MycoData

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications.

Fungi are a prolific source of diverse bioactive metabolites, yet many remain unexplored. Among these, depsidones are a rare class of compounds with significant biological potential, but they are seldom reported in mushrooms..

Immune supportEnergy & fatigueMetabolic healthRespiratory

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Functional characterization of Ganoderma lucidum polysaccharide and the mechanism of inducing tomato resistance to Tomato yellow leaf curl virus.

Using functional polysaccharides as elicitors to induce plant disease resistance has emerged as an effective plant protection strategy. In this study, we found that crude polysaccharides derived from by-products of Ganoderma lucidum can effectively prevent and control the Tomato Yellow Leaf Curl Virus (TYLCV)..

Reishi · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Ganoderma lucidum and Robinia pseudoacacia Flower Extract Complex Alleviates Kidney Inflammation and Fibrosis by Modulating Oxidative Stress.

Chronic kidney disease (CKD) is characterized by functional and structural abnormalities, with its progression strongly influenced by oxidative stress and inflammatory responses, ultimately leading to renal fibrosis..

Immune supportGut & microbiome

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum dietary fiber and lactobacillus fermentum CECT5716 alleviate constipation via regulation of gut barrier and microbiota.

The rising incidence of constipation, as well as the side effects of constipation medications, have prompted people to look for substances of natural origin to treat constipation..

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

Ganoderma lucidum Glycoprotein Microemulsion: Improved Transdermal Delivery and Protective Efficacy in UV-Induced Cell and Animal Models.

BACKGROUND: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant

Oxidative stress after spinal cord injury (SCI) significantly promotes neuronal apoptosis. The imbalance of flora leads to the destruction of the intestinal barrier, so that pro-inflammatory cytokines enter the blood and further aggravate neuroinflammation..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant.

Reishi · 2025 · Journal Article · Reproductive biology

Ganoderma lucidum mitigates oxidative stress and apoptosis in chlorpyrifos‑induced testicular toxicity in male rats.

Chlorpyrifos (CPS) is an organophosphate pesticide known to induce oxidative stress, apoptosis, and histopathological damage in male reproductive tissues. Ganoderma lucidum (GDL), a medicinal fungus rich in bioactive polysaccharides and triterpenoids, has demonstrated potent antioxidant and antiapoptotic properties in….

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-κB pathways.

Sepsis, characterized by a severe immune response to infection, remains a leading cause of mortality, with few effective strategies to prevent organ damage. Targeting inflammation, oxidative stress, and apoptosis is crucial for improving outcomes and advancing sepsis management..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2025 · Journal Article · Biomacromolecules

Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing.

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound healing process..

Reishi · 2025 · Research Article · Chinese medicine

Ganoderma lucidum spore oil alleviates psychological stress-evoked tumor progression by enhancing FcγR-mediated macrophage phagocytosis.

BACKGROUND: Ganoderma lucidum (G. lucidum), has been documented as a medicinal herb in classical texts and officially recognized in both Eastern and Western pharmacopeias.

Immune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of the science of food and agriculture

Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice.

BACKGROUND: There are few studies about the differences in the composition of moisture, ash, crude protein, crude fat, crude polysaccharide and ergothioneine in Ganoderma lucidum spore powder (GLSP) from different origins. As for GLSP after oil extraction (OE-GLSP), there are still lots of bioactive substance in it..

Immune supportEnergy & fatigueSkin & hydration

Reishi · 2025 · Research Article · Frontiers in immunology

Ganoderma lucidum spore powder alleviates rheumatoid arthritis-associated pain hypersensitivity through inhibiting accumulation, N1 polarization, and ROS production of neutrophils in mice.

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic condition characterized by joint pain that significantly impairs patients' work and daily lives. The limited understanding of the pathological mechanisms underlying RA-related pain poses challenges for effective clinical pain management..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ganoderma lucidum triterpenes ameliorate age-related cognitive impairment via regulating Eubacterium lentum-mediated serine metabolism.

BACKGROUND: Natural aging of the brain is commonly accompanied by a decline in cognitive ability, which is driven by oxidative stress, inflammation, and metabolic dysregulation. These pathological processes are further exacerbated by gut microbiota dysbiosis..

OncologyImmune supportGut & microbiome

Reishi · 2025 · Journal Article · Current pharmaceutical biotechnology

Ganoderma lucidum: A Medicinal Mushroom with Prebiotic and Anticancer Potential in Gastrointestinal Cancers.

INTRODUCTION: Ganoderma lucidum is considered a medicinal mushroom, as it primarily improves gut health by modulating the gut microbiota. As an abundant source of bioactive metabolites, antioxidants, and industrial enzymes, mushrooms make significant contributions to functional foods, nutrition, and pharmaceuticals..

OncologyImmune supportMetabolic health

Almond Mushroom · 2025 · Journal Article · International Journal of Biological Macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice

This study aims to isolate and characterize the physicochemical properties and evaluate the cytoprotective and gastroprotective potential of polysaccharides from the Agaricus blazei Murill mushroom (PAbM). The PAbM were isolated and characterized chemically..

OncologyImmune supportMetabolic health

Almond Mushroom · 2025 · Journal Article · International journal of biological macromolecules

Gastroprotective effect of polysaccharides from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice.

OncologyImmune supportMetabolic healthGut & microbiome

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharides Alleviated Cyclophosphamide-Induced Intestinal Injury Based on Microbiota, Metabolite and Immune Axis Modulation.

Grifola frondosa polysaccharides (GFP), which possess antitumor properties, can counteract intestinal injury induced by cyclophosphamide (CTX). The objective of this research was to evaluate the efficacy of GFP in protecting the intestinal barrier of mice and investigate the mechanisms behind this effect..

Immune supportMetabolic healthLiver support

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.

The functional food application of edible fungus polysaccharides has been widely studied based on their variety of potential pharmacological activities. However, the hepatoprotective effects and mechanisms of Morchella esculenta polysaccharide against nonalcoholic fatty liver disease (NAFLD) remain unknown..

OncologyImmune supportGut & microbiome

Lion's Mane · 2025 · Journal Article · Animal Nutrition

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens

Hericium erinaceus polysaccharide (HEP) is widely regarded as a potential food additive because of its rich nutritional value. This study aimed to explore the effect of HEP on the eggshell quality of aged laying hens and to reveal the mechanisms with particular emphasis on the alterations of uterine microbiota and….

OncologyImmune supportGut & microbiome

Lion's Mane · 2025 · Research Article · Animal nutrition (Zhongguo xu mu shou yi xue hui)

Hericium erinaceus polysaccharides improve eggshell quality by improving uterine health and modulating uterine microbiota in aged hens.

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · International journal of biological macromolecules

High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice.

High molecular weight polysaccharides (GLPH, ≥300 kDa) are the major compounds of Ganoderma lucidum with improving liver function. However, the effect of GLPH on improving acute liver injury (ALI) wasn't revealed..

Oyster Mushroom · 2025 · Journal Article · Fungal biology

Identifying the Pleurotus ostreatus α-amylase gene family and analyzing its expression during growth and development.

α-Amylase is a crucial enzyme modulating carbohydrate metabolism that holds a significant role in the growth and development of animals, plants, and microbes. However, its role in mushrooms remains unclear..

Immune supportCognition & nervesMetabolic health

Reishi · 2025 · Journal Article · Ecotoxicology and environmental safety

Illustrate the metabolic regulatory effects of Ganoderma Lucidum polysaccharides on cognitive dysfunction in formaldehyde-exposed mouse brain by mass spectrometry imaging.

Long-term formaldehyde (FA) exposure causes cognitive dysfunction, often associated with metabolic disorders. While some studies suggest Ganoderma lucidum polysaccharides (GLP) can improve cognitive function, such as Alzheimer's disease..

Snow Fungus · 2025 · Journal Article · Food chemistry

Improving physicochemical properties and gel formation mechanism of nutty plant-based yogurt with Tremella fuciformis polysaccharides.

Developing nutty plant-based yogurt (NPBY) with desired texture and sensory properties has been challenging. This study sought to investigate the effects of Tremella fuciformis polysaccharides (TFPS) on the physicochemical, textural, rheological, and microstructural properties of NPBY..

Immune supportCognition & nervesEnergy & fatigueGut & microbiome

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide.

Oxidative stress, driven by impaired antioxidant defence systems, is a major contributor to cognitive decline and neurodegenerative processes in brain ageing. This study investigates the neuroprotective effects of a natural compound mixture-composed of Hericium erinaceus, Palmitoylethanolamide, Bilberry extract, and….

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Influence of different bond types and polymerization degrees of glucose polymers on the fermentation of Inonotus obliquus for the production of hypoglycemic activity polysaccharides.

This research aimed to investigate the impact of different glycosidic polymers, such as maltose, cellobiose, starch, and β-glucan, on the production of bioactive polysaccharides via deep liquid fermentation using Inonotus obliquus (I. obliquus)..

Reishi · 2025 · Journal Article · Food chemistry

Innovative submerged directed fermentation: Producing high molecular weight polysaccharides from Ganoderma lucidum.

Polysaccharides from Ganoderma lucidum (GLPs) exhibit unique bioactivity, but traditional cultivation yields low quantities and unstable quality, limiting their research and application..

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2025 · Research Article · Frontiers in pharmacology

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.

Granulomatous pulmonary nodules represent a substantial health threat, with no available targeted therapies. Interventions based on medicinal plants approaches are pivotal for prevention and treatment.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Proteomics and Metabolomics Reveal Regulatory Pathways Underlying Quality Differences Between Wild and Cultivated Ophiocordyceps sinensis.

Ophiocordyceps sinensis, is an entomopathogenic fungus renowned for its medicinal properties, thriving in the frigid and high-altitude regions of the Qinghai-Tibet plateau. Given the limited availability of wild resources and the increasing recognition of their medicinal value, the cultivation of O..

OncologyImmune supportLiver support

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum.

Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects..

OncologyImmune supportGut & microbiomeSkin & hydration

Chaga · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Integrating Network Pharmacology and Experimental Validation to Explore the Effect and Mechanism of Inonotus obliquus Polysaccharide in the Treatment of Rheumatoid Arthritis.

Background/Objectives: Rheumatoid arthritis (RA) is a chronic, systemic, and progressive autoimmune-inflammatory disease primarily affecting small joints. Inonotus obliquus polysaccharide (IOP) is the main component of the parasitic fungus obliquus, which has anti-tumor, anti-inflammatory, and antioxidant effects..

Reishi · 2025 · Research Article · Frontiers in microbiology

Intercropping with Paris polyphylla and Ganoderma lucidum: regulatory effects on the rhizosphere microbial community and the quality of Polygonatum cyrtonema.

INTRODUCTION: Optimizing the cultivation of Polygonatum cyrtonema requires a comprehensive understanding of how intercropping influences both its quality and the rhizosphere microenvironment. METHODS: This study conducted a comparative analysis between monoculture cultivation of P..

Immune supportCognition & nervesLiver support

Reishi · 2025 · Research Article · Frontiers in pharmacology

Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.

BACKGROUND/OBJECTIVES: Although Alzheimer's disease (AD) is the most prevalent dementia in late life, with amyloid beta (Aβ) deposition and neuroinflammation are recognized among its primary pathological features. Currently, there is currently still a lack of effective therapeutic drugs for AD.

OncologyImmune supportMetabolic healthGut & microbiome

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Investigation of the fingerprint-activity relationship of Tremella fuciformis polysaccharides and its mitigating effect on radiation-induced intestinal injury.

The aim of this study was to conduct a comprehensive analysis of the relationship between the fingerprint of Tremella fuciformis polysaccharides (TFPs) sourced from China and their bioactivities, with an emphasis on identifying the most bioactive TFP variety that significantly mitigated radiation-induced intestinal….

Reishi · 2025 · Journal Article · Drug development and industrial pharmacy

Investigation on the protective effect of Ganoderma Lucidum spore oil on pustular acne based on molecular dynamics simulation and experimental validation.

Ganoderma lucidum spore oil (GLSO), a bioactive natural product, demonstrates notable antioxidant, anti-inflammatory, and immunomodulatory properties, suggesting therapeutic potential. Pustular acne, characterized by intrafollicular pus accumulation, is primarily mediated by oxidative stress..

Oyster Mushroom · 2025 · Journal Article · Industrial crops and products

Isolation and purification of Pleurotus ostreatus polysaccharides by corn distiller dried grains cultivation: Structural characterization and study the protective capacity against cells

Edible fungi have been used as food for thousands of years, and mushroom derived polysaccharides have received a lot of attention for their health benefits. In this study, Pleurotus ostreatus (P.ostreatus) was cultivated using corn distillers dried grains (CDDG), and P..

Immune supportGut & microbiome

Shiitake · 2025 · Research Article · Scientific reports

Lentinula edodes cultured extract intake alleviates long-term immune deregulation induced by early-life gut microbiota dysbiosis.

The establishment of gut microbiota during early life is crucial for immune system development and its disturbance within this critical period exerts enduring adverse effects on health. Perinatal antibiotic exposure perturbs early-life microbiota and leads to long-term immune dysregulation..

Immune supportSkin & hydration

Reishi · 2025 · Research Article · Bioresources and bioprocessing

Light repair effect of polysaccharides component from white Ganoderma lucidum and Laminaria japonica fermentation broth attenuates epidermal barrier dysfunction via TRPV4-Keap-1/Nrf2 pathway.

Epidermal photoinflammation has emerged as an atypical pathological response that poses a growing global threat to human health and well-being. In this study, a polysaccharide component (named LJGp) was isolated from Laminaria japonica and white Ganoderma lucidum fermentation broth, and its reparative effects on….

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Mechanism of Enzyme Activity Regulation and Strain-Specific Response of Lentinula edodes Cultivation Adaptability Under Peach Wood Substrate.

The resource utilization of peach wood as agricultural waste holds significant importance for the sustainable development of the edible fungi industry, yet its regulatory effects on the physiology and safety of Lentinula edodes (L. edodes) remain unclear.

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Mechanism Underlying Ganoderma lucidum Polysaccharide Biosynthesis Regulation by the β-1,3-Glucosyltransferase Gene gl20535.

Ganoderma lucidum polysaccharides (GLPs) are natural compounds with a broad spectrum of biological activities. β-1,3-glucosyltransferase (GL20535) plays an important role in polysaccharide synthesis by catalyzing the transfer of UDP-glucose to extend sugar chains, but its underlying mechanism remains unclear..

Immune supportEnergy & fatigueMetabolic health

Chaga · 2025 · Journal Article · Chemistry & biodiversity

Microwave Extraction of New Polysaccharides From Inonotus obliquus, Structural Characterization, and Antioxidant Activity.

To address the low extraction yield and structural degradation issues of conventional methods, this study optimized microwave-assisted extraction (61°C, 64 min, 30:1 mL/g ratio) to obtain Inonotus obliquus polysaccharides (IOP), followed by DEAE-52 and Sephadex G-100 purification to isolate two fractions: neutral….

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Food & function

Modification of Ganoderma lucidum spore shells into probiotic carriers: selective loading and colonic delivery of Lacticaseibacillus rhamnosus and effective therapy of inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammation with a high incidence rate. Many probiotics, including Lacticaseibacillus rhamnosus (L.

Immune supportEnergy & fatigueGut & microbiome

Mesima · 2025 · Research Article · Frontiers in microbiology

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers.

Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier function and intestinal microbial community in broilers under….

Immune supportMetabolic healthLiver support

Cordyceps · 2025 · Journal Article · Environmental toxicology

Modulatory Effects of Ophiocordyceps sinensis Mycelia on Hepatosteatosis Development in a High-Fat Dietary Habit.

The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Research Article · Scientific reports

Multi-omics analysis reveals inhibition of osteosarcoma progression by sporoderm-removed Ganoderma lucidum spores via targeting glycerophospholipid and fatty acid metabolism.

Osteosarcoma (OS) is a severe malignancy affecting children and adolescents, with limited effective treatments leading to poor outcomes. This study explored the potential of sporoderm-removed Ganoderma lucidum spores (RGLS) as a novel therapeutic agent against OS and elucidated its mechanism of action..

Enoki · 2025 · Journal Article · Food chemistry

Naringenin-loaded Flammulina velutipes chitin-glucan complexes gel system: structural modulation and dual lipid-lowering mechanisms.

This study developed a synergistic lipid-lowering system using chitin-glucan complex (CGC) from Flammulina velutipes through green preparation and structural optimization..

Reishi · 2025 · Journal Article · Fitoterapia

Natural cyclic peptides produced by the Ganoderma lucidum-associated endophytic Trichoderma sp. GLQ02.

Eight natural cyclopeptides (1-8), including three previously undescribed compounds (1, 4, and 7), were isolated from the endophytic fungus Trichoderma sp. GLQ02 derived from Ganoderma lucidum..