MycoData

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2023 · Research Support, Non U.S. Gov'T · The Journal of nutritional biochemistry

Auricularia polytricha and Flammulina velutipes reduce liver injury in DSS-induced Inflammatory Bowel Disease by improving inflammation, oxidative stress, and apoptosis through the regulation of TLR4/NF-κB signaling pathways.

Auricularia polytricha and Flammulina velutipes are two dietary mushrooms mostly consumed in China and known for their traditional use on gastric ulceration and to boost bowel movement..

OncologyImmune supportMetabolic health

Reishi · 2023 · Research Support, Non U.S. Gov'T · Experimental gerontology

Ganoderma lucidum polysaccharides ameliorates D-galactose-induced aging salivary secretion disorders by upregulating the rhythm and aquaporins.

Longer-term deterioration in saliva secretion has been observed to occur in response to aging. The functional deterioration of the salivary gland damages swallowing and chewing abilities and consequently reduces life quality of the elderly..

OncologyImmune supportLiver support

Reishi · 2023 · Research Support, Non U.S. Gov'T · Journal of materials chemistry. B

Improving nanochemoimmunotherapy efficacy by boosting "eat-me" signaling and downregulating "don't-eat-me" signaling with Ganoderma lucidum polysaccharide-based drug delivery.

To address the challenges posed by low immunogenicity and immune checkpoints during cancer treatment, we propose an alternative strategy that combines immunogenic cell death (ICD) effects with CD47/SIRPα blockade to reactivate phagocytosis of tumor cells by macrophages with polysaccharide-based drug delivery..

Chaga · 2023 · Research Support, Non U.S. Gov'T · Bioorganic chemistry

Inonotsutriol E from Inonotus obliquus exhibits promising anti breast cancer activity via regulating the JAK2/STAT3 signaling pathway.

The aim of the present study was to investigate the small molecule anticancer agents in the medicinal fungus Inonotus obliquus and further characterize their possible molecular mechanisms..

OncologyImmune supportGut & microbiome

Reishi · 2023 · Research Support, Non U.S. Gov'T · Aging

Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.

CPT-11 (Irinotecan) remains an important chemotherapeutic agent against various solid tumors nowadays. Potential adverse effects, especially gastrointestinal toxicities, are the main limiting factor for its clinical utility..

OncologyImmune supportCognition & nervesMetabolic health

Oyster Mushroom · 2023 · Research Support, Non U.S. Gov'T · Food research international (Ottawa, Ont.)

Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus ostreatus.

Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.

OncologyImmune supportEnergy & fatigue

Zhu Ling · 2022 · Research Support, Non U.S. Gov'T · Scientific reports

Acetylome analysis of acetylation providing new insight into sclerotial generation in medicinal fungus Polyporus umbellatus.

Sclerotium-forming fungi are ecologically diverse and possess notable pathogenic or medicinal properties. The sclerotial generation mechanism is still elusive though Polyporus umbellatus sclerotia are typical Traditional Chinese Medicine with diuretic and antitumor effects..

OncologyImmune supportGut & microbiome

Shiitake · 2022 · Brief Report · Frontiers in immunology

AHCC®, a Standardized Extract of Cultured Lentinula Edodes Mycelia, Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer.

Treatment strategies combining immune checkpoint blockade (ICB) with other agents have emerged as a promising approach in the treatment of cancers. AHCC®, a standardized extract of cultured Lentinula edodes mycelia, has been reported to inhibit tumor growth and enhance immune cell function..

OncologyImmune supportRespiratory

Reishi · 2022 · Video Audio Media · Journal of visualized experiments: JoVE

Co-Fermentation of Marsdenia tenacissima with Ganoderma lucidum and Anti-Lung Cancer Effect of the Fermentation Products.

Marsdenia tenacissima (Roxb.) Wight et Arn. (MT), as a traditional Chinese and Dai herbal medicine, has anti-inflammatory, antibacterial, and antitumor properties.

OncologyGut & microbiomeRespiratory

Shiitake · 2022 · Research Support, Non U.S. Gov'T · Journal of virological methods

Curing two predominant viruses occurring in Lentinula edodes by chemotherapy and mycelial fragmentation methods.

Previous research has established that Lentinula edodes mycovirus HKB (LeV-HKB) and L. edodes partitivirus 1(LePV1) are major mycoviruses identified in L.edodes germplasm..

Oyster Mushroom · 2022 · Research Support, Non U.S. Gov'T · Immunotherapy

Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer.

Aim: To evaluate the effect of pleuran (β-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I-II) in clinical and imaging remission..

OncologyCognition & nerves

Niu-Chang-Chih · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Solid-state-cultured mycelium of Antrodia camphorata exerts potential neuroprotective activities against 6-hydroxydopamine-induced toxicity in PC12 cells.

Antrodia camphorata (A. camphorata) is an edible fungus containing various bioactive compounds generally used for health benefits.

Niu-Chang-Chih · 2021 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters

Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities.

In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7..

Lion's Mane · 2021 · Journal Article · Journal of food biochemistry

Prospecting medicinal properties of Lion's mane mushroom.

Hericium erinaceus (Bull.) Persoon, a popular medicinal edible mushroom, owns a long history of usage in traditional Chinese medicine and also in other oriental countries. Along with this, its several bioactive compounds have been evolved into food supplements..

OncologyRespiratory

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Biomolecules

Selective Biological Effects of Selenium-Enriched Polysaccharide (Se-Le-30) Isolated from Lentinula edodes Mycelium on Human Immune Cells.

A common edible mushroom Lentinula edodes, is an important source of numerous biologically active substances, including polysaccharides, with immunomodulatory and antitumor properties..

OncologyImmune supportCognition & nerves

Almond Mushroom · 2025 · Preprint · journal metadata

Agaricus blazei extract FA-2b-β inhibits microglial pyroptosis by regulating the activation of the NF-κB signaling pathway mediated by Aβ 1-42 through the NLRP3 pathway

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Intracellular neurofibrillary tangles (NFTs) and neuroinflammatory plaques formed by amyloid-β (Aβ) are the main pathological features of AD..

Shiitake · 2024 · Preprint · journal metadata

Novel Biosynthesis and Evaluation Cytotoxic Effect of Tellurium Nano-Particle on Breast Cancer Using Co-Culture of Spirulina and Lentinula Edodes

Abstract Introduction Bio-based nanoparticle production has been an alternative method for preparing nanoparticles for pharmaceutical and biomedical applications..

OncologyImmune supportMetabolic healthSkin & hydration

Chaga · 2022 · Case Reports · Medicine

Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report.

RATIONALE: The Chaga mushroom (Hymenochaetaceae, Inonotus obliquus) is a fungus belonging to the Hymenochaetaceae family. It is parasitic on birch and other tree species.

Mesima · 2020 · Clinical Trial Protocol · Medicine

Efficacy of Phellinus linteus (sanghuang) extract for improving immune functions: Study protocol for a randomized, double-blinded, placebo-controlled pilot trial.

BACKGROUND: With the increase in the prevalence of chronic diseases, enhancing immunity has become an important challenge. Health functional foods, such as Phellitus linteus (PL), are known to improve immune function.

Shiitake · 2020 · Preprint · journal metadata

Expression and in vitro anticancer activity of Lp16-PSP, a member of the YjgF/YER057c/UK114 protein family from the mushroom Lentinula edodes C 91-3

Latcripin-16 (Lp16-PSP) is a gene that was extracted as a result of de novo characterization of the Lentinula edodes strain C 91-3 transcriptome. The aim of the present study was to clone, express and investigate the selective in vitro anticancer potential of Lp16-PSP in human cell lines..

OncologyImmune supportCognition & nerves

Chaga · 2020 · Preprint · journal metadata

Polysaccharides from the fungus Inonotus obliquus activate macrophages into a tumoricidal phenotype via interaction with TLR2, TLR4 and Dectin-1a

Background Tumor-associated macrophages (TAMs) may both promote and suppress tumor development. Therefore, molecules that are able to activate and repolarize these cells into a tumoricidal phenotype could be of great interest as a new strategy for cancer immunotherapy..

OncologyImmune supportGut & microbiome

Chaga · 2020 · Preprint · journal metadata

The apoptotic effect of polysaccharides with specific molecular weight extracted from Inonotus obliquus on HT-29 colon cancer cells

Background: Recently, natural products, particularly Inonotus obliquus ( I. obliquus ), have attracted lots of attention due to their effective anticancer effects with relatively low toxicity.

Enoki · 2019 · Preprint · journal metadata

Combining transcriptomics and metabolomics to characterize ergosterol biosynthesis in Flammulina velutipes during the fruiting process

Abstract Background: Flammulina velutipes (F. velutipes) is one of the most important mushrooms in Japan and China because of its potential medicinal and nutritional value.

OncologyMetabolic health

Cordyceps · 2015 · Journal Article · JOURNAL OF THE BREWING SOCIETY OF JAPAN

Anticancer activity of an extract of Cordyceps militaris soaked in sweetpotato shochu in human leukemia cells

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in JOURNAL OF THE BREWING SOCIETY OF JAPAN in 2015. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Cordyceps · 2015 · Journal Article · JOURNAL OF THE BREWING SOCIETY OF JAPAN

Induction of apoptosis of human colon carcinoma cells by an extract of cordyceps militaris soaked in sweetpotato shochu

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in JOURNAL OF THE BREWING SOCIETY OF JAPAN in 2015. MycoData maps the paper to oncology, gut & microbiome based on its title, species context, article metadata, and study classification..

OncologyGut & microbiome

Cordyceps · 2013 · Journal Article · Japanese Journal of Complementary and Alternative Medicine

Study on Anti-Proliferative Activities of Cultured Cordyceps Militaris on Cancer Cells

Metadata-grounded summary: This journal article indexes research on Cordyceps militaris in Japanese Journal of Complementary and Alternative Medicine in 2013. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Shiitake · 2011 · Journal Article · Oncology (Williston Park, N.Y.)

Complementary therapies, herbs, and other OTC agents. Shiitake mushroom (Lentinula edodes).

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Oncology (Williston Park, N.Y.) in 2011. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Chaga · 2011 · Journal Article · Japanese Journal of Complementary and Alternative Medicine

Inhibitory Effect of Chaga (Inonotus obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

Metadata-grounded summary: This journal article indexes research on Inonotus obliquus in Japanese Journal of Complementary and Alternative Medicine in 2011. MycoData maps the paper to oncology, skin & hydration based on its title, species context, article metadata, and study classification..

OncologySkin & hydration

Maitake · 2010 · Journal Article · Japanese Journal of Complementary and Alternative Medicine

Effect of Hericium erinaceum (Yamabusitake) and Grifola frondosa (Maitake) on the Suppression of EL4-Tumor Cell Growth

Metadata-grounded summary: This journal article indexes research on Grifola frondosa in Japanese Journal of Complementary and Alternative Medicine in 2010. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Reishi · 2008 · Journal Article · Biological and Pharmaceutical Bulletin

Possible Involvement of Long Chain Fatty Acids in the Spores of Ganoderma lucidum (Reishi Houshi) to Its Anti-tumor Activity

During our isolation of biologically active substances from the spores of Ganoderma lucidum (Reishi Houshi, G. lucidum) guided by the inhibitory activity on HL-60 cell proliferation, NMR spectroscopic and mass spectrometric data indicate the substance contains a mixture of several long chain fatty acids..

Shiitake · 2008 · Journal Article · Journal of the Society for Integrative Oncology

Shiitake Mushroom (Lentinula edodes).

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Journal of the Society for Integrative Oncology in 2008. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Cordyceps · 2006 · Journal Article · Biological and Pharmaceutical Bulletin

Induction of Apoptosis by Cordyceps militaris through Activation of Caspase-3 in Leukemia HL-60 Cells

Cordyceps militaris is a traditional herbal ingredient frequently used for tonic and medicinal purposes in eastern Asia. The hot water extract of its cultivated fruiting bodies demonstrated a potent cytotoxic effect against the proliferation of the human premyelocytic leukemia cell HL-60, with an IC50 of 0.8 mg/ml for….

Cordyceps · 2006 · Journal Article · Biological and Pharmaceutical Bulletin

Water Extract of Cordyceps militaris Enhances Maturation of Murine Bone Marrow-Derived Dendritic Cells in Vitro

Water extract (WE) of Cordyceps militaris has been reported to produce antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not been known.

OncologyImmune supportLiver support

Wood Ear · 2026 · Research Article · Medicine

AMBP gene activation promotes cholangiocarcinoma progression through the WNT/β-catenin signaling pathway: Regulatory effect of polysaccharides from Auricularia auricula-judae.

Cholangiocarcinoma (CCA), an aggressive hepatobiliary malignancy with poor prognosis, involves abnormal molecular regulatory networks. This study explores α-1-microglobulin/bikunin precursor's (AMBP's) role in CCA, its pro-carcinogenic mechanisms via the wingless/integrated (WNT) pathway, and Huaier polysaccharide's….

OncologyImmune supportCognition & nerves

Oyster Mushroom · 2026 · Journal Article · Journal of medicinal chemistry

Design, Synthesis, and Biological Evaluation of Oligosaccharides Derived from Pleurotus ostreatus Polysaccharide as Potential Neuroprotective Agents.

Neurodegeneration has attracted considerable attention due to its extensive damage to the nervous system and broad impact on the population. Studies have shown that fungal polysaccharides, particularly those from mushrooms, have neuroprotective effects.

Reishi · 2026 · Journal Article · Phytochemistry

Lucidumones L-P: Meroterpenoids from Ganoderma lucidum and their inhibitory effect on triple negative breast cancer.

Meroterpenoids in Ganoderma mushrooms have attracted attention in recent years. In this effort, lucidumones L-P (1-5), five undescribed meroterpenoids, including four without chirality (1-4) and a pair of enantiomers (5), were isolated from G.

OncologyImmune supportEnergy & fatigue

Turkey Tail · 2026 · Research Article · Biochemistry and biophysics reports

Nutritional, Anti-inflammatory, and in-silico inhibitory Studies of Trametes versicolor (L.) Lloyd and Flammulina velutipes (Curtis) on HER2 breast cancer protein.

This study evaluated the phytochemical, nutritional, anti-inflammatory, and in-silico anticancer properties of T. versicolor and F.

Oyster Mushroom · 2026 · Research Article · Microbial cell factories

Pleurotus ostreatus L-asparaginase's use in food safety and biotechnology: from processing assistance to bioactive agent.

BACKGROUND AND AIM: L-ASNase has attracted attention in many biomedical and food safety applications. Therefore, this study was designed to identify a novel and promising candidate for the sustainable biosynthesis of extracellular L-ASNase from P..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Journal Article · Mushroom Science and Biotechnology

Analysis of functional components in preserving Ganoderma lucidum fruiting bodies

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Mushroom Science and Biotechnology in 2025. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Characterization of the three-phase partitioned laccase from Trametes versicolor strain with antiproliferative activity against breast cancer cells.

An extracellular laccase from T. versicolor was 20.4-fold purified by three-phase partitioning with high recovery (245 %) and biochemically characterized in detail for the first time.

OncologyImmune supportLiver supportRespiratory

Reishi · 2025 · Journal Article · International journal of biological macromolecules

DCs-targeted full-cell nanovaccine based on chitosan oligosaccharide self-assembled with ganoderma lucidum polysaccharide for enhancing tumor immunotherapy.

Tumor vaccines, designed to deliver immunogenic antigens and initiate tumor-specific immune responses, hold significant promise for cancer prevention and therapy. However, their efficacy remains limited by the inherently low immunogenicity of tumor antigens and inefficient antigen presentation..

OncologyGut & microbiomeSkin & hydrationRespiratory

Yellow Morel · 2025 · Journal Article · International journal of medicinal mushrooms

Methanolic Extract of Morchella esculenta (Ascomycota) Prevents Chemotherapy-Related Cardiotoxicity in Tumor-Bearing Mice.

The quest for bioactives that confer protection against chemotherapy induced cardio toxicity is a front-line area of cardio oncology research. Species of genus Morchella have been used in traditional medicine to treat asthma, wound healing, cough, cold, indigestion, excessive phlegm and breathlessness.

Oyster Mushroom · 2025 · Research Article · Polymers

Physicochemical Characteristics of Chitosan Extracted from Pleurotus ostreatus and Its Anticancer Activity Against the MDA-MB-231 Breast Cancer Cell Line.

One of the main causes of death worldwide is cancer, a disorder in which a solid or liquid mass of cells known as a tumor develops when one or more cells lose the capacity to regulate their development..

Turkey Tail · 2025 · Journal Article · Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan

Regulation of lignocellulolytic genes in Trametes versicolor

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan in 2025. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune supportSkin & hydration

Reishi · 2024 · Journal Article · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[UPLC-Q-TOF-MS/MS qualitative analysis and HPLC determination of triterpenoids in Ganoderma lucidum spores].

Ganoderma spores are the dry and mature spores of G. lucidum or G.

OncologyImmune supportMetabolic health

Maitake · 2024 · Research Article · Applied microbiology and biotechnology

A newly discovered glycosyltransferase gene UGT88A1 affects growth and polysaccharide synthesis of Grifola frondosa.

Grifola frodosa polysaccharides, especially β-D-glucans, possess significant anti-tumor, antioxidant and immunostimulatory activities. However, the synthesis mechanism remains to be elucidated.

OncologyImmune supportMetabolic healthGut & microbiome

Niu-Chang-Chih · 2024 · Research Article · Nutrients

Antrodia camphorata Supplementation during Early Life Alters Gut Microbiota and Inhibits Young-Onset Intestinal Tumorigenesis in APC1638N Mice Later in Life.

Young-onset colorectal cancer is an increasing concern worldwide due to the growing prevalence of Westernized lifestyles in childhood and adolescence. Environmental factors during early life, particularly early-life nutrition, significantly contribute to the increasing incidence..

OncologyImmune supportRespiratory

Cordyceps · 2024 · Preprint · journal metadata

Cordyceps Sinensis Mycelium polysaccharides CP1 display anti-lung cancer activity mediated by inhibiting M2 polarization of tumor-associated macrophages

Cordyceps sinensis mycelium polysaccharide has been reported to regulate immune function, but its anti-lung cancer efficacy and its role in regulating the polarization of TAMs remain unelucidated..

Reishi · 2024 · Research Article · Foods (Basel, Switzerland)

Exploring Nutrient Profiles, Phytochemical Composition, and the Antiproliferative Activity of Ganoderma lucidum and Ganoderma leucocontextum: A Comprehensive Comparative Study.

Ganoderma, often hailed as a holistic "health package", comprises an array of nutritional components and active compounds, contributing to its esteemed status in the realm of healthy foods..