response of macrophages to environmental signals demonstrates its heterogeneity and plasticity. After different forms of polarized activation, macrophages reach the M1 or M2 activation state according to their respective environment..

OncologyImmune supportLiver support

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Reishi · 2023 · Research Article · Frontiers in pharmacology

The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.

Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activity. This study examined the effects of a commercial GL product (GLSF) containing the spore and fruiting body in a 30:8 ratio on tobacco smoke carcinogen-induced lung toxicity and….

OncologyImmune supportMetabolic healthRespiratory

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Reishi · 2023 · Research Article · Frontiers in pharmacology

Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria.

Introduction: In the Doxorubicin (DOX)-induced nephropathy model, proteinuria is a manifestation of progressive kidney injury. The pathophysiology of renal illness is heavily influenced by the renin-angiotensin system (RAS)..

OncologyImmune support

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King Oyster · 2023 · Research Article · Foods (Basel, Switzerland)

Three-Dimensional Appearance and Physicochemical Properties of Pleurotus eryngii under Different Drying Methods.

This study investigated the effects of different drying methods on the drying characteristics, three-dimensional (3D) appearance, color, total polysaccharide content (TPC), antioxidant activity, and microstructure of Pleurotus eryngii slices..

Immune support

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Enoki · 2022 · Journal Article · Journal of food engineering

3D printing properties of Flammulina velutipes polysaccharide-soy protein complex hydrogels

Food 3D printing targets special consumers, such as children, elderly individuals and patients. For food 3D printing, soy protein isolate hydrogels are widely used but have obstacles in hydrogel reshaping..

Immune support

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King Oyster · 2022 · Research Article · Antioxidants (Basel, Switzerland)

A Randomized Controlled Trial on Pleurotus eryngii Mushrooms with Antioxidant Compounds and Vitamin D2 in Managing Metabolic Disorders.

This study examined the effects of a Pleurotus eryngii mushroom snack on metabolically unhealthy patients. After harvest, mushrooms were baked and subjected to UV-B irradiation to enhance vitamin D2 content.

Immune supportMetabolic health

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King Oyster · 2022 · Journal Article · Fish & shellfish immunology

A synbiotic containing prebiotic prepared from a by-product of king oyster mushroom, Pleurotus eryngii and probiotic, Lactobacillus plantarum incorporated in diet to improve the growth performance and health status of white shrimp, Litopenaeus vannamei.

This study aimed to evaluate the effects of a synbiotic composite an extract from a by-product of king oyster mushroom, Pleurotus eryngii (KOME), and probiotic Lactobacillus plantarum 7-40 on the growth performance and health status of white shrimp, Litopenaeus vannamei..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

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King Oyster · 2022 · Research Article · Frontiers in microbiology

Antioxidant and Immunostimulatory Activities of Fermented Sour Soybean Milk Added With Polypeptides From Pleurotus eryngii.

The improved quality of sour soybean milk by adding polypeptide from Pleurotus eryngii was investigated in this study, and the immunomodulatory effect of sour soybean milk fermented with polypeptides from P. eryngii was also evaluated in immunosuppressed mice induced by cyclophosphamide..

Immune supportGut & microbiome

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Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Antioxidant Properties of Triterpenoids Isolated from Bagasse-Cultivated Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), at Different Developmental Stages.

Although triterpenoids are one of the main active ingredients in Ganoderma lucidum, their accumulation and antioxidant activity during the different developmental stages of G. lucidum cultivation in bagasse remains unclear..

Immune supportEnergy & fatigue

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Maitake · 2022 · Journal Article · Industrial crops and products

Aqueous two-phase simultaneous extraction and purification of a polysaccharide from Grifola frondosa: Process optimization, structural characteristics and antioxidant activity

Traditional method for Grifola frondosa polysaccharide (CGFP) separation is water extraction or other method assistance, ethanol precipitation and further purification via column chromatography..

Immune supportMetabolic health

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Cordyceps · 2022 · Journal Article · Archives of insect biochemistry and physiology

Changes of the gene expression in silkworm larvae and Cordyceps militaris at late stages of the pathogenesis.

Cordyceps militaris is an entomopathogenic fungus that forms its fruiting body. The gene expression change in C.

Immune supportEnergy & fatigue

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King Oyster · 2022 · Journal Article · Food chemistry

Characterization of polysaccharide from Pleurotus eryngii during simulated gastrointestinal digestion and fermentation.

Pleurotus eryngii is a valuable new edible mushroom variety cultivated on a large scale in China. The polysaccharides found in this mushroom are strong bioactive..

Immune supportGut & microbiome

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Reishi · 2022 · Research Article · Journal of cardiovascular development and disease

Combination of Spirulina platensis, Ganoderma lucidum and Moringa oleifera Improves Cardiac Functions and Reduces Pro-Inflammatory Biomarkers in Preclinical Models of Short-Term Doxorubicin-Mediated Cardiotoxicity: New Frontiers in Cardioncology?

Anthracyclines are essential adjuvant therapies for a variety of cancers, particularly breast, gastric and esophageal cancers. Whilst prolonging cancer-related survival, these agents can induce drug-related cardiotoxicity..

OncologyImmune supportEnergy & fatigue

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Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Comparison of the Anti-Inflammatory and Antioxidant Activities of Mycelial Polysaccharides from Different Strains of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes).

Ganoderma lucidum is a popular tonic medicine in China, and its polysaccharides are believed to promote health benefits. However, G.

Immune supportEnergy & fatigueSkin & hydration

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Cordyceps · 2022 · Research Article · Mycobiology

Cordycepin from Medicinal Fungi Cordyceps militaris Mitigates Inflammaging-Associated Testicular Damage via Regulating NF-κB/MAPKs Signaling in Naturally Aged Rats.

Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum biochemical changes in….

Immune supportMetabolic healthLiver support

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Cordyceps · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Cordyceps militaris Carotenoids Protect Human Retinal Endothelial Cells against the Oxidative Injury and Apoptosis Resulting from H2O2.

Vision loss is primarily caused by age-related macular degeneration (AMD) due to oxidative retinal pigment epithelial (RPE) cell injury. Carotenoid utilization is deemed a possible strategy for treating AMD.

OncologyImmune supportEnergy & fatigue

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Cordyceps · 2022 · Research Article · Frontiers in microbiology

Cordyceps militaris Modulates Intestinal Barrier Function and Gut Microbiota in a Pig Model.

This study investigated the effects of Cordyceps militaris (CM) on intestinal barrier function and gut microbiota in a pig model. A total of 160 pigs were randomly allocated to either a control group (fed the basal diet) or a CM group (fed the basal diet supplemented with 300 mg/kg CM)..

Immune supportGut & microbiome

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Cordyceps · 2022 · Research Article · Antioxidants (Basel, Switzerland)

Cordyceps militaris Reduces Oxidative Stress and Regulates Immune T Cells to Inhibit Metastatic Melanoma Invasion.

In this study, the water extract of Cordyceps militaris (Linn.) Link (CM) was used as a functional material to investigate the inhibitory mechanisms on B16F10 and lung metastatic melanoma (LMM) cells..

OncologyImmune supportRespiratory

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Cordyceps · 2022 · Research Article · Antioxidants (Basel, Switzerland)

Cordyceps militaris-Fruiting Bodies, Mycelium, and Supplements: Valuable Component of Daily Diet.

Cordyceps militaris has long been used in Eastern medicine for alleviating fatigue and as an immunostimulant. The present study aimed to determine the content of biologically active substances (bioelements and organic compounds), the total phenolic content, and the antioxidant activity of fruiting bodies (commercially….

Immune supportEnergy & fatigueGut & microbiome

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Wood Ear · 2022 · Research Article · Foods (Basel, Switzerland)

Dietary Supplementation of Auricularia auricula-judae Polysaccharides Alleviate Nutritional Obesity in Mice via Regulating Inflammatory Response and Lipid Metabolism.

The incidence of lipid metabolism disorder and obesity that is caused by high-calorie diets is increasing year by year, which has become an urgent global health problem..

Immune supportEnergy & fatigueMetabolic healthLiver support

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Lion's Mane · 2022 · Research Article · Frontiers in nutrition

Digestive Characteristics of Hericium erinaceus Polysaccharides and Their Positive Effects on Fecal Microbiota of Male and Female Volunteers During in vitro Fermentation.

Hericium erinaceus polysaccharides (HEPs) have attracted widespread attention in regulating gut microbiota (GM). To investigate digestibility and fermentation of HEPs and their effects on GM composition, three polysaccharide fractions, namely, HEP-30, HEP-50, and HEP-70, were fractionally precipitated with 30%, 50%,….

Immune supportGut & microbiome

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Shiitake · 2022 · Research Article · BMC complementary medicine and therapies

Edible algae (Ecklonia cava) bioprocessed with mycelia of shiitake (Lentinula edodes) mushrooms in liquid culture and its isolated fractions protect mice against allergic asthma.

BACKGROUND: Ecklonia cava is an edible marine brown alga harvested from the ocean that is widely consumed in Asian countries as a health-promoting medicinal food The objective of the present study is to evaluate the anti-asthma mechanism of a new functional food produced by bioprocessing edible algae Ecklonia cava and….

Immune supportEnergy & fatigueRespiratory

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King Oyster · 2022 · Research Article · Foods (Basel, Switzerland)

Edible Pleurotus eryngii Papery Food Prepared by Papermaking Process.

The objective of the current study was to evaluate the feasibility of papery food with Pleurotus eryngii (P. eryngii) as a raw material using the papermaking process.

Immune supportEnergy & fatigue

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Almond Mushroom · 2022 · Journal Article · Electronic Journal of Biotechnology

Effects of Agaricus blazei acidic polysaccharide on the aging of mice through keap1-Nrf2/ARE and MAPKs signal pathway

In view of the increasing human life and the aging of the population, the search for safe anti-aging drugs has become a hot topic. Agaricus blazei Murrill is a rare edible fungus, with a variety of biological activities..

Immune supportMetabolic healthSkin & hydration

High relevance

King Oyster · 2022 · Research Article · Frontiers in plant science

Effects of Different Bud Thinning Methods on Nutritional Quality and Antioxidant Activities of Fruiting Bodies of Pleurotus eryngii.

The cultivation of Pleurotus eryngii was studied by different methods, such as puncturing and fixed-point mushroom production, shading treatment at the top of the bag, and pulling the top of the bag. The agronomic characters, yield, nutritional components, and antioxidant activities in vitro of fruiting bodies of P..

Immune support

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Cordyceps · 2022 · Research Article · Frontiers in nutrition

Elucidation of physicochemical properties of polysaccharides extracted from Cordyceps militaris fruiting bodies with different drying treatments and their effects on ulcerative colitis in zebrafish.

Dry fruiting bodies of Cordyceps militaris (CMF) have been widely used in folk tonic foods and traditional herbal medicine in East Asia. Drying treatment serves as the last step in CMF industrial processes.

Immune supportGut & microbiome

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Cordyceps · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Enhancing the prebiotic and antioxidant effects of exopolysaccharides derived from Cordyceps militaris by enzyme-digestion

Cordyceps militaris is an edible and potentially medicinal mushroom. It contains various biologically active compounds, including exopolysaccharides.

Immune supportMetabolic healthGut & microbiome

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Shiitake · 2022 · Journal Article · Letters in applied microbiology

Evaluation of the biological activities of β-glucan isolated from Lentinula edodes.

Lentinula edodes (shiitake) is an edible mushroom that contains many constituents and β-glucan is considered a major polysaccharide. This study, therefore, aimed to characterize β-glucan and evaluate its activities.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2022 · Research Article · Foods (Basel, Switzerland)

Ganoderma lucidum Ethanol Extraction Promotes Dextran Sulphate Sodium Induced Colitis Recovery and Modulation in Microbiota.

Popular edible mushrooms Ganoderma lucidum and Gloeostereum incarnatum can improve physical health as a prebiotic and positively alter intestinal microbiota. Our research investigated the prebiotic effects of Ganoderma lucidum and Gloeostereum incarnatum on colon inflammation through G..

Immune supportGut & microbiome

High relevance

Reishi · 2022 · Research Article · Antioxidants (Basel, Switzerland)

Ganoderma lucidum Modulates Glucose, Lipid Peroxidation and Hepatic Metabolism in Streptozotocin-Induced Diabetic Pregnant Rats.

The consumption of functional foods, such as mushrooms, apparently influences Gestational Diabetes Mellitus (GDM), and brings benefits to maternal-fetal health. Ganoderma lucidum contains a variety of bioactive compounds, such as polysaccharides, proteins and polyphenols that are able to control blood glucose and be….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2022 · Research Article · Nutrients

Ganoderma lucidum Modulates Inflammatory Responses following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice.

Ganoderma lucidum, one of the most valued medicinal mushrooms, has been used for health supplements and medicine in China. Our previous studies have proved that Ganoderma lucidum extract (GLE) could inhibit activation of microglia and protect dopaminergic neurons in vitro..

Immune supportCognition & nerves

High relevance

Reishi · 2022 · Journal Article · Food & function

Ganoderma lucidum polysaccharide peptide alleviates hyperuricemia by regulating adenosine deaminase and urate transporters.

Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common chronic diseases. Previous studies showed that Ganoderma lucidum extract lowered HUA in animals.

Immune supportMetabolic healthLiver support

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Reishi · 2022 · Research Article · Pharmaceutical biology

Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation.

CONTEXT: Ganoderma lucidum polysaccharides (GLP), from Ganoderma lucidum (Leyss. ex Fr.) Karst.

OncologyImmune supportCognition & nervesEnergy & fatigue

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Reishi · 2022 · Research Article · Nutrients

Gastroprotective Effects of Ganoderma lucidum Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats.

Ganoderma lucidum is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different Ganoderma lucidum polysaccharides (GLPs), GLP was separated into three parts with different molecular weights using 100 kDa, 10 kDa, and 1 kDa membranes..

Immune supportGut & microbiome

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Oyster Mushroom · 2022 · Research Article · Frontiers in microbiology

GC-MS Analysis of Potentially Volatile Compounds of Pleurotus ostreatus Polar Extract: In vitro Antimicrobial, Cytotoxic, Immunomodulatory, and Antioxidant Activities.

One strategy to manage resistant pathogens and develop potential anticancer drugs is the search for new, promising, and cost-effective medicinal benefits in the field of bioactive metabolites derived from mushrooms..

OncologyImmune support

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King Oyster · 2022 · Research Article · Frontiers in nutrition

Genoprotective activity of the Pleurotus eryngii mushrooms following their in vitro and in vivo fermentation by fecal microbiota.

Pleurotus eryngii mushrooms are commercially cultivated and widely consumed due to their organoleptic properties, and the low caloric and high nutritional value. In addition, they contain various biologically active and health-promoting compounds; very recently, their genoprotective effect in Caco-2 cells after their….

Immune supportGut & microbiomeLiver support

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Maitake · 2022 · Journal Article · Applied biochemistry and biotechnology

Grifola frondosa Polysaccharide Ameliorates Early Diabetic Nephropathy by Suppressing the TLR4/NF-κB Pathway.

Grifola frondosa is a medicinal macro-fungus with a wide range of biological activities. Polysaccharides from Grifola frondosa (PGF) play a positive role in regulating blood glucose and alleviating kidney injury.

OncologyImmune supportMetabolic health

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Cordyceps · 2022 · Journal Article · Food research international (Ottawa, Ont.)

Homologous overexpression of genes in Cordyceps militaris improves the production of polysaccharides

The maximum yield of EPS produced by mutant CM-pgm-H was 4.63 ± 0.23 g/L, whereas the yield of wild-type strain was 3.43 ± 0.26 g/L. In addition, the data obtained in the present study indicated that the yield of EPS produced by the engineered strain treated with the co-overexpression of phosphoglucomutase and….

Immune supportMetabolic health

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King Oyster · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Immunomodulating Activity of Pleurotus eryngii Mushrooms Following Their In Vitro Fermentation by Human Fecal Microbiota.

Recent studies have revealed the crucial role of several edible mushrooms and fungal compounds, mainly polysaccharides, in human health and disease. The investigation of the immunomodulating effects of mushroom polysaccharides, especially β-glucans, and the link between their anticancer and immunomodulatory properties….

OncologyImmune supportGut & microbiome

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Reishi · 2022 · Journal Article · Cellular and molecular biology (Noisy-le-Grand, France)

Immunomodulatory effect of Ganoderma lucidum polysaccharide extract on peritoneal macrophage function of BALB/c mice.

Ganoderma lucidum has been suggested as a natural immunomodulator. It is not yet clear exactly which combination of this extract is responsible for its immunomodulatory effects..

Immune supportMetabolic health

High relevance

Reishi · 2022 · Journal Article · International journal of medicinal mushrooms

Immunomodulatory Effects of Extract of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Basidiocarps Cultivated on Alternative Substrate.

Ganoderma lucidum is a medicinal mushroom exhibiting numerous health benefits primarily based on strong immunostimulatory effects. The study aimed to investigate if there were differences in effects of extracts of commercially (GC) and alternatively (wheat straw) (GA) cultivated G..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Chaga · 2022 · Journal Article · Immunopharmacology and immunotoxicology

Immunomodulatory effects of Inonotus obliquus polysaccharide on splenic lymphocytes infected with Toxoplasma gondii via NF-κB and MAPKs pathways.

CONTEXT: As a medicinal and edible fungus, Inonotus obliquus has been traditionally used to prevent and treat various ailments. Inonotus obliquus polysaccharide (IOP) isolated from I..

OncologyImmune support

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King Oyster · 2022 · Journal Article · Journal of food processing and preservation

Impact of bioaccumulated selenium on nutraceutical properties and volatile compounds in submerged fermented Pleurotus eryngii mycelia

The present study highlighted the effect of micronutrient selenium in liquid cultured Pleurotus eryngii (PE) mycelia by supplementing sodium selenite (Na₂SeO₃) in the range of 2.5–20 μg/ml in dextrose‐soya peptone medium..

Immune support

High relevance

Cordyceps · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation of Cordyceps militaris.

BACKGROUND: Chronic kidney disease (CKD) is a critical public health issue with a huge financial burden for both patients and society worldwide. Unfortunately, there are currently no efficacious therapies to prevent or delay the progression of end-stage renal disease (ESRD)..

OncologyImmune supportMetabolic healthLiver support

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Chaga · 2022 · Research Article · Evidence-based complementary and alternative medicine: eCAM

In Vitro Immunomodulatory Effects of Inonotus obliquus Extracts on Resting M0 Macrophages and LPS-Induced M1 Macrophages.

BACKGROUND: Inonotus obliquus (Chaga) is a parasitic fungus that is distributed mainly in northeast China. Our literature research showed chaga polysaccharides have bilateral effects on tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels when they exert antitumor and antidiabetic activities..

OncologyImmune supportMetabolic health

High relevance

Enoki · 2022 · Research Article · Frontiers in nutrition

Inhibitory Effect of Fermented Flammulina velutipes Polysaccharides on Mice Intestinal Inflammation.

To investigate the effect of Flammulina velutipes polysaccharides (FVPs) on mice intestinal inflammation, FVPs were extracted from Flammulina velutipes (FV) using a solid anaerobic fermentation technique..

OncologyImmune supportGut & microbiome