MycoData

BACKGROUND: Ganoderma lucidum (G. lucidum), which possesses various biological effects, has been widely used as traditional medicine and functional food in Asian countries, especially China.

Metabolic health

High relevance

Lion's Mane · 2024 · Research Article · Food chemistry: X

Ultrasound-assisted enzymatic extraction of soluble dietary Fiber from Hericium erinaceus and its in vitro lipid-lowering effect.

Dietary fiber (DF) is an important active polysaccharide in Hericium erinaceus. Obesity can lead to a wide range of diseases.

Immune supportMetabolic health

High relevance

Reishi · 2023 · Review · Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences

Effect of Ganoderma lucidum on serum lipid profiles: A systematic review and meta-analysis on animal studies.

BACKGROUND: Ganoderma lucidum (G. lucidum) is one of the most popular edible mushrooms in the world which has various pharmacological components.

Metabolic health

High relevance

Reishi · 2023 · Review · Foods (Basel, Switzerland)

Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections.

Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. It has been found to have a wide range of medicinal properties, including antioxidant, anti-inflammatory, and immune-boosting effects.

Immune supportMetabolic healthRespiratory

High relevance

Yellow Morel · 2023 · Review · International journal of medicinal mushrooms

Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review.

Morchella esculenta, commonly known as yellow morels, is an edible and medicinal mushroom popular worldwide for its unique flavor and culinary purposes. The traditional medical system effectively uses morels against infertility, fatigue, cancer, muscular pain, cough, and cold.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2023 · Review · Cureus

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.

Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, diabetes, and cancer. G.

OncologyImmune supportMetabolic healthLiver support

High relevance

Snow Fungus · 2023 · Review · Archives of dermatological research

The potential cutaneous benefits of Tremella fuciformis.

Tremella fuciformis, also known as snow mushroom, is an edible mushroom that has historically been popular in herbal and Asian medicine and cuisine. The main polysaccharide ingredients have been extracted and used as treatment in a variety of conditions, demonstrating positive effects in a range of biological….

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Yellow Morel · 2022 · Review · Food research international (Ottawa, Ont.)

Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) - A review.

Mushrooms have been well known for centuries in traditional Chinese medicine for their medicinal properties. Morchella esculenta (L.) Pers.

OncologyImmune supportMetabolic healthLiver support

High relevance

Enoki · 2021 · Review · International journal of biological macromolecules

Advances in the extraction, purification, structural-property relationships and bioactive molecular mechanism of Flammulina velutipes polysaccharides: A review.

With the further research in recent years, Flammulina velutipes (F. velutipes), an edible mushroom, has great application value in many fields.

OncologyImmune supportMetabolic healthLiver support

High relevance

Chaga · 2021 · Review · Journal of traditional and complementary medicine

Inonotus obliquus - from folk medicine to clinical use.

The Inonotus obliquus (I. obliquus) mushroom was traditionally used to treat various gastrointestinal diseases.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2021 · Review Article · 3 Biotech

Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies.

Ophiocordyceps sinensis (Berk.) is a fungus closely related to medicinal mushroom, which belongs to the family Ophiocordycipitaceae. It is a well-known and rich herbal source of bioactive active constituents.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Yellow Morel · 2021 · Review · Applied biochemistry and biotechnology

Recent Advances on Bioactive Ingredients of Morchella esculenta.

Morchella esculenta (M. esculenta) is a delicious edible mushroom prized for its special flavor and strong health promoting abilities.

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2025 · Journal Article · Journal of medicinal food

Anti-Diabetic Activity of Cordyceps-Fermented Edible Insects by the Promotion of Glucose Absorption.

Insects are considered important food resources for future diet due to diverse nutrients and pharmacological effects. Fermentation is an important strategy of food processing with various beneficial effects such as increasing nutrients, promoting bioavailability, and reducing anti-nutrients..

Metabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Amino Acid Profiling and 4D-DIA Proteomics Reveal Protein Quality Divergence and Metabolic Adaptation in Cordyceps Species.

To explore the differences in protein quality among classic medicinal entomopathogenic fungi and to evaluate their metabolic adaptability, we analyzed the amino acid composition and proteomic characteristics of Cordyceps sinensis (CS), Cordyceps militaris (CM), and Cordyceps cicadae (CC)..

Energy & fatigueMetabolic healthLiver support

High relevance

Enoki · 2025 · Journal Article · Food Chemistry

Metabolic remodeling during fructification of enoki mushroom

This study investigated the patterns of change and differences in metabolites between white and golden enoki (Flammulina velutipes) mycelium and across stages of fruit-body growth of golden enoki, which was cultured under controlled conditions..

Metabolic health

High relevance

Enoki · 2025 · Journal Article · Food chemistry

Metabolic remodeling during fructification of enoki mushroom.

Metabolic health

High relevance

Cordyceps · 2025 · Research Article · Scientific reports

Quantitative detection of β-glucans in Cordyceps species using a validated Congo red assay.

β-Glucan is extensively utilized in the food industry for its functional benefits, including blood glucose and lipid regulation, enhanced food texture, and a prolonged shelf life..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Lion's Mane · 2023 · Randomized Controlled Trial · Nutrients

Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.

The aim of this study was to assess the effects of guayusa extract and Nordic Lion's Mane (LM) on cognition. Using a randomized, double-blind, placebo-controlled, crossover design, we examined the effects of a single dose of 650 mg guayusa extract (AMT: AmaTea® Max) vs.

Cognition & nervesEnergy & fatigueMetabolic health

High relevance

Chaga · 2023 · Review · Frontiers in pharmacology

Chaga mushroom: a super-fungus with countless facets and untapped potential.

Inonotus obliquus (Chaga mushroom) is an inexpensive fungus with a broad range of traditional and medicinal applications. These applications include therapy for breast, cervix, and skin cancers, as well as treating diabetes..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Shiitake · 2022 · Research Article · Animals: an open access journal from MDPI

Effect of Lentinula edodes on Morphological and Biochemical Blood Parameters of Horses.

Shiitake mushrooms have been highly regarded as possessing enormous nutritive and medicinal values. No clinical studies have yet investigated the effect of shitake supplementation on the health of horses..

Immune supportMetabolic health

High relevance

Shiitake · 2021 · Randomized Controlled Trial · International journal of medicinal mushrooms

Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial.

Shiitake (Lentinus edodes) is a culinary-medicinal mushroom that has low lipid content and is rich in protein, fiber, minerals, vitamins, antioxidant compounds, and β-glucans. We assessed the effects of L..

Metabolic healthSkin & hydration

High relevance

Reishi · 2021 · Research Article · Foods (Basel, Switzerland)

Study of the Lipolysis Effect of Nanoliposome-Encapsulated Ganoderma lucidum Protein Hydrolysates on Adipocyte Cells Using Proteomics Approach.

Excessive lipid accumulation is a serious condition. Therefore, we aimed at developing safe strategies using natural hypolipidemic products.

Metabolic health

High relevance

Yellow Morel · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Elucidating the molecular mechanisms underlying anti-inflammatory effects of Morchella esculenta in the arachidonic acid metabolic pathway by network pharmacology and molecular docking.

Morchella esculenta is an edible fungus with a uniquely delicious flavor and remarkable benefits for health. Herein, the molecular mechanism underlying the anti-inflammatory effects of Morchella esculenta was elucidated using molecular docking and network pharmacology..

Immune supportCognition & nervesMetabolic health

High relevance

Chaga · 2023 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism.

Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice.

Cachexia is a lethal muscle-wasting syndrome associated with cancer and chemotherapy use. Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cachexia..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

King Oyster · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Production performance and rumen bacterial community structure of Hu sheep fed fermented spent mushroom substrate from Pleurotus eryngii.

This study aimed to investigate the effect of fermented spent mushroom substrate from Pleurotus eryngii (SMPE) supplementation on production performance, meat quality and rumen bacterial community structure of Hu sheep..

Energy & fatigueMetabolic health

High relevance

Shiitake · 2022 · Research Support, Non U.S. Gov'T · mSystems

Cultivating Lentinula edodes on Substrate Containing Composted Sawdust Affects the Expression of Carbohydrate and Aromatic Amino Acid Metabolism-Related Genes.

In mushroom cultivation, composting the substrate can make the nutrients more easily absorbed by hyphae due to the degradation of lignin, cellulose, and other organic matter..

Immune supportMetabolic health

High relevance

Chaga · 2022 · Brief Report · Current research in pharmacology and drug discovery

Inonotus obliquus aqueous extract prevents histopathological alterations in liver induced by environmental toxicant Microcystin.

Environmental toxicants like microcystins are known to adversely impact liver physiology and lead to the increased risk for abnormal liver function and even liver carcinoma..

OncologyImmune supportMetabolic healthLiver support

High relevance

Chaga · 2022 · Research Support, Non U.S. Gov'T · Frontiers in endocrinology

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora.

Type 2 diabetes mellitus (T2DM) poses a significant risk to human health. Previous research demonstrated that Inonotus obliquus possesses good hypolipidemic, anti-inflammatory, and anti-tumor properties..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2022 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice.

Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2022 · Research Support, Non U.S. Gov'T · Biophysical chemistry

The thermodynamic and kinetic mechanisms of a Ganoderma lucidum proteoglycan inhibiting hIAPP amyloidosis.

Ganoderma lucidum is a valuable medicinal herbal which has been reported to prevent type 2 diabetes (T2D). A natural hyperbranched proteoglycan extracted from Ganoderma lucidum, namely, FYGL, has been demonstrated to inhibit the amyloidosis of human islet amyloid polypeptide (hIAPP) previously by our lab..

Immune supportMetabolic health

High relevance

Chaga · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity.

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

King Oyster · 2021 · Research Support, Non U.S. Gov'T · Scientific reports

Cultivation of Kabul Dhingri (Pleurotus eryngii) mushroom by standardizing protocols in subtropical zones of world.

The study is of great relevance with present day pandemic era where mushrooms have immunity enhancing properties and they convert agro-wastes into protein rich food..

Immune supportMetabolic health

High relevance

Cordyceps · 2021 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Homologous overexpression of genes in Cordyceps militaris improves the production of polysaccharides.

The maximum yield of EPS produced by mutant CM-pgm-H was 4.63 ± 0.23 g/L, whereas the yield of wild-type strain was 3.43 ± 0.26 g/L. In addition, the data obtained in the present study indicated that the yield of EPS produced by the engineered strain treated with the co-overexpression of phosphoglucomutase and….

Immune supportMetabolic health

High relevance

Chaga · 2021 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Inhibitory effect of triterpenoids from the mushroom Inonotus obliquus against α-glucosidase and their interaction: Inhibition kinetics and molecular stimulations.

Bioassay-guided fractionation led to the isolation of a series of triterpenoids (1-46) including 12 new ones (1-12) from the mushroom Inonotus obliquus. The structures of all the compounds were elucidated by spectroscopic analysis as well as by comparison with literature data..

Metabolic health

High relevance

Oyster Mushroom · 2020 · Preprint · journal metadata

Estimation of Protein and Productive Efficiency Profile of Locally Produced Oyster Mushroom (Pleurotus Ostreatus) in Broiler

Background: Pleurotus ostreatus (Oyster) is a worldwide used mushroom, known to have a wide range of nutrients. Effects of the ethanolic and aqueous extracts of Oyster and its isolated proteins on the production profiles and bio health markers in broiler birds were evaluated in the present research..

Immune supportMetabolic health

High relevance

Cordyceps · 2020 · Preprint · journal metadata

Homologous Overexpression of Genes in Cordyceps militaris Improves the Production of Polysaccharide

Abstract Background Cordyceps polysaccharides have been used around the globe for its bioactivity for millennia. However, the study and medicinal of Cordyceps militaris polysaccharides has been hampered by the low in natural abundances.

Immune supportMetabolic health

High relevance

Cordyceps · 2020 · Preprint · journal metadata

The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model

Administration of crude polysaccharides extract from natural product is a promising gut microbiota-targeted approach to preventing obesity and associated metabolic disorders. Dietary restrictions can change the type and number of gut bacteria, which is an important factor in delaying the onset and burden of diseases..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2026 · Randomized Controlled Trial · Food & function

A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of acute oyster mushroom intervention in healthy older adults.

The Pleurotus oyster is a common edible mushroom rich in ergothioneine, a bioactive that has shown benefits to cognition in animals when administered in extract form. The OYSACO study investigated the acute effects of oyster mushroom (OM) on cognition, mood, inflammation and metabolism in healthy older adults..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Maitake · 2023 · Preprint · journal metadata

Anti-α-glucosidase, anti-proliferative and anti-enterovirus 71 activity of secondary metabolites identified from Grifola frondosa

Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G.

OncologyMetabolic healthRespiratory

High relevance

Reishi · 2023 · Preprint · journal metadata

Optimization of chemical conditions for metabolites production by Ganoderma lucidum using response surface methodology and investigation of antimicrobial as well as anticancer activities

Ganoderma lucidum ( G. lucidum ) is a medical mushroom known for its tendency to produce physiologically active compounds with far-reaching effects on human health..

OncologyImmune supportMetabolic health

High relevance

Chaga · 2023 · Preprint · journal metadata

Protective effect of Inonotus obliquus polysaccharide on fibroblasts after MGO-induced nonenzymatic glycation

Abstract Background Nonenzymatic glycation of fibroblasts causes functional downregulation and behavioral disorders in skin. Methods To investigate the effect of Inonotus obliquus on the nonenzymatic glycation of skin, we examined advanced glycation end product (AGE) inhibition by four extract fractions: n-butanol,….

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Oyster Mushroom · 2022 · Preprint · journal metadata

Nutritional and antioxidant changes in lentil and quinoa induced by fungal solid-state fermentation with Pleurotus ostreatus

Abstract Solid-state fermentation (SSF) could be considered a suitable bioprocess to produce protein-vegetal ingredients with increased nutritional and functional value..

Metabolic health

High relevance

Snow Fungus · 2022 · Preprint · journal metadata

Structural analysis, in vitro antioxidant and lipid-lowering activities of purified Tremella fuciformis polysaccharide fractions

Abstract In order to study the composition, structure and physicochemical properties of Tremella fuciformis polysaccharide (TFPS), four new polysaccharide fractions (TFPS1, TFPS2, TFPS3 and TFPS4) were successfully isolated from the hot-water extracted crude polysaccharides by DEAE-52 cellulose column..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2021 · Preprint · journal metadata

Effect of Nutritional Factors and Copper on the Regulation of Laccase Enzymes Production in Pleurotus ostreatus

This research aimed to establish the relationship between carbon-nitrogen nutritional factors and copper sulfate on laccase activity (LA) by Pleurotus ostreatus. Culture media composition was tested to choose the nitrogen source.

Metabolic health

High relevance

Shiitake · 2021 · Preprint · journal metadata

Optimization of Culture Conditions in a Bioreactor for the Production of Biomass and Metabolites of the Macromycete Lentinula Edodes

Abstract Lentinula edodes is an edible mushroom known for its medicinal properties attributed to different secondary metabolites. In this article, the effect of glucose concentration, aeration and agitation on the production of biomass and intrametabolites in submerged fermentation was evaluated..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2021 · Preprint · journal metadata

Treatment of Rice Stubble with Pleurotus Ostreatus and Urea Improves the Growth Performance in Slow-Growing Goats

The objective of this study was to evaluate the efficacy of fungal treatment (Pleurotus ostreatus) of urea-treated rice stubble on growth performance in slow-growing goats..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Cordyceps · 2020 · Journal Article · Journal of pharmaceutical and biomedical analysis

1H NMR spectroscopy-based metabolic profiling of Ophiocordyceps sinensis and Cordyceps militaris in water-boiled and 50% ethanol-soaked extracts.

Ophiocordyceps sinensis, a well-known Chinese complementary herb, is a rare and valuable therapeutic resource. Cordyceps militaris (C.

Metabolic health

High relevance

Cordyceps · 2020 · Journal Article · Natural product research

1H NMR-based metabonomics of the hypoglycemic effect of polysaccharides from Cordyceps militaris on streptozotocin-induced diabetes in mice.

The crude polysaccharide was extracted from Cordyceps militaris. Material ratio of powder and water was 1:10.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Almond Mushroom · 2020 · Research Article · Food science & nutrition

Assessment of antioxidant and antidiabetic properties of Agaricus blazei Murill extracts.

Agaricus blazei Murill (ABM), a medicinal mushroom, has beneficial effects on various human metabolic diseases. The objective of this research was to evaluate the antioxidant and antidiabetic properties of ABM extracts (ethanol extract and ethyl acetate extract)..

Metabolic health